International journal of diabetes mellitus最新文献

{"title":"Early metabolic imprinting as a determinant of childhood obesity","authors":"C. Scerri ,&nbsp;C. Savona-Ventura","doi":"10.1016/j.ijdm.2010.08.003","DOIUrl":"10.1016/j.ijdm.2010.08.003","url":null,"abstract":"<div><h3>Aims</h3><p>Childhood obesity has seen an alarming increase in recent decades. This study was designed to assess the role of family history and perinatal programming in the aetiology of childhood obesity in a population known to have a high risk of developing metabolic syndrome.</p></div><div><h3>Methodology</h3><p>The study was carried out among two study populations of children. The first was a population of 206 mixed-gender 5-year-old children; the second of 230 mixed-gender 9-year-old children. The children underwent standard anthropomorphic measurements that were correlated to family history of metabolic syndrome-related illness, the child’s birth weight and a history of breastfeeding in early infant life.</p></div><div><h3>Results</h3><p>No statistically significant correlation was noted with a family history of metabolic syndrome; but a definite (<em>P</em> <!-->=<!--> <!-->0.04) negative correlation was noted with breastfeeding in the 5-year-old children. Children of low birth weight appeared to retain a lower body weight at five years of age than their higher birth weight counterparts (<em>P</em> <!-->=<!--> <!-->0.002). The pattern changed to suggest a U-shaped distribution of obesity among the various birth weight groups of children, though statistical significance was noted only for the macrosomic group (<em>P</em> <!-->=<!--> <!-->0.002).</p></div><div><h3>Conclusions</h3><p>The study confirms the importance of intrauterine and early infant nutrition towards the development of childhood and later obesity. Children of low or high birth weight should be considered at risk and parents are advised actively regarding health lifestyle and nutrition options.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 175-178"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and incidence of and risk factors for, micro-albuminuria among urban Africans with type 1 diabetes in South Africa: An inter-ethnic study","authors":"W.J. Kalk,&nbsp;F.J. Raal,&nbsp;B.I. Joffe","doi":"10.1016/j.ijdm.2010.10.003","DOIUrl":"10.1016/j.ijdm.2010.10.003","url":null,"abstract":"<div><h3>Background</h3><p>Type 1 diabetes (T1DM) in sub-Saharan Africans is rare and is associated with high mortality from nephropathy. We studied the prevalence and potential risk factors for microalbuminuria (MA) in African and in age-of-onset matched white patients with T1DM. Risk factors for MA were evaluated prospectively in an African cohort.</p></div><div><h3>Materials and Methods</h3><p>68 African and 134 white patients, age at diagnosis 10–40 years, duration of diabetes &gt; 2 years, were evaluated for MA; 48 Africans were followed prospectively.</p></div><div><h3>Results</h3><p>Africans had shorter duration of diabetes (median, 8 years vs 11 years), higher HbA1c (10.62(SD 2.52)%, vs 9.02(2.44)%, lower cholesterol (4.45(1.04) vs 5.45(1.16)mmol/l), and fewer (23.5% vs 54.5%) had adolescent diabetes onset (<em>p</em> 0.0030 for each); the prevalence of MA was 39.7% and 24.6% respectively (<em>p</em> <!-->=<!--> <!-->0.0155). In multiple regression analysis MA was associated with mean HbA1c (<em>p</em> <!-->&lt;<!--> <!-->0.0001), younger age at diagnosis (<em>p</em> <!-->=<!--> <!-->0.0060), SBP (<em>p</em> <!-->=<!--> <!-->0.0012) and African race (<em>p</em> <!-->=<!--> <!-->0.0287). Prospectively, Africans developing MA (45%) had higher mean HbA1c levels (<em>p</em> <!-->=<!--> <!-->0.0001), were more likely to have had adolescent onset of DM (33.3% vs 8.0%, <em>p</em> <!-->=<!--> <!-->0.0310) and lower BMI (<em>p</em> <!-->=<!--> <!-->0.0340); logistic regression revealed that higher HbA1c and SBP, and lower BMI predicted MA. Nine of 16 African subjects progressed to macroalbuminuria; they were characterised only by extremely poor glycaemic control (mean HbA1c, 13.49(2.00)%).</p></div><div><h3>Conclusions</h3><p>Microalbuminuria, and severe hyperglycaemia, are common in diabetic Africans with short duration TIDM; MA may rapidly progress to macroalbumiuria. African race may be associated with increased susceptibility to diabetic nephropathy.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 148-153"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between socio-demographic factors and diabetes mellitus in the north of Iran: A population-based study","authors":"Gholamreza Veghari,&nbsp;Mehdi Sedaghat,&nbsp;Hamidreza Joshaghani,&nbsp;Sed Ahmad Hoseini,&nbsp;Farhad Niknezad,&nbsp;Abdolhamid Angizeh,&nbsp;Ebrahim Tazik,&nbsp;Pooneh Moharloei","doi":"10.1016/j.ijdm.2010.09.001","DOIUrl":"10.1016/j.ijdm.2010.09.001","url":null,"abstract":"<div><h3>Objective</h3><p>This study considers the prevalence of DM and some related factors among adults in the Golestan province (north of Iran) in 2006.</p></div><div><h3>Methods</h3><p>This is a Cross-sectional–Descriptive and population-based study, carried out among 1999 cases (1000 men and 999 women) between 25 and 65<!--> <!-->years old. Participants were chosen by cluster and stratified sampling in urban and rural areas. Data on socio-demographic factors were collected using questionnaire, and anthropometric and biochemical indexes were measured. Fasting Blood Sugar (FBS) equal to or over 126<!--> <!-->mg/dl was classified as type 2 DM.</p></div><div><h3>Results</h3><p>Mean of age was 39.2<!--> <!-->years and mean<!--> <!-->±<!--> <!-->SD of FBS among men and women was 94.51<!--> <!-->±<!--> <!-->32.91 and 98.2<!--> <!-->±<!--> <!-->40.1<!--> <!-->mg/dl, respectively. Prevalence of DM was 8.3% [(men<!--> <!-->=<!--> <!-->6.8% and women<!--> <!-->=<!--> <!-->9.7%), (urban<!--> <!-->=<!--> <!-->10.5% and villages<!--> <!-->=<!--> <!-->6.4%)]. Twenty-five percent of patients were undiagnosed as whole, 43% of patients were unaware of their problem, in men more than in women (48.5% versus 39.2%) and in rural area more than in urban area (35.1% versus 54.4%). We showed a positive and significant correlation between FBS and age, waist circumference and BMI (<em>P</em> <!-->=<!--> <!-->0.01).</p></div><div><h3>Conclusion</h3><p>DM was the one of the biggest health problems in the north of Iran, and half of them were unaware of their morbidity. DM was influenced by socio-demographic factors.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 154-157"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum TNF-α and IL-6 with insulin secretion and insulin resistance in IFG and IGT subjects in a Bangladeshi population","authors":"Mosaraf Hossain ,&nbsp;M Omar Faruque ,&nbsp;Golam Kabir ,&nbsp;Naimul Hassan ,&nbsp;Dwaipayan Sikdar ,&nbsp;Quamrun Nahar ,&nbsp;Liaquat Ali","doi":"10.1016/j.ijdm.2010.08.004","DOIUrl":"10.1016/j.ijdm.2010.08.004","url":null,"abstract":"<div><h3>Background</h3><p>TNF-α and IL-6 have been shown to be associated with insulin resistance in T2 DM subjects. However, their causal role in the development of diabetes is still unsettled.</p></div><div><h3>Subjects and methods</h3><p>In the present study 106 prediabetic subjects (17 IFG, 60 IGT, 29 IFG-IGT) were studied along with age- and BMI-matched 56 healthy controls. Insulin was measured by ELISA; TNF-α and IL-6 were measured by chemiluminescence-based EIA.</p></div><div><h3>Results</h3><p>Fasting serum TNF-α and fasting serum IL-6 levels were not significantly different among the groups. However, a significant association of TNF-α (<em>p</em> <!-->&lt;<!--> <!-->0.013) with prediabetic (IGR) state on binary logistic regression analysis was shown when the effects of sex, BMI, WHR, HOMA B and HOMA S were adjusted. On multinomial logistic regression analysis a significant positive association of TNF-α was observed with IGT and IFG-IGT subjects (<em>p</em> <!-->=<!--> <!-->0.008, <em>p</em> <!-->=<!--> <!-->0.008) when the effects of sex, BMI, WHR, HOMA B and HOMA S were adjusted. On multiple linear regression analysis TNF-α showed a significant positive association with insulin secretory capacity when adjusting the effects of the confounding factors.</p></div><div><h3>Conclusions</h3><p>TNF-α is positively associated with IGT and IFG-IGT state and may have a causal relation with insulin secretory defect in IGR or prediabetic subjects.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 165-168"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial cell dysfunction in hyperglycemia: Phenotypic change, intracellular signaling modification, ultrastructural alteration, and potential clinical outcomes","authors":"Doina Popov","doi":"10.1016/j.ijdm.2010.09.002","DOIUrl":"10.1016/j.ijdm.2010.09.002","url":null,"abstract":"<div><p>Hyperglycemia, the hallmark of Diabetes mellitus, is a major risk factor for endothelial dysfunction and vascular complication. In recent years, significant achievements have been made in understanding endothelial cell dysfunction triggered by high glucose concentration. The purpose of this review is to discuss the results of these recent developments. First, the remarkable plasticity of vascular endothelial cell in response to the high glucose insult is emphasized. This is evident through the switch in the cell’s normal quiescent profile into new phenotypes, endowed with biosynthetic, inflammatory, adhesive, proliferative, migratory, pro-atherogenic, and pro-coagulant properties, frequently overlapping each other. Then, we underline the imbalanced expression and activity of transcription and signaling pathways, and the intense metabolic activity that accompanies the change in endothelial cell phenotype. As an adaptation to the high glucose-induced biochemical modification, a severe alteration of cell structure is produced. The review concludes with the clinical outcomes of the subject, emphasizing the high glucose-associated endothelial cell dysfunctional molecules of potential for targeting, and for reducing the impact of hyperglycemia on vascular endothelium. Such interventions may lead to a more efficient therapy for the benefit of those diabetic patients who are at increased cardiovascular risk.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 189-195"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum free IGF-1 and IGFBP-1 with insulin sensitivity in impaired glucose tolerance (IGT)","authors":"Golam Kabir ,&nbsp;Mosaraf Hossain ,&nbsp;M. Omar Faruque ,&nbsp;Naimul Hassan ,&nbsp;Zahid Hassan ,&nbsp;Quamrun Nahar ,&nbsp;Sultana Marufa Shefin ,&nbsp;Mohammad Alauddin ,&nbsp;Liaquat Ali","doi":"10.1016/j.ijdm.2010.09.003","DOIUrl":"10.1016/j.ijdm.2010.09.003","url":null,"abstract":"<div><p><em>Aim and Background:</em> Free IGF-1 and IGFBP-1 are associated with obesity which is one of the major features of insulin resistance. But very few studies exist on free IGF-1 and IGFBP-1 in IGT subjects. The present study was undertaken to investigate the association of free IGF-1 and IGFBP-1 with insulin sensitivity in IGT subjects. <em>Subjects and Methods:</em> Ninety-one subjects with impaired glucose tolerance (IGT) were studied along with age- sex- and BMI-matched sixty-one healthy Controls without family history of diabetes or prediabetes. Insulin, free IGF-1 and IGFBP-1 were measured by standard ELISA method. Insulin secretory capacity (HOMA B) and insulin sensitivity (HOMA S) were calculated using fasting glucose and fasting insulin by HOMA-CIGMA software. <em>Results:</em> Fasting free IGF-1 and IGFBP-1 levels were not significantly different among the study groups. In stepwise multiple regression analysis, when free IGF-1 was considered as a dependent variable with other independent variables, model 1 (<em>β</em> <!-->=<!--> <!-->−0.352, <em>p</em> <!-->=<!--> <!-->0.03), model 2 (<em>β</em> <!-->=<!--> <!-->−0.355, <em>p</em> <!-->=<!--> <!-->0.033) and model 5 (<em>β</em> <!-->=<!--> <!-->−0.378, <em>p</em> <!-->=<!--> <!-->0.026) have shown significant association of fasting glucose with free IGF-1. Similarly when IGFBP-1 was considered as a dependent variable, model 4 (<em>β</em> <!-->=<!--> <!-->−0.865, <em>p</em> <!-->=<!--> <!-->0.03) and model 5 (<em>β</em> <!-->=<!--> <!-->−0.1.07, <em>p</em> <!-->=<!--> <!-->0.004) have shown negative association of fasting glucose with IGFBP-1. In this analysis model 5 have also shown negative association of HOMA S with IGFBP-1 (<em>β</em> <!-->=<!--> <!-->−1.015, <em>p</em> <!-->=<!--> <!-->0.017). <em>Conclusion:</em> IGF1 and IGFBP-1 seems to be negatively associated with fasting glucose in IGT subjects and insulin sensitivity (HOMA S) may also be negatively associated with IGFBP-1 in IGT subjects.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 144-147"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive differences between drivers with type 1 diabetes with and without a recent history of recurrent driving mishaps","authors":"Laura K. Campbell,&nbsp;Linda A. Gonder-Frederick,&nbsp;Donna K. Broshek,&nbsp;Boris P. Kovatchev,&nbsp;Stacey Anderson,&nbsp;William L. Clarke,&nbsp;Daniel J. Cox","doi":"10.1016/j.ijdm.2010.05.014","DOIUrl":"10.1016/j.ijdm.2010.05.014","url":null,"abstract":"<div><h3>Objective</h3><p>A subset of drivers with type 1 diabetes mellitus (T1DM) may be at significant risk for hypoglycemia-related driving collisions and moving vehicle violations due to acute and chronic neurocognitive impairment. The present study compared drivers with T1DM with and without a recent history of multiple driving mishaps on a neurocognitive battery during euglycemia, progressive mild hypoglycemia, and recovery from hypoglycemia, to determine whether neurocognitive measures differentiate the two risk groups. We hypothesized that drivers with a history of multiple recent hypoglycemia-related driving mishaps would demonstrate greater psychomotor slowing, both during hypoglycemia and euglycemia.</p></div><div><h3>Study design</h3><p>Participants were 42 adults with T1DM and were assigned to one of two groups: those reporting no driving mishaps in the last year (−History) and those reporting two or more (+History). Neurocognitive testing was conducted before and repeated during a hyper-insulinemic clamping procedure.</p></div><div><h3>Results</h3><p>Not surprisingly, all drivers demonstrated a decrease in functioning across all neurocognitive tasks during hypoglycemia. However, in contrast to the common belief that neurocognitive functions return slowly and gradually following hypoglycemia, baseline neurocognitive functioning immediately recovered upon return of BG to euglycemia for all subjects. Between-group analyses revealed that subjects with a recent history of driving mishaps consistently demonstrated poorer performance on tasks measuring working memory.</p></div><div><h3>Conclusion</h3><p>Working memory is a potential neurocognitive indicator that may help differentiate adults with T1DM with and without a history of driving mishaps, predict future risk for driving mishaps, and provide targeted intervention programs to address this critical public health issue.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 2","pages":"Pages 73-77"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.05.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29509828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emphysematous pyelonephritis: A case report","authors":"Muhammad Ali ,&nbsp;Nauman Bashir Barlas","doi":"10.1016/j.ijdm.2010.05.008","DOIUrl":"10.1016/j.ijdm.2010.05.008","url":null,"abstract":"<div><p>Emphysematous pyelonephritis is a severe, acute necrotizing renal parenchymal and perirenal infection with formation of gas. Emphysematous pyelonephritis predominantly affects females with uncontrolled diabetes and can occur in insulin-dependent as well as non-insulin dependant patients. CT scan is the modality of choice for the staging of the parenchymal gas and to rule out obstruction.</p><p>We present a case of 83-year old female with uncontrolled diabetes mellitus who presented with dysurea and right flank pain in the emergency department. She was diagnosed as a case of emphysematous pyelonephritis. She was treated successfully in the urology department by antibiotics and percutaneous drainage.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 2","pages":"Pages 130-132"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.05.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parameters of metabolic syndrome are markers of coronary heart disease – An observational study","authors":"Faria Afsana ,&nbsp;Zafar Ahmed Latif ,&nbsp;M. Maksumul Haq","doi":"10.1016/j.ijdm.2010.05.007","DOIUrl":"10.1016/j.ijdm.2010.05.007","url":null,"abstract":"<div><h3>Aims</h3><p>This study was undertaken to identify the parameters of metabolic syndrome which can predict cardiovascular and peripheral vascular disease.</p></div><div><h3>Subject</h3><p>A total of 260 subjects were selected from Ibrahim Cardiac Hospital and Research Institute (ICHRI), who reported for coronary angiogram as per advice of a cardiologist.</p></div><div><h3>Method</h3><p>Each subject undergoing angiogram was interviewed with a preset structured questionnaire. The study subjects were screened for PVD (peripheral vascular disease) by examining peripheral pulses and ankle brachial index measured. Subjects with absent pulse or non-recordable ankle brachial index was considered as ankle brachial index &lt;0.9. Positive angiographic finding was defined by presence of mild to severe degree of coronary vascular narrowing of one or multiple of three coronary arteries.</p></div><div><h3>Result</h3><p>Among the study subjects 64.6% had metabolic syndrome, 79.2% had positive and 20.8% had normal angiographic finding. Among the CAG positive subjects 38.8% had single vessel disease, 30.0% had double vessel disease and 31.08% had triple vessel disease. CAG positive subjects are mostly 40–60<!--> <!-->years of age, 78.6% male, 54.8% smoker, 62.1% had waist circumference above normal, and about 90% have dyslipidemia and dysglycemia (DM/IGT/IFG). In this study subjects 83.9% of diabetic and 69.7% of non-diabetic had positive angiographic finding. Among the CAG positive subjects 16.6% had low ABI (&lt;0.9).</p></div><div><h3>Conclusions</h3><p>This study reveals that hypertriglyceridemia, waist circumference and hypertension are significantly related with angiographic positivity. Peripheral vascular disease was not significantly higher among CAG positive subjects and no association was observed between metabolic syndrome and PVD.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 2","pages":"Pages 83-87"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.05.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between metabolic syndrome and risk of cardiovascular disease, using different criteria and stratified by sex","authors":"Somlak Chuengsamarn ,&nbsp;Suthee Rattanamongkoulgul ,&nbsp;Alfredo Villarroel","doi":"10.1016/j.ijdm.2010.05.011","DOIUrl":"10.1016/j.ijdm.2010.05.011","url":null,"abstract":"<div><h3>Aim</h3><p>The purpose of this study is to determine the association between the components used to define metabolic syndrome and cardiovascular risk using different criteria stratified by sex.</p></div><div><h3>Methods</h3><p>A cross-sectional study with 608 subjects enrolled at the out-patients department of the Thai Internal Medicine Clinic was performed between October 2006 and September 2007. Included subjects had metabolic syndrome as defined by WHO, NCEP III, or IDF. The demographic and laboratory characteristic of the subjects including BMI, waist circumference, waist/hip ratio, fasting blood glucose, 2<!--> <!-->h postprandial blood glucose, triglyceride, HDL, blood pressure, and microalbuminuria, were measured and recorded by chart review. Cardiovascular risk was determined by pulse wave velocity. The sensitivity and specificity of the component of metabolic syndrome according to the three criteria were stratified by sex.</p></div><div><h3>Results</h3><p>The HDL sensitivity was higher in females than in males. Among the different component of metabolic syndrome, blood pressure gave the strongest association with cardiovascular risk, with odds ratios of 13.6, 11.97, and 10.5 for the criteria of IDF, NCEP III, and WHO, respectively. Moreover, when analyzing by sex, the odds ratio for female subjects were about two times higher than that of males. The rest of the components in each of criteria exceptional HDL gave odds ratios of 2–4.</p></div><div><h3>Conclusions</h3><p>The appropriate components to predict cardiovascular risks are: high blood pressure and cut off point of waist circumference in females, as defined by the IDF criterion, and high triglyceride in males, as defined by the IDF criterion.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 2","pages":"Pages 78-82"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.05.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}