Biophysical reviews and letters最新文献_第8页

Interplay Among Constitutes of Ebola Virus: Nucleoprotein, Polymerase L, Viral Proteins 埃博拉病毒各组成部分之间的相互作用:核蛋白、聚合酶L、病毒蛋白

Biophysical reviews and letters Pub Date : 2017-09-27 DOI: 10.1142/S1793048017500060

Minchuan Zhang, Peiming He, Jing Su, D. T. Singh, Hailei Su, Haibin Su

{"title":"Interplay Among Constitutes of Ebola Virus: Nucleoprotein, Polymerase L, Viral Proteins","authors":"Minchuan Zhang, Peiming He, Jing Su, D. T. Singh, Hailei Su, Haibin Su","doi":"10.1142/S1793048017500060","DOIUrl":"https://doi.org/10.1142/S1793048017500060","url":null,"abstract":"Ebola virus is a highly lethal filovirus, claimed thousands of people in its recent outbreak. Seven viral proteins constitute ebola viral structure, and four of them (nucleoprotein (NP), polymerase L, VP35 and VP30) participate majorly in viral replication and transcription. We have elucidated a conformation change of NP cleft by VP35 NP-binding protein domains through superimposing two experimental NP structure images and discussed the function of this conformation change in the replication and transcription with polymerase complex (L, VP35 and VP30). The important roles of VP30 in viral RNA synthesis have also been discussed. A “tapping” model has been proposed in this paper for a better understanding of the interplay among the four viral proteins (NP, polymerase L, VP35 and VP30). Moreover, we have pinpointed some key residue changes on NP (both NP N- and C-terminal) and L between Reston and Zaire by computational studies. Together, this paper provides a description of interactions among ebola viral proteins (NP, L, VP35, VP30 and VP40) in viral replication and transcription, and sheds light on the complex system of viral reproduction.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"12 1","pages":"117-140"},"PeriodicalIF":0.0,"publicationDate":"2017-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048017500060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47137589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermostability of DNA Complexes with Mitoxantrone at Small Fillings 米托蒽醌配合物在小填充物中的热稳定性

Biophysical reviews and letters Pub Date : 2017-09-27 DOI: 10.1142/S1793048017500072

Y. Babayan, S. Hakobyan, R. S. Ghazaryan, M. Shahinyan

引用次数: 2

Exploring the Interaction of Ethidium Bromide and HOECHST 33258 with DNA by Means of Electrochemical Approach 用电化学方法研究溴化乙啶和HOECHST 33258与DNA的相互作用

Biophysical reviews and letters Pub Date : 2017-09-27 DOI: 10.1142/S1793048017500084

L. Tavadyan, S. Minasyan, Gaspar Kocharyan, A. Antonyan, V. G. Sahakyan, M. Parsadanyan, P. O. Vardevanyan

{"title":"Exploring the Interaction of Ethidium Bromide and HOECHST 33258 with DNA by Means of Electrochemical Approach","authors":"L. Tavadyan, S. Minasyan, Gaspar Kocharyan, A. Antonyan, V. G. Sahakyan, M. Parsadanyan, P. O. Vardevanyan","doi":"10.1142/S1793048017500084","DOIUrl":"https://doi.org/10.1142/S1793048017500084","url":null,"abstract":"The binding of both ethidium bromide (EtBr) and Hoechst 33258 (H33258) to calf thymus DNA differing by the mechanism at different ionic strengths of NaCl water solutions (2, 20 and 150mM) has been quantitatively studied by square wave voltammetry (SWV). It was revealed that EtBr binds to DNA by more than one mode: at the solution ionic strengths 2 and 150mM, two modes were revealed, at 20mM — three modes. Values of EtBr binding constant (K) to DNA and the number of nucleotides per one binding site (n) for respective binding modes were determined. For H33258 under the same conditions, two binding modes were found and for both these modes values of K and n were determined. Dependence of the binding types and parameters on the solution ionic strength by SWV method was revealed, which differs by the binding type of EtBr and H33258. The obtained data are in good accordance with the ones determined by spectroscopic (absorption and fluorescence) and differential pulse voltammetry (DPV) methods. The obtained data indicate the sensibility and high precision of SWV method which may be applied to studies on interaction of different ligands with DNA, which reveal some peculiarities of their binding to DNA that are hidden and are not found by other methods.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"12 1","pages":"151-161"},"PeriodicalIF":0.0,"publicationDate":"2017-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048017500084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46946918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

External Source of Infection and Nutritional Efficiency Control Chaos in a Predator–Prey Model with Disease in the Predator 捕食者-捕食者疾病模型的外部传染源和营养效率控制混沌

Biophysical reviews and letters Pub Date : 2017-07-02 DOI: 10.1142/S1793048017500059

K. Das, P. Roy, Subhabrata Ghosh, S. Maiti

{"title":"External Source of Infection and Nutritional Efficiency Control Chaos in a Predator–Prey Model with Disease in the Predator","authors":"K. Das, P. Roy, Subhabrata Ghosh, S. Maiti","doi":"10.1142/S1793048017500059","DOIUrl":"https://doi.org/10.1142/S1793048017500059","url":null,"abstract":"This paper deals with an eco-epidemiological approach with disease circulating through the predator species. Disease circulation in the predator species can be possible by contact as well as by external sources. Here, we try to discuss the role of external source of infection along with nutritional value on system dynamics. To establish our findings, we have worked out the local and global stability analysis of the equilibrium points with Hopf bifurcation analysis associated with interior equilibrium point. The ecological consequence by ecological basic reproduction number as well as the disease basic reproduction number or basic reproductive ratio are obtained and we have analyzed the community structure of the particular system with the help of ecological and disease basic reproduction numbers. Further we pay attention to the chaotic dynamics which is produced by disease circulating in predator species by contact. Our numerical simulations reveal that eco-epidemiological system without external source of infection induced chaotic dynamics for increasing force of infection due to contact, whereas in the presence of external source of infection, it exhibits stable solution. It is also observed that nutritional value can prevent chaotic dynamics. We conclude that chaotic dynamics can be controlled by the external source of infection as well as nutritional value. We apply basic tools of nonlinear dynamics such as Poincare section and maximum Lyapunov exponent to investigate chaotic behavior of the system.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"12 1","pages":"87-115"},"PeriodicalIF":0.0,"publicationDate":"2017-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048017500059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49419229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Stability of Tumor Growth Under Immunotherapy: A Computational Study 免疫治疗下肿瘤生长稳定性的计算研究

Biophysical reviews and letters Pub Date : 2017-06-01 DOI: 10.1142/S1793048017500047

S. Singh, Prabha Sharma, Phool Singh

引用次数: 3

Nonlinear Dynamics of a Prey-Predator Model Using Precise and Imprecise Harvesting Phenomena with Biological Parameters 具有生物参数的精确和不精确捕获现象的捕食者-猎物模型的非线性动力学

Biophysical reviews and letters Pub Date : 2017-03-28 DOI: 10.1142/S1793048017500035

S. Vijaya, E. Rekha, J. J. Singh

引用次数: 3

Time-Dependent Changes of Albumin Water Solutions After Irradiation by Electromagnetic Waves with Extremely High Radio Frequencies 超高射频电磁波辐照后白蛋白水溶液的随时间变化

Biophysical reviews and letters Pub Date : 2017-03-27 DOI: 10.1142/S1793048017500011

M. Shahinyan, M. Mikaelyan, M. R. Darbinyan, P. O. Vardevanyan

引用次数: 1

Mechanical Unfolding Studies on Single-Domain SUMO and Multi-Domain Periplasmic Binding Proteins 单结构域SUMO和多结构域周质结合蛋白的机械展开研究

Biophysical reviews and letters Pub Date : 2017-03-27 DOI: 10.1142/S1793048016300024

Hema Chandra Kotamarthi, Sri Rama Koti Ainavarapu

{"title":"Mechanical Unfolding Studies on Single-Domain SUMO and Multi-Domain Periplasmic Binding Proteins","authors":"Hema Chandra Kotamarthi, Sri Rama Koti Ainavarapu","doi":"10.1142/S1793048016300024","DOIUrl":"https://doi.org/10.1142/S1793048016300024","url":null,"abstract":"Protein mechanics is a key component of many cellular and sub-cellular processes. The current review focuses on recent studies from our laboratory that probe the effect of sequence on the mechanical stability of structurally similar proteins and the unfolding mechanisms of multi-domain periplasmic binding proteins. Ubiquitin and small ubiquitin-related modifiers (SUMOs) are structurally similar and possess different mechanical stabilities, ubiquitin being stronger than SUMOs as revealed from their unfolding forces. These differences are plausibly due to the variation in number of inter-residue contacts. The unfolding potential widths determined from the pulling speed-dependent studies revealed that SUMOs are mechanically more flexible than ubiquitin. This flexibility of SUMOs plays a role in ligand binding and our single-molecule studies on SUMO interaction with SUMO binding motifs (SBMs) have shown that ligand binding decreases the SUMO flexibility and increases its mechanical stability. Studies on multi-domain periplasmic binding proteins have revealed that the unfolding energy landscape of these proteins is complex and they follow kinetic partitioning between two-state and multiple three-state pathways.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"12 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048016300024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49233366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Dynamical Behavior of a Malaria Model with Discrete Delay and Optimal Insecticide Control 具有离散延迟和最优杀虫剂控制的疟疾模型动力学行为

Biophysical reviews and letters Pub Date : 2017-03-01 DOI: 10.1142/S1793048017500023

T. Kar, Soovoojeet Jana

{"title":"Dynamical Behavior of a Malaria Model with Discrete Delay and Optimal Insecticide Control","authors":"T. Kar, Soovoojeet Jana","doi":"10.1142/S1793048017500023","DOIUrl":"https://doi.org/10.1142/S1793048017500023","url":null,"abstract":"In this paper we have proposed and analyzed a simple three-dimensional mathematical model related to malaria disease. We consider three state variables associated with susceptible human population, infected human population and infected mosquitoes, respectively. A discrete delay parameter has been incorporated to take account of the time of incubation period with infected mosquitoes. We consider the effect of insecticide control, which is applied to the mosquitoes. Basic reproduction number is figured out for the proposed model and it is shown that when this threshold is less than unity then the system moves to the disease-free state whereas for higher values other than unity, the system would tend to an endemic state. On the other hand if we consider the system with delay, then there may exist some cases where the endemic equilibrium would be unstable although the numerical value of basic reproduction number may be greater than one. We formulate and solve the optimal control problem by considering insecticide as the control variable. Optimal control problem assures to obtain better result than the noncontrol situation. Numerical illustrations are provided in support of the theoretical results.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"12 1","pages":"19-38"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048017500023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43071194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Measurement of Young’s Modulus and Internal Damping of Pork Muscle in Dynamic Mode 动态模式下猪肉肌肉杨氏模量和内阻尼的测量

Biophysical reviews and letters Pub Date : 2016-10-17 DOI: 10.1142/S1793048016500041

M. Chakroun, M. H. B. Ghozlen

{"title":"Measurement of Young’s Modulus and Internal Damping of Pork Muscle in Dynamic Mode","authors":"M. Chakroun, M. H. B. Ghozlen","doi":"10.1142/S1793048016500041","DOIUrl":"https://doi.org/10.1142/S1793048016500041","url":null,"abstract":"Automotive shocks involve various tiers’ speed for different human body tissues. Knowing the behavior of these tissues, including muscles, in different vibration frequency is therefore necessary. The muscle has viscoelatic properties. Dynamically, this material has variable mechanical properties depending on the vibration frequency. A novel technique is being employed to examine the variation of the mechanical impedance of pork muscle as a function of frequency. A force is imposed on the lower surface of the sample and acceleration is measured on its upper surface. These two parameters are measured using sensors. The sample is modeled by Kelvin–Voigt model. These measures allow deducing the change in the mechanical impedance modulus (/Zexp/ = /Force: Acceleration/) of pork muscle as a function of vibration frequency. The measured impedance has a resonance of approximately 60Hz. Best-fit parameters of theoretical impedance can be deduced by superposition with the experiment result. The variation of Young’s modulus and internal damping of pig’s muscle as a function of frequency are determined. The results obtained between 5Hz and 30Hz are the same as determined by Aimedieu and al in 2003, therefore validating our technique. The Young’s modulus of muscle increases with the frequency, on the other hand, we note a rating decrease of internal damping.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"11 1","pages":"109-116"},"PeriodicalIF":0.0,"publicationDate":"2016-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048016500041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64047755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0