Multi-omic feature reliability of deformable image registration-based images.

Purpose. To evaluate the reliability of radiomic and dosiomic (multi-omic) features extracted from synthetic CT images generated using two commercially available deformable image registration workflows.Materials and Methods. Multi-omic features were extracted from organs at risk (OAR) contoured on a cohort of 58 head and neck (HN) radiotherapy patients. The contours were propagated from the planning CT to synthetic CTs of the final fraction cone-beam CT (CBCT) anatomy using MIM and Velocity deformable image registration workflows. The workflows were validated using radiation oncologist contours on the planning CT and final fraction CBCT according to TG-132 guidelines. The OAR volumes and mean dose on the synthetic CTs from two workflows were compared using a signed Wilcoxon rank test. In addition, the dose distributions were evaluated using a gamma analysis using clinical criteria. The multi-omic features were extracted using region-of-interest extraction on the OAR with the original and wavelet filters. The feature reliability was evaluated for four OAR: spinal cord, parotid glands, submandibular glands, and pharyngeal constrictors. The reliability was evaluated using the intraclass correlation coefficient (ICC) with features exceeding 0.75 considered moderately reliable.Results. The volume and mean OAR dose were found to be statistically similar between the MIM and Velocity synthetic CT workflows. In addition, the gamma analysis resulted in 83% of plans exceeding 95% gamma passing rate at 3%/3 mm criteria. Across all HN OAR multi-omic features, fewer radiomic features (21%) were found to be moderately reliable compared to dosiomic features (59%) between the two synthetic CT workflows. The HN OAR with the most moderately reliable features was the spinal cord (46% radiomic, 85% dosiomic).Conclusion. Radiomics features presented worse reliability compared to dosiomic features across different synthetic CT deformable image registration workflows. Care should be taken when implementing predictive models using features extracted from different synthetic CT workflows.