Bioinorganic Chemistry and Applications最新文献_第10页

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy. 在癌症治疗中利用过氧化金属纳米粒子靶向肿瘤微环境

IF 4.7 3区化学

Bioinorganic Chemistry and Applications Pub Date : 2022-12-16 eCollection Date: 2022-01-01 DOI: 10.1155/2022/5041399

Simon Ngigi Mbugua

{"title":"Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy.","authors":"Simon Ngigi Mbugua","doi":"10.1155/2022/5041399","DOIUrl":"10.1155/2022/5041399","url":null,"abstract":"Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":"2022 ","pages":"5041399"},"PeriodicalIF":4.7,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10438084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Behavior of 13X Zeolite Modified with Transition Metals for Catalytic Applications. 过渡金属改性13X沸石的催化性能评价

IF 3.8 3区化学

Bioinorganic Chemistry and Applications Pub Date : 2022-10-26 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7352074

Elena David

{"title":"Evaluation of Behavior of 13X Zeolite Modified with Transition Metals for Catalytic Applications.","authors":"Elena David","doi":"10.1155/2022/7352074","DOIUrl":"https://doi.org/10.1155/2022/7352074","url":null,"abstract":"This work was intended to develop catalysts based on 13X zeolite modified with transition metals for catalytic applications. In this regard, 13X zeolite was modified by loading of transition metals such as Fe, Co, Cu and various types of catalysts such as Fe-, Co-, Cu-, Fe-Co-, Fe-Cu-, and Co-Cu/13X zeolite were obtained. To prepare these catalysts, the wet impregnation method and metallic precursors were used. The catalysts were characterized by SEM, XRD, BET, and ammonia adsorption. Then the catalytic performance was investigated during upgrading of rapeseed residual biomass pyrolysis vapors using this catalysts and a fixed-bed reactor in two stages. Experimental results showed that the addition of transition metals improved the catalytic selectivity towards aromatic hydrocarbons and Fe-Cu/13X zeolite catalyst was the best and had a high deoxygenation activity (from 62.45% to 20.56%), produced maximum monoaromatic hydrocarbons (of 27.45%), the oxygen content in bio-oil was reduced from 34.98 wt% to 16.06 wt%, the calorific value increased and thus the bio-oil quality was improved.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":" ","pages":"7352074"},"PeriodicalIF":3.8,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40471229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Facile Fabrication of CuO Nanoparticles Embedded in N-Doped Carbon Nanostructure for Electrochemical Sensing of Dopamine. 氮掺杂碳纳米结构中嵌入CuO纳米粒子的制备及其对多巴胺的电化学传感。

IF 3.8 3区化学

Bioinorganic Chemistry and Applications Pub Date : 2022-10-14 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6482133

Nebras Sobahi, Mohd Imran, Mohammad Ehtisham Khan, Akbar Mohammad, Md Mottahir Alam, Taeho Yoon, Ibrahim M Mehedi, Mohammad A Hussain, Mohammed J Abdulaal, Ahmad A Jiman

{"title":"Facile Fabrication of CuO Nanoparticles Embedded in N-Doped Carbon Nanostructure for Electrochemical Sensing of Dopamine.","authors":"Nebras Sobahi, Mohd Imran, Mohammad Ehtisham Khan, Akbar Mohammad, Md Mottahir Alam, Taeho Yoon, Ibrahim M Mehedi, Mohammad A Hussain, Mohammed J Abdulaal, Ahmad A Jiman","doi":"10.1155/2022/6482133","DOIUrl":"https://doi.org/10.1155/2022/6482133","url":null,"abstract":"In the present study, a highly selective and sensitive electrochemical sensing platform for the detection of dopamine was developed with CuO nanoparticles embedded in N-doped carbon nanostructure (CuO@NDC). The successfully fabricated nanostructures were characterized by standard instrumentation techniques. The fabricated CuO@NDC nanostructures were used for the development of dopamine electrochemical sensor. The reaction mechanism of a dopamine on the electrode surface is a three-electron three-proton process. The proposed sensor's performance was shown to be superior to several recently reported investigations. Under optimized conditions, the linear equation for detecting dopamine by differential pulse voltammetry is I pa (μA) = 0.07701 c (μM) - 0.1232 (R 2 = 0.996), and the linear range is 5-75 μM. The limit of detection (LOD) and sensitivity were calculated as 0.868 μM and 421.1 μA/μM, respectively. The sensor has simple preparation, low cost, high sensitivity, good stability, and good reproducibility.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":" ","pages":"6482133"},"PeriodicalIF":3.8,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40653517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The Adsorption Potential of Cr from Water by ZnO Nanoparticles Synthesized by Azolla pinnata. 由羽状萍合成的ZnO纳米颗粒对水中铬的吸附势。

IF 3.8 3区化学

Bioinorganic Chemistry and Applications Pub Date : 2022-10-11 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6209013

Ou Wenjie, Waqas Ahmed, Fu Xiuxian, Wang Lu, Li Jiannan, Yang Jie, Rana Muhammad Ammar Asghar, Mohsin Mahmood, Juha M Alatalo, Muhammad Imtiaz, Weidong Li, Sajid Mehmood

{"title":"The Adsorption Potential of Cr from Water by ZnO Nanoparticles Synthesized by Azolla pinnata.","authors":"Ou Wenjie, Waqas Ahmed, Fu Xiuxian, Wang Lu, Li Jiannan, Yang Jie, Rana Muhammad Ammar Asghar, Mohsin Mahmood, Juha M Alatalo, Muhammad Imtiaz, Weidong Li, Sajid Mehmood","doi":"10.1155/2022/6209013","DOIUrl":"https://doi.org/10.1155/2022/6209013","url":null,"abstract":"Aqueous solutions containing toxic elements (TEs) (such as hexavalent chromium (Cr (VI)) can be toxic to humans even at trace levels. Thus, removing TEs from the aqueous environment is essential for the protection of biodiversity, hydrosphere ecosystems, and humans. For plant fabrication of zinc oxide nanoparticles (PF-ZnONPs), Azolla pinnata plants were used, and X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), SEM, and FTIR techniques were used for the identification of PF-ZnONPs and ZnONPs, which were used to remove Cr (VI) from aqueous solution. A number of adsorption parameters were studied, including pH, dose, concentration of metal ions, and contact time. The removal efficiency of PF-ZnONPs for Cr (VI) has been found to be 96% at a time (60 min), 69.02% at pH 4, and 70.43% at a dose (10 mg·L-1). It was found that the pseudo-second-order model best described the adsorption of Cr (VI) onto PF-ZnONPs, indicating a fast initial adsorption via diffusion. The experimental data were also highly consistent with the Langmuir isotherm model calculations.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":" ","pages":"6209013"},"PeriodicalIF":3.8,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40560896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cytotoxicity and Genotoxicity of Biogenic Silver Nanoparticles in A549 and BEAS-2B Cell Lines. 生物源性纳米银对A549和BEAS-2B细胞株的细胞毒性和遗传毒性。

IF 3.8 3区化学

Bioinorganic Chemistry and Applications Pub Date : 2022-09-23 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8546079

Musthahimah Muhamad, Nurhidayah Ab Rahim, Wan Adnan Wan Omar, Nik Nur Syazni Nik Mohamed Kamal

{"title":"Cytotoxicity and Genotoxicity of Biogenic Silver Nanoparticles in A549 and BEAS-2B Cell Lines.","authors":"Musthahimah Muhamad, Nurhidayah Ab Rahim, Wan Adnan Wan Omar, Nik Nur Syazni Nik Mohamed Kamal","doi":"10.1155/2022/8546079","DOIUrl":"https://doi.org/10.1155/2022/8546079","url":null,"abstract":"Introduction: Biogenic silver nanoparticles (AgNPs-GA) were successfully synthesised using Garcinia atroviridis leaf extract as a reducing agent, which has ethnopharmacological claims against various diseases including cancer. Aim of the Study. Aim of the study is to discover whether AgNPs-GA has cytotoxic and genotoxic effects on cancerous (A549) and noncancerous (BEAS-2B) human lung cells.Materials and methods: The cytotoxicity profiles of AgNPs-GA were characterized by MTT assay, intracellular reactive oxygen species (ROS) assay, and DAPI and AOPI double staining, whilst genotoxicity was assessed using Comet Assay analysis. The level of silver ions (Ag+) and cellular uptake of AgNPs-GA were evaluated by ICP-OES and TEM analyses, respectively.Results: A significant cytotoxic effect was observed by AgNPs-GA on both A549 and BEAS-2B cell lines, with IC50 values of 20-28 μg/ml and 12-35 μg/ml, respectively. The cytotoxicity profile of AgNPs-GA was also accompanied by a pronounced increase in ROS production, DNA damage, and apoptosis. Moreover, Ag+ was also detected in cells exposed to AgNPs-GA threefold higher compared to controls. In this study, AgNPs-GA were endocytosed within lysosomes, which may direct to secondary toxicity effects including oxidative stress, impairment of the cell membrane, DNA fragmentation, and cell death.Conclusions: Taken together, novel toxicological-related mechanisms by AgNPs-GA were proposed involving the generation of ROS that causes DNA damage which led to programmed cell death in both A549 and BEAS-2B cells. Therefore, a combination of scientific assessments is constantly needed to ensure that the quality of biosynthesized nanoparticles is controlled and their safe development is promoted.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":" ","pages":"8546079"},"PeriodicalIF":3.8,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33486559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Development and Characterization of Carbon-Based Adsorbents Derived from Agricultural Wastes and Their Effectiveness in Adsorption of Heavy Metals in Waste Water. 农业废弃物碳基吸附剂的研制、表征及其对废水中重金属的吸附效果

IF 3.8 3区化学

Bioinorganic Chemistry and Applications Pub Date : 2022-09-23 eCollection Date: 2022-01-01 DOI: 10.1155/2022/1659855

L Natrayan, S Kaliappan, C Naga Dheeraj Kumar Reddy, M Karthick, N S Sivakumar, Pravin P Patil, S Sekar, Subash Thanappan

{"title":"Development and Characterization of Carbon-Based Adsorbents Derived from Agricultural Wastes and Their Effectiveness in Adsorption of Heavy Metals in Waste Water.","authors":"L Natrayan, S Kaliappan, C Naga Dheeraj Kumar Reddy, M Karthick, N S Sivakumar, Pravin P Patil, S Sekar, Subash Thanappan","doi":"10.1155/2022/1659855","DOIUrl":"https://doi.org/10.1155/2022/1659855","url":null,"abstract":"The current work focuses on peanut shells and agricultural wastes richly in many nations subjected to pyrolysis treatment at various temperatures in the range of 500-800°C to determine the feasible physiochemical characteristics of the biochar. The biochars with the high surface area were employed to adsorb Pb2+ (lead) ions, the heaviest pollutants in the water bodies. The raw material, biochar, and pyrolyzed biochar were characterized by SEM, FTIR, partial and elemental analysis, and BET tests. The adsorption characteristics of the biochar, pre- and postpyrolysis treatment, were studied with the assistance of batch adsorption tests under varying test conditions. Adsorbing conditions were determined by evaluating the effects of adsorbing parameters like initial concentration of the lead in water, pH of the adsorbent, contact time, and mixing speed on the effective adsorption of Pb2+ ions from water. Langmuir, Freundlich, and Themkin isotherm expressions were employed to study the experimental results. The adsorption kinetics study showed that the synthesized biochars were chemically stable enough to adsorb the Pb ions onto the surface.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":" ","pages":"1659855"},"PeriodicalIF":3.8,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33486558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging. 铂(II)磺胺配合物的生物学评价:合成、表征、细胞毒性和生物成像。

IF 3.8 3区化学

Bioinorganic Chemistry and Applications Pub Date : 2022-09-13 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7821284

Charini Maladeniya, Taniya Darshani, Sameera R Samarakoon, Frank R Fronczek, W M C Sameera, Inoka C Perera, Theshini Perera

{"title":"Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging.","authors":"Charini Maladeniya, Taniya Darshani, Sameera R Samarakoon, Frank R Fronczek, W M C Sameera, Inoka C Perera, Theshini Perera","doi":"10.1155/2022/7821284","DOIUrl":"https://doi.org/10.1155/2022/7821284","url":null,"abstract":"Platinum-based compounds are actively used in clinical trials as anticancer agents. In this study, two novel platinum complexes, (C1 = [PtCl2(N(SO2quin)dpa)], C2 = [PtCl2(N(SO2azobenz)dpa)]) containing quinoline and azobenzene appended dipicolylamine sulfonamide ligands were synthesized in good yield. The singlet attributable to methylene CH2 protons of the ligands of C1 and C2 appears as two doublets in 1H NMR spectra, which confirms the presence of magnetically nonequivalent protons upon coordination to platinum. Structural data of N(SO2quin)dpa (L1), N(SO2azobenz)dpa (L2) and PtCl2(N(SO2quin)dpa) confirmed the formation of the desired compounds. Time-dependent density functional theory calculations suggested that the excitation of L1 show quin-unit-based π⟶π∗ excitations (i.e., ligand-centered charge transfer, LC), while C1 shows the metal-ligand-to-ligand charge-transfer (MLLCT) character. L1 displays intense fluorescence from the 1LC excited state, while C1 gives phosphorescence from the 3LC state. Mammalian cell toxicity of ligands and complexes was assessed with NCI–H292 nonsmall-cell lung cancer cells. Further, C1 and C2 showed significantly low IC50 values compared with N(SO2azobenz)dpa and PtCl2(N(SO2quin)dpa). Fluorescence imaging data of both ligands and complexes revealed the potential fluorescence activity of these compounds for biological imaging. All four compounds are promising novel candidates that can be further investigated on their usage as potential anticancer agents and cancer cell imaging agents.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":" ","pages":"7821284"},"PeriodicalIF":3.8,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33477538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Solanum Procumbens-Derived Zinc Oxide Nanoparticles Suppress Lung Cancer In Vitro through Elevation of ROS. 原藜衍生的氧化锌纳米颗粒通过提高活性氧抑制肺癌。

IF 3.8 3区化学

Bioinorganic Chemistry and Applications Pub Date : 2022-09-13 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2724302

Ibrahim Ibrahim Abdel Aziz, Almaimani A Riyad, Almasmoum A Hussian, Ghaith M Mazen, Moorthy Kannaiyan

{"title":"Solanum Procumbens-Derived Zinc Oxide Nanoparticles Suppress Lung Cancer In Vitro through Elevation of ROS.","authors":"Ibrahim Ibrahim Abdel Aziz, Almaimani A Riyad, Almasmoum A Hussian, Ghaith M Mazen, Moorthy Kannaiyan","doi":"10.1155/2022/2724302","DOIUrl":"https://doi.org/10.1155/2022/2724302","url":null,"abstract":"Lung cancer is one of the cancers with high mortality rate. The current therapeutic regimens have only limited success rate. The current work highlights the potential of Solanum procumbens-derived zinc oxide nanoparticle (SP-ZnONP)-induced apoptosis in A549 lung cancer cells. Synthesized nanoparticles were confirmed by UV-Vis spectrophotometry, X-ray diffraction (XRD), dynamic light scattering analysis (DLS), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), and photoluminescence analysis. Lactate dehydrogenase (LDH), cytotoxicity, and cell viability assays revealed that the SP-ZnONP caused the cell death and the inhibition concentration (IC50) was calculated to be 61.28 μg/mL. Treatment with SP-ZnONPs caused morphological alterations in cells, such as rounding, which may have been caused by the substance's impact on integrins. Acridine orange/ethidium bromide dual staining revealed that the cells undergo apoptosis in a dose-dependent manner, which indicates the cell death. Furthermore, reactive oxygen species (ROS) were examined and it was shown that the nanoparticles elevated ROS levels, which led to lipid peroxidation. In short, the SP-ZnONPs increase the level of ROS, which in turn causes lipid peroxidation results in apoptosis. On the other hand, the SP-ZnONPs decrease nitric oxide level in A549 cells in a dose-dependent manner, which also supports the apoptosis. In conclusion, SP-ZnONPs would become a promising treatment option for lung cancer.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":" ","pages":"2724302"},"PeriodicalIF":3.8,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33477539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cytotoxicity and Antibacterial Activity of Mineral Trioxide Aggregate Cement with Radiopacity Introduced by ZrO₂. ZrO2引入透明矿物三氧化物骨料水泥的细胞毒性和抗菌活性。

IF 3.8 3区化学

Bioinorganic Chemistry and Applications Pub Date : 2022-09-06 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9574245

Lidia Ciołek, Zbigniew Jaegermann, Ewa Zaczyńska, Anna Czarny, Monika Biernat, Arkadiusz Gąsiński, Agnieszka Jastrzębska, Michał Gloc, Andrzej Olszyna

{"title":"Cytotoxicity and Antibacterial Activity of Mineral Trioxide Aggregate Cement with Radiopacity Introduced by ZrO2.","authors":"Lidia Ciołek, Zbigniew Jaegermann, Ewa Zaczyńska, Anna Czarny, Monika Biernat, Arkadiusz Gąsiński, Agnieszka Jastrzębska, Michał Gloc, Andrzej Olszyna","doi":"10.1155/2022/9574245","DOIUrl":"https://doi.org/10.1155/2022/9574245","url":null,"abstract":"The article presents the results of in vitro studies on cytotoxicity and antibacterial activity of new MTA-type cements, developed on the basis of the sintered tricalcium silicate enriched with ZnO, along with an agent introducing the radiopacity in the form of ZrO2. The new materials have been developed to ensure that their physical and chemical properties are suited for endodontic applications. The cements were evaluated via characterisation of setting time, compressive strength, as well as translucency on X-ray images, and bioactivity in the simulated body fluid (SBF). The μCT was used to test the influence of the ZrO2 grains in the powder component on the microstructure of the produced cement. Then, the cytotoxic action of the cements was evaluated by applying a reference L-929 cell line. The conditions of the culture upon contact with the tested materials or with extracts from the cements were assessed using image analysis or an MTT colorimetric assay. Two strains of streptococci, Streptococcus mutans and Streptococcus sanguinis, were used to study the antibacterial activity of the tested cements with ZrO2 acting as the agent introducing the radiopacity. The new cements are characterised by appropriate properties as far as retrograde root canal filling is concerned.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":" ","pages":"9574245"},"PeriodicalIF":3.8,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40361488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Physicochemical Properties and Antibacterial Activity of Gellan Gum Incorporating Zinc Oxide/Carbon Nanotubes Bionanocomposite Film for Wound Healing. 含氧化锌/碳纳米管生物纳米复合膜结冷胶伤口愈合的理化性质及抗菌活性。

IF 3.8 3区化学

Bioinorganic Chemistry and Applications Pub Date : 2022-08-28 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3158404

Jichao Liu, Nur Arifah Ismail, Mahani Yusoff, Mohd Hasmizam Razali

{"title":"Physicochemical Properties and Antibacterial Activity of Gellan Gum Incorporating Zinc Oxide/Carbon Nanotubes Bionanocomposite Film for Wound Healing.","authors":"Jichao Liu, Nur Arifah Ismail, Mahani Yusoff, Mohd Hasmizam Razali","doi":"10.1155/2022/3158404","DOIUrl":"https://doi.org/10.1155/2022/3158404","url":null,"abstract":"Wound healing dressing based on a natural polymer of gellan gum incorporating zinc oxide nanoparticles and multiwall carbon nanotubes (GG/ZnONP + MWCNT) bionanocomposite film was fabricated via the solution casting method. The physicochemical properties of the film were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM). Moreover, the antibacterial properties of the bionanocomposite film were investigated for wound healing applications. The characterization results confirmed the reinforcement of the gellan gum (GG) matrix with zinc oxide nanoparticles (ZnONP) and multiwall carbon nanotubes (MWCNT), as an amorphous GG/ZnONP + MWCNT bionanocomposite film was obtained. SEM morphological analysis shows that the addition of ZnONP and MWCNT nanofillers changed the film microstructure into a sponge-like structure that is more suitable for fluid uptake and thus more useful for wound healing. The GG/ZnONP + MWCNT bionanocomposite film demonstrated good antibacterial activity against all strains tested. Furthermore, macroscopic analysis shows that the wound treated with GG/ZnONP + MWCNT bionanocomposite film recovered completely (100%) in 14 days, compared to pure GG film (90.76%) and negative control (77.40%). As a result, the GG/ZnONP + MWCNT bionanocomposite film could be a promising wound dressing material.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":" ","pages":"3158404"},"PeriodicalIF":3.8,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6