Bioinorganic Chemistry and Applications最新文献

{"title":"In Situ Green Synthesis of Co3O4@ZnO Core-Shell Nanoparticles Using Datura stramonium Leaf Extract: Antibacterial and Antioxidant Studies","authors":"Gezahegn Tadesse, H. C. Ananda Murthy, C. R. Ravikumar, T. Naveen Kumar, Lema Teshome, Tegene Desalegn","doi":"10.1155/2023/5019838","DOIUrl":"https://doi.org/10.1155/2023/5019838","url":null,"abstract":"Investigating and synthesizing potent antibacterial NPs using biological methods is highly preferred, and it involves nontoxic, cost-effective, and environmentally friendly chemicals and methods. Antibiotic drug resistance and oxidative stress have become a serious public health issue worldwide. Hence, the key objective of this study was to biologically synthesize and characterize the potent antibacterial Co₃O₄@ZnO core-shell nanoparticles for the antibacterial application. The radical scavenging ability of green synthesized Co₃O₄@ZnO core-shell nanoparticles was also determined. In this study, Co₃O₄@ZnO core-shell nanoparticles (CZCS NPs) have been synthesized using three different core to shell materials ratios of Co₃O₄ to ZnO (0.5 : 0.25 CZCS (1), 0.5 : 0.5 CZCS (2), and 0.5 : 0.75 M CZCS (3)) by employing <i>Datura stramonium</i> leaf extract. The polycrystalline nature of Co₃O₄@ZnO core-shell nanoparticles was investigated using the XRD and SAED characterization techniques. The investigated nanostructure of Co₃O₄@ZnO core-shell nanoparticles appeared with Co₃O₄ as the core and ZnO as an outer shell. Additionally, a variety of physicochemical properties of the nanoparticles were determined using various characterization techniques. The average crystallite sizes of CZCS (1), CZCS (2), and CZCS (3) were found to be <span><svg height=\"8.69875pt\" style=\"vertical-align:-0.3499298pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.34882 23.017 8.69875\" width=\"23.017pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,6.24,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,15.386,0)\"></path></g></svg><span></span><span><svg height=\"8.69875pt\" style=\"vertical-align:-0.3499298pt\" version=\"1.1\" viewbox=\"25.872183800000002 -8.34882 15.677 8.69875\" width=\"15.677pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,25.922,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,32.162,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,35.126,0)\"><use xlink:href=\"#g113-53\"></use></g></svg>,</span></span> <span><svg height=\"8.69875pt\" style=\"vertical-align:-0.3499298pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.34882 23.017 8.69875\" width=\"23.017pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-51\"></use></g><g transform=\"matrix(.013,0,0,-0.013,6.24,0)\"><use xlink:href=\"#g113-51\"></use></g><g transform=\"matrix(.013,0,0,-0.013,15.386,0)\"><use xlink:href=\"#g117-37\"></use></g></svg><span></span><span><svg height=\"8.69875pt\" style=\"vertical-align:-0.3499298pt\" version=\"1.1\" viewbox=\"25.872183800000002 -8.34882 15.677 8.69875\" width=\"15.677pt\" xmlns=\"h","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Supramolecular Platforms Boosting Drug Delivery","authors":"Rosa Bellavita, Simone Braccia, Annarita Falanga, Stefania Galdiero","doi":"10.1155/2023/8608428","DOIUrl":"https://doi.org/10.1155/2023/8608428","url":null,"abstract":"Numerous supramolecular platforms inspired by natural self-assembly are exploited as drug delivery systems. The spontaneous arrangement of single building blocks into inorganic and organic structures is determined and controlled by noncovalent forces such as electrostatic interactions, π-π interactions, hydrogen bonds, and van der Waals interactions. This review describes the main structures and characteristics of several building blocks used to obtain stable, self-assembling nanostructures tailored for numerous biological applications. Owing to their versatility, biocompatibility, and controllability, these nanostructures find application in diverse fields ranging from drug/gene delivery, theranostics, tissue engineering, and nanoelectronics. Herein, we described the different approaches used to design and functionalize these nanomaterials to obtain selective drug delivery in a specific disease. In particular, the review highlights the efficiency of these supramolecular structures in applications related to infectious diseases and cancer.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise Construction of Dual-Promising Anticancer Drugs Associated with Gold Nanomaterials on Glioma Cancer Cells.","authors":"P Baby Shakila,&nbsp;Abdurahman Hajinur Hirad,&nbsp;Abdullah A Alarfaj,&nbsp;Samer Hasan Hussein-Al-Ali,&nbsp;Beza Mulugeta","doi":"10.1155/2023/8892099","DOIUrl":"10.1155/2023/8892099","url":null,"abstract":"<p><p>Multiple chemodrugs with nanotechnology have proven to be an effective cancer treatment technique. When taken combined, cabazitaxel (CTX) and cisplatin (PT) have more excellent cytotoxic effects than drugs used alone in the chemotherapy of several different cancers. However, several severe side effects are associated with using these chemotherapy drugs in cancer patients. Gold nanomaterials (AuNMs) are promising as drug carriers because of their small diameter, easy surface modifications, good biocompatibility, and strong cell penetration. This work aimed to determine the CTX and PT encapsulated with AuNMs against human glioma U87 cancer cells. The fabrication of the AuNMs achieved a negative surface charge, polydispersity index, and the mean sizes. The combined cytotoxic effect of CTX and PT bound to AuNMs was greater than that of either drug alone when tested on U87 cells. The half inhibitory concentration (IC₅₀) values for free PT were 54.7 <i>μ</i>g/mL (at 24 h) and 4.8 g <i>μ</i>g/mL (at 72 h). Results acquired from the MTT assay show cell growth decreases time- and concentration-dependent AuNMs, free CTX, free PT, and AuNMs@CTX/PT-induced cytotoxicity and, ultimately, the cell death of U87 cells via apoptosis. The biochemical apoptosis staining techniques investigated the cells' morphological changes of the cells (acridine orange and ethidium bromide (AO-EB) and nuclear staining (DAPI) techniques). The AO-EB and nuclear staining results reveal that the NPs effectively killed cancer cells. Furthermore, the flow cytometry analysis examined the mode of cell death. Therefore, AuNMs@CTX/PT has excellent potential in the cancer therapy of different cancer cells.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation.","authors":"Elizabeth Gómez,&nbsp;José Miguel Galván-Hidalgo,&nbsp;Guillermo Pérez-Cuéllar,&nbsp;Karoline Alondra Huerta-Landa,&nbsp;Arturo González-Hernández,&nbsp;Omar Gómez-García,&nbsp;Dulce Andrade-Pavón,&nbsp;Teresa Ramírez-Apan,&nbsp;Karla Daniela Rodríguez Hernández,&nbsp;Simón Hernández,&nbsp;Patricia Cano-Sánchez,&nbsp;Homero Gómez-Velasco","doi":"10.1155/2023/7901843","DOIUrl":"10.1155/2023/7901843","url":null,"abstract":"<p><p>Organotin complexes were prepared through a one-pot reaction with three components by reacting thiosemicarbazide or 4-methyl-3-thiosemicarbazide or 4-phenylthiosemicarbazide, dehydroacetic acid (DHA) and dibutyl, diphenyl, dicyclohexyl, and bis[(trimethylsilyl)methyl]tin(IV) oxides; all complexes were characterized by infrared (IR), ultraviolet-visible (UV-vis), mass spectrometry (MS), and nuclear magnetic resonance (NMR) spectroscopy. The ¹¹⁹Sn NMR revealed chemical shifts corresponding to a pentacoordinated environment in solution. The X-ray crystallography of the two complexes evidenced the formation of monomeric complexes with a pentacoordinated geometry around tin via three donor atoms from the ligand, the sulfur of the thiol, the nitrogen of the imine group, and the oxygen of the pyran ring. The geometries of the five-coordinated complexes <b>3a</b> (Bu₂SnL3), <b>3c</b> (Ph₂SnL3), and <b>3d</b> (Cy₂SnL3) acid were intermediate between square pyramidal and trigonal bipyramidal, and complex <b>1a</b> (Bu₂SnL1) adopted a bipyramidal trigonal geometry (BPT). The sulforhodamine B assay assessed the cytotoxicity of organotin(IV) complexes against the MDA-MB-231 and MCF-7 (human mammary adenocarcinoma) cell lines and one normal COS-7 (African green monkey kidney fibroblast). The IC₅₀ values evidenced a significant antiproliferative effect on cancer cells; the complexes were more potent than the positive cisplatin control and the corresponding ligands, dehydroacetic acid thiosemicarbazone (<b>L1</b>), dehydroacetic acid-N(4)-methylthiosemicarbazone (<b>L2</b>), and dehydroacetic acid-N(4)-phenylthiosemicarbazone (<b>L3</b>). The IC₅₀ values also indicated that the organotin(IV) complexes were more cytotoxic against the triple-negative breast cell line MDA-MB-231 than MCF-7, inducing significant morphological alterations. The interactions of organotin(IV) <b>1c</b> (Ph₂SnL1), <b>1d</b> (Cy₂SnL1), and <b>1e</b> (((CH₃)₃SiCH₂)₂SnL1) were evaluated with ss-DNA by fluorescence; intensity changes of the fluorescence were indicative of the displacement of ethidium bromide (EB), confirming the interaction of the organotin(IV) complexes with ss-DNA; the results showed a DNA binding affinity. The thermodynamic parameters obtained through isothermal titration calorimetry showed that the interaction of <b>1c</b> (Ph₂SnL1), with ss-ADN, was exothermic. Molecular docking studies also demonstrated that the organotin(IV) complexes were intercalated in DNA by conventional hydrogen bonds, carbon-hydrogen bonds, and <i>π</i>-alkyl interactions. These complexes furthermore showed a greater affinity towards DNA than cisplatin.</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Capping Agent on Structure, Composition, and Optical Properties of Low-Cost Chemically Deposited Zinc Oxide Thin Films and Their Antibacterial Activities","authors":"S. Thanikaikarasan, C. Amutha, B. Natarajan, D. Dhanasekaran, S. Rajkumar","doi":"10.1155/2023/7187387","DOIUrl":"https://doi.org/10.1155/2023/7187387","url":null,"abstract":"In the present report, pure zinc oxide and albumen-capped zinc oxide thin films were deposited on a glass substrate by a simple chemical method. The growth rate of the deposited film increases by means of number of dipping linearly. The films deposited were subjected to XRD, SEM, EDX, and UV-visible spectroscopy to analyze the crystal structure, morphology, composition, and optical properties. Structural feature reported that the deposited films were found to be a wurtzite structure. The degree of crystallinity depends on film thickness with deposition time per cycles. The parameters related to film structure, such as stress, strain, dislocation density, lattice constant, and bond length, were determined. The values of the fundamental absorption edge were at 3.28 and 3.06 eV for the deposited films of pure zinc oxide and albumen-capped zinc oxide, respectively. Photoluminescence measurements indicated that the peaks of emission were found to be 375 and 340 nm for zinc oxide and albumen-capped zinc oxide. The effects of an antibacterial activity against different positive and negative bacteria sources were determined.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135365952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Computational Study on the Inhibitory Effect of Natural Compounds against the SARS-CoV-2 Proteins.","authors":"Bioinorganic Chemistry And Applications","doi":"10.1155/2023/9804379","DOIUrl":"10.1155/2023/9804379","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/8635054.].</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41189991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: (5E,7E)-4,5,6 Trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate from <i>Euclea crispa</i> (L.) Inhibits Ovarian Cancer Cell Growth by Controlling Apoptotic and Metastatic Signaling Mechanisms.","authors":"Bioinorganic Chemistry And Applications","doi":"10.1155/2023/9854717","DOIUrl":"10.1155/2023/9854717","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/4464056.].</p>","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41189990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: The Application of Natural Camel Milk Products to Treat Autism-Spectrum Disorders: Risk Assessment and Meta-Analysis of Randomized Clinical Trials.","authors":"Bioinorganic Chemistry And Applications","doi":"10.1155/2023/9807391","DOIUrl":"10.1155/2023/9807391","url":null,"abstract":"[This retracts the article DOI: 10.1155/2022/6422208.].","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41189992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives.","authors":"Andres Alguacil,&nbsp;Franco Scalambra,&nbsp;Antonio Romerosa,&nbsp;Andreia Bento-Oliveira,&nbsp;Fernanda Marques,&nbsp;Ines Maximiano,&nbsp;Rodrigo F M de Almeida,&nbsp;Ana Isabel Tomaz,&nbsp;Andreia Valente","doi":"10.1155/2023/6669394","DOIUrl":"10.1155/2023/6669394","url":null,"abstract":"Piano-stool-{CpRu} complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA), N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA), and 3,7-dimethyl-1,3,7-triaza-5-phosphabyciclo[3.3.1]nonane (dmoPTA) were evaluated as drugs against breast cancer. The evaluated compounds include two new examples of this family, the complexes [RuCp(DMSO-κS)(HdmoPTA)(PPh3)](CF3SO3)2 (8) and [RuCp(PPh3)2-µ-dmoPTA-1κP-2κ2N,N′-PdCl2](CF3SO3) (11), which have been synthesized and characterized by NMR, IR, and single-crystal X-ray diffraction. The cytotoxic activity of compounds was evaluated against MDA-MB-231 breast cancer cells, and the three most active complexes were further tested against the hormone-dependent MCF-7 breast cancer cell line. Their cell death mechanism and ruthenium uptake were also evaluated, as well as their binding ability to human serum albumin.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41106243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Lepidium sativum</i> Seed Extract-Mediated Synthesis of Zinc Oxide Nanoparticles: Structural, Morphological, Optical, Hemolysis, and Antibacterial Studies.","authors":"Adnan Alnehia,&nbsp;Annas Al-Sharabi,&nbsp;Abdel-Basit Al-Odayni,&nbsp;A H Al-Hammadi,&nbsp;Fares H Al-Ostoot,&nbsp;Waseem Sharaf Saeed,&nbsp;Naaser A Y Abduh,&nbsp;Ali Alrahlah","doi":"10.1155/2023/4166128","DOIUrl":"https://doi.org/10.1155/2023/4166128","url":null,"abstract":"Nanomaterials have unique physicochemical properties compared to their bulk counterparts. Besides, biologically synthesized nanoparticles (NPs) have proven superior to other methods. This work aimed to biosynthesize zinc oxide (ZnO) NPs using an aqueous extract of Lepidium sativum seed. The obtained ZnO NPs were characterized by X-ray diffraction, scanning electron microscopy, Fourier transform infrared, and ultraviolet-visible spectroscopy. The in vitro antibacterial activity of ZnO NPs against Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria was assessed using the disk diffusion technique. The hemolytic impact was quantified spectrophotometrically. The results indicated a 24.2 nm crystallite size, a hexagonal structure phase, and a 3.48 eV optical bandgap. Antibacterial studies revealed a dose-dependent response with comparable activity to the standard drug (gentamicin) and higher activity against S. aureus than E. coli, e.g., the zone of inhibition at 120 mg/mL was 23 ± 1.25 and 16 ± 1.00 mm, respectively. The hemolysis assay showed no potential harm due to ZnO NPs toward red blood cells if utilized in low doses. As a result, it could be concluded that the reported biogenic method for synthesizing ZnO NPs is promising, resulting in hemocompatible NPs and comparable bactericidal agents.","PeriodicalId":8914,"journal":{"name":"Bioinorganic Chemistry and Applications","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41102401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}