Bioinorganic Chemistry and Applications最新文献

{"title":"Evaluation of the Antitumor Effects of Platinum-Based [Pt(<i>η</i>¹-C₂H₄-OR)(DMSO)(phen)]⁺ (R = Me, Et) Cationic Organometallic Complexes on Chemoresistant Pancreatic Cancer Cell Lines.","authors":"Erika Stefàno,&nbsp;Luca Giulio Cossa,&nbsp;Federica De Castro,&nbsp;Erik De Luca,&nbsp;Viviana Vergaro,&nbsp;Giulia My,&nbsp;Gianluca Rovito,&nbsp;Danilo Migoni,&nbsp;Antonella Muscella,&nbsp;Santo Marsigliante,&nbsp;Michele Benedetti,&nbsp;Francesco Paolo Fanizzi","doi":"10.1155/2023/5564624","DOIUrl":"https://doi.org/10.1155/2023/5564624","url":null,"abstract":"<p><p>Pancreatic cancer is one of the most lethal malignancies with an increasing incidence and a high mortality rate, due to its rapid progression, invasiveness, and resistance to anticancer therapies. In this work, we evaluated the antiproliferative and antimigratory activities of the two organometallic compounds, [Pt(<i>η</i>¹-C₂H₄-OMe)(DMSO)(phen)]Cl (<b>1</b>) and [Pt(<i>η</i>¹-C₂H₄-OEt)(DMSO)(phen)]Cl (<b>2</b>), on three human pancreatic ductal adenocarcinoma cell lines with different sensitivity to cisplatin (Mia PaCa-2, PANC-1, and YAPC). The two cationic analogues showed superimposable antiproliferative effects on the tested cells, without significant differences depending on alkyl chain length (Me or Et). On the other hand, they demonstrated to be more effective than cisplatin, especially on YAPC cancer cells. For the interesting cytotoxic activity observed on YAPC, further biological assays were performed, on this cancer cell line, to evaluate the apoptotic and antimetastatic properties of the considered platinum compounds (<b>1</b> and <b>2</b>). The cytotoxicity of <b>1</b> and <b>2</b> compounds appeared to be related to their intracellular accumulation, which was much faster than that of cisplatin. Both <b>1</b> and <b>2</b> compounds significantly induced apoptosis and cell cycle arrest, with a high accumulation of sub-G1 phase cells, compared to cisplatin. Moreover, phenanthroline-containing complexes caused a rapid loss of mitochondria membrane potential, ΔΨ_<i>M</i>, if compared to cisplatin, probably due to their cationic and lipophilic properties. On 3D tumor spheroids, <b>1</b> and <b>2</b> significantly reduced migrated area more than cisplatin, confirming an antimetastatic ability.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41100966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>g</i>-C₃N₄-Co₃O₄ Z-Scheme Junction with Green-Synthesized ZnO Photocatalyst for Efficient Degradation of Methylene Blue in Aqueous Solution.","authors":"Mintesinot Tamiru Mengistu, Tadele Hunde Wondimu, Dinsefa Mensur Andoshe, Jung Yong Kim, Osman Ahmed Zelekew, Fekadu Gashaw Hone, Newaymedhin Aberra Tegene, Noto Susanto Gultom, Ho Won Jang","doi":"10.1155/2023/2948342","DOIUrl":"10.1155/2023/2948342","url":null,"abstract":"<p><p>A simple wet chemical ultrasonic-assisted synthesis method was employed to prepare visible light-driven g-C₃N₄-ZnO-Co₃O₄ (GZC) heterojunction photocatalysts. X-ray diffraction (XRD), scanning electromicroscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), ultraviolet (UV), and electrochemical impedance spectroscopy (EIS) are used to characterize the prepared catalysts. XRD confirms the homogenous phase formation of g-C₃N₄, ZnO, and Co₃O₄, and the heterogeneous phase for the composites. The synthesized ZnO and Co₃O₄ by using cellulose as a template show a rod-like morphology. The specific surface area of the catalytic samples increases due to the cellulose template. The measurements of the energy band gap of a g-C₃N₄-ZnO-Co₃O₄ composite showed red-shifted optical absorption to the visible range. The photoluminescence (PL) intensity decreases due to the formation of heterojunction. The PL quenching and EIS result shows that the reduction of the recombination rate and interfacial resistance result in charge carrier kinetic improvement in the catalyst. The photocatalytic performance in the degradation of MB dye of the GZC-3 composite was about 8.2-, 3.3-, and 2.5-fold more than that of the g-C₃N₄, g-C₃N₄-ZnO, and g-C₃N₄-Co₃O₄ samples. The Mott-Schottky plots of the flat band edge position of g-C₃N₄, ZnO, Co₃O₄, and Z-scheme g-C₃N₄-ZnO-Co₃O₄ photocatalysts may be created. Based on the stability experiment, GZC-3 shows greater photocatalytic activity after four recycling cycles. As a result, the GZC composite is environmentally friendly and efficient photocatalyst and has the potential to consider in the treatment of dye-contaminated wastewater.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10005340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired Synthesis of Zinc Molybdate Nanoparticles: An Efficient Material for Growth Inhibition of <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and Dye Remediation.","authors":"Sanjeev Machindra Reddy, Smita Badur Karmankar, Hayat Ali Alzahrani, Arti Hadap, Amjad Iqbal, Rawaf Alenazy, Mounir M Salem-Bekhit, Bhawana Jain","doi":"10.1155/2023/1287325","DOIUrl":"10.1155/2023/1287325","url":null,"abstract":"<p><p>Zinc molybdate nanoparticles with molybdate are synthesized through green method with different salt precursors using <i>Moringa oleifera</i> leaf extract. Those nanoparticles had structural, vibrational, and morphological properties, which were determined by X-ray diffraction (XRD). The crystalline size of synthesized zinc molybdate was 24.9 nm. Fourier transform infrared (FTIR) spectroscopy and field emission scanning electron microscopy (FE-SEM) clearly showed the attachment of molybdate with ZnO. The synthesized nanomaterial was also characterized through UV-visible spectroscopy which had 4.40 eV band gap energy. Those nanoparticles were also characterized via thermogravimetric analysis (TGA-DTA) and photoluminance spectroscopy (PL). ZnMoO₄ had photocatalytic property via methylene blue dye. After 190 minutes, the dye changed to colourless from blue colour. The degradation efficiency was around 92.8%. It also showed their antibacterial effect via <i>Escherichia coli</i> and <i>Staphylococcusaureus</i> bacterial strains. In the presence of light and air, nanoparticles of ZnMoO₄ inhibit the growth of cells of <i>E. coli</i> and <i>S. aureus</i> bacterial strains because of ROS (reactive oxygen species) generation. Because of the formation of singlet oxygen (O₂^<i>∗</i>-), hydrogen oxide radical (-OH^<i>∗</i>), and hydrogen peroxide (H₂O₂), ZnMoO₄ showed photodegradation reaction against aq. solution of methylene blue dye at 6 pH with constant time interval. With time, the activity of ZnMoO₄ also decreased because of the generation of a layer of hydrogen oxide (-OH) on nanomaterial surface, which could be washed with ethanol and distilled water. After drying, the catalytic Zinc molybdate nanoparticles could be reused again in the next catalytic reaction.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11018371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74654771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis-Based Al₂O₃ Nanofiller from <i>Cymbopogon citratus</i> Leaf/Jute/Hemp/Epoxy-Based Hybrid Composites with Superior Mechanical Properties.","authors":"L Natrayan, Yenda Srinivasa Rao, Puthalapattu Reddy Prasad, Kul Bhaskar, Pravin P Patil, Dereje Bayisa Abdeta","doi":"10.1155/2023/9299658","DOIUrl":"10.1155/2023/9299658","url":null,"abstract":"<p><p>Metallic nanoparticles (NPs) manufactured by ecofriendly strategies have also received much interest because of their elastic scattering properties and performance in nanomaterials. Aluminium oxide nanomaterials stand out among nanomaterials due to their tremendous uses in ceramic products, fabrics, therapeutic agents, catalyst supports, sewage sludge, and biosensors. The current paper investigates the effect of the nanoparticle composition and layer sequential on the mechanical characteristics of jute (J)-hemp (H) incorporated with an aluminium oxide polymer composite. NaOH is used to change the physical aspects of both plant fibres. A total of 20 specimens were tested with varying stacking sequences and padding weight ratios. Mechanical properties like a nanocomposite's tension, bending, and ILSS was measured. Stacked series and flowability substantially impact the nanocomposite. The Group 3 nanocomposite with 2% Al₂O₃ has the highest tensile strength, 54.28% of the Group 1 and 2 combinations. The stack series significantly influences the material properties of nanomaterials. Because of the alternating layers of natural fabrics, Group 4 specimens have the maximum flexural strength. Group 3 composite materials have the highest ILSS because they have hemp on the outermost surface. It has been discovered that Group 4 material with a 2% Al₂O₃ concentration is possibly the most substantial material. The existence of Al₂O₃ nanoparticles in the green synthesis was confirmed by XRD analysis.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9399538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis of Iron Oxide Nanoparticles Using Leaf Extract of Ruellia tuberosa: Mechanical and Dynamic Mechanical Behaviour Kevlar-Based Hybrid Epoxy Composites.","authors":"L Natrayan, Yenda Srinivasa Rao, Gayatri Vaidya, Sumanta Bhattacharya, S Kaliappan, Pravin P Patil, Prabhu Paramasivam","doi":"10.1155/2023/1731931","DOIUrl":"10.1155/2023/1731931","url":null,"abstract":"<p><p>One of the more enticing, ecologically responsible, as well as safe and sustainable methodologies is eco-friendly nanomaterial synthesis. Vegetation materials will be used as reductants instead of toxic substances for synthesising nanoparticles. The current study used Ruellia tuberosa (RT) leaf extract digest to synthesise FeO nanomaterials, which were then characterised using XRD. Following that, microbially produced FeO molecules were mixed with a Kevlar-based polymeric matrix to study the blended consequences. To examine the interbreeding, the current experimental analyses were performed, including both static and dynamic mechanical characteristics. The addition of FeO nanofillers improved the elastic modulus, tensile strength, and storage modulus of the nanocomposite. Impact force uptake has been raised to a certain extent by the addition of nanoparticles. The findings of this research show that incorporating FeO nanofillers into Kevlar fabrics is a promising technique for increasing the mechanical characteristics of hybrid laminated composites. As per DMA evaluation, the sample without nanomaterials had a more volcanic lava response, which is a useful thing for body systems for missile use. Another critical aspect of a nanoparticles-filled nanocomposite that must be addressed is the relatively uniform scattering of padding as well as the development of interfacial adhesion in such a combination. The presence of FeO fillers in polymeric composites is confirmed by XRD analysis.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9394726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5-Fluorouracil-Loaded PLGA Nanoparticles: Formulation, Physicochemical Characterisation, and <i>In Vitro</i>Anti-Cancer Activity.","authors":"Reem M Gahtani, Ali Alqahtani, Taha Alqahtani, Saeed Ahmed Asiri, Jamal Moideen Muthu Mohamed, S Venkatesa Prabhu, Endalew Yaze Muluneh","doi":"10.1155/2023/2334675","DOIUrl":"10.1155/2023/2334675","url":null,"abstract":"<p><p>The major goal of this investigation was to prepare a drug delivery of polymeric nanoparticles (NPs) from 5-fluorouracil (FU) that could be delivered intravenously and improve the therapeutic index of the FU. In order to achieve this, interfacial deposition method was used to prepare FU entrapped poly-(lactic-co-glycolic acid) nanoparticles (FU-PLGA-NPs). The influence of various experimental settings on the effectiveness of FU integration into the NPs was assessed. Our findings show that the technique used to prepare the organic phase and the ratio of the organic phase to the aqueous phase had the greatest impact on the effectiveness of FU integration into NPs. The results show that the preparation process produced spherical, homogenous, negatively charged particles with a nanometric size of 200 nm that are acceptable for intravenous delivery. A quick initial release over 24 h and then slow and steady release of FU from the formed NPs, exhibiting a biphasic pattern. Through the human small cell lung cancer cell line (NCI-H69), the <i>in vitro</i> anti-cancer potential of the FU-PLGA-NPs was evaluated. It was then associated to the <i>in vitro</i> anti-cancer potential of the marketed formulation Fluracil®. Investigations were also conducted into Cremophor-EL (Cre-EL) potential activity on live cells. The viability of NCI-H69 cells was drastically reduced when they were exposed to 50 <i>µ</i>g·mL^-1 Fluracil®. Our findings show that the integration of FU in NPs significantly increases the drug cytotoxic effect in comparison to Fluracil®, with this potential effect being particularly important for extended incubation durations.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9414267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Activated Carbon: A Supporting Material for Improving <i>Clostridium beijerinckii</i> TISTR1461 Immobilized Fermentation.","authors":"Piyawat Chinwatpaiboon, Akarin Boonsombuti, Thanyalak Chaisuwan, Ancharida Savarajara, Apanee Luengnaruemitchai","doi":"10.1155/2023/3600404","DOIUrl":"10.1155/2023/3600404","url":null,"abstract":"<p><p>This study aimed to investigate the effect of activated carbon (AC) as an immobilization material in acetone-butanol-ethanol fermentation. The AC surface was modified with different physical (orbital shaking and refluxing) and chemical (nitric acid, sodium hydroxide and, (3-aminopropyl)triethoxysilane (APTES)) treatments to enhance the biobutanol production by <i>Clostridium beijerinckii</i> TISTR1461. The effect of surface modification on AC was evaluated using Fourier-transform infrared spectroscopy, field emission scanning electron microscopy, surface area analyses, and X-ray photoelectron spectroscopy, while the fermented broth was examined by high-performance liquid chromatography. The chemical functionalization significantly modified the physicochemical properties of the different treated ACs and further enhanced the butanol production. The AC treated with APTES under refluxing provided the best fermentation results at 10.93 g/L of butanol, 0.23 g/g of yield, and 0.15 g/L/h of productivity, which were 1.8-, 1.5-, and 3.0-fold higher, respectively, than that in the free-cell fermentation. The obtained dried cell biomass also revealed that the treatment improved the AC surface for cell immobilization. This study demonstrated and emphasized the importance of surface properties to cell immobilization.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9242316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomolecule Protective and Photocatalytic Potential of Cellulose Supported MoS₂/GO Nanocomposite.","authors":"Muhammad Pervaiz, Muti Ur Rehman, Faisal Ali, Umer Younas, Mika Sillanpaa, Rizwan Kausar, Asma A Alothman, Mohamed Ouladsmane, Mohammad Abdul Mazid","doi":"10.1155/2023/3634726","DOIUrl":"10.1155/2023/3634726","url":null,"abstract":"<p><p>In the current study, cellulose/MoS₂/GO nanocomposite has been synthesized by a hydrothermal method. Reports published regarding efficiency of Mo and graphene oxide-based nanocomposites for environmental remediation motivated to synthesize cellulose supported MoS₂/GO nanocomposite. Formation of nanocomposite was initially confirmed by UV-visible and FTIR spectroscopic techniques. Particle size and morphology of the nanocomposite were assessed by scanning electron microscopy (SEM), and it was found having particle size ranging from 50 to 80 nm and heterogeneous structure. The XRD analysis also confirmed the structure of the nanocomposite having cellulose, MoS₂, and GO. The synthesized nanocomposite was further tested for biomolecule protective potential employing different radical scavenging assays. Results of radical DPPH^● (50%) and ABTS ^<b>●+</b> (51%) scavenging studies indicate that nanocomposites can be used as a biomolecule protective agent. In addition, nanocomposite was also evaluated for photocatalytic potential, and the results showed excellent photocatalytic properties for the degradation of 4-nitrophenol up to 75% and methylene blue and methyl orange up to 85% and 70%, respectively. So, this study confirmed that cellulose supported/stabilized MoS₂/GO nanocomposite can be synthesized by an ecofriendly, cost-effective, and easy hydrothermal method having promising biomolecule protective and photocatalytic potential.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9145859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid MWCNT and TiO₂ Nanoparticle-Suspended Waste Tyre Oil Biodiesel for CI Engines.","authors":"T Sathish, V Mohanavel, T Raja, M Ravichandran, P Murugan, S Suresh Kumar, Sultan Alqahtani, Sultan Alshehery, J Isaac Joshua Ramesh Lalvani","doi":"10.1155/2023/8626155","DOIUrl":"10.1155/2023/8626155","url":null,"abstract":"<p><p>Nowadays, scarcity arises in almost all our basic needs, including water, fuel, and food. Recycling used and scrapped things for a valuable commodity is highly appreciable for compensating for the globally fast-growing demand. This paper aims to investigate waste tyre oil for preparing biodiesel for CI engines by enhancing their performance with hybrid nanoparticles for preparing nanofuel and hybrid nanofuel. The nanoparticles (30-40 nm) of MWCNT and TiO₂ were utilized to prepare nanofuels with nanoparticle concentrations of MWCNT (300 ppm) and TiO₂ (300 ppm), respectively. In the case of hybrid nanofuel, the nanoparticle concentration of MWCNT (150 ppm) and TiO₂ (150 ppm) was preferred. The performance of the proposed nanofuel and hybrid nanofuel with pure diesel was evaluated. The proposed fuel performance outperforms the combustion performance, has higher engine efficiency, and has fewer emissions. The best performances were noticed in hybrid nanofuel that has 32% higher brake thermal efficiency than diesel and 24% and 4% lower BSFC and peak pressure than diesel, respectively. The emission performance is also 29%, 50%, and 13% lower in CO, HC, and CO₂ emissions than that in pure diesel.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9275832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moxifloxacin Metal Complexes: Synthesis, Characterisation, Antimicrobial and Antidiabetic Activities with Docking Studies","authors":"Sajjad Ali, Huaiji Zheng, Asma Zaidi, Farhan Ahmed Khan, Syed Majid Bukhari, M. Riaz, Muhammad Mumtaz Khan, S. Sammi, Inham u-llah, Ammad Amin, M. Jahangir","doi":"10.1155/2023/3754561","DOIUrl":"https://doi.org/10.1155/2023/3754561","url":null,"abstract":"Six new metal complexes of Fe(III), Cu(II), and Hg(II) were synthesised, i.e., three (2, 4, and 5) with moxifloxacin (mono-ligand) and the other three (1, 3 and 6) with moxifloxacin and hydrazine (biligand). These were characterised through UV-Vis, FT-IR, elemental analysis (CHN), atomic absorption spectroscopy, TGA, scanning electron microscopy (SEM), and powder XRD studies. Further, all of these compounds were screened for their antimicrobial, cytotoxic, and antidiabetic potential. The study revealed that the synthesised metal complexes possess an excellent ability to become antifungal agents compared to moxifloxacin. Additionally, the cytotoxicity of compounds 1, 3, and 4 was in the acceptable range with much better antidiabetic potential as compared to the ligand moxifloxacin. Interestingly, the α-amylase inhibition activity of complexes 1 and 3 was found very close to the standard drug acarbose. Furthermore, the computational studies also authenticate the results of the antidiabetic potential of complexes 1, 3, and 4 by presenting the necessary interactions of these compounds with their respective binding sites. The overall results indicate that the antifungal and antidiabetic ability of moxifloxacin is enhanced significantly by complexation with the given metals and the secondary ligand, thereby making it a suitable lead compound for yet another avenue of an antifungal and antidiabetic agent in the field of drug discovery and development.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76490708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}