{"title":"A machine learning classifier-based approach for diabetes mellitus risk prediction.","authors":"Jai Kumar B, Mohanasundaram Ranganathan","doi":"10.1088/2057-1976/ad857b","DOIUrl":"https://doi.org/10.1088/2057-1976/ad857b","url":null,"abstract":"<p><p>Currently, Diabetes Mellitus (DM) can be life-threatening due to the dietary habits and lifestyle choices of individuals. Diabetes is characterised by elevated levels of glucose in the blood and an excess of protein in the blood. Poor eating habits and lifestyles are largely responsible for the rise in overweight, obesity, and various related conditions. This study investigated many diabetes-related risk forecasting techniques and algorithms. The eight machine learning (ML) algorithms used the diabetes dataset to test various prediction techniques, including a Support Vector Classifier, gradient-boosting, multilayer perceptron, random forest, K-nearest neighbors, logistic regression, extreme gradient boosting, and decision tree. To enhance the diabetic prediction ability of the model, we suggested using Feature Engineering (FE) and feature scaling. For our investigation, we utilized the Mendeley dataset on diabetes to assess the capacity of the model to predict diabetes. We developed a model by using Python programming and eight classification techniques. The Random Forest with 99.21%, Gradient Boosting with 99.61%, Extreme Gradient Boosting, and Decision Tree achieved the highest F1 score (99.81%), accuracy rate (99.80%), precision (99.81%), and recall (99.81%) of all classification approaches.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amira Mohamed, Doha Eid, Mariam M Ezzat, Mayar Ehab, Maye Khaled, Sarah Gaber, Amira Gaber
{"title":"Facia-fix: mobile application for bell's palsy diagnosis and assessment using computer vision and deep learning.","authors":"Amira Mohamed, Doha Eid, Mariam M Ezzat, Mayar Ehab, Maye Khaled, Sarah Gaber, Amira Gaber","doi":"10.1088/2057-1976/ad8094","DOIUrl":"10.1088/2057-1976/ad8094","url":null,"abstract":"<p><p>Facial paralysis (FP) is a condition characterized by the inability to move some or all of the muscles on one or both sides of the face. Diagnosing FP presents challenges due to the limitations of traditional methods, which are time-consuming, uncomfortable for patients, and require specialized clinicians. Additionally, more advanced tools are often uncommonly available to all healthcare providers. Early and accurate detection of FP is crucial, as timely intervention can prevent long-term complications and improve patient outcomes. To address these challenges, our research introduces Facia-Fix, a mobile application for Bell's palsy diagnosis, integrating computer vision and deep learning techniques to provide real-time analysis of facial landmarks. The classification algorithms are trained on the publicly available YouTube FP (YFP) dataset, which is labeled using the House-Brackmann (HB) method, a standardized system for assessing the severity of FP. Different deep learning models were employed to classify the FP severity, such as MobileNet, CNN, MLP, VGG16, and Vision Transformer. The MobileNet model which uses transfer learning, achieved the highest performance (Accuracy: 0.9812, Precision: 0.9753, Recall: 0.9727, F1 Score: 0.974), establishing it as the optimal choice among the evaluated models. The innovation of this approach lies in its use of advanced deep learning models to provide accurate, objective, non-invasive and real-time comprehensive quantitative assessment of FP severity. Preliminary results highlight the potential of Facia-Fix to significantly improve the diagnostic and follow-up experiences for both clinicians and patients.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Green synthesis of cerium oxide nanoparticles using<i>Tribulus terrestris</i>: characterization and evaluation of antioxidant, anti-inflammatory and antibacterial efficacy against wound isolates.","authors":"Maganti Raghav Prasad Choudary, Muthuvel Surya, Muthupandian Saravanan","doi":"10.1088/2057-1976/ad7f59","DOIUrl":"10.1088/2057-1976/ad7f59","url":null,"abstract":"<p><p>Multi-drug resistance (MDR) infections are a significant global challenge, necessitating innovative and eco-friendly approaches for developing effective antimicrobial agents. This study focuses on the synthesis, characterization, and evaluation of cerium oxide nanoparticles (CeO<sub>2</sub>NPs) for their antioxidant, anti-inflammatory, and antibacterial properties. The CeO<sub>2</sub>NPs were synthesized using a<i>Tribulus terrestris</i>aqueous extract through an environmentally friendly process. Characterization techniques included UV-visible spectroscopy, Fourier Transform Infrared Spectroscopy (FT-IR), x-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Energy Dispersive x-ray (EDX) analysis. The UV-vis spectroscopy shows the presence of peak at 320 nm which confirms the formation of CeO<sub>2</sub>NPs. The FT-IR analysis of the CeO<sub>2</sub>NPs revealed several distinct functional groups, with peak values at 3287, 2920, 2340, 1640, 1538, 1066, 714, and 574 cm<sup>-1</sup>. These peaks correspond to specific functional groups, including C-H stretching in alkynes and alkanes, C=C=O, C=C, alkanes, C-O-C, C-Cl, and C-Br, indicating the presence of diverse chemical bonds within the CeO<sub>2</sub>NPs. XRD revealed that the nanoparticles were highly crystalline with a face-centered cubic structure, and SEM images showed irregularly shaped, agglomerated particles ranging from 100-150 nm. In terms of biological activity, the synthesized CeO<sub>2</sub>NPs demonstrated significant antioxidant and anti-inflammatory properties. The nanoparticles exhibited 82.54% antioxidant activity at 100 μg ml<sup>-1</sup>, closely matching the 83.1% activity of ascorbic acid. Additionally, the CeO<sub>2</sub>NPs showed 65.2% anti-inflammatory activity at the same concentration, compared to 70.1% for a standard drug. Antibacterial testing revealed that the CeO<sub>2</sub>NPs were particularly effective against multi-drug resistant strains, including<i>Pseudomonas aeruginosa</i>,<i>Enterococcus faecalis</i>, and MRSA, with moderate activity against<i>Klebsiella pneumoniae</i>. These findings suggest that CeO<sub>2</sub>NPs synthesized via<i>T. terrestris</i>have strong potential as antimicrobial agents in addressing MDR infections.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amna Ghani, Hartmut Heinrich, Trevor Brown, Klaus Schellhorn
{"title":"Enhancing EEG data quality and precision for cloud-based clinical applications: an evaluation of the SLOG framework.","authors":"Amna Ghani, Hartmut Heinrich, Trevor Brown, Klaus Schellhorn","doi":"10.1088/2057-1976/ad7e2d","DOIUrl":"10.1088/2057-1976/ad7e2d","url":null,"abstract":"<p><p>Automation is revamping our preprocessing pipelines, and accelerating the delivery of personalized digital medicine. It improves efficiency, reduces costs, and allows clinicians to treat patients without significant delays. However, the influx of multimodal data highlights the need to protect sensitive information, such as clinical data, and safeguard data fidelity. One of the neuroimaging modalities that produces large amounts of time-series data is Electroencephalography (EEG). It captures the neural dynamics in a task or resting brain state with high temporal resolution. EEG electrodes placed on the scalp acquire electrical activity from the brain. These electrical potentials attenuate as they cross multiple layers of brain tissue and fluid yielding relatively weaker signals than noise-low signal-to-noise ratio. EEG signals are further distorted by internal physiological artifacts, such as eye movements (EOG) or heartbeat (ECG), and external noise, such as line noise (50 Hz). EOG artifacts, due to their proximity to the frontal brain regions, are particularly challenging to eliminate. Therefore, a widely used EOG rejection method, independent component analysis (ICA), demands manual inspection of the marked EOG components before they are rejected from the EEG data. We underscore the inaccuracy of automatized ICA rejection and provide an auxiliary algorithm-Second Layer Inspection for EOG (SLOG) in the clinical environment. SLOG based on spatial and temporal patterns of eye movements, re-examines the already marked EOG artifacts and confirms no EEG-related activity is mistakenly eliminated in this artifact rejection step. SLOG achieved a 99% precision rate on the simulated dataset while 85% precision on the real EEG dataset. One of the primary considerations for cloud-based applications is operational costs, including computing power. Algorithms like SLOG allow us to maintain data fidelity and precision without overloading the cloud platforms and maxing out our budgets.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Negin Piran Nanekaran, Tony H Felefly, Nicola Schieda, Scott C Morgan, Richa Mittal, Eran Ukwatta
{"title":"Prediction of prostate cancer recurrence after radiotherapy using a fused machine learning approach: Utilizing radiomics from pretreatment T2W MRI images with clinical and pathological information.","authors":"Negin Piran Nanekaran, Tony H Felefly, Nicola Schieda, Scott C Morgan, Richa Mittal, Eran Ukwatta","doi":"10.1088/2057-1976/ad8201","DOIUrl":"https://doi.org/10.1088/2057-1976/ad8201","url":null,"abstract":"<p><strong>Background: </strong>The risk of biochemical recurrence (BCR) after radiotherapy for localized prostate cancer (PCa) varies widely within standard risk groups. There is a need for low-cost tools to more robustly predict recurrence and personalize therapy. Radiomic features from pretreatment MRI show potential as noninvasive biomarkers for BCR prediction. However, previous research has not fully combined radiomics with clinical and pathological data to predict BCR in PCa patients following radiotherapy.
Purpose: This study aims to predict 5-year BCR using radiomics from pretreatment T2W MRI and clinical-pathological data in PCa patients treated with radiation therapy, and to develop a unified model compatible with both 1.5T and 3T MRI scanners.
Methods: A total of 150 T2W scans and clinical parameters were preprocessed. Of these, 120 cases were used for training and validation, and 30 for testing. Four distinct machine learning models were developed: Model 1 used radiomics, Model 2 used clinical and pathological data, and Model 3 combined these using late fusion. Model 4 integrated radiomic and clinical-pathological data using early fusion.
Results: Model 1 achieved an AUC of 0.73, while Model 2 had an AUC of 0.64 for predicting outcomes in 30 new test cases. Model 3, using late fusion, had an AUC of 0.69. Early fusion models showed strong potential, with Model 4 reaching an AUC of 0.84, highlighting the effectiveness of the early fusion model.
Conclusions: This study is the first to use a fusion technique for predicting BCR in PCa patients following radiotherapy, utilizing pre-treatment T2W MRI images and clinical-pathological data. The methodology improves predictive accuracy by fusing radiomics with clinical-pathological information, even with a relatively small dataset, and introduces the first unified model for both 1.5T and 3T MRI images.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiang Gu, Chen Dang, Tianyu Shi, Lihan Tang, Kai Wang, Xiangsheng Luo, Yu Zhu, Yuan Feng, Guisen Wu, Ling Zou, Li Sun
{"title":"A Novel Brain Network Analysis Method for Pediatric ADHD Using RFE-GA Feature Selection Strategy.","authors":"Xiang Gu, Chen Dang, Tianyu Shi, Lihan Tang, Kai Wang, Xiangsheng Luo, Yu Zhu, Yuan Feng, Guisen Wu, Ling Zou, Li Sun","doi":"10.1088/2057-1976/ad8162","DOIUrl":"https://doi.org/10.1088/2057-1976/ad8162","url":null,"abstract":"<p><p>Attention Deficit Hyperactivity Disorder (ADHD) is a highly prevalent childhood disorder, and related research has been increasing in recent years. However, it remains a challenging issue to accurately identify individuals with ADHD. The research proposes a method for ADHD detection using Recursive Feature Elimination-Genetic Algorithm (RFE-GA) for the feature selection of EEG data. Firstly, this study employed Transfer Entropy (TE) to construct brain networks from the EEG data of the ADHD and Normal groups, conducting an analysis of effective connectivity to unveil causal relationships in the brain's information exchange activities. Subsequently, a dual-layer feature selection method combining Recursive Feature Elimination (RFE) and Genetic Algorithm (GA) was proposed. Using the global search capability of GA and the feature selection ability of RFE, the performance of each feature subset is evaluated to find the optimal feature subset. Finally, a Support Vector Machine (SVM) classifier was employed to classify the ultimate feature set. The results revealed the control group exhibited lower connectivity strength in the left temporal alpha and beta bands, but higher frontal connectivity strength compared to the ADHD group. Additionally, in the gamma frequency band, the control group had higher top lobe connectivity strength than the ADHD group. Through the RFE-GA feature selection method, the optimized feature set was more concise, achieving classification accuracies of 91.3%, 94.1%, and 90.7% for the alpha, beta, and gamma frequency bands, respectively. The proposed RFE-GA feature selection method significantly reduced the number of features, thereby improving classification accuracy.
.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing pap smear image classification: integrating transfer learning and attention mechanisms for improved detection of cervical abnormalities.","authors":"Tamanna Sood, Padmavati Khandnor, Rajesh Bhatia","doi":"10.1088/2057-1976/ad7bc0","DOIUrl":"10.1088/2057-1976/ad7bc0","url":null,"abstract":"<p><p>Cervical cancer remains a major global health challenge, accounting for significant morbidity and mortality among women. Early detection through screening, such as Pap smear tests, is crucial for effective treatment and improved patient outcomes. However, traditional manual analysis of Pap smear images is labor-intensive, subject to human error, and requires extensive expertise. To address these challenges, automated approaches using deep learning techniques have been increasingly explored, offering the potential for enhanced diagnostic accuracy and efficiency. This research focuses on improving cervical cancer detection from Pap smear images using advanced deep-learning techniques. Specifically, we aim to enhance classification performance by leveraging Transfer Learning (TL) combined with an attention mechanism, supplemented by effective preprocessing techniques. Our preprocessing pipeline includes image normalization, resizing, and the application of Histogram of Oriented Gradients (HOG), all of which contribute to better feature extraction and improved model performance. The dataset used in this study is the Mendeley Liquid-Based Cytology (LBC) dataset, which provides a comprehensive collection of cervical cytology images annotated by expert cytopathologists. Initial experiments with the ResNet model on raw data yielded an accuracy of 63.95%. However, by applying our preprocessing techniques and integrating an attention mechanism, the accuracy of the ResNet model increased dramatically to 96.74%. Further, the Xception model, known for its superior feature extraction capabilities, achieved the best performance with an accuracy of 98.95%, along with high precision (0.97), recall (0.99), and F1-Score (0.98) on preprocessed data with an attention mechanism. These results underscore the effectiveness of combining preprocessing techniques, TL, and attention mechanisms to significantly enhance the performance of automated cervical cancer detection systems. Our findings demonstrate the potential of these advanced techniques to provide reliable, accurate, and efficient diagnostic tools, which could greatly benefit clinical practice and improve patient outcomes in cervical cancer screening.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":"10 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biological Cell Response to Electric Field: A Review of Equivalent Circuit Models and Future Challenges.","authors":"MirHojjat Seyedi","doi":"10.1088/2057-1976/ad8092","DOIUrl":"https://doi.org/10.1088/2057-1976/ad8092","url":null,"abstract":"<p><p>Biological cells, characterized by complex and dynamic structures, demand precise models for comprehensive understanding, especially when subjected to external factors such as electric fields (EF) for manipulation or treatment. This interaction is integral to technologies like pulsed electric fields (PEF), inducing reversible and irreversible structural variations. Our study explores both simplified and sophisticated equivalent circuit models for biological cells under the influence of an external EF, covering diverse cell structures from single- to double-shell configurations. The paper highlights challenges in circuit modeling, specifically addressing the incorporation of reversible or irreversible pores in the membrane during external EF interactions, emphasizing the need for further research to refine technical aspects in this field. Additionally, we review a comparative analysis of the performance and applicability of the proposed circuit models, providing insights into their strengths and limitations. This contributes to a deeper insight of the complexities associated with modeling biological cells under external EF influences, paving the way for enhanced applications in medical and technological domains in future.
.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3-1-3 Weight averaging technique-based performance evaluation of deep neural networks for Alzheimer's disease detection using structural MRI.","authors":"Priyanka Gautam, Manjeet Singh","doi":"10.1088/2057-1976/ad72f7","DOIUrl":"10.1088/2057-1976/ad72f7","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a progressive neurological disorder. It is identified by the gradual shrinkage of the brain and the loss of brain cells. This leads to cognitive decline and impaired social functioning, making it a major contributor to dementia. While there are no treatments to reverse AD's progression, spotting the disease's onset can have a significant impact in the medical field. Deep learning (DL) has revolutionized medical image classification by automating feature engineering, removing the requirement for human experts in feature extraction. DL-based solutions are highly accurate but demand a lot of training data, which poses a common challenge. Transfer learning (TL) has gained attention for its knack for handling limited data and expediting model training. This study uses TL to classify AD using T1-weighted 3D Magnetic Resonance Imaging (MRI) from the Alzheimer's Disease Neuroimaging (ADNI) database. Four modified pre-trained deep neural networks (DNN), VGG16, MobileNet, DenseNet121, and NASNetMobile, are trained and evaluated on the ADNI dataset. The 3-1-3 weight averaging technique and fine-tuning improve the performance of the classification models. The evaluated accuracies for AD classification are VGG16: 98.75%; MobileNet: 97.5%; DenseNet: 97.5%; and NASNetMobile: 96.25%. The receiver operating characteristic (ROC), precision-recall (PR), and Kolmogorov-Smirnov (KS) statistic plots validate the effectiveness of the modified pre-trained model. Modified VGG16 excels with area under the curve (AUC) values of 0.99 for ROC and 0.998 for PR curves. The proposed approach shows effective AD classification by achieving high accuracy using the 3-1-3 weight averaging technique and fine-tuning.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher M McGraw, Samvrit Rao, Shashank Manjunath, Jin Jing, M Brandon Westover
{"title":"Automated quantification of periodic discharges in human electroencephalogram.","authors":"Christopher M McGraw, Samvrit Rao, Shashank Manjunath, Jin Jing, M Brandon Westover","doi":"10.1088/2057-1976/ad6c53","DOIUrl":"10.1088/2057-1976/ad6c53","url":null,"abstract":"<p><p>Periodic discharges (PDs) are pathologic patterns of epileptiform discharges repeating at regular intervals, commonly detected in the human electroencephalogram (EEG) signals in patients who are critically ill. The frequency and spatial extent of PDs are associated with the tendency of PDs to cause brain injury, existing automated algorithms do not quantify the frequency and spatial extent of PDs. The present study presents an algorithm for quantifying frequency and spatial extent of PDs. The algorithm quantifies the evolution of these parameters within a short (10-14 second) window, with a focus on lateralized and generalized periodic discharges. We test our algorithm on 300 'easy', 300 'medium', and 240 'hard' examples (840 total epochs) of periodic discharges as quantified by interrater consensus from human experts when analyzing the given EEG epochs. We observe 95.0% agreement with a 95% confidence interval (CI) of [94.9%, 95.1%] between algorithm outputs with reviewer clincal judgement for easy examples, 92.0% agreement (95% CI [91.9%, 92.2%]) for medium examples, and 90.4% agreement (95% CI [90.3%, 90.6%]) for hard examples. The algorithm is also computationally efficient and is able to run in 0.385 ± 0.038 seconds for a single epoch using our provided implementation of the algorithm. The results demonstrate the algorithm's effectiveness in quantifying these discharges and provide a standardized and efficient approach for PD quantification as compared to existing manual approaches.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}