Inmunologia (Barcelona, Spain : 1987)最新文献_第10页

Inmunología y nuestra identidad como sociedad científica 免疫学和我们作为一个科学社会的身份

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-01-01 Epub Date: 2011-06-22 DOI: 10.1016/S0213-9626(11)70007-5

Ignacio Melero , Dolores Jaraquemada

引用次数: 1

Informe técnico del IX Taller de Citometría de Flujo: inmunofenotipo de leucemias 第九届流式细胞术研讨会技术报告:白血病免疫表型

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-01-01 Epub Date: 2011-06-22 DOI: 10.1016/S0213-9626(11)70010-5

Berta Sánchez Sánchez

引用次数: 0

César Milstein: 35 años de anticuerpos monoclonales cesar Milstein: 35年的单克隆抗体研究

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-01-01 Epub Date: 2011-06-22 DOI: 10.1016/S0213-9626(11)70012-9

África González-Fernández , Fernando Díaz de Espada

引用次数: 2

Stiff person syndrome and cerebellar ataxia associated with glutamic acid decarboxylase antibodies and type 1 diabetes: What is the link between neurological diseases and autoimmunity to the beta cell? 与谷氨酸脱羧酶抗体和1型糖尿病相关的僵硬者综合征和小脑性共济失调:神经系统疾病与β细胞自身免疫之间的联系是什么?

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2010-10-01 Epub Date: 2011-05-19 DOI: 10.1016/S0213-9626(10)70003-2

Marta Vives-Pi , Lidia Sabater

引用次数: 0

Patrones diferenciales de distribución de los alelos y genotipos HLA-DPA1* en asociación con leucemias linfoides agudas y leucemias mieloides crónicas en pacientes del estado Zulia, Venezuela 委内瑞拉Zulia州患者急性淋巴细胞白血病和慢性髓细胞白血病相关HLA-DPA1*等位基因分布和基因型的差异模式

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2010-10-01 Epub Date: 2011-05-19 DOI: 10.1016/S0213-9626(10)70002-0

Miriam Echeverría , Sergio Rivera Pirela , Georgina Márquez , Zuhey Carrillo , Yennis Parra , Carmen Cecilia Villalobos

{"title":"Patrones diferenciales de distribución de los alelos y genotipos HLA-DPA1* en asociación con leucemias linfoides agudas y leucemias mieloides crónicas en pacientes del estado Zulia, Venezuela","authors":"Miriam Echeverría , Sergio Rivera Pirela , Georgina Márquez , Zuhey Carrillo , Yennis Parra , Carmen Cecilia Villalobos","doi":"10.1016/S0213-9626(10)70002-0","DOIUrl":"10.1016/S0213-9626(10)70002-0","url":null,"abstract":"<div>Little is known about the relevance of the polymorphisms in the function of HLA-DP. Acute lymphoblastic leukemia (ALL) is the most frequent cancer in children and adolescents in Zulia population. Chronic myeloid leukemia (CML) is similar in adolescents, young adults and mild adults. The epidemiologic studies suggest the presence of several factors related to the susceptibility. Forty-eight patients with ALL and 48 with CML, were compared with 48 controls from The Blood Bank of Zulia State, Venezuela, all of them unrelated racially mestizos. To evaluate the positive and negative associations between HLA allele and leukemias, the HLA-DPA1 locus and HLA-DPA1*01,*02,*03 and *04 alleles were studied using PCR Olerup SSPTM (Genovision). HLA-DPA1*01:05 (RR = 3.65; P ≤ .05) and DPA1*01:06 (RR = 13.88; P ≤ .05) alleles showed a positive association with ALL. Furthermore, HLA-DPA1*01:03:01-01:03:02 (RR = 0.46; P ≤ .05), DPA1*01:07 (RR = 10; P ≤ .05) and DPA1*02:01:01-02:01:06 (RR = 0.29; P ≤ .05) were negatively associated with ALL. Moreover, HLA-DPA1*01:05 (RR = 0.08; P ≤ .05), DPA1*01:08 (RR = 0.06; P ≤ .05) and DPA1*01:09 (RR = 0.14; P ≤ .05) showed a negative association with CML. Curiously, the genotype HLA-DPA1*01:03:01-01:03:02/02:01:01-02:02:06 showed a frequency of 40.4% in controls, 8.5% in ALL patients and 64.6% in CML patients. These marked differences in the frequency of distribution of HLA-DPA1* alleles and genotypes in CML and ALL patients, probably reveals a important pathogenic differences for the two types of leukemia.</div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"29 4","pages":"Pages 115-118"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0213-9626(10)70002-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56138741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Inmunorregulación: un nuevo paradigma terapéutico 免疫调节:一种新的治疗范式

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2010-10-01 Epub Date: 2011-05-19 DOI: 10.1016/S0213-9626(10)70005-6

Irene Pradas Barriga, María Luisa del Río González, José Ignacio Rodríguez Barbosa

引用次数: 0

Biological aspects of human plasmacytoid dendritic cells and their leukemic counterparts; similarities and differences 人浆细胞样树突状细胞及其白血病对应物的生物学特性异同

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2010-10-01 Epub Date: 2011-05-19 DOI: 10.1016/S0213-9626(10)70004-4

Laura Bover , Mar Naranjo-Gómez , Shino Hanabuchi , Begoña Pérez-Cabezas , Francesc E. Borràs

引用次数: 0

Influenza outbreak, a year after the pandemic, what have we learned? 流感大流行一年后爆发，我们学到了什么?

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2010-10-01 Epub Date: 2011-05-19 DOI: 10.1016/S0213-9626(10)70006-8

María Montoya , Francesc E. Borràs

引用次数: 0

Ilusión y determinación 幻想与决心

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2010-10-01 Epub Date: 2011-05-19 DOI: 10.1016/S0213-9626(10)70001-9

Francesc E. Borràs

引用次数: 1

Predicción de unión de péptidos de MSP-1 y EBA-140 de Plasmodium falciparum al HLA clase II 恶性疟原虫MSP-1和EBA-140肽与HLA II类肽结合的预测

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2010-07-01 Epub Date: 2011-10-01 DOI: 10.1016/S0213-9626(10)70016-0

Javier Rodríguez, Pedro Bernal, Luisa Álvarez, Sandra Pabón, Sandra Ibáñez, Nanyid Chapuel, Héctor Pérez, Alexandra Correa, Luis Carlos Salazar, Raúl Walteros

{"title":"Predicción de unión de péptidos de MSP-1 y EBA-140 de Plasmodium falciparum al HLA clase II","authors":"Javier Rodríguez, Pedro Bernal, Luisa Álvarez, Sandra Pabón, Sandra Ibáñez, Nanyid Chapuel, Héctor Pérez, Alexandra Correa, Luis Carlos Salazar, Raúl Walteros","doi":"10.1016/S0213-9626(10)70016-0","DOIUrl":"10.1016/S0213-9626(10)70016-0","url":null,"abstract":"<div>The MSP-1 merozoite surface protein is related to the invasion phenomenon of malaria to red cells, while the EBA-140 antigen protein interacts with the sialoglycoproteins on the surface of erythrocytes. The identification of peptides from both proteins that bind to HLA class II has a particular importance for the development of vaccines.In the present work, a predictive binding to HLA class II theory, based on S/k proportion of entropy was applied, for the prediction of proteins MSP-1 and EBA-140 binding phenomenon to the totality of 20 amino acid sequences of both molecules. The probability, combinatory and entropy values were calculated for 948 and 732 nonamer overlapping sequences of MSP-1 and EBA-140, respectively. Three theoretical proteins of 500 aminoacids of lenght each were computationally built in order to apply the developed binding theory to all their nonamer overlapping peptides.It was predicted that for the two studied merozoite proteins, 298 sequences are related to the binding macrostate and 1409 to the not-binding macrostate. The developed theoretical prediction can facilitate the selection of peptides during the process of vaccine development. For the three theoretical proteins built, it was found that 111, 84 and 72 are predicted as included into the binding macrostate, while sequences 381, 408, and 420 are predicted as related to the not-binding macrostate.The predictions are an evidence of a physical and mathematical order in antigen presentation, which can be useful to the development of vaccines.</div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"29 3","pages":"Pages 91-99"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0213-9626(10)70016-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56139531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15