Biologia futura最新文献_第10页

Effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins. 脑室注入MOTS-c对甲状腺激素和解偶联蛋白的影响。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00163-6

Mehmet Refik Bahar, Suat Tekin, Asiye Beytur, Ebru Etem Onalan, Fatma Ozyalin, Cemil Colak, Süleyman Sandal

引用次数: 0

Do pathogens always evolve to be less virulent? The virulence-transmission trade-off in light of the COVID-19 pandemic. 病原体总是进化得毒性更小吗?COVID-19大流行背景下的毒力传播权衡。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00159-2

Ádám Kun, András G Hubai, Adrienn Král, Judit Mokos, Benjámin Áron Mikulecz, Ádám Radványi

引用次数: 2

Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations. exportin-1 介导的 RNA 核输出对细胞外囊泡亚群 RNA 含量的不同影响。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 Epub Date: 2023-04-25 DOI: 10.1007/s42977-023-00157-4

Krisztina Pálóczi, Edit I Buzas, András Falus

{"title":"Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations.","authors":"Krisztina Pálóczi, Edit I Buzas, András Falus","doi":"10.1007/s42977-023-00157-4","DOIUrl":"10.1007/s42977-023-00157-4","url":null,"abstract":"Extracellular vesicles (EVs) are membrane-enclosed subcellular structures released by all cell types. EVs have important roles in both cellular homeostasis and intercellular communication. Recent progress in the field revealed substantial heterogeneity of EVs even within the size-based EV categories. Here we addressed the question whether the exportin-1 (XPO1)-mediated nuclear export of RNAs contributed to the EV heterogeneity. Size-based populations were separated from the conditioned media of three cell lines (U937, THP-1 and 5/4E8) in steady-state condition. The effects of activation and leptomycin B treatment (to inhibit the XPO1-mediated nuclear export of RNAs) were also tested in the case of the two monocytic cell lines. Agilent Pico and Small chips were used to characterize RNAs, fragment analysis was performed, and EV-associated miRNAs were tested by Taqman assays. As expected, we found the highest small RNA/total RNA ratio and the lowest rRNA/total RNA proportion in small EVs (~ 50-150 nm). Profiles of the small RNAs within different size-based EV categories significantly differed based on the activation status of the EV releasing cells. Leptomycin B had a differential inhibition on the tested small RNAs in EVs, even within the same EV size category. A similar heterogeneity of the EV miRNA content was observed upon cellular activation and nuclear export inhibition. Here we complement the already existing knowledge on EV heterogeneity by providing evidence that the RNA cargo varies depending on the EV size-based category, the releasing cell type, the functional status of the releasing cells and the exportin-1-mediated nuclear export of RNAs.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"91-99"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9830136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact analysis of different applications of cyantraniliprole on control of horse chestnut leaf miner (Cameraria ohridella) larvae supported by biophoton emission. 氰氨酰胺不同应用对生物光子辐射支持的七叶螨幼虫防治效果分析

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00169-0

Sándor Keszthelyi, Bálint Gerbovits, Ildikó Jócsák

引用次数: 0

Changes in polyamine contents during Fusarium graminearum and Fusarium verticillioides inoculation in maize seedlings with or without seed-priming. 玉米幼苗接种禾本科和黄萎病镰刀菌前后多胺含量的变化

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00162-7

Blanka Kovács, Anett Kovács, Magda Pál, Tamás Spitkó, Csaba L Marton, Csaba Szőke

{"title":"Changes in polyamine contents during Fusarium graminearum and Fusarium verticillioides inoculation in maize seedlings with or without seed-priming.","authors":"Blanka Kovács, Anett Kovács, Magda Pál, Tamás Spitkó, Csaba L Marton, Csaba Szőke","doi":"10.1007/s42977-023-00162-7","DOIUrl":"https://doi.org/10.1007/s42977-023-00162-7","url":null,"abstract":"Maize (Zea mays L.) is the most produced field crop all over the world. One of its most critical diseases that results in economic loss is ear rot caused by various Fusarium species. Previous researches have shown that polyamines, found in all living cells, play crucial role in biotic stress responses. At the same time, biosynthesis of polyamines is of paramount importance not only for plants but also for their pathogens to promote stress tolerance and pathogenicity. In our study, we investigated the polyamine content changes induced in the seedlings of two maize genotypes of different susceptibility by isolates of Fusarium verticillioides and Fusarium graminearum, two Fusarium species of different lifestyles. Apart from that, it was examined how infection efficiency and changes in polyamine contents were modified by salicylic acid or putrescine seed soaking pre-treatments. Our observations confirmed that initial and stress-induced changes in the polyamine contents are not directly related to tolerance in either coleoptile or radicle. However, the two pathogens with different lifestyles induced remarkably distinct changes in the polyamine contents. The effect of the seed soaking pre-treatments depended on the pathogens and plant resistance as well: both salicylic acid and putrescine seed soaking had positive results against F. verticillioides, while in the case of infection with F. graminearum, seed soaking with distilled water alone affected biomass parameters positively in the tolerant genotype.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"145-157"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10187977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The importance of pseudouridylation: human disorders related to the fifth nucleoside. 假尿嘧啶化的重要性:与第五核苷有关的人类疾病。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00158-3

Tália Magdolna Keszthelyi, Kálmán Tory

引用次数: 1

Induced defense responses in cultivated and wild chickpea genotypes against Helicoverpa armigera infestation. 栽培和野生鹰嘴豆基因型对棉铃虫侵染的诱导防御反应。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-022-00151-2

Harpreet Singh, Satvir Kaur Grewal, Ravinder Singh, Rachana D Bhardwaj

{"title":"Induced defense responses in cultivated and wild chickpea genotypes against Helicoverpa armigera infestation.","authors":"Harpreet Singh, Satvir Kaur Grewal, Ravinder Singh, Rachana D Bhardwaj","doi":"10.1007/s42977-022-00151-2","DOIUrl":"https://doi.org/10.1007/s42977-022-00151-2","url":null,"abstract":"Five desi (GL 12,021, GL 29,095, GL 29,078, H11 22 and CSJ 515) and three wild (GLW 22, GLW 58 and GLW 187) chickpea cultivars showed induced defense response against Helicoverpa armigera infestation as a result of enhanced activities of superoxide dismutase, catalase, peroxidase, ascorbate peroxidase, glutathione reductase, polyphenol oxidase, phenylalanine ammonia lyase, tyrosine ammonia lyase in leaves, pod walls and seeds. Catalase activity increased in leaves of GL 12,021, H11 22, GL 29,095, CSJ 515, GLW 22, and GL 29,078 after infestation compared to resistant check; catalase and peroxidase activities in GL 29,095 and GL 29,078; ascorbate peroxidase and glutathione reductase activities in leaves of GLW 58. The increased activity of superoxide dismutase in pod wall of H1122; catalase in pod wall of 29,078, GL 29,095 and GL 22; ascorbate peroxidase and glutathione reductase in pod wall of GLW 58; phenylalanine ammonia lyase and tyrosine ammonia lyase in pod wall of GLW 187, H11 22, GL 20,978, GLW 22 and GLW 58 after infestation as compared to resistant check might be responsible for mitigating infestation induced oxidative stress. MDA content decreased in leaves, pod wall and seeds of GLW 187 and GL 12,021 after infestation. Lower percent pod damage (9.58-12.44%) in GL 12,021, GLW 187, GL 29,095, H11 22, GL 29,078, GLW 22 and GLW 58 as compared to resistant (16.18%) and susceptible (21.50) checks might be attributed to differential induced defense mechanism in them. The identified desi and wild genotypes might be used in breeding program to develop cultivars with improved resistance to herbivore.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"231-246"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

One locus, several functional RNAs-emerging roles of the mechanisms responsible for the sequence variability of microRNAs. 一个位点，几个功能性rna -负责microRNAs序列变异性机制的新兴角色。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00154-7

Tamás I Orbán

{"title":"One locus, several functional RNAs-emerging roles of the mechanisms responsible for the sequence variability of microRNAs.","authors":"Tamás I Orbán","doi":"10.1007/s42977-023-00154-7","DOIUrl":"https://doi.org/10.1007/s42977-023-00154-7","url":null,"abstract":"With the development of modern molecular genetics, the original \"one gene-one enzyme\" hypothesis has been outdated. For protein coding genes, the discovery of alternative splicing and RNA editing provided the biochemical background for the RNA repertoire of a single locus, which also serves as an important pillar for the enormous protein variability of the genomes. Non-protein coding RNA genes were also revealed to produce several RNA species with distinct functions. The loci of microRNAs (miRNAs), encoding for small endogenous regulatory RNAs, were also found to produce a population of small RNAs, rather than a single defined product. This review aims to present the mechanisms contributing to the astonishing variability of miRNAs revealed by the new sequencing technologies. One important source is the careful balance of arm selection, producing sequentially different 5p- or 3p-miRNAs from the same pre-miRNA, thereby broadening the number of regulated target RNAs and the phenotypic response. In addition, the formation of 5', 3' and polymorphic isomiRs, with variable end and internal sequences also leads to a higher number of targeted sequences, and increases the regulatory output. These miRNA maturation processes, together with other known mechanisms such as RNA editing, further increase the potential outcome of this small RNA pathway. By discussing the subtle mechanisms behind the sequence diversity of miRNAs, this review intends to reveal this engaging aspect of the inherited \"RNA world\", how it contributes to the almost infinite molecular variability among living organisms, and how this variability can be exploited to treat human diseases.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"17-28"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9829307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The role of post-transcriptional modifications during development. 转录后修饰在发育过程中的作用。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-022-00142-3

Renáta Hamar, Máté Varga

引用次数: 0

Innovation in the 21st century: following the footsteps of Katalin Karikó. 21世纪的创新:追随卡塔林Karikó。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00161-8

Csaba Deák, Norbert Pardi, Ádám Miklósi

{"title":"Innovation in the 21st century: following the footsteps of Katalin Karikó.","authors":"Csaba Deák, Norbert Pardi, Ádám Miklósi","doi":"10.1007/s42977-023-00161-8","DOIUrl":"https://doi.org/10.1007/s42977-023-00161-8","url":null,"abstract":"Innovation is a critical component of human society, setting us apart from other animals. We possess a unique capacity to design and produce new things through cultivating a culture that values and encourages innovation. One remarkable instance of innovation in the field of biology and medicine is the mRNA vaccine platform developed by Katalin Karikó and her colleagues. In this article, we delve into the evolution of mRNA-based therapy, beginning with animal models and concluding with the first clinical trials. The history of mRNA research began with the identification of its role in protein synthesis, leading to the development of mRNA vaccine technology. Karikó's pivotal innovation was discovering the need to integrate modified nucleosides into the mRNA, decreasing its recognition by the immune system. Her story offers valuable lessons, including the importance of market demand as a booster effect, the role of emerging technologies, the significance of universities and academic institutions in fostering innovation, the role of perseverance and faith, and the role of chance.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"101-108"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0