用于放射治疗研究平台的微束治疗输送系统的设计和验证。

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Biomedical Physics & Engineering Express Pub Date : 2025-05-27 DOI:10.1088/2057-1976/adcf2c

Steven Herchko, Sridhar Yaddanapudi, C-K Chris Wang

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引用次数: 0

摘要

微束放射治疗（MBRT）在临床应用的早期阶段是一种很有前途的治疗技术。在这项工作中，设计，制造了两个六边形微型光束准直器，并使用薄膜测量和蒙特卡罗模拟进行了验证。薄膜和蒙特卡罗结果显示出很强的一致性，在光束中心轴附近一致性最大。然后对先前验证的MBRT准直器之一进行修改，以允许在小鼠锥束计算机断层扫描（CBCT）数据集中进行剂量计算，并在动物数据集中保留MBRT剂量分布。这个经过验证的系统可以用于未来的细胞和小动物研究，以进一步探索MBRT在临床前的应用。

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Design and validation of a minibeam treatment delivery system for use with a radiation therapy research platform.

Minibeam radiation therapy (MBRT) is a promising treatment technique in the early stages of clinical use. In this work, two hexagonal minibeam collimators were designed, fabricated, and validated using film measurements and Monte Carlo simulations. Film and Monte Carlo results demonstrated strong agreement, with the greatest agreement near the beam central axis. One of the previously validated MBRT collimators was then modified to allow for dose calculations on a mouse cone beam computed tomography (CBCT) dataset, and a MBRT dose distribution was preserved in the animal dataset. This validated system can be used in future cell and small animal studies to further explore MBRT in a preclinical setting.

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来源期刊

Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

2.80

自引率

0.00%

发文量

153

期刊介绍： BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.