Biologia futura最新文献_第9页

Biologia Futura: does the aging process contribute to the relativity of time? 《未来生物学》:衰老过程对时间的相对性有贡献吗?

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00167-2

Vladimir Z Ajdžanović, Branka T Šošić-Jurjević, Jovan T Ranin, Branko R Filipović

{"title":"Biologia Futura: does the aging process contribute to the relativity of time?","authors":"Vladimir Z Ajdžanović, Branka T Šošić-Jurjević, Jovan T Ranin, Branko R Filipović","doi":"10.1007/s42977-023-00167-2","DOIUrl":"https://doi.org/10.1007/s42977-023-00167-2","url":null,"abstract":"In his Theory of relativity, Einstein determined that the time is relative to the reference frame of the observer. Under specific conditions, there is a difference in the elapsed time between two clocks, known as time dilation. A similar relativistic effect could be attributed to the brain operating at different frequencies, e.g., while it is slow and during the thought process. Time flow and the aging process are causally linked. Herein, we introduce physical relativity into the mind/thought context and elaborate changed perception of the time flow (the impression of the time acceleration) with aging. The phenomenology of time is observed in the context of physical and biological clock, as well as by introducing the category of 'mind time.' Mental processing impairment is crucial for the \"aging-caused relativity of time,\" while adjusting of its' perception seems to be a matter of body/mind rest, mental hygiene and physical activity of the aging subject. We also provide a brief overview of the perception of time flow in some disease states that coincide with aging. Our main idea has a perspective for future development in the interdisciplinary synergy of philosophy, physical-mathematical elaboration, experimental biology and clinical investigations.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"137-143"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learning from cancer to address COVID-19. 从癌症中学习应对COVID-19。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00156-5

Edit Oláh

{"title":"Learning from cancer to address COVID-19.","authors":"Edit Oláh","doi":"10.1007/s42977-023-00156-5","DOIUrl":"https://doi.org/10.1007/s42977-023-00156-5","url":null,"abstract":"Patients with cancer have been disproportionately affected by the novel coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Knowledge collected during the last three decades of cancer research has helped the medical research community worldwide to respond to many of the challenges raised by COVID-19, during the pandemic. The review, briefly summarizes the underlying biology and risk factors of COVID-19 and cancer, and aims to present recent evidence on cellular and molecular relationship between the two diseases, with a focus on those that are related to the hallmarks of cancer and uncovered in the first less than three years of the pandemic (2020-2022). This may not only help answer the question \"Why cancer patients are considered to be at a particularly high risk of developing severe COVID-19 illness?\", but also helped treatments of patients during the COVID-19 pandemic. The last session highlights the pioneering mRNA studies and the breakthrough discovery on nucleoside-modifications of mRNA by Katalin Karikó, which led to the innovation and development of the mRNA-based SARSCoV-2 vaccines saving lives of millions and also opened the door for a new era of vaccines and a new class of therapeutics.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"29-43"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9831162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryptogamic communities on flatroofs in the city of Debrecen (East Hungary). 德布勒森市(东匈牙利)屋顶上的神秘社区。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00166-3

Rebeka Aszalósné Balogh, Gábor Matus, László Lőkös, Balázs Adorján, Csongor Freytag, Ilona Mészáros, Viktor Oláh, Péter Szűcs, Peter Erzberger, Edit Farkas

{"title":"Cryptogamic communities on flatroofs in the city of Debrecen (East Hungary).","authors":"Rebeka Aszalósné Balogh, Gábor Matus, László Lőkös, Balázs Adorján, Csongor Freytag, Ilona Mészáros, Viktor Oláh, Péter Szűcs, Peter Erzberger, Edit Farkas","doi":"10.1007/s42977-023-00166-3","DOIUrl":"https://doi.org/10.1007/s42977-023-00166-3","url":null,"abstract":"Cryptogams of ten urban flatroofs, contrasting in their age and size, were studied between 2016 and 2018. Siliceous (bituminous felt, gravel, brick) and calcareous (concrete) substrata occurred at each site. Microclimate (T, RH) at two sites of contrasting shading was monitored from September 2016 to January 2017. Biomass of two differently aged, exposed flatroofs was sampled in October 2018. Taxa of Cladonia and Xanthoparmelia have been identified by spot tests and HPTLC. A total of 61 taxa (25 bryophytes, 36 lichens), mostly widespread synanthropic species, have been detected with an explicit difference of species composition between shaded and exposed sites. Floristically interesting species included acidophilous bryophytes (Hedwigia ciliata, Racomitrium canescens) and lichens (Xanthoparmelia conspersa, Stereocaulon tomentosum) of montane character. The most widespread lichen is Cladonia rei which accounted for a significant part of the biomass at selected sites. Species-area curves for bryophytes at exposed sites have become saturated at 100-150 m2. In contrast, saturation of lichen diversity has not been reached even at the largest sites. Flatroofs with traditional roofing techniques can harbour relatively diverse microhabitats and species-rich synanthropic vegetation. It is urgent to study these sites before renovation with modern roofing techniques eliminates them. Diversification of urban surroundings is possible in the future via application of various substrats in renovated and newly constructed roofs.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"183-197"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9860060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lipoamide dehydrogenase (LADH) deficiency: medical perspectives of the structural and functional characterization of LADH and its pathogenic variants. 脂酰胺脱氢酶(LADH)缺乏:LADH及其致病变异的结构和功能特征的医学观点

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00155-6

Eszter Szabó, Attila Ambrus

{"title":"Lipoamide dehydrogenase (LADH) deficiency: medical perspectives of the structural and functional characterization of LADH and its pathogenic variants.","authors":"Eszter Szabó, Attila Ambrus","doi":"10.1007/s42977-023-00155-6","DOIUrl":"https://doi.org/10.1007/s42977-023-00155-6","url":null,"abstract":"(Dihydro)lipoamide dehydrogenase (LADH) deficiency is an autosomal recessive genetic metabolic disorder. It generally presents with an onset in the neonatal age and premature death. The clinical picture usually involves metabolic decompensation and lactic acidosis that lead to neurological, cardiological, and/or hepatological outcomes. Severity of the disease is due to the fact that LADH is a common E3 subunit to the pyruvate, alpha-ketoglutarate, alpha-ketoadipate, and branched-chain alpha-keto acid dehydrogenase complexes and is also part of the glycine cleavage system; hence, a loss in LADH activity adversely affects several central metabolic pathways simultaneously. The severe clinical manifestations, however, often do not parallel the LADH activity loss, which implies the existence of auxiliary pathological pathways; stimulated reactive oxygen species (ROS) production as well as dissociation from the relevant multienzyme complexes proved to be auxiliary exacerbating pathomechanisms for selected disease-causing LADH mutations. This review provides an overview on the therapeutic challenges of inherited metabolic diseases, structural and functional characteristics of the mitochondrial alpha-keto acid dehydrogenase complexes, molecular pathogenesis and structural basis of LADH deficiency, and relevant potential future medical perspectives.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"109-118"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9819908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Genes regulating oxidative-inflammatory response in circulating monocytes and neutrophils in septic syndrome. 脓毒症综合征循环单核细胞和中性粒细胞中调节氧化-炎症反应的基因。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 Epub Date: 2023-06-08 DOI: 10.1007/s42977-023-00168-1

Nesrine Elloumi, Mabrouk Bahloul, Emna Benabdallah, Sana Kharrat, Raouia Fakhfakh, Karama Bouchaala, Olfa Abida, Kamilia Chtara, Hatem Masmoudi, Mounir Bouaziz

{"title":"Genes regulating oxidative-inflammatory response in circulating monocytes and neutrophils in septic syndrome.","authors":"Nesrine Elloumi, Mabrouk Bahloul, Emna Benabdallah, Sana Kharrat, Raouia Fakhfakh, Karama Bouchaala, Olfa Abida, Kamilia Chtara, Hatem Masmoudi, Mounir Bouaziz","doi":"10.1007/s42977-023-00168-1","DOIUrl":"10.1007/s42977-023-00168-1","url":null,"abstract":"Despite significant progress in the past decades, sepsis still lacks a specific treatment. Under normal conditions, leucocytes play a critical role in controlling infection and it is suggested that their activity is impaired during sepsis which contribute to the dysregulation of immune reactions. Indeed, in response to infection, several intracellular pathways are affected mainly those regulating the oxidative- inflammatory axis. Herein, we focused on the contribution of NF-kB, iNOS, Nrf2, HO-1 and MPO genes in the pathophysiology of septic syndrome, by analyzing the differential expression of their transcripts in circulating monocytes and neutrophils, and monitoring the nitrosative/oxidative status in septic syndrome patients. Circulating neutrophils of septic patients displayed a significant overexpression of NF-kB compared to other groups. In monocytes, patients with septic shock expressed the highest levels of iNOS and NF-kB mRNA. However, genes involved in cytoprotective response had increased expression in patients with sepsis, in particular, the Nrf2 and its target gene HO-1. Moreover, patient monitoring indicates that the iNOS enzyme expression and NO plasma levels may play a role in assessing the severity of septic conditions. Overall, in either monocytes or neutrophils, we pointed out the major role of NF-κB and Nrf2 in the pathophysiological process. Therefore, therapies targeted to redox abnormalities may be useful for better management of septic patients.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"199-207"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9820938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of equally accessible genomic surveillance in the age of pandemics. 在大流行病时代平等地进行基因组监测的重要性。

IF 1.8 4区生物学

Biologia futura Pub Date : 2023-06-01 Epub Date: 2023-05-18 DOI: 10.1007/s42977-023-00164-5

Safia Zeghbib, Gábor Kemenesi, Ferenc Jakab

{"title":"The importance of equally accessible genomic surveillance in the age of pandemics.","authors":"Safia Zeghbib, Gábor Kemenesi, Ferenc Jakab","doi":"10.1007/s42977-023-00164-5","DOIUrl":"10.1007/s42977-023-00164-5","url":null,"abstract":"Genomic epidemiology is now a core component in investigating the spread of a disease during an outbreak and for future preparedness to tackle emerging zoonoses. During the last decades, several viral diseases arose and emphasized the importance of molecular epidemiology in tracking the dispersal route, supporting proper mitigation measures, and appropriate vaccine development. In this perspective article, we summarized what has been done so far in the genomic epidemiology field and what should be considered in the future. We traced back the methods and protocols employed over time for zoonotic disease response. Either to small outbreaks such as the severe acute respiratory syndrome (SARS) outbreak identified first in 2002 in Guangdong, China, or to a global pandemic like the one that we are experiencing now since 2019 when the severe acute respiratory syndrome 2 (SARS-CoV-2) virus emerged in Wuhan, China, following several pneumonia cases, and subsequently spread worldwide. We explored both the benefits and shortages encountered when relying on genomic epidemiology, and we clearly present the disadvantages of inequity in accessing these tools around the world, especially in countries with less developed economies. For effectively addressing future pandemics, it is crucial to work for better sequencing equity around the globe.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"81-89"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9827302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The fire of research: Katalin Karikó's legacy. 研究之火:Katalin Karikó的遗产。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00160-9

Norbert Pardi, Ádám Miklósi

引用次数: 0

Delineating the twin role of autophagy in lung cancer. 描述自噬在肺癌中的双重作用。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00165-4

Shaoqin Zhang, Ye Qian, Luhai Ye

{"title":"Delineating the twin role of autophagy in lung cancer.","authors":"Shaoqin Zhang, Ye Qian, Luhai Ye","doi":"10.1007/s42977-023-00165-4","DOIUrl":"https://doi.org/10.1007/s42977-023-00165-4","url":null,"abstract":"Autophagy represents an intracellular defense mechanism equipped within each eukaryotic cells to enable them to cope with variety of physical, chemical, and biological stresses. This mechanism helps to restore the homeostasis and preserve the cellular integrity and function of the cells. In these conditions, such as hypoxia, nutrient deprivation, inhibition of protein synthesis or microbial attack, the process of autophagy is upregulated to maintain cellular homeostasis. The role of autophagy in cancer is an intriguing topic which needs further exploration. This process of autophagy has been many times referred as a double-edged sword in the process of tumorigenesis. In the initial stages, it may act as a tumor suppressor and enable to quench the damaged organelles and harmful molecules generated. In more advanced stages, autophagy has been shown to act as a tumor-promoting system as it may help the cancer cells to cope better with stressful microenvironments. Besides this, autophagy has been associated with development of resistance to anticancer drugs as well as promoting the immune evasion in cancer cells, representing a serious obstacle in cancer treatment and its outcome. Also, autophagy is associated with hallmarks of cancer that may lead to activation of invasion and metastasis. The information on this twin role needs further exploration and deeper understanding of the pathways involved. In this review, we discuss the various aspects of autophagy during tumor development, from early to late stages of tumor growth. Both the protective role of autophagy in preventing tumor growth and the underlying mechanisms adopted with evidence from past studies have been detailed. Further, the role of autophagy in conferring resistance to distinct lung cancer treatment and immune shielding properties has also been discussed. This is essential for further improving on treatment outcome and success rates.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"119-135"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9830145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Herbicides widely used in the world: an investigation of toxic effects on Caenorhabditis elegans. 世界上广泛使用的除草剂:对秀丽隐杆线虫毒性作用的研究。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00152-9

Alper Zöngür, Musa Sari

引用次数: 2

Curcumin displays a potent caloric restriction mimetic effect in an accelerated senescent model of rat. 姜黄素在大鼠加速衰老模型中表现出强有力的热量限制模拟效应。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00170-7

Akanksha Singh, Parisha Srivastava, Avnish Kumar Verma, Jitendra Kumar Arya, Syed Ibrahim Rizvi

{"title":"Curcumin displays a potent caloric restriction mimetic effect in an accelerated senescent model of rat.","authors":"Akanksha Singh, Parisha Srivastava, Avnish Kumar Verma, Jitendra Kumar Arya, Syed Ibrahim Rizvi","doi":"10.1007/s42977-023-00170-7","DOIUrl":"https://doi.org/10.1007/s42977-023-00170-7","url":null,"abstract":"Curcumin, a strong natural compound with numerous health benefits, is extracted from the Curcuma longa. According to recent research findings, it also acts as a calorie restriction mimetic. We examined established aging biomarkers in erythrocytes and plasma and tested a persistent oral dietary dose of curcumin in young and D-galactose-induced accelerated rat aging models. For four weeks, D-gal (300 mg/kg b.w. subcutaneously) and curcumin (200 mg/kg b.w. oral) were administered simultaneously to test the protective effects of curcumin against D-galactose-induced accelerated aging and oxidative stress. In the accelerated senescent rat model, we discovered a significant rise in protein carbonyl, malonaldehyde (MDA), and advanced oxidation protein products. Increased levels of catalase, superoxide dismutase, ferric-reducing antioxidant potential, and reduced glutathione (GSH) were observed. Our findings reveal that curcumin has characteristics resembling a calorie restriction mimic and can successfully maintain redox equilibrium throughout the aging process in rat erythrocytes and plasma.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":"74 1-2","pages":"221-229"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1