Inmunologia (Barcelona, Spain : 1987)最新文献_第6页

Informe del Taller Ibérico de Histocompatibilidad 2012. Componente de estandarización de resultados de anticuerpos anti-HLA mediante ensayo en fase sólida 伊比利亚组织相容性研讨会报告2012。固相分析抗hla抗体结果的标准化组成部分

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2012-10-01 DOI: 10.1016/j.inmuno.2012.07.004

Manuel Muro , Antonio Balas , Alberto Torio , Jeanette Braz , Artur Paiva , María Azkarate , Juan José Gimeno , Luis Marín , María José Castro , Estela Paz , Raquel Ruiz , Arantza Arrieta , Abelardo Caballero , Luis Larrad , Pilar Lasierra , Javier Gonzalo Ocejo , Iván Bernardo , Antonio López , Rebeca Alonso , Antonio Garrido , Clara Alonso

引用次数: 3

Patologías mediadas por la inmunoglobulina E: de la inmunoglobulina E al omalizumab 免疫球蛋白E介导的病理:从免疫球蛋白E到奥玛珠单抗

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2012-10-01 DOI: 10.1016/j.inmuno.2012.08.001

María del Carmen Vennera , César Picado

引用次数: 1

Neutralization of early pregnancy factor by passive immunization alters normal embryonic development and cytokine balance 通过被动免疫来中和早孕因子会改变胚胎的正常发育和细胞因子的平衡

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2012-10-01 DOI: 10.1016/j.inmuno.2012.09.003

María C. Grosso , Romina V. Bellingeri , Rüdiger Schade , Adriana B. Vivas

{"title":"Neutralization of early pregnancy factor by passive immunization alters normal embryonic development and cytokine balance","authors":"María C. Grosso , Romina V. Bellingeri , Rüdiger Schade , Adriana B. Vivas","doi":"10.1016/j.inmuno.2012.09.003","DOIUrl":"10.1016/j.inmuno.2012.09.003","url":null,"abstract":"<div><p><span><span><span>The aim of this study was to evaluate the effects of passive immunization with polyclonal anti-swine </span>early pregnancy factor (EPF) antibody in pregnant rats during the pre-implantation period, and to analyse the regional distribution of EPF in </span>placenta of rats. The immunodetection of EPF in rat placenta, as well as </span>fertilization<span>, development and immunological parameters, was evaluated. The average number of embryos and the embryo/corpora lutea ratio of rats treated with anti-EPF antibody were significantly lower than control groups. Also, as expected, the embryos showed a delay in their development. Furthermore, while IL-10 and INF-γ levels increased, serum and placental TGF-β decreased significantly in the group treated with anti-EPF. EPF was present in giant and decidual cells<span>, as well as in blood vessels and trophoblastic lacuna cells, as demonstrated by positive immunostaining. This study provides new results on the function and location of EPF, and has demonstrated the usefulness of polyclonal anti-swine EPF antibody.</span></span></p></div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"31 4","pages":"Pages 106-114"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2012.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54642625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

2011-2012, el bienio mediático de la Inmunología? 2011-2012，免疫学媒体双年展?

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2012-07-01 DOI: 10.1016/j.inmuno.2012.07.002

Francesc E. Borràs

引用次数: 0

Los primeros pobladores de América y sus relaciones con poblaciones del Océano Pacífico según los genes HLA 根据HLA基因，美洲的第一批定居者及其与太平洋人口的关系

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2012-07-01 DOI: 10.1016/j.inmuno.2011.12.002

Diego Rey , Cristina Areces , Mercedes Enríquez-de-Salamanca , Carlos Parga-Lozano , Sedeka Abd-El-Fatah , Mercedes Fernández , Antonio Arnaiz-Villena

{"title":"Los primeros pobladores de América y sus relaciones con poblaciones del Océano Pacífico según los genes HLA","authors":"Diego Rey , Cristina Areces , Mercedes Enríquez-de-Salamanca , Carlos Parga-Lozano , Sedeka Abd-El-Fatah , Mercedes Fernández , Antonio Arnaiz-Villena","doi":"10.1016/j.inmuno.2011.12.002","DOIUrl":"10.1016/j.inmuno.2011.12.002","url":null,"abstract":"<div><p>HLA allele frequencies were compared with those of other First American Natives and also those of other worldwide populations in order to clarify the still unclear peopling of the Americas and the origins of Amerindians. All possible HLA data already obtained on early Native American populations are used. Genetic distances and N-J dendrogram methods are applied. Results and discussion have led to the following conclusions: 1) North West Canadian Athabaskans have had gene flow with close neighbouring populations, Amerindians, Pacific Islanders, including East Australians, and Siberians, since they share <em>DRB1-DQB1</em> haplotypes with these populations (i.e.: <em>DRB1*14:01-DQB1*05:03</em>, <em>DRB1*09:01-DQB1*03:03</em>); 2) Amerindians entrance to America may have been different to that of Athabaskans, Aleuts and Eskimos; Amerindians may have been in their lands long before Athabaskans and Eskimos as they present an altogether different set of <em>HLA-DRB1</em> allele frequencies; 3) Amerindians show very few “particular” single-locus alleles (i.e.: <em>DRB1*04:11</em>, <em>DRB1*04:17</em>), but have unique extended haplotypes (i.e.: <em>A*02-B*35-DRB1*04:07-DQB1*03:02</em>, <em>A*02-B*35-DRB1*08:02-DQB1*04:02</em>); 4) Our results do not support the three-wave model of American peopling but another model, where the Pacific Coast is also an entrance point. Pacific Ocean sea voyages may have contributed to the HLA genetic American profile. Reverse migration (America to Asia) is not discarded, and different movements of people in either direction in different times are supported by the Athabaskan population admixture with Asian-Pacific population and with Amerindians.</p></div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"31 3","pages":"Pages 83-91"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2011.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54641971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Micropartículas como sustrato antigénico en lupus eritematoso sistémico 作为系统性红斑狼疮抗原底物的微粒

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2012-07-01 DOI: 10.1016/j.inmuno.2012.04.001

Carolina Muñoz Grajales , Gloria María Vásquez Duque

引用次数: 0

¿Anticuerpos antinucleares o anticuerpos frente a ciertos antígenos nucleares? 抗核抗体还是抗某些核抗原的抗体?

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2012-07-01 DOI: 10.1016/j.inmuno.2012.07.001

Marcos López Hoyos , Delia Almeida González , María Rosa Juliá Benique , Álvaro Prada Iñurrategui , Belén Aparicio Hernández

引用次数: 1

Relevancia de TLR4 en la infección por virus de la hepatitis C TLR4与丙型肝炎病毒感染的相关性

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2012-07-01 DOI: 10.1016/j.inmuno.2012.04.002

Lorena Álvarez-Rodríguez , Ignacio Beares , Carlos López de Urcelay , Marta González-Paz , Carolina Santa Cruz , Marcos López-Hoyos

{"title":"Relevancia de TLR4 en la infección por virus de la hepatitis C","authors":"Lorena Álvarez-Rodríguez , Ignacio Beares , Carlos López de Urcelay , Marta González-Paz , Carolina Santa Cruz , Marcos López-Hoyos","doi":"10.1016/j.inmuno.2012.04.002","DOIUrl":"10.1016/j.inmuno.2012.04.002","url":null,"abstract":"<div><h3>Objective</h3><p>The presence of the Asp-299Gly and Thr-399Ile polymorphisms in the toll-like receptor 4 (TLR4) gene was studied in subjects with HCV infection and HCV+HIV coinfection. The expression and function of TLR4 as regards these polymorphisms is assessed.</p></div><div><h3>Material and methods</h3><p>The study included 53 patients infected with HCV, among whom 27 had coinfection HCV+HIV, and 30 healthy subjects. The polymorphisms were studied by PCR-RFLP. The number of lymphocyte subsets, as well as TLR4 expression, was determined by flow cytometry, and the concentration of cytokines was measured in serum by (cytometric bead assay) CBA.</p></div><div><h3>Results</h3><p>CD4<sup>+</sup> T cells were significantly decreased in patients coinfected with HCV+HIV. There was no association between the presence of any of the two studied polymorphisms and the susceptibility to suffer from infection. TLR4 was less expressed in B cells, whereas it was increased in T cells and, in particular, monocytes. A significant increase in the levels of circulating pro-inflammatory cytokines was found, being two-fold increased in coinfected subjects as compared with patients with isolated HCV infection. None of the findings in cell subsets, TLR4 expression and cytokines was associated with the studied TLR4 polymorphism.</p></div><div><h3>Discussion</h3><p>The expression of TLR4 in T cells and monocytes is increased in HCV infection and is accompanied by increased serum levels of proinflammatory cytokines. These findings do not have any relationship with the Asp-299Gly and Thr-399Ile polymorphisms.</p></div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"31 3","pages":"Pages 65-77"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2012.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54642376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Células dendríticas II: utilización clínica en vacunación antitumoral 树突状细胞II:抗肿瘤疫苗的临床应用

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2012-04-01 DOI: 10.1016/j.inmuno.2011.10.002

Manuel Sureda, M. Begoña Vázquez, Joseba Rebollo

引用次数: 1

HLA class I association with progression to end-stage renal disease in patients from Zulia, Venezuela HLA I类与委内瑞拉苏利亚患者进展到终末期肾病的关系

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2012-04-01 DOI: 10.1016/j.inmuno.2011.12.001

Sergio Rivera P. , Georgina Márquez , Ana Maria Cipriani , Manzur Hassanhi , Carmen C. Villalobos , Alba Fuenmayor , Maribel Chavez , Milagros Montiel

{"title":"HLA class I association with progression to end-stage renal disease in patients from Zulia, Venezuela","authors":"Sergio Rivera P. , Georgina Márquez , Ana Maria Cipriani , Manzur Hassanhi , Carmen C. Villalobos , Alba Fuenmayor , Maribel Chavez , Milagros Montiel","doi":"10.1016/j.inmuno.2011.12.001","DOIUrl":"10.1016/j.inmuno.2011.12.001","url":null,"abstract":"<div><p><span><span>The aim of this study was to determine HLA associations with progression to end-stage renal disease (ESRD) in the mixed Zulian population in Venezuela, regardless of other factors. A retrospective study to determine HLA Class I association was performed on 188 patients with ESRD due to different types of </span>glomerulonephritis, and 202 healthy controls. Patients and control groups were serologically typed by Terasaki microlymphocytotoxicity technique using commercial Class I plates including 26 HLA-A and 48 HLA-B specificities. The antigens positively associated to the ESRD were: HLA-B38, B51, B53 and B62. Negatively associated antigens were: HLA-A9, </span>B12, B17, B40 and B48. The haplotypes positively associated were: HLA-A2-B51, A2-B53, A23-B38 and A68-B38. The negatively associated haplotypes were: HLA-A2-B12, A2-B48, A9-B35 and A28-B40. The high Odds ratio observed and its statistical corroboration reflect the strength of the described association between HLA antigens and ESRD. Further molecular studies should clarify types and subtypes of the HLA class I alleles involved in the progression to ESRD.</p></div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"31 2","pages":"Pages 37-42"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2011.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54641956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17