Biogerontology最新文献_第6页

SENS vs. the hallmarks of aging: competing visions, shared challenges. SENS与衰老的标志：相互竞争的愿景，共同的挑战。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-05 DOI: 10.1007/s10522-025-10248-5

Pablo García-Barranquero, Saúl Pérez-González

引用次数: 0

CHIP and aging: a key regulator of proteostasis and cellular senescence. CHIP与衰老：蛋白质平衡和细胞衰老的关键调节因子。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-05 DOI: 10.1007/s10522-025-10247-6

Surya Nath Pandey, Neetu Agrawal, Ehssan Moglad, G Padma Priya, Manish Srivastava, Kattela Chennakesavulu, Biswaranjan Mohanty, Renu Arya, Imran Kazmi, Sami I Alzarea, Waleed Hassan Almalk, Kavita Goyal

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Synbiotic pineapple beverage increases life span in Caenorhabditis elegans, ameliorates cognitive impairment, and restores gut microbiome diversity in D-galactose-induced aged C57BL/6 mice. 在d -半乳糖诱导的衰老C57BL/6小鼠中，合成菠萝饮料可延长秀丽隐杆线虫的寿命，改善认知障碍，并恢复肠道微生物群多样性。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-03 DOI: 10.1007/s10522-025-10239-6

Neelam Anil Revankar, Siddaraju Anusha, Serva Peddha Muthukumar, Pradeep Singh Negi

{"title":"Synbiotic pineapple beverage increases life span in Caenorhabditis elegans, ameliorates cognitive impairment, and restores gut microbiome diversity in D-galactose-induced aged C57BL/6 mice.","authors":"Neelam Anil Revankar, Siddaraju Anusha, Serva Peddha Muthukumar, Pradeep Singh Negi","doi":"10.1007/s10522-025-10239-6","DOIUrl":"10.1007/s10522-025-10239-6","url":null,"abstract":"The incidence of age-associated ailments has increased proportionately with the expansion of the aging demographic. This study aimed to evaluate the anti-aging potential of synbiotic pineapple beverage formulated with 100% pineapple juice, 1% inulin, and Lacticaseibacillus rhamnosus ATCC 53103 (10 log CFU) in Caenorhabditis elegans and D-galactose age-induced mice. The synbiotic juice-treated nematodes exhibited a 24.52% increase in their lifespan, accompanied by lower levels of reactive oxygen species and improved structural functions. In vivo studies demonstrated that synbiotic treatment positively influences age-induced mice's cerebellar function and spatial memory. Additionally, the synbiotic beverage containing 8-10 log CFU of Lacticaseibacillus rhamnosus showed a protective effect against hippocampal neuron damage. The control group displayed a higher Firmicutes/Bacteroides (F/B) ratio, whereas the significantly lower F/B ratio in the diseased groups indicated a reversal of microbial imbalance caused by D-galactose exposure. Furthermore, the consumption of synbiotic beverage mitigated telomere shortening in aged mice. The results highlight the anti-aging effects of a pineapple beverage formulated with Lacticaseibacillus rhamnosus and inulin as a synbiotic intervention. This study suggests that dietary interventions incorporating prebiotics and probiotics may serve as promising strategy for combating age-related disorders and promoting healthy aging.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"99"},"PeriodicalIF":4.4,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain. 更正：在出生后早期大脑发育过程中参与突触可塑性的免疫基因有助于衰老的雄性大鼠大脑中风后的损伤。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-03 DOI: 10.1007/s10522-025-10241-y

Denisa F V Pirscoveanu, Denissa Greta Olaru, Dirk M Hermann, Thorsten R Doeppner, Flavia Semida Ghinea, Aurel Popa-Wagner

引用次数: 0

Lifestyle, environment and other major determinants of frailty in older adults: a population-based study from the UK Biobank. 生活方式、环境和其他影响老年人身体虚弱的主要因素：来自英国生物银行的一项基于人群的研究。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-03 DOI: 10.1007/s10522-025-10242-x

Ali Hemadeh, Carlota Lema-Arranz, Stefano Bonassi, Leonardo Buscarini, Francesco Infarinato, Paola Romano, Alessia Finti, Franco Marinozzi, Fabiano Bini, Natalia Fernández-Bertólez, João Paulo Teixeira, Laura Lorenzo-López, Vanessa Valdiglesias, Blanca Laffon

{"title":"Lifestyle, environment and other major determinants of frailty in older adults: a population-based study from the UK Biobank.","authors":"Ali Hemadeh, Carlota Lema-Arranz, Stefano Bonassi, Leonardo Buscarini, Francesco Infarinato, Paola Romano, Alessia Finti, Franco Marinozzi, Fabiano Bini, Natalia Fernández-Bertólez, João Paulo Teixeira, Laura Lorenzo-López, Vanessa Valdiglesias, Blanca Laffon","doi":"10.1007/s10522-025-10242-x","DOIUrl":"10.1007/s10522-025-10242-x","url":null,"abstract":"Frailty is a geriatric multidimensional syndrome characterized by a loss of physiologic reserves and disproportionate vulnerability to external stressors and associated with increased risk of multiple negative health outcomes. Since frailty can be prevented, controlled, and even reverted in its early stages, identifying the main factors involved in its development is crucial to implement preventive and/or restorative interventions. The aim of this study was to assess the impact of a broad range of parameters, including host factors, lifestyle, diet, and environmental and occupational conditions, on the development of frailty in later life. A cross-sectional study was conducted on 221,896 individuals aged 60 and over classified as non-frail (119,332, 53.8%), pre-frail (93,180, 42.0%), and frail (9384, 4.2%) according to the frailty phenotype. Using principal component analysis and machine learning to streamline the data, significant associations were found between frailty risk and air quality, diet, smoking, working conditions, and heavy alcohol consumption. Early-life factors, including breastfed as a baby and maternal smoking around birth, also emerged as predictors of frailty, which was further characterized by clinical indicators like polypharmacy, levels of C-reactive protein and other biomarkers of inflammageing. This study provided robust and original evidence on the association between a large battery of potential risk factors, from early to later stages of life, and the occurrence of frailty in older age. These results will contribute to the development of effective prevention strategies and facilitate the early detection of individuals at high risk of developing frailty.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"100"},"PeriodicalIF":4.4,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vorinostat, a potential hormetin, extends lifespan and enhances stress resistance via the SKN-1 pathway in Caenorhabditis elegans. Vorinostat是一种潜在的激素，通过SKN-1通路延长秀丽隐杆线虫的寿命并增强抗逆性。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-04-25 DOI: 10.1007/s10522-025-10236-9

Shuai Huang, Hang Shi, Zhidan Shi, Jiawei Wu, Ling He

{"title":"Vorinostat, a potential hormetin, extends lifespan and enhances stress resistance via the SKN-1 pathway in Caenorhabditis elegans.","authors":"Shuai Huang, Hang Shi, Zhidan Shi, Jiawei Wu, Ling He","doi":"10.1007/s10522-025-10236-9","DOIUrl":"10.1007/s10522-025-10236-9","url":null,"abstract":"Vorinostat, a pan histone deacetylases (HDACs) inhibitor clinically approved for cutaneous T-cell lymphoma, exerts therapeutic effects by inducing tumor cell death and cycle arrest. Intriguingly, a previously unrecognized hormetic role of low-dose vorinostat in Caenorhabditis elegans. Subtoxic concentrations of vorinostat (1 μM) significantly extended lifespan, enhanced healthspan, and improved resistance to oxidative and heat stress, while ameliorating Aβ-induced paralysis. qPCR analysis demonstrated dose-dependent bidirectional regulation of stress-resistance genes (sod-3, hsp-16.2, skn-1, gst-4, act-1), with low doses of vorinostat upregulating these genes whereas higher doses (10 μM) exerted suppressive or neutral effects. Mechanistically, vorinostat-induced hormesis required functional SKN-1 signaling, as evidenced by its capacity to activate skn-1 and downstream targets (hsp-16.2, gst-4, act-1). Crucially, RNAi-mediated skn-1 knockdown completely abolished the pro-longevity and stress-resistant phenotypes. These findings establish vorinostat as a novel hormetin that enhances organismal resilience through SKN-1 pathway activation, providing new insights into HDAC inhibitor biology and aging intervention strategies.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"97"},"PeriodicalIF":4.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sirt2 deficiency aggravates intramuscular adipose tissue infiltration and impairs myogenesis with aging in male mice. 在雄性小鼠中，Sirt2缺乏会加剧肌内脂肪组织的浸润，并随着年龄的增长损害肌肉的发生。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-04-21 DOI: 10.1007/s10522-025-10238-7

Eun-Joo Lee, SunYoung Park, Kyu-Shik Jeong

{"title":"Sirt2 deficiency aggravates intramuscular adipose tissue infiltration and impairs myogenesis with aging in male mice.","authors":"Eun-Joo Lee, SunYoung Park, Kyu-Shik Jeong","doi":"10.1007/s10522-025-10238-7","DOIUrl":"10.1007/s10522-025-10238-7","url":null,"abstract":"Sarcopenia, closely associated with other diseases such as diabetes, metabolic syndrome, and osteoporosis, significantly impacts aging populations. It is characterized by muscle atrophy, increased intramuscular adipose tissue, impaired myogenesis, chronic low-grade inflammation, and reduced muscle function. The mechanisms behind aging muscle remain incompletely understood. This study aims to elucidate the role of Sirt2 in the aging process of skeletal muscles and enhance our understanding of the underlying mechanisms. Sirt2 expression was reduced in aging muscle of male mice by 40%, compared to young muscle. Aged male Sirt2 knockout mice exhibit increased intramuscular adipose tissue infiltration by 8.5-fold changes. Furthermore, the deletion of Sirt2 exacerbated myogenesis impairment in aged muscle by decreasing the expression of Pax7 (50%) and NogoA (80%), compared to age- and sex- matched counterparts, emphasizing the role of Sirt2 in pathology of aging muscle. Additionally, long-term Sirt2 deletion affected other Sirtuin subfamily members, with decreased expressions of Sirt1 (65%), Sirt4 (94%), and Sirt5 (71%), and increased expressions of Sirt6 (4.6-fold) and Sirt7 (2.8-fold) in old male Sirt2 knockout mice, while there was no difference of these gene expression in young male mice. This study underscores the critical need for a deeper investigation into Sirt2, promising new insights that could lead to targeted therapies for sarcopenia, ultimately improving the quality of life in the elderly.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"93"},"PeriodicalIF":4.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longevity mechanisms in cardiac aging: exploring calcium dysregulation and senescence. 心脏老化中的长寿机制：探索钙失调和衰老。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-04-21 DOI: 10.1007/s10522-025-10229-8

Neetu Agrawal, Muhammad Afzal, Waleed Hassan Almalki, Suhas Ballal, Girish Chandra Sharma, T Krithiga, Rajashree Panigrahi, Suman Saini, Haider Ali, Kavita Goyal, Mohit Rana, Abida Khan

{"title":"Longevity mechanisms in cardiac aging: exploring calcium dysregulation and senescence.","authors":"Neetu Agrawal, Muhammad Afzal, Waleed Hassan Almalki, Suhas Ballal, Girish Chandra Sharma, T Krithiga, Rajashree Panigrahi, Suman Saini, Haider Ali, Kavita Goyal, Mohit Rana, Abida Khan","doi":"10.1007/s10522-025-10229-8","DOIUrl":"10.1007/s10522-025-10229-8","url":null,"abstract":"Cardiac aging is a multistep process that results in a loss of various structural and functional heart abilities, increasing the risk of heart disease. Since its remarkable discovery in the early 1800s, when limestone is heated, calcium's importance has been defined in numerous ways. It can help stiffen shells and bones, function as a reducing agent in chemical reactions, and play a central role in cellular signalling. The movement of calcium ions in and out of cells and between those is referred to as calcium signalling. It influences the binding of the ligand, enzyme activity, electrochemical gradients, and other cellular processes. Calcium signalling is critical for both contraction and relaxation under the sliding filament model of heart muscle. However, with age, the heart undergoes changes that lead to increases in cardiac dysfunction, such as myocardial fibrosis, decreased cardiomyocyte function, and noxious disturbances in calcium homeostasis. Additionally, when cardiac tissues age, cellular senescence, a state of irreversible cell cycle arrest, accumulates and begins to exacerbate tissue inflammation and fibrosis. This review explores the most recent discoveries regarding the role of senescent cell accumulation and calcium signalling perturbances in cardiac aging. Additionally, new treatment strategies are used to reduce aged-related heart dysfunction by targeting senescent cells and modulating calcium homeostasis.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"94"},"PeriodicalIF":4.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary inflammatory index (DII) and telomere length: a systematic review. 膳食炎症指数（DII）和端粒长度：一项系统综述。

IF 4.1 4区医学

Biogerontology Pub Date : 2025-04-21 DOI: 10.1007/s10522-025-10237-8

Joice da Silva Castro, Carolynne Martins Teixeira, Daniela Mayumi Usuda Prado Rocha, Andréia Queiroz Ribeiro, Ana Claudia Pelissari Kravchychyn, Helen Hermana Miranda Hermsdorff

{"title":"Dietary inflammatory index (DII) and telomere length: a systematic review.","authors":"Joice da Silva Castro, Carolynne Martins Teixeira, Daniela Mayumi Usuda Prado Rocha, Andréia Queiroz Ribeiro, Ana Claudia Pelissari Kravchychyn, Helen Hermana Miranda Hermsdorff","doi":"10.1007/s10522-025-10237-8","DOIUrl":"10.1007/s10522-025-10237-8","url":null,"abstract":"Dietary intake influences inflammation and may impact telomere length (TL), a biomarker of biological aging. However, the relationship between the inflammatory potential of the diet and TL remains unclear. This review systematically assessed whether higher Dietary Inflammatory Index (DII) scores, indicative of pro-inflammatory diets, are associated with shorter TL. Searches in PubMed, Embase, Scopus, Web of Science, and Cochrane up to October 2024 identified nine eligible studies, involving 123,923 participants (53% women), aged 9-80 years. Seven studies were cross-sectional, and two were longitudinal, with follow-ups of 5-10 years. Most studies (n = 4) examined adult and older adult populations of both sexes. DII values ranged from -6.48 (anti-inflammatory) to 3.98 (pro-inflammatory). None included all DII parameters, and three adjusted for energy intake. Four studies linked higher DII to shorter TL, focusing on European adults with and without cardiovascular risk, healthy American adults, and Chinese older adults with mild cognitive impairment. This systematic review presents limited data to provide a definitive conclusion on the association between higher DII and shorter TL. Additional studies that address the limitations identified in this review are needed.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"95"},"PeriodicalIF":4.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stem cells and their derivatives as potential longevity-promoting tools. 间充质干细胞及其衍生物作为潜在的长寿促进工具。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-04-21 DOI: 10.1007/s10522-025-10240-z

Ekaterina Rudnitsky, Alex Braiman, Marina Wolfson, Khachik K Muradian, Vera Gorbunova, Gadi Turgeman, Vadim E Fraifeld

{"title":"Mesenchymal stem cells and their derivatives as potential longevity-promoting tools.","authors":"Ekaterina Rudnitsky, Alex Braiman, Marina Wolfson, Khachik K Muradian, Vera Gorbunova, Gadi Turgeman, Vadim E Fraifeld","doi":"10.1007/s10522-025-10240-z","DOIUrl":"10.1007/s10522-025-10240-z","url":null,"abstract":"Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity and treat age-related diseases. MSCs have low immunogenicity and tumorigenicity, and their efficacy is relatively independent of the donor age in humans (but not in rodents). Systemic administration of MSCs and stem cell/blood-derived EVs modified the omic profiles of various organs of aged rodents towards the young ones. The application of EVs appears to be even more beneficial than MSCs. Remarkably, over 70% of microRNAs, which are over-presented in ESC-derived EVs, were found to target longevity-associated genes. Along with MSCs, other types of stem cells were reported to display health- and lifespan-extending effects. Pluripotent Muse cells, a specific subpopulation of MSCs, which possess a number of unique features, could be particularly relevant for promoting healthspan. The rejuvenation potential of MSCs, EVs, and Muse cells warrants further investigation in both animal models and clinical trials, using aging clocks for biological age determination as one of the endpoints.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"96"},"PeriodicalIF":4.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0