促进药物传递的超分子平台综述

IF 4.7 3区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Rosa Bellavita, Simone Braccia, Annarita Falanga, Stefania Galdiero
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引用次数: 0

摘要

许多受自然自组装启发的超分子平台被用作药物输送系统。单个构建块自发排列成无机和有机结构是由非共价力决定和控制的,如静电相互作用、π-π相互作用、氢键和范德华相互作用。这篇综述描述了几种构建块的主要结构和特征,这些构建块用于获得稳定的、自组装的纳米结构,为许多生物应用量身定制。由于其通用性、生物相容性和可控性,这些纳米结构在药物/基因传递、治疗学、组织工程和纳米电子学等各个领域都有应用。在此,我们描述了用于设计和功能化这些纳米材料的不同方法,以在特定疾病中获得选择性药物递送。特别强调了这些超分子结构在与传染病和癌症相关的应用中的效率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Overview of Supramolecular Platforms Boosting Drug Delivery
Numerous supramolecular platforms inspired by natural self-assembly are exploited as drug delivery systems. The spontaneous arrangement of single building blocks into inorganic and organic structures is determined and controlled by noncovalent forces such as electrostatic interactions, π-π interactions, hydrogen bonds, and van der Waals interactions. This review describes the main structures and characteristics of several building blocks used to obtain stable, self-assembling nanostructures tailored for numerous biological applications. Owing to their versatility, biocompatibility, and controllability, these nanostructures find application in diverse fields ranging from drug/gene delivery, theranostics, tissue engineering, and nanoelectronics. Herein, we described the different approaches used to design and functionalize these nanomaterials to obtain selective drug delivery in a specific disease. In particular, the review highlights the efficiency of these supramolecular structures in applications related to infectious diseases and cancer.
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来源期刊
Bioinorganic Chemistry and Applications
Bioinorganic Chemistry and Applications 化学-生化与分子生物学
CiteScore
7.00
自引率
5.30%
发文量
105
审稿时长
>12 weeks
期刊介绍: Bioinorganic Chemistry and Applications is primarily devoted to original research papers, but also publishes review articles, editorials, and letter to the editor in the general field of bioinorganic chemistry and its applications. Its scope includes all aspects of bioinorganic chemistry, including bioorganometallic chemistry and applied bioinorganic chemistry. The journal welcomes papers relating to metalloenzymes and model compounds, metal-based drugs, biomaterials, biocatalysis and bioelectronics, metals in biology and medicine, metals toxicology and metals in the environment, metal interactions with biomolecules and spectroscopic applications.
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