Bioinorganic Chemistry and Applications最新文献

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Biogenic Synthesis of Photosensitive Magnesium Oxide Nanoparticles Using Citron Waste Peel Extract and Evaluation of Their Antibacterial and Anticarcinogenic Potential. 利用香橼废皮提取物生物合成光敏氧化镁纳米粒子并评估其抗菌和抗癌潜力
IF 4.7 3区 化学
Bioinorganic Chemistry and Applications Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8180102
Nawal M Al Musayeib, Musarat Amina, Farah Maqsood, Kholoud A Bokhary, Nada S Alrashidi
{"title":"Biogenic Synthesis of Photosensitive Magnesium Oxide Nanoparticles Using Citron Waste Peel Extract and Evaluation of Their Antibacterial and Anticarcinogenic Potential.","authors":"Nawal M Al Musayeib, Musarat Amina, Farah Maqsood, Kholoud A Bokhary, Nada S Alrashidi","doi":"10.1155/2024/8180102","DOIUrl":"10.1155/2024/8180102","url":null,"abstract":"<p><strong>Background: </strong>Magnesium oxide nanoparticles (MgONPs) have been fabricated by several approaches, including green chemistry approach due to diverse application and versatile features.</p><p><strong>Objectives: </strong>The current study aimed to prepare a convenient, biocompatible, and economically viable MgONPs using waste citron peel extract (CP-MgONPs) to evaluate their biological applications.</p><p><strong>Methods: </strong>The CP-MgONPs were synthesized by a sustainable approach from extract of waste citron peel both as capping and reducing agents without use of any hazardous material. The physicochemical features of formed CP-MgONPs were determined by sophisticated analytical and microscopic techniques. The biogenic CP-MgONPs were examined for their antibacterial, anticarcinogenic, and photocatalytic attributes.</p><p><strong>Results: </strong>A prominent absorption peak in the UV-Vis spectra at 284 nm was the distinguishing characteristic of the CP-MgONPs. The scanning electron microscopy (SEM) reveals polyhedral morphology of nanoparticles with slight agglomeration of CP-MgONPs. The CP-MgONPs exerted excellent antibacterial potencies against six bacterial strains. The CP-MgONPs displayed significant susceptibility towards <i>E. coli</i> (20.72 ± 0.33 mm) and <i>S. aureus</i> (19.52 ± 0.05 mm) with the highest inhibition zones. The anticancer effect of CP-MgONPs was evaluated against HepG2 (IC<sub>50</sub> : 15.3 <i>μ</i>g·mL<sup>-1</sup>) cancer cells and exhibited potential anticancer activity. A prompt inversion of cellular injury manifested as impairment of the integrity of the cell membrane, apoptosis, and oxidative stress was observed in treated cells with CP-MgONPs. The biosynthesized CP-MgONPs also conducted successful photocatalytic potential as much as MgO powder under the UV-light using acid orange 8 (AO-8) dye. The degradation performance of CP-MgONPs showed over 94% photocatalytic degradation efficiency of acid orange 8 (AO-8) dyes within a short time.</p><p><strong>Conclusions: </strong>Outcomes of this research signify that biogenic CP-MgONPs may be advantageous at low concentrations, with positive environmental impacts.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":"2024 ","pages":"8180102"},"PeriodicalIF":4.7,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Structure, Spectroscopic, Frontier Molecular Orbital Analysis, Molecular Docking Studies, and In Vitro DNA-Binding Studies of Osmium(II)-Cymene Complexes with Aryl Phosphine and Aryl Phosphonium Assemblies 带有芳基膦和芳基鏻组装的锇(II)-百里香配合物的分子结构、光谱、前沿分子轨道分析、分子对接研究和体外 DNA 结合研究
IF 3.8 3区 化学
Bioinorganic Chemistry and Applications Pub Date : 2024-05-29 DOI: 10.1155/2024/6697523
Kgaugelo C. Tapala, Nqobile G. Ndlangamandla, Mpho P. Ngoepe, Hadley S. Clayton
{"title":"Molecular Structure, Spectroscopic, Frontier Molecular Orbital Analysis, Molecular Docking Studies, and In Vitro DNA-Binding Studies of Osmium(II)-Cymene Complexes with Aryl Phosphine and Aryl Phosphonium Assemblies","authors":"Kgaugelo C. Tapala, Nqobile G. Ndlangamandla, Mpho P. Ngoepe, Hadley S. Clayton","doi":"10.1155/2024/6697523","DOIUrl":"https://doi.org/10.1155/2024/6697523","url":null,"abstract":"X-ray crystallography, spectroscopy, computational methods, molecular docking studies, and <i>in vitro</i> DNA-binding studies have been useful in the investigations of intermolecular and intramolecular interactions of osmium-cymene oxalato complexes with aryl phosphine and aryl phosphonium groups in both primary and secondary coordination spheres, respectively. Molecular structures of the novel complexes PPh<sub>4</sub>[Os(<i>η</i><sup>6</sup>-<i>p</i>-cymene)Br(<i>κ</i><sup>2</sup>-<i>O,O′</i>-C<sub>2</sub>O<sub>4</sub>)] (<b>1</b>) and [Os(<i>η</i><sup>6</sup>-<i>p</i>-cymene) (<i>κ</i><sup>2</sup>-<i>O,O′</i>-C<sub>2</sub>O<sub>4</sub>)PPh<sub>3</sub>] (<b>2</b>) were resolved by single-crystal X-ray diffraction (XRD). Primary and secondary coordination sphere contacts were investigated using Hirshfeld surface analysis which was supported by molecular docking (MD) studies. The MD data obtained predicted significant differences in binding energy across three receptors for the two osmium complexes. An <i>in vitro</i> DNA-binding study was accomplished using UV-Vis spectroscopy which showed that both <b>1</b> and <b>2</b> bond with DNA through an intercalation approach. The optimized molecular geometry, frontier molecular orbital (E<sub>HOMO</sub> and E<sub>LUMO</sub>) energies, global electrophilicity index (<i>ω</i>), chemical hardness (<i>η</i>), chemical potential (<i>µ</i>), and the energy band gap (E<sub>HOMO</sub>–E<sub>LUMO</sub>) were calculated utilizing density functional theory (DFT) methods. Computed structural parameters (bond lengths and angles) support the experimental single-crystal XRD data.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":"41 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141168581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Tin (IV) and Organotin (IV) Complexes with a Hybrid Thiosemicarbazone/Hydrazone Ligand: Synthesis, Crystal Structure, and Antiproliferative Activity 新的锡(IV)和有机锡(IV)配合物与混合硫代氨基甲酸酮/腙配体:合成、晶体结构和抗增殖活性
IF 3.8 3区 化学
Bioinorganic Chemistry and Applications Pub Date : 2024-04-03 DOI: 10.1155/2024/1018375
Belén Blázquez-Tapias, Satyajit Halder, M. Antonia Mendiola, Nivedita Roy, Nilima Sahu, Chittaranjan Sinha, Kuladip Jana, Elena López-Torres
{"title":"New Tin (IV) and Organotin (IV) Complexes with a Hybrid Thiosemicarbazone/Hydrazone Ligand: Synthesis, Crystal Structure, and Antiproliferative Activity","authors":"Belén Blázquez-Tapias, Satyajit Halder, M. Antonia Mendiola, Nivedita Roy, Nilima Sahu, Chittaranjan Sinha, Kuladip Jana, Elena López-Torres","doi":"10.1155/2024/1018375","DOIUrl":"https://doi.org/10.1155/2024/1018375","url":null,"abstract":"Nowadays, the search for new chemotherapeutic agents with low toxicity and high selectivity is a major concern. In this paper, we report the synthesis and characterization of a hybrid thiosemicarbazone/hydrazone ligand in its neutral form (L<sup>1</sup>H<sub>2</sub>) and as the chloride salt ([L<sup>1</sup>H<sub>3</sub>]Cl)-, three diorganotin (IV) complexes, and one complex with Sn (IV). The compounds have been fully characterized by IR, mass spectra, <sup>1</sup>H, <sup>13</sup>C, and <sup>119</sup>Sn NMR, <sup>119</sup>Sn CP/MAS NMR, and by single crystal X-ray diffraction. The organotin compounds have the empirical formula [SnR<sub>2</sub>L<sup>1</sup>] (<i>R</i> = Me, Bu, and Ph), but in the solid state, they are polymeric species with seven coordination number due to weak coordination of the pyridine nitrogen, whereas in solution, the polymeric structure is lost to afford hexacoordinate monomeric species. Reaction with SnI<sub>4</sub> yields complex [Sn (L<sup>1</sup>)<sub>2</sub>]·EtOH, with the metal in a distorted dodecahedral arrangement. We have evaluated the antiproliferative activity of the two forms of the ligands and the four coordination compounds against MDA-MB-231, HeLa, PC3, and HepG2 cancer cell lines, and WI-38 normal cell line, and all the compounds present higher activity than cisplatin, used as the standard control. To investigate the mode of action, we have selected the most active complex, containing phenyl substituents, and used the triple negative breast cancer cell line MDA-MB-231. The results show that the complex induces apoptotic cell death promoted by generation of reactive oxygen species and by disruption of mitochondrial membrane potential.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":"50 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140580973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity 紫杉醇负载银纳米粒子的合成与表征:细胞毒性效应和抗菌活性评估
IF 3.8 3区 化学
Bioinorganic Chemistry and Applications Pub Date : 2024-02-13 DOI: 10.1155/2024/9916187
Tutku Tunç, Ceylan Hepokur, Afşin Kari̇per
{"title":"Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity","authors":"Tutku Tunç, Ceylan Hepokur, Afşin Kari̇per","doi":"10.1155/2024/9916187","DOIUrl":"https://doi.org/10.1155/2024/9916187","url":null,"abstract":"Carrier system therapies based on combining cancer drugs with nanoparticles have been reported to control tumor growth and significantly reduce the side effects of cancer drugs. We thought that paclitaxel-loaded silver nanoparticles (AgNPs-PTX) were the right carrier to target cancer cells. We also carried out antimicrobial activity experiments as systems formed with nanoparticles have been shown to have antimicrobial activity. In our study, we used easy-to-synthesize and low-cost silver nanoparticles (AgNPs) with biocatalytic and photocatalytic advantages as drug carriers. We investigated the antiproliferative activities of silver nanoparticles synthesized by adding paclitaxel on MCF-7 (breast adenocarcinoma cell line), A549 (lung carcinoma cell line), C6 (brain glioma cell line) cells, and healthy WI-38 (fibroblast normal cell line) cell lines and their antimicrobial activities on 10 different microorganisms. The synthesized AgNPs and AgNPs-PTX were characterized by dynamic light scattering (DLS), scanning transmission electron microscopy, UV-visible spectroscopy, Fourier transform infrared spectroscopy, and X-ray spectroscopy. The nanoparticles were spherical in shape, with AgNPs ranging in size from 2.32 to 5.6 nm and AgNPs-PTXs from 24.36 to 58.77 nm. AgNPs demonstrated well stability of −47.3 mV, and AgNPs-PTX showed good stability of −25.4 mV. The antiproliferative effects of the synthesized nanoparticles were determined by XTT (tetrazolium dye; 2,3-bis-(2-methoxy-4-nitro-5-sulfenyl)-(2H)-tetrazolium-5-carboxanilide), and the proapoptotic effects were determined by annexin V/propidium iodide (PI) staining. The effect of AgNPs-PTX was more effective, and anticancer activity was higher than PTX in all cell lines. When selectivity indices were calculated, AgNPs-PTX was more selective in the A549 cell line (SI value 6.53 <i>μ</i>g/mL). AgNPs-PTX was determined to increase apoptosis cells by inducing DNA fragmentation. To determine the antimicrobial activity, the MIC (minimum inhibitory concentration) test was performed using 8 different bacteria and 2 different fungi. Seven of the 10 microorganisms tested exhibited high antimicrobial activity according to the MIC ≤100 <i>μ</i>g/mL standard, reaching MIC values below 100 <i>μ</i>g/mL and 100 <i>μ</i>g/mL for both AgNPs and AgNPs-PTX compared to reference sources. Compared to standard antibiotics, AgNPs-PTX was highly effective against 4 microorganisms.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":"38 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139761965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria-Targeting and Oxygen Self-Supplying Eccentric Hollow Nanoplatform for Enhanced Breast Cancer Photodynamic Therapy 用于增强乳腺癌光动力疗法的线粒体靶向和氧自给偏心中空纳米平台
IF 3.8 3区 化学
Bioinorganic Chemistry and Applications Pub Date : 2024-02-01 DOI: 10.1155/2024/6618388
Jing Li, Yu Wang, Jun Tao, Xiaodan Su, Feipeng Zhu, Wei Lu, Xiaolin Han, Meng Dang, Lixing Weng
{"title":"Mitochondria-Targeting and Oxygen Self-Supplying Eccentric Hollow Nanoplatform for Enhanced Breast Cancer Photodynamic Therapy","authors":"Jing Li, Yu Wang, Jun Tao, Xiaodan Su, Feipeng Zhu, Wei Lu, Xiaolin Han, Meng Dang, Lixing Weng","doi":"10.1155/2024/6618388","DOIUrl":"https://doi.org/10.1155/2024/6618388","url":null,"abstract":"Photodynamic therapy (PDT) has received increasing attention for tumor therapy due to its minimal invasiveness and spatiotemporal selectivity. However, the poor targeting of photosensitizer and hypoxia of the tumor microenvironment limit the PDT efficacy. Herein, eccentric hollow mesoporous organic silica nanoparticles (EHMONs) are prepared by anisotropic encapsulation and hydrothermal etching for constructing PDT nanoplatforms with targeting and hypoxia-alleviating properties. The prepared EHMONs possess a unique eccentric hollow structure, a uniform size (300 nm), a large cavity, and ordered mesoporous channels (2.3 nm). The EHMONs are modified with the mitochondria-targeting molecule triphenylphosphine (CTPP) and photosensitizers chlorin e6 (Ce6). Oxygen-carrying compound perfluorocarbons (PFCs) are further loaded in the internal cavity of EHMONs. Hemolytic assays and <i>in vitro</i> toxicity experiments show that the EHMONs-Ce6-CTPP possesses very good biocompatibility and can target mitochondria of triple-negative breast cancer, thus increasing the accumulation of photosensitizers Ce6 at mitochondria after entering cancer cells. The EHMONs-Ce6-CTPP@PFCs with oxygen-carrying ability can alleviate hypoxia after entering in the cancer cell. Phantom and cellular experiments show that the EHMONs-Ce6-CTPP@PFCs produce more singlet oxygen reactive oxygen species (ROSs). Thus, in vitro and in vivo experiments demonstrated that the EHMONs-Ce6-CTPP@PFCs showed excellent treatment effects for triple-negative breast cancer. This research provides a new method for a targeting and oxygen-carrying nanoplatform for enhancing PDF effectiveness.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":"6 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139658540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Different Degrees of Sulfated Laminaria Polysaccharides Recovered Damaged HK-2 Cells and Inhibited Adhesion of Nano-COM and Nano-COD Crystals 不同程度的硫酸化层状多糖可恢复受损的 HK-2 细胞并抑制纳米-COM 和纳米-COD 晶体的粘附性
IF 3.8 3区 化学
Bioinorganic Chemistry and Applications Pub Date : 2024-01-02 DOI: 10.1155/2024/8843214
Qiu-Shi Xu, Zhi-Jian Wu, Jian-Ming Sun, Jing-Hong Liu, Wei-Bo Huang, Jian-Ming Ouyang
{"title":"Different Degrees of Sulfated Laminaria Polysaccharides Recovered Damaged HK-2 Cells and Inhibited Adhesion of Nano-COM and Nano-COD Crystals","authors":"Qiu-Shi Xu, Zhi-Jian Wu, Jian-Ming Sun, Jing-Hong Liu, Wei-Bo Huang, Jian-Ming Ouyang","doi":"10.1155/2024/8843214","DOIUrl":"https://doi.org/10.1155/2024/8843214","url":null,"abstract":"<i>Purpose</i>. The crystal adhesion caused by the damage of renal tubular epithelial cells (HK-2) is the key to the formation of kidney stones. However, no effective preventive drug has been found. This study aims to explore the recovery effects of four Laminaria polysaccharides (SLPs) with different sulfate (–OSO<sub>3</sub><sup>–</sup>) contents on damaged HK-2 cells and the difference in the adhesion of damaged cells to nanometer calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD) before and after recovery. <i>Methods</i>. Sodium oxalate (2.6 mmol/L) was used to damage HK-2 cells to establish a damaged model. SLPs (LP0, SLP1, SLP2, and SLP3) with –OSO<sub>3</sub><sup>–</sup> contents of 0.73%, 15.1%, 22.8%, and 31.3%, respectively, were used to restore the damaged cells, and the effects of SLPs on the adhesion of COM and COD, with a size of about 100 nm before and after recovery, were measured. <i>Results</i>. The following results were observed after SLPs recovered the damaged HK-2 cells: increased cell viability, restored cell morphology, decreased reactive oxygen levels, increased mitochondrial membrane potential, decreased phosphatidylserine eversion ratio, increased cell migration ability, reduced expression of annexin A1, transmembrane protein, and heat shock protein 90 on the cell surface, and reduced adhesion amount of cells to COM and COD. Under the same conditions, the adhesion ability of cells to COD crystals was weaker than that to COM crystals. <i>Conclusions</i>. As the sulfate content in SLPs increases, the ability of SLPs to recover damaged HK-2 cells and inhibit crystal adhesion increases. SLP3 with high –OSO<sub>3</sub><sup>–</sup> content may be a potential drug to prevent kidney stones.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":"21 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139077928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidant Activity of Auricularia auricula Polysaccharides with Different Molecular Weights and Cytotoxicity Difference of Polysaccharides Regulated CaOx to HK-2 Cells 不同分子量的黑木耳多糖的抗氧化活性及多糖调节 CaOx 对 HK-2 细胞的细胞毒性差异
IF 3.8 3区 化学
Bioinorganic Chemistry and Applications Pub Date : 2023-12-23 DOI: 10.1155/2023/9968886
Bao-Li Heng, Fan-Yu Wu, Jing-Hong Liu, Jian-Ming Ouyang
{"title":"Antioxidant Activity of Auricularia auricula Polysaccharides with Different Molecular Weights and Cytotoxicity Difference of Polysaccharides Regulated CaOx to HK-2 Cells","authors":"Bao-Li Heng, Fan-Yu Wu, Jing-Hong Liu, Jian-Ming Ouyang","doi":"10.1155/2023/9968886","DOIUrl":"https://doi.org/10.1155/2023/9968886","url":null,"abstract":"<i>Objective</i>. This study aimed to investigate the growth of calcium oxalate (CaOx) crystals regulated by <i>Auricularia auricular</i> polysaccharides (AAPs) with different viscosity-average molecular weights (<span><svg height=\"11.9453pt\" style=\"vertical-align:-3.309401pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 16.9831 11.9453\" width=\"16.9831pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"></path></g><g transform=\"matrix(.0091,0,0,-0.0091,12.22,3.132)\"></path></g></svg>),</span> the toxicity of AAP-regulated CaOx crystals toward HK-2 cells, and the prevention and treatment capabilities of AAPs for CaOx stones. <i>Methods</i>. The scavenging capability and reducing capacity of four kinds of AAPs (<svg height=\"11.9453pt\" style=\"vertical-align:-3.309401pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 16.9831 11.9453\" width=\"16.9831pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-78\"></use></g><g transform=\"matrix(.0091,0,0,-0.0091,12.22,3.132)\"><use xlink:href=\"#g185-40\"></use></g></svg> of 31.52, 11.82, 5.86, and 3.34 kDa) on hydroxyl, ABTS, and DPPH free radicals and their capability to chelate divalent iron ions were detected. AAP-regulated CaOx crystals were evaluated by using zeta potential, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. The cytotoxicity of AAP-regulated crystals was evaluated through examination of cell viability, cell death, malondialdehyde (MDA) content, and cell surface hyaluronic acid (HA) expression. <i>Results</i>. The in vitro antioxidant activities of the four AAPs were observed in the following order: AAP0 &lt; AAP1 &lt; AAP2 &lt; AAP3. Thus, AAP3, which had the smallest <span><svg height=\"11.9453pt\" style=\"vertical-align:-3.309401pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 16.9831 11.9453\" width=\"16.9831pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-78\"></use></g><g transform=\"matrix(.0091,0,0,-0.0091,12.22,3.132)\"><use xlink:href=\"#g185-40\"></use></g></svg>,</span> had the strongest antioxidant activity. AAPs can inhibit the growth of CaOx monohydrate (COM), induce the formation of CaOx dihydrate (COD), and reduce the degree of crystal aggregation, with AAP3 exhibiting the strongest capability. Cell experiments showed the lowest cytotoxicity in AAP3-regulated CaOx crystals, along with the lowest MDA content, HA expression, and cell mortality. In addition, COD presented less cytotoxicity than COM. Meanwhile, the cytotoxicity of blunt crystals was less than that of sharp crystals. <i>Conclusion</i>. AAPs, particularly AAP3, showed an excellent antioxidative capability in vitro, and AAP3-regulated CaOx crystals presented minimal cytotoxicity.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":"41 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139027784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: Pisonia Alba Assisted Synthesis of Nanosilver for Wound Healing Activity 撤回:白皮松辅助合成纳米银以提高伤口愈合活性
IF 3.8 3区 化学
Bioinorganic Chemistry and Applications Pub Date : 2023-12-20 DOI: 10.1155/2023/9841820
Bioinorganic Chemistry and Applications
{"title":"Retracted: Pisonia Alba Assisted Synthesis of Nanosilver for Wound Healing Activity","authors":"Bioinorganic Chemistry and Applications","doi":"10.1155/2023/9841820","DOIUrl":"https://doi.org/10.1155/2023/9841820","url":null,"abstract":"<jats:p />","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":"118 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138953937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: Synthesis and Workability Behavior of Cu-X wt.% TiC (x = 0, 4, 8, and 12) Powder Metallurgy Composites 撤回:Cu-X wt.% TiC(x = 0、4、8 和 12)粉末冶金复合材料的合成与加工性能
IF 3.8 3区 化学
Bioinorganic Chemistry and Applications Pub Date : 2023-12-20 DOI: 10.1155/2023/9873501
Bioinorganic Chemistry and Applications
{"title":"Retracted: Synthesis and Workability Behavior of Cu-X wt.% TiC (x = 0, 4, 8, and 12) Powder Metallurgy Composites","authors":"Bioinorganic Chemistry and Applications","doi":"10.1155/2023/9873501","DOIUrl":"https://doi.org/10.1155/2023/9873501","url":null,"abstract":"<jats:p />","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":"79 6","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138957795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: Biosynthesis of Iron Oxide Nanoparticles Using Leaf Extract of Ruellia tuberosa: Mechanical and Dynamic Mechanical Behaviour Kevlar-Based Hybrid Epoxy Composites. 撤回:利用块茎鸢尾叶提取物生物合成氧化铁纳米颗粒:基于 Kevlar 的混合环氧树脂复合材料的力学和动态力学行为。
IF 3.8 3区 化学
Bioinorganic Chemistry and Applications Pub Date : 2023-12-20 eCollection Date: 2023-01-01 DOI: 10.1155/2023/9869405
Bioinorganic Chemistry And Applications
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