Biomedical reports最新文献

{"title":"Semaglutide and major adverse cardiovascular events in patients with and without DM: A systematic review and meta-analysis.","authors":"Yanhua Li, Chunmei Lv, Lianlian Cao, Sun Lihua, Yanqu Ma","doi":"10.3892/br.2026.2165","DOIUrl":"10.3892/br.2026.2165","url":null,"abstract":"<p><p>Semaglutide, a once-weekly glucagon-like peptide-1 receptor agonist (GLP-1 RA), has been associated with cardiovascular benefits, whereas the consistency of its effect across various clinical settings, as well as its safety-economic profile, remains uncertain. MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, ClinicalTrials.gov and WHO International Clinical Trials Registry Platform were searched up to January 2025 and identified 11 randomized controlled trials (12 comparisons; 25,067 participants) comparing semaglutide with placebo or active control. Using a DerSimonian-Laird random-effects model, semaglutide reduced major adverse cardiovascular events by 32% [pooled odds ratio (OR)=0.68; 95%; confidence interval 0.52-0.91; 95% prediction interval 0.44-1.04]. Point estimates remained unchanged after censoring all STEP obesity trials (OR=0.70) or both heart-failure trials (OR=0.66), indicating a negligible institution-level effect. Mixed-effects meta-regression analysis revealed greater benefit with lower body weight, LDL- and total cholesterol levels, and lesser benefit with higher age, HbA1c and blood pressure (all P<0.01). Safety pooling found higher risks of any gastrointestinal (GI) disorder [relative risk (RR)=1.47], gallbladder events (RR=2.37), and discontinuation due to GI intolerance (RR 2.32). A total of seven out of 11 trials enrolled ≥75% White patients, none of whom were from low-income countries, limiting generalizability. Besides, U.S. cost-utility models published in the literature report incremental cost-effectiveness ratios of US$ 180,000-260,000 per quality-adjusted life-year, above conventional willingness-to-pay thresholds. Overall, semaglutide demonstrated marked cardiovascular risk reduction at all doses and across all populations, with low statistical heterogeneity. However, this benefit must be weighed against GI intolerance, limited racial and geographic representation and uncertain cost-effectiveness outside high-income regions. Future trials must oversample underrepresented minorities, extend to low- and middle-income regions, and include formal economic evaluations to further refine population-specific benefit-risk profiles and value estimates.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"92"},"PeriodicalIF":2.5,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and pharmacological study of <i>Cnidium monnieri</i> volatile oil cream.","authors":"Tingting Sun, Leyao Dang, Binyue Zheng, Xingyu Dang, Xinyu Gou, Jie Wang, Jinhui Wang, Xiaofei Zhang, Jing Sun, Yajun Shi, Dongyan Guo, Junbo Zou, Henglei Niu, Xin Sui, Ying Wang","doi":"10.3892/br.2026.2164","DOIUrl":"10.3892/br.2026.2164","url":null,"abstract":"<p><p>Eczema, a chronic inflammatory skin condition, causes persistent discomfort and impairs patients' quality of life. <i>Cnidium monnieri</i> has been traditionally used for its anti-inflammatory and antipruritic properties. The present study aimed to develop an optimized formulation of <i>Cnidium monnieri</i> volatile oil cream (CMVOC) and evaluate its anti-inflammatory effects in an eczema model. A single-factor and response surface optimization approach was used to determine the optimal cream formulation. The formulation was evaluated based on appearance, physical stability, particle size and moisturizing capacity. An eczema model was induced using 2,4-dinitrochlorobenzene (DNCB) in mice. Serum levels of IL-6 and IL-17 were measured by ELISA, skin pathology was assessed by hematoxylin and eosin and toluidine blue staining and JAK2/STAT3 expression was detected by immunohistochemistry to determine the activation status of the related signaling pathway. The optimized formulation contained 4.45 g octadecanol, 4 g Vaseline, 2.2 g liquid paraffin, 0.81 g isopropyl myristate Estergel^®, 1.6 g <i>Cnidium monnieri</i> volatile oil, 0.39 g sodium dodecyl sulfate, 1.16 g glycerol, 0.04 g nibergin ethyl ester and 25.35 g Distilled Water. <i>In vivo</i>, CMVOC markedly improved skin lesions in DNCB-induced mice, reduced serum IL-6 and IL-17 levels and alleviated epidermal thickening, edema and inflammatory infiltration. Immunohistochemistry further demonstrated suppressed activation of the JAK2-STAT3 signaling pathway. CMVOC effectively mitigated eczema-related inflammation by reducing pro-inflammatory cytokines and inhibiting JAK2-STAT3 pathway activation, providing experimental support for its potential as a topical therapy for eczema.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"91"},"PeriodicalIF":2.5,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pink lotus flower (<i>Nelumbo nucifera</i>) oil extract alleviates imiquimod-induced psoriasis-like dermatitis.","authors":"Kamonwan Jongsomchai, Somyoth Sridurongrit, Passanesh Sukphopetch, Tawut Rudtanatip, Tichanon Promsrisuk, Laorrat Phuapittayalert, Sataporn Jamsuwan, Teera Chanmanee, Sarinthorn Thummayot, Sitthisak Thongrong, Amnart Onsa-Ard, Arnon Pudgerd","doi":"10.3892/br.2026.2163","DOIUrl":"10.3892/br.2026.2163","url":null,"abstract":"<p><p>Pink lotus (<i>Nelumbo nucifera</i> Gaertn.) contains bioactive flavonoids and alkaloids that exert anti-inflammatory and antioxidant activities, and inhibit TNF-α, IL-1β, IL-6 and NF-κB signaling pathways implicated in the pathogenesis of psoriasis. However, the effects of pink lotus flower oil (PLO) on psoriasis-like skin inflammation remain unexplored. Therefore, the present study aimed to evaluate the effects of PLO treatment on imiquimod (IMQ)-induced psoriasis-like skin inflammation in a mouse model. Briefly, BALB/c mice with IMQ-induced psoriasis were administered PLO (100 and 200 mg/kg), and the psoriasis area and severity index were measured. Histopathology, proinflammatory cytokine levels, antioxidant gene expression, oxidative stress and antioxidant marker levels, and immunoreactivity were also assessed. PLO treatment markedly reduced erythema, scaling and epidermal thickening, and suppressed keratinocyte proliferation, as evidenced by decreased proliferating cell nuclear antigen immunoreactivity, and downregulated mRNA levels of keratin-encoding genes <i>keratin</i> 6 (<i>K6</i>), <i>K16</i> and <i>K17</i>. Moreover, PLO significantly downregulated the levels of proinflammatory cytokines, including TNF-α, IL-17A, IL-23 and <i>IL-6</i>, and reduced the infiltration of CD4⁺ and mast cells. Mechanistically, PLO treatment decreased phosphorylated (p)-JAK2, p-JAK3 and p-STAT3 immunoreactivity by inhibiting JAK2/JAK3/STAT3 signaling. Oxidative stress was attenuated, as evidenced by reduced malondialdehyde levels, and increased nuclear factor erythroid 2-related factor 2, Cu/Zn-superoxide dismutase (<i>Cu/Zn-SOD</i>), <i>Mn-SOD</i>, catalase and glutathione peroxidase mRNA expression levels. PLO treatment also mitigated IMQ-induced splenomegaly, and suppressed <i>IL-1b and IL-6</i> expression in the spleen, and reduced <i>IL-6</i> expression in the axillary lymph nodes. In conclusion, PLO treatment ameliorated IMQ-induced psoriasis by enhancing antioxidant defenses, and by inhibiting JAK2 and JAK3/STAT3 signaling, supporting its potential as a therapeutic candidate for psoriasis.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 2","pages":"90"},"PeriodicalIF":2.5,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive dysfunction after cardiac surgery: A systematic review and meta-analysis on the mini-mental state examination findings.","authors":"Hu Cheng, Yali Yasen, Xiao Cheng, Zhenfei Hu, Xueyan Li, Jianjiang Wu, Wenbing Yu, Jiang Wang","doi":"10.3892/br.2026.2162","DOIUrl":"10.3892/br.2026.2162","url":null,"abstract":"<p><p>Postoperative cognitive dysfunction (POCD) is a frequent complication of cardiac surgery. The present study aimed to quantify changes in Mini-Mental State Examination (MMSE) scores following on-pump cardiac surgery and explore potential study-level moderators associated with variability in cognitive outcomes. A systematic review and random-effects meta-analysis was performed following PRISMA guidelines. MEDLINE, Embase, Cumulative Index to Nursing & Allied Health Literature, Cochrane, PsycINFO, Web of Science, and Scopus were searched up to May 2025; eight prospective single-center cohorts (867 patients) met predefined criteria, providing 14 independent pre/postoperative comparisons of cognitive function. The mean MMSE score was extracted at baseline and final reported follow-up (7 days to 6 months). Hedges' g was pooled using a random-effects model; heterogeneity was summarized with τ² and I², and a 95% prediction interval (PI) was calculated. Overall, cardiac surgery was associated with a moderate decline in MMSE scores (g=-0.60, 95% confidence interval, -0.85 to -0.35; P<0.001). Heterogeneity was high (τ²=0.178; I²=88.8%), yet leave-one-out and Hartung-Knapp adjustments produced similar estimates. The 95% PI (-1.56 to 0.36) spans both negative and slightly positive values, indicating that while most cohorts show cognitive decline, the inclusion of values above zero suggests that small improvements remain possible in some populations. Subgroup analysis showed a large decline among patients meeting POCD criteria (g=-0.893) compared with a small, non-significant change in non-POCD patients (g=-0.274; Q_between=9.08, P=0.003). Meta-regression identified cardiopulmonary-bypass time as the only statistically significant moderator (β=-0.014 MMSE SD units/min; P=0.023), explaining ~50% of between-study variance. Funnel-plot tests suggested possible small-study effects, but trim-and-fill imputed no missing studies and Rosenthal's fail-safe N was 431, supporting the robustness of the pooled estimate. These findings suggest that on-pump cardiac surgery is frequently associated with a moderate decline in global cognitive performance as measured by the MMSE, particularly among patients who develop clinical POCD. Awareness of this association may support perioperative cognitive monitoring and efforts to minimize modifiable intraoperative factors such as prolonged cardiopulmonary bypass duration.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 1","pages":"89"},"PeriodicalIF":2.5,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between lncRNAs and RNA binding proteins, and their potential as drug targets in the therapy of liver cancer (Review).","authors":"Jiawei Liu, Dong Chen","doi":"10.3892/br.2026.2161","DOIUrl":"10.3892/br.2026.2161","url":null,"abstract":"<p><p>Liver cancer, including hepatocellular carcinoma (HCC) as the major type, is a serious malignant tumor with high morbidity and mortality worldwide. Long noncoding RNAs (lncRNAs) play an essential role in the pathogenesis and development of liver cancer, as they can cooperate with and modulate other molecules, particularly RNA binding proteins (RBPs), to perform regulatory functions. Conversely, RBPs also deeply influence the functional manner of lncRNAs in cancer cells. Thus, it is critical to decipher how lncRNAs and RBPs interact with each other, affect the expression, localization, structure, modification, or function of their partners, and induce the following biological programs. In the present review, the interactions between lncRNAs and RBPs identified over the past years are examined, and their modes of cooperation and downstream effects on liver cancer progression are explored. Briefly, lncRNA-RBP pairs were classified into different categories according to their mechanisms of interaction and their influence on liver cancer development, including how their interactions affect one another, how they cooperate to regulate targets, and the resulting functional outcomes on liver cancer. In addition, the current state-of-the-art databases and technologies used to identify potential interactions between lncRNAs and RBPs were also emphasized, including crosslinking and immunoprecipitation, RNA immunoprecipitation, RNA pull-down and mass spectrometry. In summary, the present review systematically summarized the regulatory functions of lncRNA-RBP pairs in liver cancer, which suggests the potential to harness RNA-based therapeutics as an alternative treatment modality for liver cancer.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 1","pages":"88"},"PeriodicalIF":2.5,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13238478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tricellulin regulates the tight junctions and cytoskeleton of pancreatic acinar cells through the NF-κB pathway in hypertriglyceridemic acute pancreatitis.","authors":"Guifang Wei, Zhenni Liang, Haixing Wei, Qing Wu, Jie Wang, Lianjie Lin, Zhihai Liang, Huiying Yang, Mengbin Qin","doi":"10.3892/br.2026.2160","DOIUrl":"10.3892/br.2026.2160","url":null,"abstract":"<p><p>Hypertriglyceridemic acute pancreatitis (HTGAP) is a clinical emergency. Tight junctions (TJs) and the cytoskeleton are essential for cell-cell junctions and cell survival, and although tricellulin is a key protein regulating cell junctions, its role in regulating TJ proteins and the cytoskeleton in pancreatic acinar cells in HTGAP is not currently clear. In the present study, 24 female hamsters were assigned to the control, hypertriglyceridemia (HTG), HTGAP and HTGAP + SC75741 groups. HTG was induced by a high-fat diet and HTGAP was established by retrograde sodium taurocholate injection. Serum triglyceride levels, pancreatic histopathological changes, and pancreatic expression of tricellulin, claudin-1 and NF-κB p65 were assessed. Furthermore, AR42J cell models with tricellulin overexpression and knockdown were cultured under HTG conditions, and protein levels were semi-quantified by western blotting. F-actin organization was assessed by immunofluorescence staining and intercellular morphology was examined by scanning electron microscopy. The results revealed that tricellulin expression was decreased and p65 expression was increased under hypertriglyceridemic conditions, whereas pancreatic histopathological injury was not significantly increased in the HTG group. The HTGAP group showed significantly more severe pancreatic injury than the control and HTG groups, accompanied by significantly decreased tricellulin and claudin-1 expression, and significantly increased p65 expression. After SC75741 (an inhibitor of the NF-κB signaling pathway) treatment, pancreatic injury and p65 expression were significantly decreased, whereas tricellulin and claudin-1 showed only partial recovery. In AR42J cells, tricellulin overexpression was associated with increased claudin-1 expression, reduced NF-κB activation, improved F-actin organization and better-preserved intercellular morphology, whereas tricellulin knockdown exhibited the opposite pattern. In conclusion, hypertriglyceridemic conditions were associated with impaired TJ integrity and cytoskeletal disorganization in pancreatic acinar cells, accompanied by reduced tricellulin expression and increased NF-κB activation. These findings suggest that tricellulin may contribute to HTGAP-related junctional and cytoskeletal injury, potentially involving NF-κB signaling.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 1","pages":"87"},"PeriodicalIF":2.5,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13216753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal clear cell sarcoma in children: A case report.","authors":"Lingfei Li, Hui Yang, Fang Li, Ning Zhou, Ying Luo, Hailan Ma, Zhengfu Wang, Liren Jian, Ling Dang, Hongyan Xiao","doi":"10.3892/br.2026.2159","DOIUrl":"10.3892/br.2026.2159","url":null,"abstract":"<p><p>Clear cell sarcoma of the kidney (CCSK), a rare renal interstitial tumor in children, poses a notable threat to the physical and mental health of children because of its highly aggressive nature, tendency to compress surrounding tissue and potential for metastasis. The present study reports two cases of pediatric CCSK treated at the Peking University First Hospital Ningxia Women and Children's Hospital (Ningxia Hui Autonomous Region Maternal and Child Health Hospital, Ningxia, China; July 2024-2025.7). Both patients were female infants aged 1 year. Upon initial admission, they were misdiagnosed with nephroblastoma and received radical nephrectomy and vincristine chemotherapy. Pathological consultation and advanced molecular sequencing identified specific expression of the BCL6 corepressor gene in patient tumor tissue, leading to a definitive diagnosis of CCSK. Furthermore, the present study aimed to provide an overview of the aberrant genes associated with CCSK to provide a useful reference for future research on the pathogenesis of CCSK and improvement of molecular pathology.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 1","pages":"86"},"PeriodicalIF":2.5,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of copy number variations and affected gene networks in breast cancer.","authors":"Violeta Larios-Serrato, Hilda-Alicia Valdez-Salazar, Javier Torres, Margarita Camorlinga-Ponce, Patricia Piña-Sánchez, Héctor Mayani, Martha-Eugenia Ruiz-Tachiquín","doi":"10.3892/br.2026.2158","DOIUrl":"10.3892/br.2026.2158","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) is a highly aggressive form characterized by limited therapeutic options and notable molecular diversity. The present study performed a genome-wide analysis of copy number variations (CNVs) using high-density microarrays in tumor tissue (TUM), adjacent non-tumor tissue (ADJ) and leukocytes (LEU) obtained from five patients with TNBC. The present study identified both unique and shared CNVs across tissue samples, including alterations in key chromosomal regions such as 1q23.3, 1q32.1 and 8q24.3, which harbor oncogenes such as MYC, myeloid cell leukemia 1 (MCL1) and BCL9. Losses in 6q25.2 affecting estrogen receptor 1 (ESR1) gene were also detected. CNVs were enriched in genes associated with Hallmarks of Cancer, with TUM samples showing profiles associated with 'proliferation', 'metastasis' and 'immune evasion', ADJ samples with 'growth suppression' and LEU samples with 'genomic instability'. Pathway enrichment analyses revealed disrupted functions in 'DNA repair', 'extracellular matrix organization' and 'TP53 signaling' in TUM. Notably, EGFR, excision repair cross-complementing group 4 (ERCC4) and heat shock protein 90 alpha family class B member 1 (HSP90AB1) genes emerged as potential central nodes in interaction networks and may serve as markers or therapeutic targets. To the best of our knowledge, the present study is the first CNV profiling study in TNBC in Mexican patients, highlighting the importance of including underrepresented populations in genomic research to uncover distinct molecular signatures and potential diagnostic or therapeutic avenues. Bioinformatically predicted molecular signatures of TNBC involve both common and distinct CNV-associated Hallmarks of Cancer genes, which represent candidates for screening as potential TNBC biomarkers.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 1","pages":"85"},"PeriodicalIF":2.5,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13216850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular signaling crosstalk between osteoporosis and diabetes: Common mechanisms and therapeutic targets (Review).","authors":"Yangyi Cheng, Jingyuan Gao, Yuyang Yang, Lei Xing, Xiaoli Hou, Liu Zhang, Faming Tian","doi":"10.3892/br.2026.2157","DOIUrl":"10.3892/br.2026.2157","url":null,"abstract":"<p><p>Osteoporosis and diabetes typically occur together. The present review aimed to summarize the molecular mechanisms and intracellular signaling pathways that connect osteoporosis and diabetes. In diabetic conditions, persistent hyperglycemia triggers excessive oxidative stress, sustains low-grade inflammation and perturbs insulin signaling pathways. In turn, bone metabolic abnormalities affect glucose regulation through the bone-pancreas axis and osteoimmune signaling pathways, highlighting a bidirectional relationship between skeletal and metabolic health. Several antidiabetic agents (metformin, glucagon-like peptide-1 receptor agonists) protect against bone loss, while certain anti-osteoporotic drugs (bisphosphonates, denosumab) exert favorable effects on glucose metabolism and diabetic complications. These dual benefits suggest overlapping molecular pathways and shared therapeutic targets. The present review aimed to summarize the inflammation-insulin signaling axis, RANKL/OPG system, Wnt/β-catenin pathway, AGE/RAGE signaling and bone-derived endocrine factors as key mediators of interorgan communication. It also underscores the importance of systems biology and integrated cross-tissue analyses in uncovering the mechanisms underlying diabetes-associated bone disorder. Future research defining the molecular basis of intercellular and interorgan crosstalk may lead to precise, mechanism-driven strategies for the integrated treatment of diabetes and osteoporosis.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 1","pages":"84"},"PeriodicalIF":2.5,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13199948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148026467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of narrow-diameter implants in restoring dentition defects in patients with diabetes: A systematic review and meta-analysis.","authors":"Zhihong Zhang, Ding Wang, Jun Li","doi":"10.3892/br.2026.2156","DOIUrl":"10.3892/br.2026.2156","url":null,"abstract":"<p><p>The aim of the present study was to systematically evaluate the efficacy of narrow-diameter implants (NDIs) for restoring dentition defects in patients with diabetes and compare their clinical/radiographic outcomes with patients without diabetes (controls). Databases (PubMed, Embase, Web of Science, Cochrane Library and Google Scholar) were searched (January 1, 2000-July 15, 2025) for studies comparing NDI outcomes between patients with and without diabetes. The methodological quality and risk of bias of the included studies were assessed using the Newcastle-Ottawa Scale and the Joanna Briggs Institute Critical Appraisal Checklist. Meta-analysis was performed using RevMan v5.4 software. The nine included studies (410 patients; 688 implants) demonstrated high overall methodological quality. There was no significant intergroup difference in the survival rate [risk ratio (RR)=1.00; 95% confidence interval (CI) 0.93, 1.07; P=1.00]. Regarding radiographic outcomes, the diabetic group exhibited greater distal bone loss [mean difference (MD)=0.28 mm, 95% CI 0.02, 0.5; P=0.03), whereas the mesial bone level (MD=0.31 mm; P=0.08] and overall marginal bone level (MD=-0.02 mm; P=0.83) showed no significant differences. Furthermore, the diabetic group had markedly higher long-term (≥3 years) probing depth (MD=0.31 mm; P<0.0001), bleeding on probing (MD=14.41%; P=0.02), and plaque index (MD=13.77%; P=0.04). There was notable heterogeneity among the studies included in the meta-analysis, suggesting that individual studies may have influenced the overall findings. NDIs demonstrated satisfactory short-term survival in patients with diabetes. However, diabetes markedly increased long-term peri-implant inflammation risk and distal bone resorption, necessitating enhanced postoperative monitoring and personalized maintenance.</p>","PeriodicalId":8863,"journal":{"name":"Biomedical reports","volume":"25 1","pages":"83"},"PeriodicalIF":2.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13203316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}