Biomedical reports最新文献_第6页

Advances in the management of neuroendocrine tumours: Evidence from a systematic review. 神经内分泌肿瘤治疗的进展：来自系统综述的证据。

IF 2.5

Biomedical reports Pub Date : 2026-03-03 eCollection Date: 2026-05-01 DOI: 10.3892/br.2026.2127

Andreea-Daniela Caloian, Sorin Deacu, Miruna Cristian, Laura Mazilu, Lavinia Simona Neculai-Candea, Andreea-Corina Ilie-Petrov, Radu Adrian Nitu, Carmen Aida Ciufu, Nicolae Ciufu

{"title":"Advances in the management of neuroendocrine tumours: Evidence from a systematic review.","authors":"Andreea-Daniela Caloian, Sorin Deacu, Miruna Cristian, Laura Mazilu, Lavinia Simona Neculai-Candea, Andreea-Corina Ilie-Petrov, Radu Adrian Nitu, Carmen Aida Ciufu, Nicolae Ciufu","doi":"10.3892/br.2026.2127","DOIUrl":"10.3892/br.2026.2127","url":null,"abstract":"Neuroendocrine tumours (NETs) are rare, biologically diverse neoplasms with a rising incidence due to improved diagnostics. Their management remains challenging, with multiple therapeutic strategies under evaluation. The present systematic review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Literature searches were conducted across PubMed, Cochrane Library and ScienceDirect between January 2018 and July 2025. Eligible studies included randomized controlled trials, cohort studies and observational analyses involving adult patients with NETs. The primary outcomes were progression-free survival (PFS) and overall survival (OS). A total of 271 studies were screened and 22 met the inclusion criteria. Median PFS across therapies ranged between 2 and 23 months, whereas OS ranged between 9.6 and 60 months, depending on treatment type. Dual checkpoint inhibitors (nivolumab plus ipilimumab) demonstrated durable benefits, with OS time exceeding 55 months in some cohorts, whereas peptide receptor radionuclide therapy (PRRT) achieved a median PFS time of 22.8 months compared with 8.5 months for high-dose octreotide. Furthermore, targeted agents, such as sunitinib and nintedanib, improved PFS to ~11 months, with OS time extending beyond 30 months. Chemotherapy regimens such as CAPTEM yielded a PFS of 7-11 months. In conclusion, the present study revealed that NET therapies show heterogeneous but clinically meaningful benefits. PRRT, targeted therapy and combination regimens were revealed to be associated with the most durable outcomes, whereas immunotherapy demonstrated promise in selected patients. Tailored approaches remain crucial to optimize survival and quality of life of patients.","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"24 5","pages":"54"},"PeriodicalIF":2.5,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting ULK1 and USP20 to modulate autophagy and chemosensitivity in cancer cell lines. 靶向ULK1和USP20调节癌细胞自噬和化学敏感性。

IF 2.5

Biomedical reports Pub Date : 2026-02-25 eCollection Date: 2026-04-01 DOI: 10.3892/br.2026.2124

Tuqa Abu Thiab, Malek Zihlif, Dana Alqudah, Amer Imraish

{"title":"Targeting ULK1 and USP20 to modulate autophagy and chemosensitivity in cancer cell lines.","authors":"Tuqa Abu Thiab, Malek Zihlif, Dana Alqudah, Amer Imraish","doi":"10.3892/br.2026.2124","DOIUrl":"10.3892/br.2026.2124","url":null,"abstract":"Autophagy is a conserved catabolic process essential for maintaining cellular homeostasis by degrading and recycling damaged organelles and misfolded proteins. In cancer, autophagy plays a dual role, acting as both a tumor suppressor and promoter depending on the stage and context. Unc-51-like kinase 1 (ULK1), a key initiator of autophagy, is tightly regulated by USP20, a de-ubiquitinase that stabilizes ULK1 by preventing its lysosomal degradation. However, their roles in cancer progression and treatment response remain poorly understood. The present study investigated the baseline expression of ULK1 and USP20 across several cancer cell lines and evaluates the effects of their silencing on chemosensitivity. The findings of the present study showed that ULK1 was highly expressed in MCF-7 breast cancer cells and minimally in U87 glioblastoma cells. USP20 showed high expression in MCF-7, MDA-MB-231 and HepG2, and low expression in others. Combined silencing of ULK1 and USP20 with chemotherapy altered drug sensitivity across cancer types. ULK1 knockdown increased drug sensitivity and induced cell death in HepG2, MDA-MB-231 and PanC1 cell lines, but conferred chemoresistance in MCF-7, A549 and U87 cancer cells. Similarly, USP20 silencing sensitized MCF-7, HepG2 and PanC1 cells to chemotherapy, while enhancing survival in U87 cells. These results suggest that ULK1 and USP20 have cancer-type-specific roles in modulating autophagy and chemotherapy response. Targeting these proteins may provide novel therapeutic strategies to overcome chemoresistance and promote apoptosis in cancer treatment.","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"24 4","pages":"51"},"PeriodicalIF":2.5,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of genetic and lifestyle risk factors associated with Epstein-Barr virus reactivation in the Thai population. 泰国人群中与eb病毒再激活相关的遗传和生活方式风险因素的调查

IF 2.5

Biomedical reports Pub Date : 2026-02-20 eCollection Date: 2026-04-01 DOI: 10.3892/br.2026.2123

Janpen Bamrungthai, Tipaya Ekalaksananan, Sutida Pongpakdeesakul, Theeradon Rueankaew, Wanpiya Fhakdee, Darin Duangchai, Fernladda Kattiwong, Pornsiri Lanpol, Sasiwimon Sumala, Kachain Chantawong, Sureewan Duangjit, Sureewan Bumrungthai, Chamsai Pientong

{"title":"Investigation of genetic and lifestyle risk factors associated with Epstein-Barr virus reactivation in the Thai population.","authors":"Janpen Bamrungthai, Tipaya Ekalaksananan, Sutida Pongpakdeesakul, Theeradon Rueankaew, Wanpiya Fhakdee, Darin Duangchai, Fernladda Kattiwong, Pornsiri Lanpol, Sasiwimon Sumala, Kachain Chantawong, Sureewan Duangjit, Sureewan Bumrungthai, Chamsai Pientong","doi":"10.3892/br.2026.2123","DOIUrl":"10.3892/br.2026.2123","url":null,"abstract":"Current data on the genetic and lifestyle factors associated with Epstein-Barr virus (EBV) reactivation in the oral cavity are limited for the Thai population. Furthermore, comprehensive data linking EBV reactivation to head and neck cancers in Thailand remains scarce. The present study aimed to detect EBV reactivation using quantitative PCR in normal oral buccal cells and to examine the associated risk factors. A total of 982 oral buccal cell samples collected across Thailand were analyzed. EBV was detected in 36% (350/974) of samples when targeting the Epstein-Barr nuclear antigen-1 gene, 52% (458/885) of samples when targeting latent membrane protein-1 (LMP-1) and 20% (196/981) of samples when both genes were investigated. The highest prevalence of LMP-1 and dual gene positivity was observed in individuals aged 11-20 years. Several SNPs in the TNF-α promoter region, including rs1452146766, rs1799964, rs1554283139, rs924800313, rs1799724 and rs1771099055, were more frequently observed in EBV-positive samples than in EBV-negative samples. Notably, the TNF-α mutation rs1799964 (-1031 TC and CC) was present in 17.3% vs. 9.3% of EBV-positive cases, respectively. Multivariate analysis identified sex, smoking, alcohol consumption, soft drink intake, age of 21-30 years and having four children as significant factors associated with EBV reactivation. In the 21-30-year-old age group, LMP-1 positivity was elevated, and higher rates of alcohol use, sexual activity and oral ulcers were observed. Furthermore, in individuals with mouth ulcers, the TNF-α mutation (TC; n=81) was more common than wild-type TNF-α (CC; n=16).","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"24 4","pages":"50"},"PeriodicalIF":2.5,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Description of the novel variant c.784delG;p. (Ala262Profs*68) at BSND gene and its association with Bartter Syndrome Type Iva. 新变种c.784delG的描述；（Ala262Profs*68） BSND基因与Bartter综合征Iva型的相关性研究。

IF 2.5

Biomedical reports Pub Date : 2026-02-19 eCollection Date: 2026-04-01 DOI: 10.3892/br.2026.2122

Jéssica Hilário Bonomo, Lívia Cláudio De Oliveira, Maria Do Carmo Sorci Dias Scher, Anderson Ferreira Da Cunha, Amélia Trindade

{"title":"Description of the novel variant c.784delG;p. (Ala262Profs*68) at BSND gene and its association with Bartter Syndrome Type Iva.","authors":"Jéssica Hilário Bonomo, Lívia Cláudio De Oliveira, Maria Do Carmo Sorci Dias Scher, Anderson Ferreira Da Cunha, Amélia Trindade","doi":"10.3892/br.2026.2122","DOIUrl":"10.3892/br.2026.2122","url":null,"abstract":"Bartter syndrome (BS) is a group of diseases caused by variants in genes related to salt reabsorption in the thick ascending limb of the loop of Henle. It causes dysregulation in salt homeostasis and is characterized by hyperplasia and hypertrophy of the juxtaglomerular apparatus, hyperaldosteronism, hypokalemic alkalosis and impaired growth and development. BS type IVa is caused by variants in BSND, which encodes Barttin, a subunit for chloride channels (CLC). This specific subtype also causes sensorineural deafness due to its impact on CLC-kidney a (Ka), a channel important for the production of endolymph in the inner ear. In the present study, the case of a Brazilian girl diagnosed with BS Iva was presented, whose molecular diagnosis revealed a novel variant, c.784delG;p.(Ala262Profs*68), compound heterozygous with c.139G>A;p.Gly47Arg. This novel variant appears to be the first BS IVa causing variant described in exon 4, which encodes for the later part of the cytoplasmatic C-terminal unstructured tail. In silico analysis of this variant predicted the resulting frameshift as disease causing, due to alteration in significant portion of the protein. While the authors suggest this variant may cause erroneous membrane sorting of the CLC type channels, further studies are necessary to elucidate the mechanism.","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"24 4","pages":"49"},"PeriodicalIF":2.5,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histone lactylation modification and its role in cerebral ischemia-reperfusion injury (Review). 组蛋白乳酸化修饰及其在脑缺血再灌注损伤中的作用（综述）。

IF 2.5

Biomedical reports Pub Date : 2026-02-18 eCollection Date: 2026-04-01 DOI: 10.3892/br.2026.2121

Jing Tao, Juan Xu, Lu Zhou

引用次数: 0

Comparison of point-of-care HbA1c devices with laboratory HPLC methods: A systematic review and meta-analysis. 即时护理HbA1c设备与实验室HPLC方法的比较：系统回顾和荟萃分析。

IF 2.5

Biomedical reports Pub Date : 2026-02-13 eCollection Date: 2026-04-01 DOI: 10.3892/br.2026.2120

Yongzhong Wei, Mingze Gu, Yuqing Ren, Zhongshuang Hu

{"title":"Comparison of point-of-care HbA1c devices with laboratory HPLC methods: A systematic review and meta-analysis.","authors":"Yongzhong Wei, Mingze Gu, Yuqing Ren, Zhongshuang Hu","doi":"10.3892/br.2026.2120","DOIUrl":"10.3892/br.2026.2120","url":null,"abstract":"Hemoglobin A1c (HbA1c), also known as glycated hemoglobin, is a cornerstone biomarker for diagnosing and monitoring diabetes. While high-performance liquid chromatography (HPLC) is the reference standard, point-of-care (POC) devices are increasingly used due to convenience and rapid results. However, concerns remain about their analytical accuracy. This systematic review and meta-analysis evaluated the agreement between POC HbA1c devices and laboratory HPLC-based methods. A total of 11 studies involving 1,593 participants and 3,285 paired measurements were included. The pooled mean difference between POC and HPLC was 0.01% [95% confidence interval (CI), -0.08 to 0.11%; 95% prediction interval (PI), -0.443 to 0.471%; P=0.779], well within the clinically acceptable margin of ±0.5%. However, substantial heterogeneity was observed and extensive subgroup analyses across device model, analytical principle, and study characteristics did not fully explain this variability. Notably, some platforms, such as lateral flow immunoassays, exhibited larger biases approaching thresholds relevant to clinical decision-making. Although most POC devices demonstrated acceptable agreement, results highlight the importance of careful validation and interpretation. Future research should prioritize standardized protocols, comparative studies across platforms, and assessment in real-world decentralized settings to enhance confidence in POC HbA1c measurement.","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"24 4","pages":"47"},"PeriodicalIF":2.5,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COX-2 rs20417 polymorphism and susceptibility to type 2 diabetes mellitus. COX-2 rs20417多态性与2型糖尿病易感性的关系

IF 2.5

Biomedical reports Pub Date : 2026-02-12 eCollection Date: 2026-04-01 DOI: 10.3892/br.2026.2119

Nosayba Al-Azzam, Shrouq Al Fraihat, Lina Elsalem, Khawla Mhedat, Nesreen Saadeh

{"title":"COX-2 rs20417 polymorphism and susceptibility to type 2 diabetes mellitus.","authors":"Nosayba Al-Azzam, Shrouq Al Fraihat, Lina Elsalem, Khawla Mhedat, Nesreen Saadeh","doi":"10.3892/br.2026.2119","DOIUrl":"10.3892/br.2026.2119","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a multifactorial disease influenced by environmental and genetic factors. The present case-control study aimed to evaluate the association between three cyclooxygenase-2 (COX-2) gene polymorphisms (rs689466, rs20417 and rs2066826) and the susceptibility to T2DM in the Jordanian population. A total of 202 participants were enrolled, comprising 101 patients with T2DM and 101 healthy controls matched by sex and age (±5 years). Genotyping was performed using PCR-restriction fragment length polymorphism, and clinical and biochemical parameters were assessed. The rs20417 polymorphism showed a significant association with T2DM. In multivariate logistic regression analysis adjusted for age, sex, body mass index, hypertension and triglyceride levels, individuals carrying the CG genotype were more likely to develop T2DM [odds ratio (OR)=5.09; 95% CI: 1.18-21.96; P=0.0290], as did those with the CC genotype (OR=5.39; 95% CI: 1.34-21.72; P=0.0178), compared with those with the GG genotype. No significant associations were observed for rs689466 or rs2066826. Haplotype analysis identified the T-C-C haplotype (rs689466-rs20417-rs2066826) as a risk haplotype associated with increased susceptibility to T2DM (OR=1.52; 95% CI: 1.01-2.30; P=0.046). These findings suggest that the COX-2 rs20417 polymorphism is independently associated with T2DM risk in Jordanians, supporting a role for COX-2-mediated inflammatory pathways in the pathogenesis of diabetes.","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"24 4","pages":"46"},"PeriodicalIF":2.5,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentially expressed circular RNA profile in hemorrhagic and ischemic moyamoya disease. 出血性和缺血性烟雾病中不同表达的环状RNA谱。

IF 2.5

Biomedical reports Pub Date : 2026-02-10 eCollection Date: 2026-04-01 DOI: 10.3892/br.2026.2118

Meng Zhao, Wenjie Li, Xun Ye, Qian Zhang, Yan Zhang, Jizong Zhao

{"title":"Differentially expressed circular RNA profile in hemorrhagic and ischemic moyamoya disease.","authors":"Meng Zhao, Wenjie Li, Xun Ye, Qian Zhang, Yan Zhang, Jizong Zhao","doi":"10.3892/br.2026.2118","DOIUrl":"10.3892/br.2026.2118","url":null,"abstract":"Hemorrhage is a frequent manifestation in patients with moyamoya disease (MMD). Compared with MMD patients with other subtypes, patients with hemorrhagic MMD (hMMD) are at higher risk of poor prognostic outcomes, Circular RNAs (circRNAs) frequently display dysregulated expression in several human diseases. In the present study, the role of circRNAs in the pathogenesis of hemorrhage in MMD was investigated. Microarray profiling on 12 moyamoya disease samples, consisting of six hMMD and six matching ischemic MMD (iMMD) samples, was performed. Reverse transcription-quantitative PCR was then used to confirm the microarray analysis findings. Bioinformatics tools, including Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis, were used for further assessment. A network map of circRNA-microRNA-gene interactions was also constructed. In total, 3,607 differentially expressed circRNAs, in which 1,940 circRNAs were upregulated and 1,967 circRNAs were downregulated, were identified in hMMD (fold change ≥2.0 and P<0.05) samples. Gene Ontology revealed that the differentially expressed circRNAs were mainly involved in 'cell cycle phase transition' and 'mitotic cell cycle phase transition'. In addition, the ubiquitin mediated proteolysis pathway was found to be the most significantly enriched pathway in hMMD samples. The results of the present study suggested that clusters of circRNAs were differently expressed in hMMD compared with those in iMMD samples, which provides novel insights into hemorrhage in moyamoya disease pathophysiology and potential targets for future therapy.","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"24 4","pages":"45"},"PeriodicalIF":2.5,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethanolic extracts from deep marine sponges: A new frontier in antibacterial discovery from the Jordanian Gulf of Aqaba. 深海海绵乙醇提取物：约旦亚喀巴湾抗菌发现的新前沿。

IF 2.5

Biomedical reports Pub Date : 2026-02-09 eCollection Date: 2026-04-01 DOI: 10.3892/br.2026.2117

Fatima F Al-Jamal, Razan Ataallah Abuassaf, Osama H Abusara, Malek Zihlif, Ahmad A Deeb, Mamoon M D Al-Rshaidat

{"title":"Ethanolic extracts from deep marine sponges: A new frontier in antibacterial discovery from the Jordanian Gulf of Aqaba.","authors":"Fatima F Al-Jamal, Razan Ataallah Abuassaf, Osama H Abusara, Malek Zihlif, Ahmad A Deeb, Mamoon M D Al-Rshaidat","doi":"10.3892/br.2026.2117","DOIUrl":"10.3892/br.2026.2117","url":null,"abstract":"The urgent need for new antibiotics to counter bacterial resistance has led to renewed interest in marine natural products. The present study evaluated the antibacterial potential of ethanolic extracts from three deep-sea sponges: Stelletta sp., Dactylospongia cf. elegans (D. cf. elegans) and Axinella sp., which were collected from the Gulf of Aqaba off the coast of Jordan. Antibacterial activity was assessed against Gram-negative and Gram-positive bacteria using the well diffusion method, followed by determination of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Only D. cf. elegans exhibited potent activity, which was limited to Gram-positive bacteria and showed inhibition zones of 7 to 21 mm and MIC and MBC values of 1 and 2 mg/ml, respectively. Stelletta sp. showed no detectable activity, and Axinella sp. displayed minimal effects. DNA barcoding (28S rRNA) confirmed that all three species belong to the class Demospongiae. LC-MS/MS analysis of the extract from D. cf. elegans identified bioactive constituents, including bolinaquinone, dactyloquinone, gallic acid and caffeic acid, which are compounds known for antibacterial properties and likely contributed to the observed activity. Thus, D. cf. elegans could be a promising source of antibacterial agents against Gram-positive pathogens and warrants further evaluation of the mechanisms involved, its toxicity, and its effects in vivo.","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"24 4","pages":"44"},"PeriodicalIF":2.5,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polychlorinated biphenyl 153 alters the intestinal epithelial cell transcriptome. 多氯联苯153改变肠上皮细胞转录组。

IF 1.9

Biomedical reports Pub Date : 2025-12-22 eCollection Date: 2026-02-01 DOI: 10.3892/br.2025.2100

Hanna Ham, Prakrti Senthil, Stephanie C Tan, Robert M Sargis, Gail S Prins, Hua Geng

{"title":"Polychlorinated biphenyl 153 alters the intestinal epithelial cell transcriptome.","authors":"Hanna Ham, Prakrti Senthil, Stephanie C Tan, Robert M Sargis, Gail S Prins, Hua Geng","doi":"10.3892/br.2025.2100","DOIUrl":"10.3892/br.2025.2100","url":null,"abstract":"Polychlorinated biphenyl 153 (PCB153) is one of the most persistent environmental pollutants and abundant PCB congeners detected in human tissues, primarily acquired through dietary exposure. The intestinal epithelium therefore represents a critical initial target for PCB-related toxicity. However, the molecular mechanisms by which PCB153 disrupts normal intestinal epithelial function remain incompletely understood. The present study investigated the effects of PCB153 exposure on non-transformed human intestinal epithelial cells (IECs) using transcriptomic profiling. The data revealed that PCB153 induced dose-dependent alterations in the IEC transcriptome. Key pathways affected by PCB153 included Wnt signaling, ABC transporters, cGMP-PKG signaling and metallothionein-mediated metal homeostasis. High-dose exposure further activated inflammatory and tumorigenic pathways such as TNF and NF-κB signaling, while suppressing mitochondrial metabolism, oxidative phosphorylation and cellular detoxification processes. To the best of our knowledge, this is the first report that reveals the extensive transcriptomic remodeling in normal human IECs in response to PCB153 exposure, highlighting the disrupted intestinal regeneration, immune response and metabolic regulation. These findings provide novel mechanistic insights into how PCB153 compromises intestinal epithelial health, and establishes a transcriptomic framework for identifying biomarkers and therapeutic targets related to environmental toxicant exposure.","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"24 2","pages":"27"},"PeriodicalIF":1.9,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12766560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0