{"title":"免疫治疗下肿瘤生长稳定性的计算研究","authors":"S. Singh, Prabha Sharma, Phool Singh","doi":"10.1142/S1793048017500047","DOIUrl":null,"url":null,"abstract":"We present a mathematical model to study the growth of a solid tumor in the presence of regular doses of lymphocytes. We further extend it to take care of the periodic behavior of the lymphocytes, which are used for stimulating the immune system. Cell carrying capacity has been specified and a cell kill rate under immunotherapy is used to take care of how different metabolisms will react to the treatment. We analyze our model with respect to its stability and its sensitivity to the various parameters used.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"12 1","pages":"69-85"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048017500047","citationCount":"3","resultStr":"{\"title\":\"Stability of Tumor Growth Under Immunotherapy: A Computational Study\",\"authors\":\"S. Singh, Prabha Sharma, Phool Singh\",\"doi\":\"10.1142/S1793048017500047\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We present a mathematical model to study the growth of a solid tumor in the presence of regular doses of lymphocytes. We further extend it to take care of the periodic behavior of the lymphocytes, which are used for stimulating the immune system. Cell carrying capacity has been specified and a cell kill rate under immunotherapy is used to take care of how different metabolisms will react to the treatment. We analyze our model with respect to its stability and its sensitivity to the various parameters used.\",\"PeriodicalId\":88835,\"journal\":{\"name\":\"Biophysical reviews and letters\",\"volume\":\"12 1\",\"pages\":\"69-85\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1142/S1793048017500047\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biophysical reviews and letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1142/S1793048017500047\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysical reviews and letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1142/S1793048017500047","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Stability of Tumor Growth Under Immunotherapy: A Computational Study
We present a mathematical model to study the growth of a solid tumor in the presence of regular doses of lymphocytes. We further extend it to take care of the periodic behavior of the lymphocytes, which are used for stimulating the immune system. Cell carrying capacity has been specified and a cell kill rate under immunotherapy is used to take care of how different metabolisms will react to the treatment. We analyze our model with respect to its stability and its sensitivity to the various parameters used.
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