International journal of diabetes mellitus最新文献

{"title":"Public health and prevention of blindness in diabetes","authors":"Einar Stefánsson , Anna Bryndís Einarsdóttir","doi":"10.1016/j.ijdm.2011.01.011","DOIUrl":"10.1016/j.ijdm.2011.01.011","url":null,"abstract":"","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"3 1","pages":"Pages 1-3"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2011.01.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive impairment in type 2 diabetes mellitus","authors":"Mohammed Abdul Hannan Hazari ,&nbsp;Barra Ram Reddy ,&nbsp;Nazia Uzma ,&nbsp;Bhaskarpillai Santhosh Kumar","doi":"10.1016/j.ijdm.2011.01.001","DOIUrl":"10.1016/j.ijdm.2011.01.001","url":null,"abstract":"<div><h3>Background</h3><p>Type 2 diabetes mellitus (T2DM) is a modern day epidemic. Chronic course of diabetes is detrimental to the cognitive functions.</p></div><div><h3>Aim</h3><p>To decipher the pattern of cognitive impairment in relation to the duration of diabetes.</p></div><div><h3>Study design</h3><p>Cross-sectional.</p></div><div><h3>Material and methods</h3><p>T2DM patients (Group I: ⩽5 years duration of diabetes, <em>n</em> <!-->=<!--> <!-->11; Group II: &gt;5 years duration of diabetes, <em>n</em> <!-->=<!--> <!-->17) without clinical evidence of central nervous system damage and non-diabetic controls (<em>n</em> <!-->=<!--> <!-->18) were studied clinically and P300 event-related potentials (ERPs) recorded using three stimuli oddball paradigm. Subjects were examined with Folstein mini-mental state examination (MMSE) for cognitive function and those showing scores more than 26 (maximum score<!--> <!-->=<!--> <!-->30) were enrolled for the study. Patients with known diabetic complications were excluded.</p></div><div><h3>Results</h3><p>P300 latencies in diabetic group did not relate linearly to the duration of diabetes. Diabetic subgroups with ⩽5 years and &gt;5 years duration of diabetes showed striking differences, patients with over 5 years of disease duration had much prolonged P300 latencies in contrast to patients with 5 years or less disease duration who showed trends similar to that of control group. Differences in P300 amplitudes between groups were non-significant. Hypertensive diabetics showed much prolongation in P300 latencies compared to normotensive diabetics.</p></div><div><h3>Conclusions</h3><p>P300 ERPs revealed cognitive dysfunction which was not detected by neuro-psychometric test (MMSE). Patients with T2DM have decreased cognitive function which is more prominent when the disease duration exceeds 5 years. Co-existence of hypertension with T2DM further increases the risk of cognitive impairment.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"3 1","pages":"Pages 19-24"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2011.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methanolic extract of Marrubium vulgare ameliorates hyperglycemia and dyslipidemia in streptozotocin-induced diabetic rats","authors":"Ahmed A. Elberry ,&nbsp;Fathalla M. Harraz ,&nbsp;Salah A. Ghareib ,&nbsp;Salah A. Gabr ,&nbsp;Ayman A. Nagy ,&nbsp;Essam Abdel-Sattar","doi":"10.1016/j.ijdm.2011.01.004","DOIUrl":"10.1016/j.ijdm.2011.01.004","url":null,"abstract":"<div><h3>Aim and background</h3><p><em>Marrubium vulgare</em> is used in traditional medicine in some countries such as Mexico in the treatment of diabetes. On the other hand, some studies reported the antioxidant effect of the extract due to its flavonoid content. The current study was designed to investigate the antidiabetic and antidyslipidemic effects of the methanolic extract of the aerial part of <em>M. vulgare</em> in streptozotocin-induced diabetic rats.</p></div><div><h3>Materials and methods</h3><p>The antidiabetic activity of a daily single oral dose of 500<!--> <!-->mg/kg/day of <em>M. vulgare</em> for 28<!--> <!-->days was evaluated by measuring the fasting blood glucose and the peak of blood glucose level within 120<!--> <!-->min of oral glucose tolerance test (OGTT) in diabetic rats. In addition, the effect of the extract on blood plasma insulin was measured as well as its effect on tissue glycogen contents in muscles and liver. Moreover, its effect on the oxidant status was evaluated.</p></div><div><h3>Results</h3><p><em>M. vulgare</em> significantly reduced the blood glucose level starting on the second week. Furthermore, the extract of <em>M. vulgare</em> showed significant increase in plasma insulin and tissue glycogen contents. The antidyslipidemic effect was demonstrated by a significant reduction in plasma total cholesterol (TC), triglycerides (TG), and low density lipoprotein-cholesterol (LDL-C), while the cardio-protective lipid, high density lipoprotein-cholesterol (HDL-C), was increased.</p></div><div><h3>Conclusion</h3><p>The present data suggest that <em>M. vulgare</em>’s methanolic extract has antihyperglycemic with antidyslipidemic effect. The protective effect of the extract may be in part due to its antioxidant activity.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"3 1","pages":"Pages 37-44"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2011.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of CD36 gene variants rs1761667 (G > A) and rs1527483 (C > T) with Type 2 diabetes in North Indian population","authors":"Monisha Banerjee ,&nbsp;Sunaina Gautam ,&nbsp;Madhukar Saxena ,&nbsp;Hemant Kumar Bid ,&nbsp;C.G. Agrawal","doi":"10.1016/j.ijdm.2010.08.002","DOIUrl":"10.1016/j.ijdm.2010.08.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Type 2 diabetes mellitus (T2DM) affects huge populations in India and abroad. Genetic polymorphisms (SNPs) in scavenger receptors such as CD36 have been implicated in the pathogenesis of diabetic atherosclerosis and cardiovascular diseases. Since <em>CD36</em> gene expression contributes to T2DM, we proposed to study the association of two of its polymorphisms.</p></div><div><h3>Methods</h3><p>A population of 400 subjects from North India was analyzed according to clinical parameters. Out of them 150 controls and 250 T2DM patients were genotyped for two SNPs namely rs1761667 (G<!--> <!-->&gt;<!--> <!-->A) and rs1527483 (C<!--> <!-->&gt;<!--> <!-->T) in the <em>CD36</em> gene using polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP) followed by statistical analysis.</p></div><div><h3>Results and discussion</h3><p>No association of rs1527483 (C<!--> <!-->&gt;<!--> <!-->T) SNP was observed in T2DM patients. The GA genotype was prevalent in 76.0% diabetic population and a highly significant genotypic association of rs1761667 (G<!--> <!-->&gt;<!--> <!-->A) SNP in <em>CD36</em> gene was observed in them (<em>P</em> <!-->=<!--> <!-->&lt;0.001; OR 3.173; CI 1.098–9.174). Sample characteristics showed a highly significant association with lipid profile (<em>P</em> <!-->=<!--> <!-->&lt;0.001). The ‘GA’ genotype in combination with CC genotype showed a significant association with TC (<em>P</em> <!-->=<!--> <!-->0.020), LDL (<em>P</em> <!-->=<!--> <!-->0.005) and VLDL (<em>P</em> <!-->=<!--> <!-->0.029). In addition, the haplotype analysis CC/GA (−/+) and CT/GA (−/+) showed a strong association with TC and LDL (<em>P</em> <!-->&lt;<!--> <!-->0.05). The presence of −31118<!--> <!-->A∗ allele in haplotypes showed strong association with T2DM (<em>P</em> <!-->=<!--> <!-->&lt;0.005).</p></div><div><h3>Conclusion</h3><p>Out of the two <em>CD36</em> gene polymorphisms tested, rs1761667 SNP is significantly associated with T2DM with the GA heterozygous genotype showing highest frequency among the T2DM patients.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 179-183"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current clinical status and complications among type 2 diabetic patients in Universiti Sains Malaysia hospital","authors":"Salwa Selim Ibrahim Abougalambou ,&nbsp;Mafauzy Mohamed ,&nbsp;Syed Azhar Syed Sulaiman ,&nbsp;Ayman S. Abougalambou ,&nbsp;Mohamed Azmi Hassali","doi":"10.1016/j.ijdm.2010.08.001","DOIUrl":"10.1016/j.ijdm.2010.08.001","url":null,"abstract":"<div><h3>Objective</h3><p>To identify current clinical status of type 2 diabetic outpatients and to determine the prevalence of diabetic complications and risk factors.</p></div><div><h3>Material and method</h3><p>Prospective cross-sectional study design was used in the data collection process. The study sample consists of 1077 type 2 Diabetes Mellitus outpatients who fit the inclusion criteria. All the patients were recruited from the diabetic outpatient clinics from Hospital Universiti Sains Malaysia (HUSM). The study period was from January till December 2007. Demographic data, clinical status of diabetes and its complications were collected and analyzed for the prevalence of complications and risk factors.</p></div><div><h3>Results</h3><p>One thousand and seventy seven type 2 diabetes outpatients were included in the present study. Mean age was 58.3<!--> <!-->years and duration of diabetes was 11<!--> <!-->years. Only 23.4% of the subjects achieved HbA1c of ⩽7%, 53.5% of patients had achieved target FPG ⩽6.7<!--> <!-->mmol/l, and 60.4% of the patients had achieved optimal postprandial plasma glucose level &lt;10<!--> <!-->mmol/l. The overall prevalence of dyslipidaemia was 93.7%, hypertension was 92.7% and obesity was 81.5%. Nephropathy was the most common complication accounting for 91.0% followed by neuropathy 54.4%, retinopathy 39.3%, and macrovascular complications 17.5%. The vascular complications were significantly associated with the age (<em>P</em> <!-->&lt;<!--> <!-->0.001), BMI (<em>P</em> <!-->&lt;<!--> <!-->0.001), and triglyceride (<em>P</em> <!-->&lt;<!--> <!-->0.001).</p></div><div><h3>Conclusion</h3><p>The prevalence of dyslipidaemia, hypertension and obesity were high. The high prevalence of vascular complications was associated with age, BMI and triglyceride of diabetic patients. Effort to treat triglyceride appropriately among elderly diabetic patients could be considered as a prime target.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 184-188"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free radical activity in hypertensive type 2 diabetic patients","authors":"Suvarna Prasad,&nbsp;Ajay Kumar Sinha","doi":"10.1016/j.ijdm.2010.10.002","DOIUrl":"10.1016/j.ijdm.2010.10.002","url":null,"abstract":"<div><h3>Background</h3><p>Free radical activity is an important cause of vascular complications in type 1 diabetes mellitus. But data regarding vascular complications in type 2 diabetes mellitus are scant.</p></div><div><h3>Objectives</h3><p>The aim of this study was to examine free radical activity in type 2 diabetic patients with hypertension compared to those without hypertension.</p></div><div><h3>Materials and Methods</h3><p>The serum levels of lipid peroxidation product, MDA malondialdehyde), the free radical scavenger, SOD (superoxide dismutase) and NO (nitric oxide) were studied in 50 type 2 diabetic outpatients. Controls were regarded as those diabetic outpatients who did not have hypertension.</p></div><div><h3>Result</h3><p>Among 50 patients thus studied 19 were hypertensive. The concentration (median (range)) of both SOD (21.31(5.33–26.64) vs. 16.65(6.66–22.64)<!--> <!-->U/dl; <em>p</em> <!-->&lt;<!--> <!-->0.05) and NO (18.54 (11.40–37.07) vs. 21.39(15.69–35.65)<!--> <!-->U/dl; <em>p</em> <!-->&lt;<!--> <!-->0.05) were reduced in the hypertensive group. Similarly, concentration (median (range) of MDA (359(231–718) vs. 385(256–666)<!--> <!-->μmoles/dl; <em>p</em> <!-->&lt;<!--> <!-->0.01 were increased in the hypertensive group.</p></div><div><h3>Conclusion</h3><p>The reduction in serum levels of SOD and NO with a concomitant increase in serum MDA levels is consistent with an increase in free radical activity in hypertensive type 2 diabetics.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 141-143"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High glucose-induced DNA-binding activities of nuclear factor of activated T cells 5 and carbohydrate response element binding protein to the myo-inositol oxygenase gene are inhibited by sorbinil in peripheral blood mononuclear cells from patients with type 1 diabetes mellitus and nephropathy","authors":"Bingmei Yang,&nbsp;Andrea Hodgkinson,&nbsp;Beverley A. Millward,&nbsp;Andrew G. Demaine","doi":"10.1016/j.ijdm.2010.08.005","DOIUrl":"https://doi.org/10.1016/j.ijdm.2010.08.005","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate whether high glucose induces myo-inositol oxygenase (MIOX) expression in peripheral blood mononuclear cells through transcription factors, nuclear factor of activated T cells 5 (NFAT5) and carbohydrate response element binding protein (ChREBP), which may contribute to the pathogenesis of diabetic nephropathy.</p></div><div><h3>Methods</h3><p>34 patients with type 1 diabetes mellitus (20 with nephropathy, 14 without complications) and 9 healthy controls were recruited in this study. Peripheral blood mononuclear cells were exposed to normal, high glucose conditions with/without an aldose reductase inhibitor (ARI), using electrophoretic mobility shift assays the DNA-binding activities of NFAT5 and ChREBP to corresponding sites in the promoter region of MIOX gene were analysed. The protein levels and the enzyme activity of MIOX were measured.</p></div><div><h3>Results</h3><p>DNA-binding activities of NFAT5 and ChREBP were increased under high glucose conditions and decreased in the presence of the ARI in all groups. In the presence of ARI, the DNA-binding activities of NFAT5 and ChREBP were significantly decreased by 41% (NFAT5: 0.91<!--> <!-->±<!--> <!-->0.06 vs. 1.54<!--> <!-->±<!--> <!-->0.12; <em>p</em> <!-->=<!--> <!-->0.01) and 49% (ChREBP: 0.92<!--> <!-->±<!--> <!-->0.08 vs. 1.81<!--> <!-->±<!--> <!-->0.22; <em>p</em> <!-->=<!--> <!-->0.001) compared with high glucose in patients with nephropathy. ARI treatment decreased the protein levels of MIOX under high glucose conditions in patients with nephropathy (0.81<!--> <!-->+<!--> <!-->0.19 vs. 1.3<!--> <!-->+<!--> <!-->0.04; <em>p</em> <!-->=<!--> <!-->0.049).</p></div><div><h3>Summary/conclusions</h3><p>There was a trend for increased binding activities of NFAT5 and ChREBP accompanied with increased protein levels under high glucose, particularly in patients with nephropathy. ARI treatment prevented these increases and this effect was more obvious in the patients with nephropathy compared to the uncomplicated subjects.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 169-174"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.08.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136849657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous gas gangrene of the scrotum in patient with severe diabetic ketoacidosis","authors":"Chu Zhang,&nbsp;Lizhen Ma,&nbsp;Fengying Peng,&nbsp;Yin Wu,&nbsp;Yu Chen,&nbsp;Yuhong Zhan,&nbsp;Xianfeng Zhang","doi":"10.1016/j.ijdm.2010.09.004","DOIUrl":"10.1016/j.ijdm.2010.09.004","url":null,"abstract":"<div><p>A 52-year-old Chinese man presented with severe diabetic ketoacidosis and markedly inflated scrotum. Computed tomographic scans of the lower pelvis show extensive gas accumulation and inflammatory changes in both sides of the scrotum. Gas gangrene of the scrotum was diagnosed and radical debridement along with other proactive anti-ketoacidosis therapy was performed immediately. Clostridium perfringens was found in cultures of necrotic tissue that verified the diagnosis and the patient was cured through multiple proactive treatments.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 196-198"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raising the priority accorded to diabetes in global health and development: A promising response…","authors":"Ala Alwan","doi":"10.1016/j.ijdm.2010.10.001","DOIUrl":"10.1016/j.ijdm.2010.10.001","url":null,"abstract":"","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 139-140"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new paradigm between mechanical scaling and root planing combined with adjunctive chemotherapy for glycated hemoglobin improvement in diabetics","authors":"Sultan Al Mubarak ,&nbsp;Marwan Abou Rass ,&nbsp;Abdulaziz Alsuwyed ,&nbsp;Khalid Al-Zoman ,&nbsp;Abdulaziz Al Sohail ,&nbsp;Samia Sobki ,&nbsp;Mohammed Tariq ,&nbsp;Asirvatham Alwin Robert ,&nbsp;Sebastian Ciancio ,&nbsp;Paresh Dandona","doi":"10.1016/j.ijdm.2010.08.006","DOIUrl":"10.1016/j.ijdm.2010.08.006","url":null,"abstract":"<div><h3>Aim</h3><p>The objective of the study was to evaluate the effectiveness of scaling and root planing (SRP) and adjunctive chemotherapy (doxycycline hyclate, 20<!--> <!-->mg) on gingival health, specific cytokines and glycemic control in diabetic subjects.</p></div><div><h3>Methods</h3><p>Three hundred and forty-six type 1 and 2 diabetic subjects were randomized into four test groups: (1) one session of SRP at the baseline visit and placebo tablets twice/day, started at the baseline visit, for 3<!--> <!-->months, (2) one session of SRP at the baseline visit, and doxycycline hyclate (20<!--> <!-->mg, twice/day) started at the baseline visit for 3<!--> <!-->months, (3) two sessions of SRP, first at the baseline visit and second at the 6<!--> <!-->months, with placebo tablets twice/day started at the baseline visit and 6-month visit, for 3<!--> <!-->months at each visit, and (4) two sessions of SRP, first at the baseline visit and the second at the 6-month visit, and doxycycline hyclate 20<!--> <!-->mg twice/day, started at the baseline visit and the 6-month visit, for 3<!--> <!-->months at each visit. Venous blood samples were obtained to evaluate TNF-α, IL-1α and glycated hemoglobin (HbA1c); dental measurements were also included.</p></div><div><h3>Results</h3><p>HbA1c showed significant improvement (<em>P</em> <!-->&lt;<!--> <!-->0.05) only for subjects with glycated hemoglobin ⩽8.8% within each group, as well as when subjects were combined together. All groups achieved statistically significant improvements for most of the dental parameters at follow-up visits (<em>P</em> <!-->&lt;<!--> <!-->0.05) compared to the baseline.</p></div><div><h3>Conclusions</h3><p>Eliminating periodontal inflammation may significantly reduce glycated hemoglobin levels for subjects with HbA1c ⩽8.8%; furthermore, SRP and adjunctive therapy improved periodontal inflammation in diabetics.</p></div>","PeriodicalId":89155,"journal":{"name":"International journal of diabetes mellitus","volume":"2 3","pages":"Pages 158-164"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijdm.2010.08.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54385150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}