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Gallein increases prostaglandin F2α‑induced osteoprotegerin and IL‑6 secretion in osteoblasts. galgalin增加前列腺素F2α诱导的骨保护素和成骨细胞IL - 6的分泌。
IF 2.3
Biomedical reports Pub Date : 2024-08-14 eCollection Date: 2024-11-01 DOI: 10.3892/br.2024.1835
Gen Kuroyanagi, Tomoyuki Hioki, Rie Matsushima-Nishiwaki, Takuya Omura, Osamu Kozawa, Haruhiko Tokuda
{"title":"Gallein increases prostaglandin F2α‑induced osteoprotegerin and IL‑6 secretion in osteoblasts.","authors":"Gen Kuroyanagi, Tomoyuki Hioki, Rie Matsushima-Nishiwaki, Takuya Omura, Osamu Kozawa, Haruhiko Tokuda","doi":"10.3892/br.2024.1835","DOIUrl":"10.3892/br.2024.1835","url":null,"abstract":"<p><p>Gallein is a known Gβγ subunit inhibitor, but its function in bone metabolism, especially in osteoblasts, and its molecular mechanism remains to be elucidated. Osteoprotegerin (OPG), which is secreted from osteoblasts, binds to nuclear factor kB receptor activator (RANK) ligand (RANKL) as a decoy receptor, prevents RANKL-RANK binding, and inhibits bone resorption. IL-6 is not only a bone resorption factor but also as a bone metabolism regulator. Prostaglandin F2α (PGF2α) promotes p44/p42 MAPK, p38 MAPK and stress-activated protein kinase/JNK phosphorylation in osteoblast-like MC3T3-E1 cells. In MC3T3-E1 cells, activated p44/p42 and p38 MAPKs promote IL-6 secretion and activated p44/p42 and p38 MAPKs and JNK promote OPG secretion. The present study aimed to investigate the effect and mechanism of gallein on PGF2α-induced OPG and IL-6 secretion using an osteoblastic MC3T3-E1 cell line. It was found that gallein significantly increased PGF2α-induced OPG and IL-6 secretion in the MC3T3-E1 cell. By contrast, fluorescein, which is a gallein-like compound that does not bind to Gβγ, did not affect PGF2α-induced OPG and IL-6 secretion. Gallein significantly improved the PGF2α-induced OPG and IL-6 mRNA expression levels. Gallein did not affect the PGF2α-activated phosphorylation of p44/p42 and p38 MAPKs and JNK. Gallein increased PGF2α-induced OPG and IL-6 secretion in osteoblasts, indicating that gallein may regulate bone remodeling via OPG/IL-6 in bone metabolism.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"21 5","pages":"147"},"PeriodicalIF":2.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti‑angiogenic and cytotoxic evaluation of green‑synthesized Fe2ZnO4 nanoparticles against MCF‑7 cell line 绿色合成的 Fe2ZnO4 纳米粒子对 MCF-7 细胞系的抗血管生成和细胞毒性评估
IF 2.3
Biomedical reports Pub Date : 2024-01-10 DOI: 10.3892/br.2024.1724
Asma' Al‑Zabin, Tuqa Abu Thiab, M. Zihlif, A. Al-Hunaiti, Hamzeh J. Al-Ameer, W. Al-Awaida, Amer Imraish
{"title":"Anti‑angiogenic and cytotoxic evaluation of green‑synthesized Fe2ZnO4 nanoparticles against MCF‑7 cell line","authors":"Asma' Al‑Zabin, Tuqa Abu Thiab, M. Zihlif, A. Al-Hunaiti, Hamzeh J. Al-Ameer, W. Al-Awaida, Amer Imraish","doi":"10.3892/br.2024.1724","DOIUrl":"https://doi.org/10.3892/br.2024.1724","url":null,"abstract":"","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"5 17","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real‑world performance and safety of vaginal ovules in reducing the vaginal symptoms associated with vulvovaginal atrophy and postmenopausal sexual dysfunction 阴道卵巢在减轻与外阴阴道萎缩和绝经后性功能障碍相关的阴道症状方面的实际表现和安全性
IF 2.3
Biomedical reports Pub Date : 2024-01-09 DOI: 10.3892/br.2024.1723
Dominic-Gabriel Iliescu, R. Petrita, Cristina Teodorescu, R. Olaru, Andreea Alexa, Izabella Petre
{"title":"Real‑world performance and safety of vaginal ovules in reducing the vaginal symptoms associated with vulvovaginal atrophy and postmenopausal sexual dysfunction","authors":"Dominic-Gabriel Iliescu, R. Petrita, Cristina Teodorescu, R. Olaru, Andreea Alexa, Izabella Petre","doi":"10.3892/br.2024.1723","DOIUrl":"https://doi.org/10.3892/br.2024.1723","url":null,"abstract":"","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"32 34","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of two retinal fractures with ultrabroad‑angle fundus photography systems 利用超广角眼底摄影系统对两种视网膜骨折进行比较分析
IF 2.3
Biomedical reports Pub Date : 2024-01-04 DOI: 10.3892/br.2024.1722
Yong Guo, Hong Yan, Chenjun Guo, Jue Wang
{"title":"Comparative analysis of two retinal fractures with ultrabroad‑angle fundus photography systems","authors":"Yong Guo, Hong Yan, Chenjun Guo, Jue Wang","doi":"10.3892/br.2024.1722","DOIUrl":"https://doi.org/10.3892/br.2024.1722","url":null,"abstract":"","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"59 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139385760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanism of honeysuckle + forsythia in treatment of acute lung injury based on network pharmacology 基于网络药理学的金银花+连翘治疗急性肺损伤的分子机制
IF 2.3
Biomedical reports Pub Date : 2024-01-03 DOI: 10.3892/br.2024.1720
Xin Wen, Min Cheng, Zhongxing Song, Jinhang Hu, Xuhu Liang, Wuying Lang, Mengqi Yang, Ruina Zhou, Yunjing Hao
{"title":"Molecular mechanism of honeysuckle + forsythia in treatment of acute lung injury based on network pharmacology","authors":"Xin Wen, Min Cheng, Zhongxing Song, Jinhang Hu, Xuhu Liang, Wuying Lang, Mengqi Yang, Ruina Zhou, Yunjing Hao","doi":"10.3892/br.2024.1720","DOIUrl":"https://doi.org/10.3892/br.2024.1720","url":null,"abstract":"","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"52 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139451928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of decompressive craniectomy in the management of acute ischemic stroke (Review) 减压开颅术在急性缺血性脑卒中治疗中的作用（综述）
IF 2.3
Biomedical reports Pub Date : 2024-01-03 DOI: 10.3892/br.2024.1721
George Fotakopoulos, Charalambos Gatos, V. Georgakopoulou, Ioannis G. Lempesis, Demetrios A. Spandidos, N. Trakas, P. Sklapani, Kostas Fountas
{"title":"Role of decompressive craniectomy in the management of acute ischemic stroke (Review)","authors":"George Fotakopoulos, Charalambos Gatos, V. Georgakopoulou, Ioannis G. Lempesis, Demetrios A. Spandidos, N. Trakas, P. Sklapani, Kostas Fountas","doi":"10.3892/br.2024.1721","DOIUrl":"https://doi.org/10.3892/br.2024.1721","url":null,"abstract":"","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"19 23","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139389430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An update on recent studies of extracellular vesicles and their role in hypercoagulability in thalassemia (Review) 细胞外囊泡及其在地中海贫血高凝状态中的作用的最新研究（综述）
IF 2.3
Biomedical reports Pub Date : 2023-12-28 DOI: 10.3892/br.2023.1719
P. Klaihmon, K. Pattanapanyasat, Phatchariya Phannasil
{"title":"An update on recent studies of extracellular vesicles and their role in hypercoagulability in thalassemia (Review)","authors":"P. Klaihmon, K. Pattanapanyasat, Phatchariya Phannasil","doi":"10.3892/br.2023.1719","DOIUrl":"https://doi.org/10.3892/br.2023.1719","url":null,"abstract":"","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"17 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of bloodletting puncture and cupping in postherpetic neuralgia: A systematic review and meta‑analysis 放血穿刺和拔罐治疗带状疱疹后遗神经痛的有效性和安全性：系统回顾与荟萃分析
IF 2.3
Biomedical reports Pub Date : 2023-12-28 DOI: 10.3892/br.2023.1718
Wenyun Kui, Lei Xie, Yanan Li, Zhen Gu, Shuang Liu, Chunchun Xue, Kaiqiang Wang
{"title":"Efficacy and safety of bloodletting puncture and cupping in postherpetic neuralgia: A systematic review and meta‑analysis","authors":"Wenyun Kui, Lei Xie, Yanan Li, Zhen Gu, Shuang Liu, Chunchun Xue, Kaiqiang Wang","doi":"10.3892/br.2023.1718","DOIUrl":"https://doi.org/10.3892/br.2023.1718","url":null,"abstract":"","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"68 10","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fructus Ligustri Lucidi inhibits ferroptosis in ovariectomy‑induced osteoporosis in rats via the Nrf2/HO‑1 signaling pathway 女贞子通过 Nrf2/HO-1 信号通路抑制卵巢切除术诱发的大鼠骨质疏松症中的铁沉积现象
IF 2.3
Biomedical reports Pub Date : 2023-12-22 DOI: 10.3892/br.2023.1715
Pei Li, Yuhan Wang, Qiqi Yan, Ying Yang, Ruyuan Zhu, Jiayi Ma, Yanjing Chen, Haixia Liu, Zhiguo Zhang
{"title":"Fructus Ligustri Lucidi inhibits ferroptosis in ovariectomy‑induced osteoporosis in rats via the Nrf2/HO‑1 signaling pathway","authors":"Pei Li, Yuhan Wang, Qiqi Yan, Ying Yang, Ruyuan Zhu, Jiayi Ma, Yanjing Chen, Haixia Liu, Zhiguo Zhang","doi":"10.3892/br.2023.1715","DOIUrl":"https://doi.org/10.3892/br.2023.1715","url":null,"abstract":"","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"14 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138944970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infection with multi‑drug resistant organisms in patients with limb fractures: Analysis of risk factors and pathogens 四肢骨折患者感染多重耐药菌：风险因素和病原体分析
IF 2.3
Biomedical reports Pub Date : 2023-12-22 DOI: 10.3892/br.2023.1716
Honggang Sun, Dagao Dong, Min Zhao, Jie Jian
{"title":"Infection with multi‑drug resistant organisms in patients with limb fractures: Analysis of risk factors and pathogens","authors":"Honggang Sun, Dagao Dong, Min Zhao, Jie Jian","doi":"10.3892/br.2023.1716","DOIUrl":"https://doi.org/10.3892/br.2023.1716","url":null,"abstract":"","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"59 30","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138945945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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