International journal of diabetes mellitus最新文献_第8页

Obesity, diabetes and longevity in the Gulf: Is there a Gulf Metabolic Syndrome? 海湾地区的肥胖、糖尿病和寿命:是否存在海湾代谢综合征?

International journal of diabetes mellitus Pub Date : 2009-04-01 Epub Date: 2009-06-25 DOI: 10.1016/j.ijdm.2009.05.001

Geoffrey W. Guy , Alistair V.W. Nunn , Louise E. Thomas , Jimmy D. Bell

引用次数: 19

Genetics of type 2 diabetes in Arabs: What we know to date 阿拉伯人2型糖尿病的遗传学:迄今为止我们所知道的

International journal of diabetes mellitus Pub Date : 2009-04-01 Epub Date: 2009-05-21 DOI: 10.1016/j.ijdm.2009.03.003

Brian F. Meyer , Osama Alsmadi , Salma Wakil , Khalid Al-Rubeaan

{"title":"Genetics of type 2 diabetes in Arabs: What we know to date","authors":"Brian F. Meyer , Osama Alsmadi , Salma Wakil , Khalid Al-Rubeaan","doi":"10.1016/j.ijdm.2009.03.003","DOIUrl":"10.1016/j.ijdm.2009.03.003","url":null,"abstract":"<div><p>Type 2 diabetes (T2D) is among the most challenging health issues of the 21st century and is associated with an alarming rise in the incidence. The Arab population is no exception to this trend. The pathophysiological processes that lead to development of T2D are still unclear, however impairment in insulin secretion and/or action is clearly indicated. T2D is a complex disease with susceptibility being governed by the interaction of multiple genetic and environmental effects. Previous studies indicated that variants in genes encoding the pancreatic <em>β</em>-cell K+ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) are associated with type 2 diabetes. The common Pro12Ala polymorphism in peroxisome proliferator-activated receptor-<em>γ</em> gene (PPAR-<em>γ</em>) was confirmed in several studies to be associated with type 2 diabetes as well. More recently, studies reported variants within a novel gene, TCF7L2, as a putative susceptibility gene for type 2 diabetes across many ethnic backgrounds around the world. However, studies to date in Arab cohorts remain limited.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"1 1","pages":"Pages 32-34"},"PeriodicalIF":0.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Mitochondrial tRNALeu(UUR) gene mutation and maternally inherited diabetes mellitus in Pakistani population 巴基斯坦人群线粒体tRNALeu(UUR)基因突变与母系遗传性糖尿病

International journal of diabetes mellitus Pub Date : 2009-04-01 Epub Date: 2009-05-21 DOI: 10.1016/j.ijdm.2009.03.012

Abdul Khaliq Naveed, Maryam Wahid, Ayesha Naveed

{"title":"Mitochondrial tRNALeu(UUR) gene mutation and maternally inherited diabetes mellitus in Pakistani population","authors":"Abdul Khaliq Naveed, Maryam Wahid, Ayesha Naveed","doi":"10.1016/j.ijdm.2009.03.012","DOIUrl":"10.1016/j.ijdm.2009.03.012","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Maternally Inherited Diabetes Mellitus and Deafness (MIDD) occurs due to the mutations in mitochondrial DNA (mtDNA). The most common heteroplasmic point mutation reported, is in the tRNA<sup>Leu(UUR)</sup> gene, i.e., <em>A</em>3243<em>G</em>, accompanied with deafness. The objectives of the present study were to determine whether the cause of MIDD in selected Pakistani population, is also the mutation of <em>A</em>3243<em>G</em> in mitochondrial tRNA<sup>Leu(UUR)</sup> gene or not, and is there any genotype–phenotype correlation for the MIDD in this population.</p></div><div><h3>Subjects and methods</h3><p>The present study was conducted in the Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, Pakistan, during the period November 2005 to November 2007. The patients and control subjects were randomly selected from the two cities; Rawalpindi and Multan (both rural and urban areas) and were divided into three groups. (1) Fifty patients with T2DM and maternal history with feature(s) of MIDD. (2) Fifty non-diabetic first-degree relatives of patients with T2DM. (3) Fifty non-diabetic controls with no maternal history of T2DM. The patients and control subjects were scanned for the detection of potential mutations in mitochondrial DNA tRNA<sup>Leu(UUR)</sup> gene (np 3035–3456, 422 bp fragment).</p></div><div><h3>Results</h3><p>On the basis of a polymerase chain reaction, electrophoresis and mtDNA sequencing along with insulin dependence, degree of deafness in patients and subjects, it is proved that there is no <em>A</em>-to-<em>G</em> mutation at np 3243 of mitochondrial leucine tRNA gene in any of the groups studied.</p></div><div><h3>Conclusion</h3><p>It is concluded that in the Pakistani population, selected for the present study, the MIDD is not due to <em>A</em>3243<em>G</em> mutation in mitochondrial tRNA<sup>Leu(UUR)</sup> gene.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"1 1","pages":"Pages 11-15"},"PeriodicalIF":0.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.03.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Adding rosiglitazone to metformin in patients with type 2 diabetes: Effect on diabetes control and metabolic parameters 二甲双胍联合罗格列酮治疗2型糖尿病:对糖尿病控制和代谢参数的影响

International journal of diabetes mellitus Pub Date : 2009-04-01 Epub Date: 2009-05-21 DOI: 10.1016/j.ijdm.2009.03.001

Hussein Raef , Abdulraof Al-Mahfouz , Abdullah Al-Khonaizan

{"title":"Adding rosiglitazone to metformin in patients with type 2 diabetes: Effect on diabetes control and metabolic parameters","authors":"Hussein Raef , Abdulraof Al-Mahfouz , Abdullah Al-Khonaizan","doi":"10.1016/j.ijdm.2009.03.001","DOIUrl":"10.1016/j.ijdm.2009.03.001","url":null,"abstract":"<div><h3>Aim</h3><p>To evaluate the efficacy and tolerability, any changes in lipid parameters including free fatty acids and effect on weight and blood pressure, of adding Rosiglitazone to patients with type 2 DM who are not adequately controlled on maintenance dose of Metformin.</p></div><div><h3>Methods</h3><p>Prospective study of 14 patients with type 2 DM who were maintained on Metformin alone (1.5–2.5g/day). Twelve patients met the inclusion criteria, and received 4mg of Rosiglitazone daily in addition to Metformin. Patients were followed for 24 weeks and seen for 6–7 visits. The dose of Rosiglitazone was increased after 8 weeks if FBG was still ⩾160mg/dl. Full biochemical evaluation was done and safety parameters were observed at base line, at intervals during the study and at the end of the study. All patients completed the study. <em>T</em> test was used for comparison.</p></div><div><h3>Results</h3><p>Eight males and four females were studied. They had the following characteristics: Mean age was (52±6.9) years, weight was (78.2±10.1)kg BMI was (28±4)kg/m<sup>2</sup>, waist circumference was (97.5±6.5)cm, and duration of DM was (7.3±6) years. Four patients required an increase of Rosiglitazone dose to 8mg after 8 weeks.</p><p>All patients showed improvement of HbA1c levels by the end of the study. When mean base line parameters were compared to those at the end of study: HbA1c level dropped from (8.9%±1.5) to (7.1%±1.1) (<em>P</em>: 0.00003) and FBG from (205±50.6) to (150±28)mg/dl (<em>P</em>: 0.002). Free Fatty Acids (FFA) dropped from (703±213) to (510±303.6) by 8 weeks and to (574±184.6) μeq/L by the end of the study, (<em>P</em>: 0.01 and 0.06, respectively). Improvement in HbA1c did not however correlate with the level of FFA drop. There was also significant increase in HDL level (1.15±0.14)–(1.27±0.2)mmol/L, (<em>P</em>: 0.02), and weight (78.2±10.1)–(80.1± 10.9)kg (<em>P</em>: 0.01). The changes in LDL (3.02±0.57)–(3.23±0.5)mmol/L, TG (2.16±1.1)–(2.2±1.33)mmol/L, waist circumference (97.5±6.5)–(99±8.1)cm, and BP (132.5±17)–(130.2±18.8)mm Hg (systolic), were not significant.</p><p>When “Good Responders”, (HbA1c drop of >1.5%), (nine subjects) were compared to those with less than 1.5% drop (three subjects), there were no specific characteristics to define responders.</p></div><div","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"1 1","pages":"Pages 2-6"},"PeriodicalIF":0.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Thickness of the intima media as a new correlate for atherosclerosis risk factors in Indian type 2 diabetes patients 内膜中膜厚度作为印度2型糖尿病患者动脉粥样硬化危险因素的新相关性

International journal of diabetes mellitus Pub Date : 2009-04-01 Epub Date: 2009-05-21 DOI: 10.1016/j.ijdm.2009.03.002

Syed Abdus Saboor Aftab

{"title":"Thickness of the intima media as a new correlate for atherosclerosis risk factors in Indian type 2 diabetes patients","authors":"Syed Abdus Saboor Aftab","doi":"10.1016/j.ijdm.2009.03.002","DOIUrl":"10.1016/j.ijdm.2009.03.002","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The evaluation of the Common Carotid Intima Media Thickness (CCIMT) assumes a special role in patients with diabetes mellitus because of being an indicator of the pan effect of atherosclerotic risk factors and an important predictor of catastrophic vascular events. Therefore, the present study was undertaken with the objective of correlating CCIMT with the numerous risk factors of atherosclerosis in diabetes patients.</p></div><div><h3>Subjects and methods</h3><p>In the present study, 90 type 2 diabetic patients [67 males and 23 females, having assessed the CCIMT] with an age range from 32 to 78 years, with and without atherosclerotic events were recruited. Measurement of common carotid intima media thickness was measured on B-mode ultrasonography using high frequency linear transducer on a “GE LogiQ 700”.</p></div><div><h3>Results</h3><p>The results showed that significant positive correlation and independent association of CCIMT turned out with the variables <em>age</em> and <em>proteinuria</em>. However, waist/hip ratio, duration of diabetes mellitus, systolic blood pressure, glycosylated hemoglobin, triglyceride, and total cholesterol/HDL cholesterol also had positive correlation with CCIMT, but they could not achieve the level of statistical significance. The patients who had higher CCIMT values and high odds ratios for atherosclerotic events had significantly higher durations of diabetes, hypertension and presence of dyslipidemia.</p></div><div><h3>Conclusion</h3><p>This study has proven that <em>age</em> and <em>proteinuria</em> are the strongest correlates of CCIMT in type 2 diabetes mellitus. It is also suggested that further large size studies are needed to reconfirm similar results.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"1 1","pages":"Pages 7-10"},"PeriodicalIF":0.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Nutritional challenges in the elderly with diabetes 老年糖尿病患者的营养问题

International journal of diabetes mellitus Pub Date : 2009-04-01 Epub Date: 2009-05-21 DOI: 10.1016/j.ijdm.2009.05.002

Ali A. Rizvi

{"title":"Nutritional challenges in the elderly with diabetes","authors":"Ali A. Rizvi","doi":"10.1016/j.ijdm.2009.05.002","DOIUrl":"10.1016/j.ijdm.2009.05.002","url":null,"abstract":"<div><p>Adults age 60 and older will comprise two-thirds of the diabetic population by the year 2025. Older patients with diabetes are more likely to have coexistent chronic conditions like hypertension, dyslipidemia, and cardiovascular disease that may impact their nutritional requirements. The issue of attainment and maintenance of an optimal body weight in elderly diabetic persons may not be as straightforward as in other age groups, and the risk-benefit ratio may be different as well. Although increased prevalence of overweight and obesity in the elderly contributes to insulin resistance and hyperglycemia, older inhabitants of long-term care facilities who suffer from diabetes tend to be underweight. Both may signify inadequate nutritional status and lead to increased morbidity and mortality. The attendant problems of appetite changes, palatability of food, dietary restrictions, loneliness, and depression may affect the type and quantity of food consumed by elderly persons. Structured screening tools may identify nutrition-related issues that warrant evidence-based interventions. Although glucose control and health concerns are important factors in diet modification in the older population, other considerations include quality of life and individual preferences. Customizing of nutritional guidelines to the needs of the older diabetic patient makes sense.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"1 1","pages":"Pages 26-31"},"PeriodicalIF":0.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2009.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54384579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Diabetes mellitus: Health and wealth threat 糖尿病:健康和财富的威胁

International journal of diabetes mellitus Pub Date : 2009-04-01 Epub Date: 2009-05-21 DOI: 10.1016/j.ijdm.2009.03.007

Sultan Ayoub Meo

引用次数: 24

A future hope for the treatment of diabetic retinopathy, manipulating hypoxia-inducible factor-1 alpha pathway 操纵缺氧诱导因子-1 α通路是治疗糖尿病视网膜病变的未来希望

International journal of diabetes mellitus Pub Date : 2009-04-01 Epub Date: 2009-05-21 DOI: 10.1016/j.ijdm.2009.03.010

Ahmed M. Abu El-Asrar

引用次数: 0

Use of chitosan/polyamine biopolymers based cotton as a model system to prepare antimicrobial wound dressing 壳聚糖/多胺生物聚合物棉为模型体系制备抗菌创面敷料

International journal of diabetes mellitus Pub Date : 2009-04-01 Epub Date: 2009-06-09 DOI: 10.1016/j.ijdm.2009.05.005

Moustafa M.G. Fouda, R. Wittke, D. Knittel, E. Schollmeyer

引用次数: 48