Biologia futura最新文献

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Fight against cold: photosynthetic and antioxidant responses of different bell pepper cultivars (Capsicum annuum L.) to cold stress. 抗寒:不同甜椒品种(辣椒)对冷胁迫的光合和抗氧化反应。
IF 2.1 4区 生物学
Biologia futura Pub Date : 2023-09-01 Epub Date: 2023-09-27 DOI: 10.1007/s42977-023-00182-3
A Rácz, Gy Czégény, D Kutyáncsánin, N Nagy, É Hideg, K Csepregi
{"title":"Fight against cold: photosynthetic and antioxidant responses of different bell pepper cultivars (Capsicum annuum L.) to cold stress.","authors":"A Rácz,&nbsp;Gy Czégény,&nbsp;D Kutyáncsánin,&nbsp;N Nagy,&nbsp;É Hideg,&nbsp;K Csepregi","doi":"10.1007/s42977-023-00182-3","DOIUrl":"10.1007/s42977-023-00182-3","url":null,"abstract":"<p><p>The special metabolites of bell pepper (Capsicum annuum L.) leaves can protect the plant under possibly damaging circumstances, such as high light, UV, unfavorable temperatures, or other environmental effects. In this study, we examined the cold stress tolerance of three different Hungarian pepper varieties (Darina, Édesalma, Rekord), focusing on the antioxidant and photosynthetic responses. The plants were developed in growth chambers under optimal temperature conditions (day/night 25 °C/20 °C) until the leaves on the fourth node became fully developed, then half of the plants received a cold treatment (day/night 15 °C/10 °C). Via a detailed pigment analysis, the PS II chlorophyll fluorescence responses, gas exchange parameters and total antioxidant capacities, leaf acclimation to low temperatures has been characterized. Our results display some of the developing physiological and antioxidant properties, which are among the main factors in monitoring the damaging effects of cold temperatures. Nevertheless, despite their differences, the tested pepper varieties did not show different cold responses.</p>","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41100909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The bZIP-type transcription factors NapA and RsmA modulate the volumetric ratio and the relative superoxide ratio of mitochondria in Aspergillus nidulans. bZIP型转录因子NapA和RsmA调节巢状曲霉线粒体的体积比和相对超氧化物比。
IF 2.1 4区 生物学
Biologia futura Pub Date : 2023-09-01 Epub Date: 2023-10-09 DOI: 10.1007/s42977-023-00184-1
Bernadett Bákány, Réka Antal, Péter Szentesi, Tamás Emri, Éva Leiter, László Csernoch, Nancy P Keller, István Pócsi, Beatrix Dienes
{"title":"The bZIP-type transcription factors NapA and RsmA modulate the volumetric ratio and the relative superoxide ratio of mitochondria in Aspergillus nidulans.","authors":"Bernadett Bákány,&nbsp;Réka Antal,&nbsp;Péter Szentesi,&nbsp;Tamás Emri,&nbsp;Éva Leiter,&nbsp;László Csernoch,&nbsp;Nancy P Keller,&nbsp;István Pócsi,&nbsp;Beatrix Dienes","doi":"10.1007/s42977-023-00184-1","DOIUrl":"10.1007/s42977-023-00184-1","url":null,"abstract":"<p><p>Basic leucine zipper (bZIP) transcription factors are crucial components of differentiation, cellular homeostasis and the environmental stress defense of eukaryotes. In this work, we further studied the consequence of gene deletion and overexpression of two bZIP transcription factors, NapA and RsmA, on superoxide production, mitochondrial morphology and hyphal diameter of Aspergillus nidulans. We have found that reactive oxygen species production was influenced by both gene deletion and overexpression of napA under tert-butylhydroperoxide (tBOOH) elicited oxidative stress. Furthermore, gene expression of napA negatively correlated with mitochondrial volumetric ratio as well as sterigmatocystin production of A. nidulans. High rsmA expression was accompanied with elevated relative superoxide ratio in the second hyphal compartment. A negative correlation between the expression of rsmA and catalase enzyme activity or mitochondrial volumetric ratio was also confirmed by statistical analysis. Hyphal diameter was independent on either rsmA and napA expression as well as 0.2 mM tBOOH treatment.</p>","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peppers and their constituents against obesity. 辣椒及其成分对抗肥胖。
IF 2.1 4区 生物学
Biologia futura Pub Date : 2023-09-01 Epub Date: 2023-07-26 DOI: 10.1007/s42977-023-00174-3
Alexander V Sirotkin
{"title":"Peppers and their constituents against obesity.","authors":"Alexander V Sirotkin","doi":"10.1007/s42977-023-00174-3","DOIUrl":"10.1007/s42977-023-00174-3","url":null,"abstract":"<p><p>Phytotherapy can be an efficient tool for prevention and treatment of disorders including obesity. The purpose of this narrative review is to summarize the available knowledge concerning the positive effects of peppers (Capsicum spp.) and their alkaloid capsaicin on human health, in particular on fat and obesity. Search for literature was performed in Medline/Pubmed, Web of Science and SCOPUS databases between the year 2000 and 2023. Words used to search were pepper, Capsicum, capsaicin, review, obesity, fat, weight loss and mechanisms. The available data demonstrate that both pepper extract and capsaicin can positively influence human health and treat several disorders. Moreover, they can reduce fat storage affecting brain centres responsible for the sensation of hunger, nutrient uptake by gastrointestinal tract, state of adipocytes, increase in carbohydrate and fat oxidation, metabolism and thermogenesis and other mechanisms. Therefore, despite some possible limitations, these substances could be useful for treatment of obesity.</p>","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10248351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigation of the expansin gene family in sugar beet (Beta vulgaris) by the genome-wide level and their expression responses under abiotic stresses. 从全基因组水平研究甜菜膨胀素基因家族及其在非生物胁迫下的表达反应。
IF 2.1 4区 生物学
Biologia futura Pub Date : 2023-09-01 Epub Date: 2023-08-29 DOI: 10.1007/s42977-023-00176-1
Dima Faris Abdulkhadum Al-Mamoorı, Yasemin Celik Altunoglu, Erdoğan Horuz, Büşra Özkan Kök
{"title":"Investigation of the expansin gene family in sugar beet (Beta vulgaris) by the genome-wide level and their expression responses under abiotic stresses.","authors":"Dima Faris Abdulkhadum Al-Mamoorı,&nbsp;Yasemin Celik Altunoglu,&nbsp;Erdoğan Horuz,&nbsp;Büşra Özkan Kök","doi":"10.1007/s42977-023-00176-1","DOIUrl":"10.1007/s42977-023-00176-1","url":null,"abstract":"<p><p>Sugar beet (Beta vulgaris ssp. vulgaris) is primarily used in sugar production worldwide. Expansins are a gene family of cell wall proteins effective in regulating cell wall structure. They also participate in developmental stages, including cell and leaf growth, root development, and fruit ripening. This study comprehensively characterizes the expansin gene family members found in the sugar beet genome. In addition, in silico expression analysis of sugar beet expansin genes under variable abiotic stress conditions and expression profiles of expansin genes under combined drought and heat stresses by the qRT-PCR method were evaluated in the study. A total of 31 sugar beet expansin genes were identified. BvuEXLA-02 and BvuEXLB-02 genes can have abiotic stress tolerance roles besides their roles in normal development. Determining the properties of sugar beet expansin, family members can help enable the cellulose hydrolysis mechanism and raise plant biomass. Elucidating expression profiles of the sugar beet expansin genes under variable stress conditions can support improving plant productivity. The results of the current study may also contribute to the deep understanding of sugar beet expansin genes in the future.</p>","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10467722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biofilm-forming plant growth-promoting rhizobacterial consortia isolated from mines and dumpsites assist green remediation of toxic metal (Ni and Pb) using Brassica juncea. 从矿山和垃圾场分离出的形成生物膜的促进植物生长的根际细菌群落有助于使用芥菜对有毒金属(Ni和Pb)进行绿色修复。
IF 2.1 4区 生物学
Biologia futura Pub Date : 2023-09-01 Epub Date: 2023-09-21 DOI: 10.1007/s42977-023-00179-y
Sarita Sharma, Meenu Saraf
{"title":"Biofilm-forming plant growth-promoting rhizobacterial consortia isolated from mines and dumpsites assist green remediation of toxic metal (Ni and Pb) using Brassica juncea.","authors":"Sarita Sharma,&nbsp;Meenu Saraf","doi":"10.1007/s42977-023-00179-y","DOIUrl":"10.1007/s42977-023-00179-y","url":null,"abstract":"<p><p>To study how biofilm-forming rhizobacteria isolated from mines and dumpsites improved the phytoremediation efficacy of B. juncea in metal-contaminated soil. Out of 91 isolates, six were chosen for research based on their tolerance to metals, and their efficient PGPR properties, and subjected to the design of a consortium. A compatibility study revealed no antagonistic interaction between rhizobacterial-consortiums. The results of the biofilm formation and FEG-SEM studies revealed that a consortium-BC8 formed a strong biofilm on the root surface of B. juncea seedlings. Based on results obtained with the phytoextraction efficiency of B. juncea in consortium-BC8 (SMHMZ46 and SMHMP23), they were identified as Klebsiella variicola and Pseudomonas otitidis, respectively, and submitted to NCBI GenBank with accession numbers MZ145092 and OK560623. This rhizobacteria is the first to be reported as assisting Ni and Pb phytoremediation by employing B. juncea. Soil inoculation with consortium-BC8 increased the amount of soluble Ni and Pb by 13.25-fold and 10.69-fold, respectively, when compared to the control. These consortiums-BC8 significantly increased vegetative growth and metal accumulation in root and shoot with a translocation-factor of 1.58 for Ni and soil to root with a bioconcentration-factor of 1.3 for Pb in B. juncea grown in individual soil contamination with 96.05 mg/kg NiCl<sub>2</sub> and 89.63 mg/kg Pb(NO<sub>3</sub>)<sub>2</sub>, which are significantly higher than other consortium treatments and the non-inoculated control. B. juncea amendments with a biofilm-forming consortium-BC8 having TF, BCF, and BAC > 1 for Ni, whereas BCF > 1, TF, and BAC < 1 for Pb, are appropriate for green remediation of Ni and phytostabilization of Pb.</p>","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41099436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How much (evil) intelligence can be encoded by 30 kb? 30 kb可以编码多少(邪恶的)情报?
IF 2.1 4区 生物学
Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00153-8
Ernő Duda
{"title":"How much (evil) intelligence can be encoded by 30 kb?","authors":"Ernő Duda","doi":"10.1007/s42977-023-00153-8","DOIUrl":"https://doi.org/10.1007/s42977-023-00153-8","url":null,"abstract":"<p><p>Genomes of most RNA viruses are rarely larger than the size of an average human gene (10-15 kb) and still code for a number of biologically active polypeptides that modify the immune system and metabolism of the host organism in an amazingly complex way. Prolonged coevolution developed tricks by which viruses can dodge many protective mechanisms of the host and lead to the formation of molecular mimicry patterns. Some viruses inhibit the interferon response, interfere with the membrane destroying effects of the activated complement cascade. They can replicate in cellular compartments formed by inner membranes of the cell hiding their characteristic features from diverse pattern recognition receptors. In many cases-and in this respect, the new coronavirus is a champion-they can exploit our own defensive mechanisms to cause serious harm, severe symptoms and frequently deadly disease.</p>","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9884670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biologia Futura: does the aging process contribute to the relativity of time? 《未来生物学》:衰老过程对时间的相对性有贡献吗?
IF 2.1 4区 生物学
Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00167-2
Vladimir Z Ajdžanović, Branka T Šošić-Jurjević, Jovan T Ranin, Branko R Filipović
{"title":"Biologia Futura: does the aging process contribute to the relativity of time?","authors":"Vladimir Z Ajdžanović,&nbsp;Branka T Šošić-Jurjević,&nbsp;Jovan T Ranin,&nbsp;Branko R Filipović","doi":"10.1007/s42977-023-00167-2","DOIUrl":"https://doi.org/10.1007/s42977-023-00167-2","url":null,"abstract":"<p><p>In his Theory of relativity, Einstein determined that the time is relative to the reference frame of the observer. Under specific conditions, there is a difference in the elapsed time between two clocks, known as time dilation. A similar relativistic effect could be attributed to the brain operating at different frequencies, e.g., while it is slow and during the thought process. Time flow and the aging process are causally linked. Herein, we introduce physical relativity into the mind/thought context and elaborate changed perception of the time flow (the impression of the time acceleration) with aging. The phenomenology of time is observed in the context of physical and biological clock, as well as by introducing the category of 'mind time.' Mental processing impairment is crucial for the \"aging-caused relativity of time,\" while adjusting of its' perception seems to be a matter of body/mind rest, mental hygiene and physical activity of the aging subject. We also provide a brief overview of the perception of time flow in some disease states that coincide with aging. Our main idea has a perspective for future development in the interdisciplinary synergy of philosophy, physical-mathematical elaboration, experimental biology and clinical investigations.</p>","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Learning from cancer to address COVID-19. 从癌症中学习应对COVID-19。
IF 2.1 4区 生物学
Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00156-5
Edit Oláh
{"title":"Learning from cancer to address COVID-19.","authors":"Edit Oláh","doi":"10.1007/s42977-023-00156-5","DOIUrl":"https://doi.org/10.1007/s42977-023-00156-5","url":null,"abstract":"<p><p>Patients with cancer have been disproportionately affected by the novel coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Knowledge collected during the last three decades of cancer research has helped the medical research community worldwide to respond to many of the challenges raised by COVID-19, during the pandemic. The review, briefly summarizes the underlying biology and risk factors of COVID-19 and cancer, and aims to present recent evidence on cellular and molecular relationship between the two diseases, with a focus on those that are related to the hallmarks of cancer and uncovered in the first less than three years of the pandemic (2020-2022). This may not only help answer the question \"Why cancer patients are considered to be at a particularly high risk of developing severe COVID-19 illness?\", but also helped treatments of patients during the COVID-19 pandemic. The last session highlights the pioneering mRNA studies and the breakthrough discovery on nucleoside-modifications of mRNA by Katalin Karikó, which led to the innovation and development of the mRNA-based SARSCoV-2 vaccines saving lives of millions and also opened the door for a new era of vaccines and a new class of therapeutics.</p>","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9831162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryptogamic communities on flatroofs in the city of Debrecen (East Hungary). 德布勒森市(东匈牙利)屋顶上的神秘社区。
IF 2.1 4区 生物学
Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00166-3
Rebeka Aszalósné Balogh, Gábor Matus, László Lőkös, Balázs Adorján, Csongor Freytag, Ilona Mészáros, Viktor Oláh, Péter Szűcs, Peter Erzberger, Edit Farkas
{"title":"Cryptogamic communities on flatroofs in the city of Debrecen (East Hungary).","authors":"Rebeka Aszalósné Balogh,&nbsp;Gábor Matus,&nbsp;László Lőkös,&nbsp;Balázs Adorján,&nbsp;Csongor Freytag,&nbsp;Ilona Mészáros,&nbsp;Viktor Oláh,&nbsp;Péter Szűcs,&nbsp;Peter Erzberger,&nbsp;Edit Farkas","doi":"10.1007/s42977-023-00166-3","DOIUrl":"https://doi.org/10.1007/s42977-023-00166-3","url":null,"abstract":"<p><p>Cryptogams of ten urban flatroofs, contrasting in their age and size, were studied between 2016 and 2018. Siliceous (bituminous felt, gravel, brick) and calcareous (concrete) substrata occurred at each site. Microclimate (T, RH) at two sites of contrasting shading was monitored from September 2016 to January 2017. Biomass of two differently aged, exposed flatroofs was sampled in October 2018. Taxa of Cladonia and Xanthoparmelia have been identified by spot tests and HPTLC. A total of 61 taxa (25 bryophytes, 36 lichens), mostly widespread synanthropic species, have been detected with an explicit difference of species composition between shaded and exposed sites. Floristically interesting species included acidophilous bryophytes (Hedwigia ciliata, Racomitrium canescens) and lichens (Xanthoparmelia conspersa, Stereocaulon tomentosum) of montane character. The most widespread lichen is Cladonia rei which accounted for a significant part of the biomass at selected sites. Species-area curves for bryophytes at exposed sites have become saturated at 100-150 m<sup>2</sup>. In contrast, saturation of lichen diversity has not been reached even at the largest sites. Flatroofs with traditional roofing techniques can harbour relatively diverse microhabitats and species-rich synanthropic vegetation. It is urgent to study these sites before renovation with modern roofing techniques eliminates them. Diversification of urban surroundings is possible in the future via application of various substrats in renovated and newly constructed roofs.</p>","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9860060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Lipoamide dehydrogenase (LADH) deficiency: medical perspectives of the structural and functional characterization of LADH and its pathogenic variants. 脂酰胺脱氢酶(LADH)缺乏:LADH及其致病变异的结构和功能特征的医学观点
IF 2.1 4区 生物学
Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00155-6
Eszter Szabó, Attila Ambrus
{"title":"Lipoamide dehydrogenase (LADH) deficiency: medical perspectives of the structural and functional characterization of LADH and its pathogenic variants.","authors":"Eszter Szabó,&nbsp;Attila Ambrus","doi":"10.1007/s42977-023-00155-6","DOIUrl":"https://doi.org/10.1007/s42977-023-00155-6","url":null,"abstract":"<p><p>(Dihydro)lipoamide dehydrogenase (LADH) deficiency is an autosomal recessive genetic metabolic disorder. It generally presents with an onset in the neonatal age and premature death. The clinical picture usually involves metabolic decompensation and lactic acidosis that lead to neurological, cardiological, and/or hepatological outcomes. Severity of the disease is due to the fact that LADH is a common E3 subunit to the pyruvate, alpha-ketoglutarate, alpha-ketoadipate, and branched-chain alpha-keto acid dehydrogenase complexes and is also part of the glycine cleavage system; hence, a loss in LADH activity adversely affects several central metabolic pathways simultaneously. The severe clinical manifestations, however, often do not parallel the LADH activity loss, which implies the existence of auxiliary pathological pathways; stimulated reactive oxygen species (ROS) production as well as dissociation from the relevant multienzyme complexes proved to be auxiliary exacerbating pathomechanisms for selected disease-causing LADH mutations. This review provides an overview on the therapeutic challenges of inherited metabolic diseases, structural and functional characteristics of the mitochondrial alpha-keto acid dehydrogenase complexes, molecular pathogenesis and structural basis of LADH deficiency, and relevant potential future medical perspectives.</p>","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9819908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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