Mesenchymal stem cells and their derivatives as potential longevity-promoting tools.

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2025-04-21 DOI:10.1007/s10522-025-10240-z

Ekaterina Rudnitsky, Alex Braiman, Marina Wolfson, Khachik K Muradian, Vera Gorbunova, Gadi Turgeman, Vadim E Fraifeld

{"title":"Mesenchymal stem cells and their derivatives as potential longevity-promoting tools.","authors":"Ekaterina Rudnitsky, Alex Braiman, Marina Wolfson, Khachik K Muradian, Vera Gorbunova, Gadi Turgeman, Vadim E Fraifeld","doi":"10.1007/s10522-025-10240-z","DOIUrl":null,"url":null,"abstract":"<p><p>Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity and treat age-related diseases. MSCs have low immunogenicity and tumorigenicity, and their efficacy is relatively independent of the donor age in humans (but not in rodents). Systemic administration of MSCs and stem cell/blood-derived EVs modified the omic profiles of various organs of aged rodents towards the young ones. The application of EVs appears to be even more beneficial than MSCs. Remarkably, over 70% of microRNAs, which are over-presented in ESC-derived EVs, were found to target longevity-associated genes. Along with MSCs, other types of stem cells were reported to display health- and lifespan-extending effects. Pluripotent Muse cells, a specific subpopulation of MSCs, which possess a number of unique features, could be particularly relevant for promoting healthspan. The rejuvenation potential of MSCs, EVs, and Muse cells warrants further investigation in both animal models and clinical trials, using aging clocks for biological age determination as one of the endpoints.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"96"},"PeriodicalIF":4.4000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011939/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biogerontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10522-025-10240-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity and treat age-related diseases. MSCs have low immunogenicity and tumorigenicity, and their efficacy is relatively independent of the donor age in humans (but not in rodents). Systemic administration of MSCs and stem cell/blood-derived EVs modified the omic profiles of various organs of aged rodents towards the young ones. The application of EVs appears to be even more beneficial than MSCs. Remarkably, over 70% of microRNAs, which are over-presented in ESC-derived EVs, were found to target longevity-associated genes. Along with MSCs, other types of stem cells were reported to display health- and lifespan-extending effects. Pluripotent Muse cells, a specific subpopulation of MSCs, which possess a number of unique features, could be particularly relevant for promoting healthspan. The rejuvenation potential of MSCs, EVs, and Muse cells warrants further investigation in both animal models and clinical trials, using aging clocks for biological age determination as one of the endpoints.

查看原文本刊更多论文

间充质干细胞及其衍生物作为潜在的长寿促进工具。

间充质干细胞（MSCs）和血浆/间充质干细胞衍生的细胞外囊泡（EVs）为延长寿命和治疗与年龄有关的疾病提供了有前途的工具。MSCs具有较低的免疫原性和致瘤性，其功效相对独立于人类的供体年龄（但在啮齿动物中则不是）。系统给药MSCs和干细胞/血源性ev可以改变老年啮齿动物各器官的组学特征。电动汽车的应用似乎比间充质干细胞更有益。值得注意的是，在esc衍生的ev中，超过70%的microrna被发现靶向长寿相关基因。据报道，除了间充质干细胞外，其他类型的干细胞也显示出健康和延长寿命的作用。多能缪斯细胞是间充质干细胞的一个特定亚群，具有许多独特的特征，可能与促进健康寿命特别相关。MSCs、ev和Muse细胞的年轻化潜力值得在动物模型和临床试验中进一步研究，使用衰老时钟作为生物年龄测定的终点之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.