Biologia futura最新文献_第9页

Genes regulating oxidative-inflammatory response in circulating monocytes and neutrophils in septic syndrome. 脓毒症综合征循环单核细胞和中性粒细胞中调节氧化-炎症反应的基因。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 Epub Date: 2023-06-08 DOI: 10.1007/s42977-023-00168-1

Nesrine Elloumi, Mabrouk Bahloul, Emna Benabdallah, Sana Kharrat, Raouia Fakhfakh, Karama Bouchaala, Olfa Abida, Kamilia Chtara, Hatem Masmoudi, Mounir Bouaziz

{"title":"Genes regulating oxidative-inflammatory response in circulating monocytes and neutrophils in septic syndrome.","authors":"Nesrine Elloumi, Mabrouk Bahloul, Emna Benabdallah, Sana Kharrat, Raouia Fakhfakh, Karama Bouchaala, Olfa Abida, Kamilia Chtara, Hatem Masmoudi, Mounir Bouaziz","doi":"10.1007/s42977-023-00168-1","DOIUrl":"10.1007/s42977-023-00168-1","url":null,"abstract":"Despite significant progress in the past decades, sepsis still lacks a specific treatment. Under normal conditions, leucocytes play a critical role in controlling infection and it is suggested that their activity is impaired during sepsis which contribute to the dysregulation of immune reactions. Indeed, in response to infection, several intracellular pathways are affected mainly those regulating the oxidative- inflammatory axis. Herein, we focused on the contribution of NF-kB, iNOS, Nrf2, HO-1 and MPO genes in the pathophysiology of septic syndrome, by analyzing the differential expression of their transcripts in circulating monocytes and neutrophils, and monitoring the nitrosative/oxidative status in septic syndrome patients. Circulating neutrophils of septic patients displayed a significant overexpression of NF-kB compared to other groups. In monocytes, patients with septic shock expressed the highest levels of iNOS and NF-kB mRNA. However, genes involved in cytoprotective response had increased expression in patients with sepsis, in particular, the Nrf2 and its target gene HO-1. Moreover, patient monitoring indicates that the iNOS enzyme expression and NO plasma levels may play a role in assessing the severity of septic conditions. Overall, in either monocytes or neutrophils, we pointed out the major role of NF-κB and Nrf2 in the pathophysiological process. Therefore, therapies targeted to redox abnormalities may be useful for better management of septic patients.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9820938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delineating the twin role of autophagy in lung cancer. 描述自噬在肺癌中的双重作用。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00165-4

Shaoqin Zhang, Ye Qian, Luhai Ye

{"title":"Delineating the twin role of autophagy in lung cancer.","authors":"Shaoqin Zhang, Ye Qian, Luhai Ye","doi":"10.1007/s42977-023-00165-4","DOIUrl":"https://doi.org/10.1007/s42977-023-00165-4","url":null,"abstract":"Autophagy represents an intracellular defense mechanism equipped within each eukaryotic cells to enable them to cope with variety of physical, chemical, and biological stresses. This mechanism helps to restore the homeostasis and preserve the cellular integrity and function of the cells. In these conditions, such as hypoxia, nutrient deprivation, inhibition of protein synthesis or microbial attack, the process of autophagy is upregulated to maintain cellular homeostasis. The role of autophagy in cancer is an intriguing topic which needs further exploration. This process of autophagy has been many times referred as a double-edged sword in the process of tumorigenesis. In the initial stages, it may act as a tumor suppressor and enable to quench the damaged organelles and harmful molecules generated. In more advanced stages, autophagy has been shown to act as a tumor-promoting system as it may help the cancer cells to cope better with stressful microenvironments. Besides this, autophagy has been associated with development of resistance to anticancer drugs as well as promoting the immune evasion in cancer cells, representing a serious obstacle in cancer treatment and its outcome. Also, autophagy is associated with hallmarks of cancer that may lead to activation of invasion and metastasis. The information on this twin role needs further exploration and deeper understanding of the pathways involved. In this review, we discuss the various aspects of autophagy during tumor development, from early to late stages of tumor growth. Both the protective role of autophagy in preventing tumor growth and the underlying mechanisms adopted with evidence from past studies have been detailed. Further, the role of autophagy in conferring resistance to distinct lung cancer treatment and immune shielding properties has also been discussed. This is essential for further improving on treatment outcome and success rates.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9830145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The fire of research: Katalin Karikó's legacy. 研究之火:Katalin Karikó的遗产。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00160-9

Norbert Pardi, Ádám Miklósi

引用次数: 0

Herbicides widely used in the world: an investigation of toxic effects on Caenorhabditis elegans. 世界上广泛使用的除草剂:对秀丽隐杆线虫毒性作用的研究。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00152-9

Alper Zöngür, Musa Sari

引用次数: 2

The importance of equally accessible genomic surveillance in the age of pandemics. 在大流行病时代平等地进行基因组监测的重要性。

IF 1.8 4区生物学

Biologia futura Pub Date : 2023-06-01 Epub Date: 2023-05-18 DOI: 10.1007/s42977-023-00164-5

Safia Zeghbib, Gábor Kemenesi, Ferenc Jakab

{"title":"The importance of equally accessible genomic surveillance in the age of pandemics.","authors":"Safia Zeghbib, Gábor Kemenesi, Ferenc Jakab","doi":"10.1007/s42977-023-00164-5","DOIUrl":"10.1007/s42977-023-00164-5","url":null,"abstract":"Genomic epidemiology is now a core component in investigating the spread of a disease during an outbreak and for future preparedness to tackle emerging zoonoses. During the last decades, several viral diseases arose and emphasized the importance of molecular epidemiology in tracking the dispersal route, supporting proper mitigation measures, and appropriate vaccine development. In this perspective article, we summarized what has been done so far in the genomic epidemiology field and what should be considered in the future. We traced back the methods and protocols employed over time for zoonotic disease response. Either to small outbreaks such as the severe acute respiratory syndrome (SARS) outbreak identified first in 2002 in Guangdong, China, or to a global pandemic like the one that we are experiencing now since 2019 when the severe acute respiratory syndrome 2 (SARS-CoV-2) virus emerged in Wuhan, China, following several pneumonia cases, and subsequently spread worldwide. We explored both the benefits and shortages encountered when relying on genomic epidemiology, and we clearly present the disadvantages of inequity in accessing these tools around the world, especially in countries with less developed economies. For effectively addressing future pandemics, it is crucial to work for better sequencing equity around the globe.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9827302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins. 脑室注入MOTS-c对甲状腺激素和解偶联蛋白的影响。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00163-6

Mehmet Refik Bahar, Suat Tekin, Asiye Beytur, Ebru Etem Onalan, Fatma Ozyalin, Cemil Colak, Süleyman Sandal

引用次数: 0

Impact analysis of different applications of cyantraniliprole on control of horse chestnut leaf miner (Cameraria ohridella) larvae supported by biophoton emission. 氰氨酰胺不同应用对生物光子辐射支持的七叶螨幼虫防治效果分析

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00169-0

Sándor Keszthelyi, Bálint Gerbovits, Ildikó Jócsák

引用次数: 0

Do pathogens always evolve to be less virulent? The virulence-transmission trade-off in light of the COVID-19 pandemic. 病原体总是进化得毒性更小吗?COVID-19大流行背景下的毒力传播权衡。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00159-2

Ádám Kun, András G Hubai, Adrienn Král, Judit Mokos, Benjámin Áron Mikulecz, Ádám Radványi

引用次数: 2

Curcumin displays a potent caloric restriction mimetic effect in an accelerated senescent model of rat. 姜黄素在大鼠加速衰老模型中表现出强有力的热量限制模拟效应。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 DOI: 10.1007/s42977-023-00170-7

Akanksha Singh, Parisha Srivastava, Avnish Kumar Verma, Jitendra Kumar Arya, Syed Ibrahim Rizvi

{"title":"Curcumin displays a potent caloric restriction mimetic effect in an accelerated senescent model of rat.","authors":"Akanksha Singh, Parisha Srivastava, Avnish Kumar Verma, Jitendra Kumar Arya, Syed Ibrahim Rizvi","doi":"10.1007/s42977-023-00170-7","DOIUrl":"https://doi.org/10.1007/s42977-023-00170-7","url":null,"abstract":"Curcumin, a strong natural compound with numerous health benefits, is extracted from the Curcuma longa. According to recent research findings, it also acts as a calorie restriction mimetic. We examined established aging biomarkers in erythrocytes and plasma and tested a persistent oral dietary dose of curcumin in young and D-galactose-induced accelerated rat aging models. For four weeks, D-gal (300 mg/kg b.w. subcutaneously) and curcumin (200 mg/kg b.w. oral) were administered simultaneously to test the protective effects of curcumin against D-galactose-induced accelerated aging and oxidative stress. In the accelerated senescent rat model, we discovered a significant rise in protein carbonyl, malonaldehyde (MDA), and advanced oxidation protein products. Increased levels of catalase, superoxide dismutase, ferric-reducing antioxidant potential, and reduced glutathione (GSH) were observed. Our findings reveal that curcumin has characteristics resembling a calorie restriction mimic and can successfully maintain redox equilibrium throughout the aging process in rat erythrocytes and plasma.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations. exportin-1 介导的 RNA 核输出对细胞外囊泡亚群 RNA 含量的不同影响。

IF 2.1 4区生物学

Biologia futura Pub Date : 2023-06-01 Epub Date: 2023-04-25 DOI: 10.1007/s42977-023-00157-4

Krisztina Pálóczi, Edit I Buzas, András Falus

{"title":"Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations.","authors":"Krisztina Pálóczi, Edit I Buzas, András Falus","doi":"10.1007/s42977-023-00157-4","DOIUrl":"10.1007/s42977-023-00157-4","url":null,"abstract":"Extracellular vesicles (EVs) are membrane-enclosed subcellular structures released by all cell types. EVs have important roles in both cellular homeostasis and intercellular communication. Recent progress in the field revealed substantial heterogeneity of EVs even within the size-based EV categories. Here we addressed the question whether the exportin-1 (XPO1)-mediated nuclear export of RNAs contributed to the EV heterogeneity. Size-based populations were separated from the conditioned media of three cell lines (U937, THP-1 and 5/4E8) in steady-state condition. The effects of activation and leptomycin B treatment (to inhibit the XPO1-mediated nuclear export of RNAs) were also tested in the case of the two monocytic cell lines. Agilent Pico and Small chips were used to characterize RNAs, fragment analysis was performed, and EV-associated miRNAs were tested by Taqman assays. As expected, we found the highest small RNA/total RNA ratio and the lowest rRNA/total RNA proportion in small EVs (~ 50-150 nm). Profiles of the small RNAs within different size-based EV categories significantly differed based on the activation status of the EV releasing cells. Leptomycin B had a differential inhibition on the tested small RNAs in EVs, even within the same EV size category. A similar heterogeneity of the EV miRNA content was observed upon cellular activation and nuclear export inhibition. Here we complement the already existing knowledge on EV heterogeneity by providing evidence that the RNA cargo varies depending on the EV size-based category, the releasing cell type, the functional status of the releasing cells and the exportin-1-mediated nuclear export of RNAs.","PeriodicalId":8853,"journal":{"name":"Biologia futura","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9830136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0