Inmunologia (Barcelona, Spain : 1987)最新文献_第9页

Fiebre Q aguda con hepatitis autoinmune y anticuerpos antifosfolípido secundarios 急性Q热伴自身免疫性肝炎和继发性抗磷脂抗体

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-07-01 DOI: 10.1016/j.inmuno.2011.05.004

David Antón-Martínez , Francisco-Javier Polo-Romero , M. Paz Atienza-Morales , María Esteso-Perona

引用次数: 0

Informe de la 2.a Reunión de la Sociedad de Inmunología de la Comunidad Autónoma de Madrid (SICAM) 2号报告。马德里自治社区免疫学会(SICAM)会议

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-04-01 DOI: 10.1016/S0213-9626(11)70017-8

Julia Sequí , Eduardo Fernández-Cruz , Dolores Jaraquemada , María Luisa Toribio

引用次数: 0

Myeloid-derived suppressor cells (MDSC): Another player in the orchestra 髓源性抑制细胞(MDSC):乐队中的另一个演奏者

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-04-01 DOI: 10.1016/S0213-9626(11)70015-4

Ramón Gimeno, Jordi Barquinero

引用次数: 8

Eje interleucina 12/interferón gamma en pacientes de tuberculosis en una región europea con alta incidencia de enfermedad 白介素12/干扰素γ轴在高发病率欧洲地区结核病患者中的应用

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-04-01 DOI: 10.1016/S0213-9626(11)70014-2

Luis Anibarro , Elina Garet , Irene Felpeto , Víctor del Campo , Julio Montes , África González-Fernández

{"title":"Eje interleucina 12/interferón gamma en pacientes de tuberculosis en una región europea con alta incidencia de enfermedad","authors":"Luis Anibarro , Elina Garet , Irene Felpeto , Víctor del Campo , Julio Montes , África González-Fernández","doi":"10.1016/S0213-9626(11)70014-2","DOIUrl":"10.1016/S0213-9626(11)70014-2","url":null,"abstract":"<div><p>The integrity of the interleukin 12/interferon gamma (IL-12/INF-γ) axis has been shown to be essential in the control of the <em>Mycobacterium tuberculosis</em> infection<em>.</em> The aim of this study was to assess whether the high incidence of tuberculosis (TB) in Galicia, Spain, could be related to an altered response in the IL-12/INF-γ axis in patients with TB. We studied 20 TB patients and 21 healthy controls: 7 with positive Tuberculin Skin test (TST+) and another 14 with TST–. The study of the IL-12/INF-γ axis was conducted by the analysis of INF-γ levels (in serum and supernatants of non-activated and activated cells) and by the cellular expression of IL-12Rβ1 and INF-γR1 in lymphocytes and monocytes, respectively. The assays were performed at baseline levels and after <em>in vitro</em> stimulation of peripheral blood mononuclear cells with phytohaemagglutinin (PHA) and purified protein derivative (PPD). Responses in patients and in healthy controls were analysed and compared. PHA and PPD <em>in vitro</em> stimulation significantly increased INF-gamma levels and the cellular expression of IL-12Rβ1 and INF-γR1 receptors compared to baseline levels in both TB patients and healthy controls (either with positive or negative TST). Our results suggest that there is an adequate immune response in all groups. Although the IL-12/INF-γ axis may have other abnormalities not analysed in this work, the functionality of the IL-12/INF-γ axis is preserved in the patients analysed with TB in Galicia. The high rates of disease historically observed in this community does not seem to be caused by a malfunction of the immune response at this level.</p></div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"30 2","pages":"Pages 36-44"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0213-9626(11)70014-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56140265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Resultados del Taller de Autoinmunidad de la Sociedad Española de Inmunología (SEI) 2010 西班牙免疫学会(SEI) 2010年自身免疫讲习班的结果

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-04-01 DOI: 10.1016/S0213-9626(11)70016-6

María Teresa Sanz, Esther Moga, Carmen Gelpí

引用次数: 1

Seguimos avanzando 继续前进

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-04-01 DOI: 10.1016/S0213-9626(11)70013-0

Francesc E. Borràs

引用次数: 0

Semblanza Francisco Borrás Semblanza Francisco Borrás

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-04-01 DOI: 10.1016/S0213-9626(11)70018-X

Juan José Lasarte , Pablo Sarobe

引用次数: 0

GECLID: una iniciativa de la Sociedad Española de Inmunología con beneficios para todos GECLID:西班牙免疫学会的一项倡议，惠及所有人

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-01-01 DOI: 10.1016/S0213-9626(11)70011-7

María del Carmen Martín , Roberto Reinoso , María Martino , Alfredo Corell

引用次数: 1

Influence of Toll-like receptor 2 and interleukin 10 on the intestinal epithelial barrier and their roles in inflammatory bowel disease toll样受体2和白细胞介素10对肠上皮屏障的影响及其在炎症性肠病中的作用

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-01-01 DOI: 10.1016/S0213-9626(11)70009-9

Josep Mañé Almero

{"title":"Influence of Toll-like receptor 2 and interleukin 10 on the intestinal epithelial barrier and their roles in inflammatory bowel disease","authors":"Josep Mañé Almero","doi":"10.1016/S0213-9626(11)70009-9","DOIUrl":"10.1016/S0213-9626(11)70009-9","url":null,"abstract":"<div><p>Different polymorphisms in key genes of innate and adaptive immunity disrupt the intestinal host-microbiotic balance in inflammatory bowel disease (IBD). In most cases these alterations affect the maintenance of the intestinal epithelium. Because of this, actions taken in order to reinforce or help intestinal epithelium recovery can provide benefits to idiopathic illnesses such as IBD. With this in mind, several studies support the idea that actions derived from the Toll-like receptor (TLR) 2 of the epithelial cells may help to maintain the epithelial barrier. However, in inflammatory conditions TLR-2 disappears from the intestinal epithelium and acquires a pivotal role in dendritic cells. In this event, the interleukin (IL)-10 production by sub-epithelial dendritic cells mediated by TLR-2 activation, thus leading to T-reg phenotypes in the <em>lamina propria</em>, may favour the recovery from epithelial damage. Therefore, the TLR-2/IL-10 axis can help to reinforce and recover the epithelial lining in IBD. In this way, several data suggest that early epithelial repair diminishes the antigen load reaching the <em>lamina propria</em>, which reduces inflammation and improves therapeutic performance. However, there is currently a lack of knowledge regarding molecular regulation of epithelial barrier by TLR-2 and IL-10.</p></div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"30 1","pages":"Pages 8-16"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0213-9626(11)70009-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56139921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Inmunología y nuestra identidad como sociedad científica 免疫学和我们作为一个科学社会的身份

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-01-01 DOI: 10.1016/S0213-9626(11)70007-5

Ignacio Melero , Dolores Jaraquemada

引用次数: 1