Free radical activity in hypertensive type 2 diabetic patients

International journal of diabetes mellitus Pub Date : 2010-12-01 Epub Date: 2010-11-03 DOI:10.1016/j.ijdm.2010.10.002

Suvarna Prasad, Ajay Kumar Sinha

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引用次数: 15

Abstract

Background

Free radical activity is an important cause of vascular complications in type 1 diabetes mellitus. But data regarding vascular complications in type 2 diabetes mellitus are scant.

Objectives

The aim of this study was to examine free radical activity in type 2 diabetic patients with hypertension compared to those without hypertension.

Materials and Methods

The serum levels of lipid peroxidation product, MDA malondialdehyde), the free radical scavenger, SOD (superoxide dismutase) and NO (nitric oxide) were studied in 50 type 2 diabetic outpatients. Controls were regarded as those diabetic outpatients who did not have hypertension.

Result

Among 50 patients thus studied 19 were hypertensive. The concentration (median (range)) of both SOD (21.31(5.33–26.64) vs. 16.65(6.66–22.64) U/dl; p < 0.05) and NO (18.54 (11.40–37.07) vs. 21.39(15.69–35.65) U/dl; p < 0.05) were reduced in the hypertensive group. Similarly, concentration (median (range) of MDA (359(231–718) vs. 385(256–666) μmoles/dl; p < 0.01 were increased in the hypertensive group.

Conclusion

The reduction in serum levels of SOD and NO with a concomitant increase in serum MDA levels is consistent with an increase in free radical activity in hypertensive type 2 diabetics.

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高血压2型糖尿病患者的自由基活性

背景自由基活性是1型糖尿病血管并发症的重要原因。但是关于2型糖尿病血管并发症的数据很少。目的本研究的目的是比较2型糖尿病合并高血压患者与无高血压患者的自由基活性。材料与方法测定50例2型糖尿病门诊患者血清脂质过氧化产物、丙二醛(MDA)、自由基清除剂、超氧化物歧化酶(SOD)、一氧化氮(NO)水平。对照组为没有高血压的糖尿病门诊患者。结果50例患者中高血压19例。两种SOD的浓度中位数(范围)分别为21.31(5.33-26.64)和16.65(6.66-22.64)U/dl;p & lt;0.05)和(18.54(11.40 - -37.07)和21.39 (15.69 - -35.65)U / dl;p & lt;高血压组降低0.05)。同样，MDA浓度(中位数(范围))分别为359(231-718)和385(256-666)μmol /dl;p & lt;高血压组升高0.01。结论高血压2型糖尿病患者血清SOD、NO水平降低，同时血清MDA水平升高，与自由基活性升高一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of diabetes mellitus

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