Dietary inflammatory index (DII) and telomere length: a systematic review.

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2025-04-21 DOI:10.1007/s10522-025-10237-8

Joice da Silva Castro, Carolynne Martins Teixeira, Daniela Mayumi Usuda Prado Rocha, Andréia Queiroz Ribeiro, Ana Claudia Pelissari Kravchychyn, Helen Hermana Miranda Hermsdorff

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Abstract

Dietary intake influences inflammation and may impact telomere length (TL), a biomarker of biological aging. However, the relationship between the inflammatory potential of the diet and TL remains unclear. This review systematically assessed whether higher Dietary Inflammatory Index (DII) scores, indicative of pro-inflammatory diets, are associated with shorter TL. Searches in PubMed, Embase, Scopus, Web of Science, and Cochrane up to October 2024 identified nine eligible studies, involving 123,923 participants (53% women), aged 9-80 years. Seven studies were cross-sectional, and two were longitudinal, with follow-ups of 5-10 years. Most studies (n = 4) examined adult and older adult populations of both sexes. DII values ranged from -6.48 (anti-inflammatory) to 3.98 (pro-inflammatory). None included all DII parameters, and three adjusted for energy intake. Four studies linked higher DII to shorter TL, focusing on European adults with and without cardiovascular risk, healthy American adults, and Chinese older adults with mild cognitive impairment. This systematic review presents limited data to provide a definitive conclusion on the association between higher DII and shorter TL. Additional studies that address the limitations identified in this review are needed.

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膳食炎症指数（DII）和端粒长度：一项系统综述。

饮食摄入影响炎症，并可能影响端粒长度（TL），这是生物衰老的生物标志物。然而，饮食的炎症潜能与TL之间的关系尚不清楚。本综述系统评估了较高的饮食炎症指数（Dietary Inflammatory Index， DII）评分是否与较短的TL相关。截至2024年10月，在PubMed、Embase、Scopus、Web of Science和Cochrane中检索了9项符合条件的研究，涉及123,923名参与者（53%为女性），年龄9-80岁。7项研究是横断面研究，2项是纵向研究，随访5-10年。大多数研究（n = 4）调查了成年和老年男女人群。DII值从-6.48（抗炎）到3.98（促炎）不等。没有一个包括所有DII参数，三个根据能量摄入进行了调整。四项研究将较高的DII与较短的TL联系起来，重点关注有或没有心血管风险的欧洲成年人、健康的美国成年人和有轻度认知障碍的中国老年人。本系统综述提供了有限的数据，无法就较高的DII和较短的TL之间的关系得出明确的结论。需要进一步的研究来解决本综述中发现的局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.