Biomedical reports最新文献

{"title":"Assessment of biliary tree anatomy and its clinical implications.","authors":"Wafaa Mahmoud, Naser Obeidat, Hadeel Al-Jarrah, Ahmad Alrawashdeh, Abdulla Mohammed, Ala Abu Dalou, Saad Mahmoud","doi":"10.3892/br.2026.2175","DOIUrl":"10.3892/br.2026.2175","url":null,"abstract":"<p><p>Anatomical variations in the intrahepatic duct (IHD) and cystic duct (CD) are common, and their accurate identification is essential for preoperative planning. The present study aimed to assess the prevalence of biliary ductal variations using magnetic resonance cholangiopancreatography (MRCP), to explore the association between IHD and CD and to evaluate potential associations with common biliary disorders. In the present retrospective study, a total of 259 patients, who were referred for MRCP due to various biliary-related clinical indications, including biliary stones, cholecystitis and obstructive jaundice, between January 2019 and December 2023, were included. Variations of the IHD and CD were classified based on imaging findings. Associations with biliary stones, cholecystitis and obstructive jaundice were assessed using the χ² test and univariable and multivariable logistic regression analyses. IHD variations were identified in 38.6% of cases, which was most commonly attributed to a trifurcation pattern (22%), followed by drainage of the right posterior duct into the common hepatic duct (8.5%) or the left hepatic duct (7.7%). CD variations were observed in 36.7% of cases, which were most commonly medial anterior (17.8%) or posterior (18.9%) spiral insertions. A significant association was found between IHD and CD variations (P=0.010). CD variations were also associated with a higher prevalence of biliary stones (P=0.023) and cholecystitis (P=0.048). In multivariable analysis, IHD variation [adjusted odds ratio (aOR)=1.95; 95% confidence interval (CI), 1.14-3.35; P=0.015] and biliary stones (aOR=1.79; 95% CI, 1.03-3.12; P=0.041) were independent predictors of CD anatomical variants. In conclusion, anatomical variations of the IHD and CD were common and strongly associated. Recognizing these variants could be essential for preoperative planning and aid in anticipating complications, particularly given their association with stone formation and cholecystitis.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"102"},"PeriodicalIF":2.5,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148444250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbamazepine-induced Stevens-Johnson syndrome in Chinese with negative HLA-A*3101 and HLA-B*1502 genes: A case report.","authors":"Zidan Yang, Jimin Lu, Fan Yang","doi":"10.3892/br.2026.2174","DOIUrl":"10.3892/br.2026.2174","url":null,"abstract":"<p><p>Stevens-Johnson syndrome (SJS) is a severe, potentially life-threatening disease primarily induced by medications, which often involves lesions of the oral mucosa, eyes and skin. Its pathogenesis is partially associated with genetic factors. The present study reported a case of SJS following oral administration of carbamazepine (CBZ). A total of ~2 weeks after initiating the medication, the patient developed generalized skin rashes with pruritus, which progressively evolved into patchy erythema on the face, neck, chest, back, oral cavity and lips; oral herpes also emerged. As the condition advanced, the patient experienced blurred vision, along with rupture and exudation of the oral and labial herpes. The patient was diagnosed with SJS. However, genotyping results revealed a negative status for both major histocompatibility complex, class I, A (HLA-A)^*3101 and HLA-B^*1502 genes, indicating that the risk of SJS induced by CBZ cannot be excluded, even if the genetic test yields negative results. After confirmation of the diagnosis, CBZ was discontinued and the patient received treatment including intravenous dexamethasone. Significant clinical improvement was observed within ~10 days. The present study emphasized that the potential risk of CBZ-associated SJS cannot be ignored, despite negative results for both HLA-A^*3101 and HLA-B^*1502.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"101"},"PeriodicalIF":2.5,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148444309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and feasibility of immediate implant placement in diabetic patients: A systematic review and meta-analysis.","authors":"Zhangyi Li, Hengyang Yu, Hong Liang","doi":"10.3892/br.2026.2173","DOIUrl":"10.3892/br.2026.2173","url":null,"abstract":"<p><p>The increasing use of dental implants raises questions about their efficacy in diabetic patients, particularly for immediate implant placement (IIP). Well-controlled diabetic patients may achieve success rates comparable with healthy individuals. To the best of our knowledge, however, comprehensive meta-analyses on IIP outcomes in diabetics remain limited. The present study aimed to judge whether IIP could be adopted in diabetic patients. A systematic search was conducted in PubMed, Embase, Web of Science, Cochrane, Google Scholar and China National Knowledge Infrastructure databases (January 2000 to March 2025). Studies comparing implant survival rates (SR), marginal bone loss (MBL), probing depth (PD) and bleeding on probing (BOP) between diabetic (well-/poorly controlled) and healthy patients undergoing IIP were included. The methodological quality and risk of bias of the included studies were assessed using the Newcastle-Ottawa Scale. Meta-analysis was performed using RevMan 5.4 software to calculate mean difference (MD) and risk ratio (RR) with 95% confidence interval (CI). A random-effects model was employed to address heterogeneity. A total of 10 studies (1,350 patients, 1,623 implants) were included in the analysis, demonstrating moderate to high methodological quality overall. Compared with healthy patients, well-controlled diabetic patients showed no significant difference in SR (RR=1.00, 95% CI: 0.97-1.02, P=0.79); similarly, poorly controlled diabetic patients also exhibited SR comparable with what of healthy patients (RR=0.96, 95% CI: 0.88-1.06, P=0.47). However, well-controlled diabetic patients had significantly higher MBL than healthy patients (MD=0.08, 95% CI: 0.03-0.14, P=0.004), while poorly-controlled diabetic patients showed greater MBL (MD=0.39, 95% CI: 0.25-0.53, P<0.00001). Additionally, well-controlled diabetic patients showed no significant difference in PD compared with healthy patients (MD=0.17, 95% CI: -0.02-0.37, P=0.09), but had significantly higher BOP (MD=0.12, 95% CI: 0.07-0.17, P<0.00001). Poorly-controlled diabetic patients demonstrated significantly higher PD (MD=0.62, 95% CI: 0.38-0.86) and BOP (MD=0.24, 95% CI: 0.23-0.24; both P<0.00001). There was notable heterogeneity among studies included in the meta-analysis and individual studies may influence the overall findings. Despite these limitations, the present results suggested that for diabetic patients, particularly those with optimal glycemic control, IIP demonstrates comparable implant SR with healthy individuals, confirming its clinical feasibility. However, diabetic patients, especially those with poor glycemic control, face increased risks of peri-implant bone loss and inflammation. Strict preoperative glycemic management and diligent postoperative care are key to minimize complications and ensure long-term implant SR.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"100"},"PeriodicalIF":2.5,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity evaluation and anti-ischemic stroke activity of selected natural extracts in zebrafish.","authors":"Ni Made Dwi Mara Widyani Nayaka, Ari Muktiah, Rifat Adriana Ibrahim, I Ketut Adnyana, Kusnandar Anggadiredja, Han Wang, Indra Wibowo","doi":"10.3892/br.2026.2172","DOIUrl":"10.3892/br.2026.2172","url":null,"abstract":"<p><p>Natural products are used in the discovery of novel therapeutic agents. Ischemic stroke is a neurological disorder caused by the obstruction of cerebral blood vessels, sometimes leading to paralysis and potentially death. Despite the complexity of this condition, therapeutic options are limited and typically associated with severe side effects, including intracranial hemorrhage. The present study aimed to explore the toxicity and anti-ischemic stroke activity of aqueous extracts from the aerial parts of gotu kola (<i>Centella asiatica</i>; CA), moringa leaves (<i>Moringa oleifera</i>; MO), turmeric rhizomes (<i>Curcuma longa</i>; CL), black pepper seeds (<i>Piper nigrum</i>; PN), and snakehead fish fillets (<i>Channa striata</i>; CS) in zebrafish. Toxicity tests were conducted in zebrafish embryos for 96 h. Ischemic stroke was induced in zebrafish larvae incubated in ponatinib (Pon) solution. In total, three concentrations of each extract, namely ¼ of the 10% lethal concentration (LC₁₀), ½ LC₁₀ and LC₁₀, were derived from toxicity testing and applied in anti-ischemic stroke assays. All extracts were considered non-toxic as their LC₅₀ values were >100 µg/ml. At certain concentrations, the extracts decreased hatching (>625 µg/ml CA and CL, >250 µg/ml MO, and >125 µg/ml CS) and survival rates (>625 µg/ml CA, >250 µg/ml MO, >156.25 µg/ml, >125 µg/ml PN and CS) and resulted in morphological deformity. Moreover, CA, MO, CL and CS, especially at their highest concentrations, significantly decreased the area of cerebral thrombosis compared with the Pon group. CA, MO, PN and CS ameliorated locomotor deficits following ischemia, as evidenced by significant improvements in average speed and total distance traveled. Among all extracts, CS at 29 µg/ml showed the greatest potential for development as an ischemic stroke treatment, exhibiting the strongest effects in preventing blood vessel blockage and restoring locomotor function following ischemia.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"99"},"PeriodicalIF":2.5,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the mechanisms of baicalin in diabetic cardiomyopathy: Insights from network pharmacology and experimental validation.","authors":"Xuyong Zhao, Lina Xie, Ning Zhu","doi":"10.3892/br.2026.2170","DOIUrl":"10.3892/br.2026.2170","url":null,"abstract":"<p><p>Baicalin has protective effects against a range of cardiovascular conditions, such as myocardial ischemia-reperfusion injury, cardiac dysfunction, and apoptosis in cardiomyocytes. However, the underlying protective mechanisms in diabetic cardiomyopathy (DCM) remain unclear. The present study aimed to investigate the specific molecular mechanism activated by baicalin to ameliorate DCM. The effects of baicalin were investigated <i>in vitro</i> and its potential targets and pathways were identified using network pharmacology, molecular docking, echocardiography, reverse transcription PCR, ELISA, histopathology, immunofluorescence staining and western blotting. Baicalin significantly alleviated high-glucose (HG)-induced injury in H9c2 cells by inhibiting fibrotic markers, inflammatory factors and pyroptosis. Moreover, protein tyrosine phosphatase non-receptor type 22 (PTPN22) and tumor necrosis factor (TNF) were identified as crucial targets for baicalin. Molecular docking indicated that baicalin exhibited a strong binding affinity for PTPN22 and TNF. Baicalin successfully suppressed HG-induced pyroptosis, inflammation and fibrotic markers in addition to inhibiting the activation of TNF-α and PTPN22 signaling pathways. In addition, PTPN22-small interfering RNA treatment modulated pyroptosis <i>in vitro</i>. The present study offers insight into the key therapeutic mechanisms activated by baicalin, and its potential therapeutic targets, PTPN22 and TNF-α.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"97"},"PeriodicalIF":2.5,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between tidal volume and mortality in patients without acute respiratory distress syndrome: A systematic review and meta-analysis.","authors":"Mingyuan Gu, Feiping Xia, Zhonghua Lu, Shanshan Meng, Fengmei Guo","doi":"10.3892/br.2026.2171","DOIUrl":"10.3892/br.2026.2171","url":null,"abstract":"<p><p>The optimal tidal volume for mechanically ventilated patients without acute respiratory distress syndrome (ARDS) remains unclear. The present systematic review and meta-analysis compared the effects of low compared with high tidal volume (Vt) ventilation in non-ARDS patients. Randomized controlled trials and observational studies comparing low and high Vt in adults without ARDS were included. The primary outcome was short-term mortality (28- or 30-day mortality in the ICU or hospital). Secondary outcomes were days of ventilation, pulmonary complications and length of hospital stay. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model. In total, 18 studies were included (1,530 low Vt vs. 1,512 high Vt patients). No significant difference in short term mortality was observed between low and high Vt ventilation (n=12; OR, 0.88; 95% CI, 0.71-1.09; P=0.24). However, subgroup analysis by maximum airway pressure (Pmax) showed that low Vt with low Pmax significantly reduced short-term mortality compared with low Vt with Pmax (OR, 0.50; 95% CI, 0.34-0.75; P=0.0007). Low Vt also decreased days of ventilation [mean difference (MD), -1.00; 95% CI, -1.76--0.24; P=0.01], pulmonary complications (n=11 studies; OR, 0.40; 95% CI, 0.30-0.54; P<0.00001) and hospital stay (n=11 studies; MD, -1.49; 95% CI, -2.54--0.44; P=0.006). Trial sequential analysis indicated conclusive evidence, suggesting further trials are unlikely to change the conclusion. In conclusion, low Vt combined with low Pmax, but not low Vt alone, improved short-term mortality in non-ARDS patients with respiratory failure. Clinically, this suggests that limiting both tidal volume and airway pressure may offer a protective ventilation strategy for non-ARDS patients, potentially guiding bedside titration of ventilatory settings to reduce mortality. The present study was registered in PROSPERO (https://www.crd.york.ac.uk/PROSPERO/view/CRD42019119453).</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"98"},"PeriodicalIF":2.5,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cariprazine-induced obsessive-compulsive symptoms in a patient with bipolar II disorder: A case report.","authors":"Suwanan Pornlertkochakorn, Krittisak Anuroj","doi":"10.3892/br.2026.2168","DOIUrl":"10.3892/br.2026.2168","url":null,"abstract":"<p><p>Drug-induced obsessive-compulsive (OC) symptoms have been described for clozapine and several second-generation antipsychotics, whereas reports involving cariprazine remain scarce. The present report describes the case of a 28-year-old Thai female patient with bipolar II disorder who had premorbid, subclinical counting compulsion, which had remained stable since its onset in adolescence. After 3 days of cariprazine treatment during a regimen switch for bipolar disorder, the pre-existing counting compulsion worsened and additional patterns of OC symptoms emerged. At seven days after discontinuation of cariprazine, the newly emerged symptoms were fully resolved, while the counting compulsion returned to its baseline subclinical severity. The present report highlights the need for clinical vigilance regarding OC symptom exacerbation with cariprazine treatment as a part of comprehensive follow-up of the mental health and wellbeing of psychiatric patients. Potential mechanistic considerations involving serotonergic and dopaminergic systems are discussed. The literature review of drug-induced OC symptomatology in the present study also identified limited documentation of premorbid OC symptomatology and age-at-onset phenotypes. Future reports incorporating detailed phenotypic characterization may improve the identification of patients at risk of symptom exacerbation.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"95"},"PeriodicalIF":2.5,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise and dietary interventions in the regulation of hepatic mitophagy and liver recovery (Review).","authors":"Julia Windi Gunadi, Diana Krisanti Jasaputra, Faysal Kastella, Shanti Shanti, Ronny Lesmana","doi":"10.3892/br.2026.2169","DOIUrl":"10.3892/br.2026.2169","url":null,"abstract":"<p><p>The high metabolic demand of the liver renders it dependent on mitophagy for mitochondrial quality control. While exercise and nutritional interventions are known to influence hepatic mitophagy, the precise regulatory mechanisms remain incompletely understood. Mitophagy in the liver is influenced by a combination of exercise-related parameters, dietary factors and sex-specific biological factors. Drawing from 19 animal studies published between 2016 and 2026, the present narrative review examines how different exercise modalities and dietary interventions regulate hepatic mitophagy. Among models of obesity and metabolic dysfunction, structured endurance training and higher-intensity exercise protocols yield better capacity to re-establish coordinated mitochondrial quality control than voluntary or low-intensity physical activity protocols. Notably, a single bout of exercise can produce a transient elevation in mitophagic flux, whereas sustained training over time expands mitophagy capacity without necessarily maintaining heightened flux at rest. Moderate-intensity continuous training more effectively restores canonical PTEN-induced kinase 1/Parkin-dependent flux, whereas high-intensity interval training favors structural mitochondrial recovery and upstream energetic signaling, although the relative efficacy depends on the model, disease severity and readout assessed. In high-fat or Western dietary settings, mitophagy is often compromised, with exercise producing incomplete recovery unless paired with improved diet or weight loss. These responses are also influenced by sex differences: Females tend to maintain higher intrinsic mitochondrial quality with less inducible mitophagy, whereas males exhibit a greater reliance on exercise-induced activation of mitophagy. Paternal and maternal developmental programming has also emerged as an important modulator of mitophagy induction. In conclusion, mitophagy in the liver is modified by different exercise and dietary interventions in a manner that is further conditioned by sex and developmental history.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"96"},"PeriodicalIF":2.5,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-6/STAT3 signaling pathway-mediated apoptosis induced by medical ozone water in liver cancer: A mechanistic study.","authors":"Shixiang Qiu, Chao Chen, Zihang Zhang, Ningjun Yu, Jingang Huang, Dan Deng, Liming Zhong","doi":"10.3892/br.2026.2167","DOIUrl":"10.3892/br.2026.2167","url":null,"abstract":"<p><p>Liver cancer is one of the most common and aggressive malignancies worldwide, with high rates of proliferation, migration and invasion contributing to poor patient outcomes. Ozonated water has potential anti-tumor effects. However, the underlying mechanisms, particularly its interaction with key signaling pathways such as IL-6/STAT3, remain poorly understood. The IL-6/STAT3 pathway serves a critical role in cancer progression, regulating processes such as cell survival and metastasis. To the best of our knowledge, however, the association between ozonated water and this pathway in liver cancer cells has not been thoroughly investigated. Therefore, the objective of the present study was to explore the effects of ozonated water on the proliferation, migration and invasion of HepG2 and Huh-7 liver cancer cells and determine the relationship between ozone and the IL-6/STAT3 signaling pathway, and the potential mechanism of this pathway in HepG2 cells. Proliferation was evaluated using the Cell Counting Kit-8 assay. Wound healing assay was used to evaluate migration ability. Transwell assay with Matrigel was used to evaluate invasion ability. Flow cytometry was used for cell apoptosis analysis. Protein expression was estimated by western blot analysis. Treatment with ozone at a concentration of 20 µg for 24 h inhibited liver cancer cell proliferation, migration and invasion capacities. Flow cytometric analysis revealed a marked increase in apoptosis rate in ozone-treated HepG2 cells (25.15±0.72 vs. 12.90±0.83% in control treated with MEM). Western blotting indicated downregulation of IL-6/STAT3 pathway components in ozone-treated HepG2 cells, with IL-6 and phosphorylated (p-)STAT3 expression levels showing the most pronounced reduction. Concurrently, Bcl-2 protein expression significantly decreased in the ozone-treated cells, whereas cleaved caspase-3 exhibited upregulated expression in treated cells. Ozone inhibited the proliferation, migration and invasion of and induced the apoptosis of liver cancer cells. Medical ozone water may induce liver cancer cell apoptosis by downregulating the IL-6/STAT3 signaling pathway, as evidenced by decreased expression of p-STAT3 and downstream anti-apoptotic proteins (Bcl-2) alongside apoptotic induction.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"94"},"PeriodicalIF":2.5,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and pathological analysis of pediatric patients with primary pulmonary tumors at a single center.","authors":"Yi Chen, Wei-Zhong Gu, Tong-Yu Yang, Yu Huang, Shao-Jia Mao, Min Liu, Xiang-Zhi Wang, Lan-Fang Tang, Chen Yuan","doi":"10.3892/br.2026.2166","DOIUrl":"10.3892/br.2026.2166","url":null,"abstract":"<p><p>Primary pulmonary tumors in pediatric patients are rare; however, they are frequently malignant, posing significant diagnostic challenges. Therefore, the present study aimed to systematically investigate the clinical, imaging and pathological characteristics of primary pulmonary tumors in children. A total of 36 pediatric patients diagnosed with primary pulmonary tumors were included. Clinical data were collected, including clinical manifestations, imaging findings, pathological analysis, diagnosis and therapy. Among 36 pediatric patients with primary pulmonary tumors, 19 were girls and 17 were boys. The age at diagnosis was 2.0-9.8 years with a median of 4 years. A total of 11 histopathologic tumor types were identified, with pleuropulmonary blastoma (PPB) being the most prevalent. The clinical manifestations were nonspecific, primarily presenting as respiratory symptoms, including cough and fever. These symptoms were frequently associated with complications, including pleural effusion and atelectasis. The maximum tumor diameter ranged from 2.0 to 7.0 cm (median: 4.0 cm), with a predominance of unilateral and unifocal lesions. Furthermore, younger age at diagnosis, solitary lesions and larger non-cystic tumors are indicative of a higher likelihood of PPB. The surgical treatment of thirty-five patients was primarily comprised of open thoracotomy and thoracoscopic surgery. Chemotherapy was administered to 16 patients, while two received a combination of chemotherapy and radiotherapy. Follow-up data were available for 33 patients, with a median follow-up time of 15.0 months and three patients experienced tumor recurrence. The clinical manifestations of primary pulmonary tumors in children are not specific. Imaging and pathological characteristics are valuable in the differential diagnosis of benign and malignant tumors. Younger age at diagnosis, solitary lesions and larger non-cystic tumors are indicative of a higher likelihood of PPB. Integrating molecular diagnostics is an important direction for future research to improve early detection and treatment outcomes.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"93"},"PeriodicalIF":2.5,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}