Biologia futura最新文献_第8页

The bZIP-type transcription factors NapA and RsmA modulate the volumetric ratio and the relative superoxide ratio of mitochondria in Aspergillus nidulans. bZIP型转录因子NapA和RsmA调节巢状曲霉线粒体的体积比和相对超氧化物比。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-09-01 Epub Date: 2023-10-09 DOI: 10.1007/s42977-023-00184-1

Bernadett Bákány, Réka Antal, Péter Szentesi, Tamás Emri, Éva Leiter, László Csernoch, Nancy P Keller, István Pócsi, Beatrix Dienes

{"title":"The bZIP-type transcription factors NapA and RsmA modulate the volumetric ratio and the relative superoxide ratio of mitochondria in Aspergillus nidulans.","authors":"Bernadett Bákány, Réka Antal, Péter Szentesi, Tamás Emri, Éva Leiter, László Csernoch, Nancy P Keller, István Pócsi, Beatrix Dienes","doi":"10.1007/s42977-023-00184-1","DOIUrl":"10.1007/s42977-023-00184-1","url":null,"abstract":"Basic leucine zipper (bZIP) transcription factors are crucial components of differentiation, cellular homeostasis and the environmental stress defense of eukaryotes. In this work, we further studied the consequence of gene deletion and overexpression of two bZIP transcription factors, NapA and RsmA, on superoxide production, mitochondrial morphology and hyphal diameter of Aspergillus nidulans. We have found that reactive oxygen species production was influenced by both gene deletion and overexpression of napA under tert-butylhydroperoxide (tBOOH) elicited oxidative stress. Furthermore, gene expression of napA negatively correlated with mitochondrial volumetric ratio as well as sterigmatocystin production of A. nidulans. High rsmA expression was accompanied with elevated relative superoxide ratio in the second hyphal compartment. A negative correlation between the expression of rsmA and catalase enzyme activity or mitochondrial volumetric ratio was also confirmed by statistical analysis. Hyphal diameter was independent on either rsmA and napA expression as well as 0.2 mM tBOOH treatment.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":" ","pages":"337-346"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peppers and their constituents against obesity. 辣椒及其成分对抗肥胖。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-09-01 Epub Date: 2023-07-26 DOI: 10.1007/s42977-023-00174-3

Alexander V Sirotkin

引用次数: 1

Investigation of the expansin gene family in sugar beet (Beta vulgaris) by the genome-wide level and their expression responses under abiotic stresses. 从全基因组水平研究甜菜膨胀素基因家族及其在非生物胁迫下的表达反应。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-09-01 Epub Date: 2023-08-29 DOI: 10.1007/s42977-023-00176-1

Dima Faris Abdulkhadum Al-Mamoorı, Yasemin Celik Altunoglu, Erdoğan Horuz, Büşra Özkan Kök

{"title":"Investigation of the expansin gene family in sugar beet (Beta vulgaris) by the genome-wide level and their expression responses under abiotic stresses.","authors":"Dima Faris Abdulkhadum Al-Mamoorı, Yasemin Celik Altunoglu, Erdoğan Horuz, Büşra Özkan Kök","doi":"10.1007/s42977-023-00176-1","DOIUrl":"10.1007/s42977-023-00176-1","url":null,"abstract":"Sugar beet (Beta vulgaris ssp. vulgaris) is primarily used in sugar production worldwide. Expansins are a gene family of cell wall proteins effective in regulating cell wall structure. They also participate in developmental stages, including cell and leaf growth, root development, and fruit ripening. This study comprehensively characterizes the expansin gene family members found in the sugar beet genome. In addition, in silico expression analysis of sugar beet expansin genes under variable abiotic stress conditions and expression profiles of expansin genes under combined drought and heat stresses by the qRT-PCR method were evaluated in the study. A total of 31 sugar beet expansin genes were identified. BvuEXLA-02 and BvuEXLB-02 genes can have abiotic stress tolerance roles besides their roles in normal development. Determining the properties of sugar beet expansin, family members can help enable the cellulose hydrolysis mechanism and raise plant biomass. Elucidating expression profiles of the sugar beet expansin genes under variable stress conditions can support improving plant productivity. The results of the current study may also contribute to the deep understanding of sugar beet expansin genes in the future.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":" ","pages":"295-307"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10467722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofilm-forming plant growth-promoting rhizobacterial consortia isolated from mines and dumpsites assist green remediation of toxic metal (Ni and Pb) using Brassica juncea. 从矿山和垃圾场分离出的形成生物膜的促进植物生长的根际细菌群落有助于使用芥菜对有毒金属（Ni和Pb）进行绿色修复。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-09-01 Epub Date: 2023-09-21 DOI: 10.1007/s42977-023-00179-y

Sarita Sharma, Meenu Saraf

{"title":"Biofilm-forming plant growth-promoting rhizobacterial consortia isolated from mines and dumpsites assist green remediation of toxic metal (Ni and Pb) using Brassica juncea.","authors":"Sarita Sharma, Meenu Saraf","doi":"10.1007/s42977-023-00179-y","DOIUrl":"10.1007/s42977-023-00179-y","url":null,"abstract":"To study how biofilm-forming rhizobacteria isolated from mines and dumpsites improved the phytoremediation efficacy of B. juncea in metal-contaminated soil. Out of 91 isolates, six were chosen for research based on their tolerance to metals, and their efficient PGPR properties, and subjected to the design of a consortium. A compatibility study revealed no antagonistic interaction between rhizobacterial-consortiums. The results of the biofilm formation and FEG-SEM studies revealed that a consortium-BC8 formed a strong biofilm on the root surface of B. juncea seedlings. Based on results obtained with the phytoextraction efficiency of B. juncea in consortium-BC8 (SMHMZ46 and SMHMP23), they were identified as Klebsiella variicola and Pseudomonas otitidis, respectively, and submitted to NCBI GenBank with accession numbers MZ145092 and OK560623. This rhizobacteria is the first to be reported as assisting Ni and Pb phytoremediation by employing B. juncea. Soil inoculation with consortium-BC8 increased the amount of soluble Ni and Pb by 13.25-fold and 10.69-fold, respectively, when compared to the control. These consortiums-BC8 significantly increased vegetative growth and metal accumulation in root and shoot with a translocation-factor of 1.58 for Ni and soil to root with a bioconcentration-factor of 1.3 for Pb in B. juncea grown in individual soil contamination with 96.05 mg/kg NiCl2 and 89.63 mg/kg Pb(NO3)2, which are significantly higher than other consortium treatments and the non-inoculated control. B. juncea amendments with a biofilm-forming consortium-BC8 having TF, BCF, and BAC > 1 for Ni, whereas BCF > 1, TF, and BAC < 1 for Pb, are appropriate for green remediation of Ni and phytostabilization of Pb.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":" ","pages":"309-325"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41099436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How much (evil) intelligence can be encoded by 30 kb? 30 kb可以编码多少(邪恶的)情报?

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00153-8

Ernő Duda

引用次数: 0

Biologia Futura: does the aging process contribute to the relativity of time? 《未来生物学》:衰老过程对时间的相对性有贡献吗?

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00167-2

Vladimir Z Ajdžanović, Branka T Šošić-Jurjević, Jovan T Ranin, Branko R Filipović

{"title":"Biologia Futura: does the aging process contribute to the relativity of time?","authors":"Vladimir Z Ajdžanović, Branka T Šošić-Jurjević, Jovan T Ranin, Branko R Filipović","doi":"10.1007/s42977-023-00167-2","DOIUrl":"https://doi.org/10.1007/s42977-023-00167-2","url":null,"abstract":"In his Theory of relativity, Einstein determined that the time is relative to the reference frame of the observer. Under specific conditions, there is a difference in the elapsed time between two clocks, known as time dilation. A similar relativistic effect could be attributed to the brain operating at different frequencies, e.g., while it is slow and during the thought process. Time flow and the aging process are causally linked. Herein, we introduce physical relativity into the mind/thought context and elaborate changed perception of the time flow (the impression of the time acceleration) with aging. The phenomenology of time is observed in the context of physical and biological clock, as well as by introducing the category of 'mind time.' Mental processing impairment is crucial for the \"aging-caused relativity of time,\" while adjusting of its' perception seems to be a matter of body/mind rest, mental hygiene and physical activity of the aging subject. We also provide a brief overview of the perception of time flow in some disease states that coincide with aging. Our main idea has a perspective for future development in the interdisciplinary synergy of philosophy, physical-mathematical elaboration, experimental biology and clinical investigations.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"137-143"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learning from cancer to address COVID-19. 从癌症中学习应对COVID-19。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00156-5

Edit Oláh

{"title":"Learning from cancer to address COVID-19.","authors":"Edit Oláh","doi":"10.1007/s42977-023-00156-5","DOIUrl":"https://doi.org/10.1007/s42977-023-00156-5","url":null,"abstract":"Patients with cancer have been disproportionately affected by the novel coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Knowledge collected during the last three decades of cancer research has helped the medical research community worldwide to respond to many of the challenges raised by COVID-19, during the pandemic. The review, briefly summarizes the underlying biology and risk factors of COVID-19 and cancer, and aims to present recent evidence on cellular and molecular relationship between the two diseases, with a focus on those that are related to the hallmarks of cancer and uncovered in the first less than three years of the pandemic (2020-2022). This may not only help answer the question \"Why cancer patients are considered to be at a particularly high risk of developing severe COVID-19 illness?\", but also helped treatments of patients during the COVID-19 pandemic. The last session highlights the pioneering mRNA studies and the breakthrough discovery on nucleoside-modifications of mRNA by Katalin Karikó, which led to the innovation and development of the mRNA-based SARSCoV-2 vaccines saving lives of millions and also opened the door for a new era of vaccines and a new class of therapeutics.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"29-43"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9831162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryptogamic communities on flatroofs in the city of Debrecen (East Hungary). 德布勒森市(东匈牙利)屋顶上的神秘社区。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00166-3

Rebeka Aszalósné Balogh, Gábor Matus, László Lőkös, Balázs Adorján, Csongor Freytag, Ilona Mészáros, Viktor Oláh, Péter Szűcs, Peter Erzberger, Edit Farkas

{"title":"Cryptogamic communities on flatroofs in the city of Debrecen (East Hungary).","authors":"Rebeka Aszalósné Balogh, Gábor Matus, László Lőkös, Balázs Adorján, Csongor Freytag, Ilona Mészáros, Viktor Oláh, Péter Szűcs, Peter Erzberger, Edit Farkas","doi":"10.1007/s42977-023-00166-3","DOIUrl":"https://doi.org/10.1007/s42977-023-00166-3","url":null,"abstract":"Cryptogams of ten urban flatroofs, contrasting in their age and size, were studied between 2016 and 2018. Siliceous (bituminous felt, gravel, brick) and calcareous (concrete) substrata occurred at each site. Microclimate (T, RH) at two sites of contrasting shading was monitored from September 2016 to January 2017. Biomass of two differently aged, exposed flatroofs was sampled in October 2018. Taxa of Cladonia and Xanthoparmelia have been identified by spot tests and HPTLC. A total of 61 taxa (25 bryophytes, 36 lichens), mostly widespread synanthropic species, have been detected with an explicit difference of species composition between shaded and exposed sites. Floristically interesting species included acidophilous bryophytes (Hedwigia ciliata, Racomitrium canescens) and lichens (Xanthoparmelia conspersa, Stereocaulon tomentosum) of montane character. The most widespread lichen is Cladonia rei which accounted for a significant part of the biomass at selected sites. Species-area curves for bryophytes at exposed sites have become saturated at 100-150 m2. In contrast, saturation of lichen diversity has not been reached even at the largest sites. Flatroofs with traditional roofing techniques can harbour relatively diverse microhabitats and species-rich synanthropic vegetation. It is urgent to study these sites before renovation with modern roofing techniques eliminates them. Diversification of urban surroundings is possible in the future via application of various substrats in renovated and newly constructed roofs.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"183-197"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9860060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lipoamide dehydrogenase (LADH) deficiency: medical perspectives of the structural and functional characterization of LADH and its pathogenic variants. 脂酰胺脱氢酶(LADH)缺乏:LADH及其致病变异的结构和功能特征的医学观点

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00155-6

Eszter Szabó, Attila Ambrus

{"title":"Lipoamide dehydrogenase (LADH) deficiency: medical perspectives of the structural and functional characterization of LADH and its pathogenic variants.","authors":"Eszter Szabó, Attila Ambrus","doi":"10.1007/s42977-023-00155-6","DOIUrl":"https://doi.org/10.1007/s42977-023-00155-6","url":null,"abstract":"(Dihydro)lipoamide dehydrogenase (LADH) deficiency is an autosomal recessive genetic metabolic disorder. It generally presents with an onset in the neonatal age and premature death. The clinical picture usually involves metabolic decompensation and lactic acidosis that lead to neurological, cardiological, and/or hepatological outcomes. Severity of the disease is due to the fact that LADH is a common E3 subunit to the pyruvate, alpha-ketoglutarate, alpha-ketoadipate, and branched-chain alpha-keto acid dehydrogenase complexes and is also part of the glycine cleavage system; hence, a loss in LADH activity adversely affects several central metabolic pathways simultaneously. The severe clinical manifestations, however, often do not parallel the LADH activity loss, which implies the existence of auxiliary pathological pathways; stimulated reactive oxygen species (ROS) production as well as dissociation from the relevant multienzyme complexes proved to be auxiliary exacerbating pathomechanisms for selected disease-causing LADH mutations. This review provides an overview on the therapeutic challenges of inherited metabolic diseases, structural and functional characteristics of the mitochondrial alpha-keto acid dehydrogenase complexes, molecular pathogenesis and structural basis of LADH deficiency, and relevant potential future medical perspectives.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"109-118"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9819908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Genes regulating oxidative-inflammatory response in circulating monocytes and neutrophils in septic syndrome. 脓毒症综合征循环单核细胞和中性粒细胞中调节氧化-炎症反应的基因。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 Epub Date: 2023-06-08 DOI: 10.1007/s42977-023-00168-1

Nesrine Elloumi, Mabrouk Bahloul, Emna Benabdallah, Sana Kharrat, Raouia Fakhfakh, Karama Bouchaala, Olfa Abida, Kamilia Chtara, Hatem Masmoudi, Mounir Bouaziz

{"title":"Genes regulating oxidative-inflammatory response in circulating monocytes and neutrophils in septic syndrome.","authors":"Nesrine Elloumi, Mabrouk Bahloul, Emna Benabdallah, Sana Kharrat, Raouia Fakhfakh, Karama Bouchaala, Olfa Abida, Kamilia Chtara, Hatem Masmoudi, Mounir Bouaziz","doi":"10.1007/s42977-023-00168-1","DOIUrl":"10.1007/s42977-023-00168-1","url":null,"abstract":"Despite significant progress in the past decades, sepsis still lacks a specific treatment. Under normal conditions, leucocytes play a critical role in controlling infection and it is suggested that their activity is impaired during sepsis which contribute to the dysregulation of immune reactions. Indeed, in response to infection, several intracellular pathways are affected mainly those regulating the oxidative- inflammatory axis. Herein, we focused on the contribution of NF-kB, iNOS, Nrf2, HO-1 and MPO genes in the pathophysiology of septic syndrome, by analyzing the differential expression of their transcripts in circulating monocytes and neutrophils, and monitoring the nitrosative/oxidative status in septic syndrome patients. Circulating neutrophils of septic patients displayed a significant overexpression of NF-kB compared to other groups. In monocytes, patients with septic shock expressed the highest levels of iNOS and NF-kB mRNA. However, genes involved in cytoprotective response had increased expression in patients with sepsis, in particular, the Nrf2 and its target gene HO-1. Moreover, patient monitoring indicates that the iNOS enzyme expression and NO plasma levels may play a role in assessing the severity of septic conditions. Overall, in either monocytes or neutrophils, we pointed out the major role of NF-κB and Nrf2 in the pathophysiological process. Therefore, therapies targeted to redox abnormalities may be useful for better management of septic patients.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"199-207"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9820938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0