Beneficial microbes最新文献

{"title":"Effects of Traditional Asian Diet on dietary fibre requirement, gut microbiome composition, and faecal and urine metabolomes in healthy Asian women: a pilot study.","authors":"N-F Sahran, C W Chong, I H Ismail, F Taib, P S Hoo, U D Palanisamy, U Sundralingam, C S J Teh, Z X Kong, Q Ayub, F Yoke Ling, S N H Hazlan, M Azlan, S Abdul Razak, T A D A-A Tengku Din, N Abdullah, N Tagiling, V Tee, M Ehab Ayad, F M Zheng, E El-Omar, Y Y Lee","doi":"10.1163/18762891-bja00074","DOIUrl":"https://doi.org/10.1163/18762891-bja00074","url":null,"abstract":"<p><p>The Traditional Asian Diet (TAD) is characterised by high dietary fibre and functional foods. This study investigated TAD's effects on meeting fibre requirements, gut microbiome, and faecal and urine metabolomes. A four-week randomised controlled trial was conducted among healthy Asian women allocated into the TAD group (n = 11) following a newly developed TAD program and the control group (n = 11). Assessments included dietary intake, gut health (symptoms, faecal form, frequency), serum fatty acids binding protein-2 (FABP-2) levels, faecal microbiome via 16s rRNA sequencing, and faecal and urine metabolites which were analysed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR), respectively. The TAD group showed significant increases in dietary fibre ( P < 0.001), reduced fat ( P < 0.05), and improved faecal form ( P = 0.009) compared to the control group. The TAD group was enriched with Parabacteroides merdae, while Bacteroides uniformis was more abundant in the control group. Individuals with baseline Prevotella copri showed its enrichment following TAD and higher butyrate levels, unlike the control group. The TAD led to lower urine levels of creatinine, dimethylamine, and phenethylamine compared to the control diet. In conclusion, the TAD program has proven beneficial effects in achieving dietary fibre, enriching the beneficial microbiota and metabolites, reducing harmful metabolites, and improving faecal form compared to a control diet. Clinical trial registration: NCT04885959, clinicaltrials.gov.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"d-Allulose and erythritol increase butyrate production and impact the gut microbiota in healthy adults and adults with type-2 diabetes ex vivo.","authors":"K Adolphus, P Van den Abbeele, J Poppe, S Deyaert, A Baudot, I Laurie, K Karnik, D Risso","doi":"10.1163/18762891-bja00071","DOIUrl":"https://doi.org/10.1163/18762891-bja00071","url":null,"abstract":"<p><p>Type-2 diabetes mellitus (T2DM) is associated with a reduction of butyrate-producing gut bacteria. d-allulose and erythritol are low-no-calorie sweeteners (LNCS) used as sugar substitutes to reduce high free sugar intakes associated with non-communicable diseases, including T2DM. This is the first study to investigate the impact of representative and physiologically relevant doses of d-allulose and erythritol on the human gut microbiota of T2DM ( n = 6) and co-living healthy adults ( n = 6). Using the clinically predictive ex vivo SIFR® technology, d-allulose and erythritol were shown to significantly increase butyrate production 24-48 h after treatment and significantly increased the abundance of particular microbial families or species in both healthy individuals and those with T2DM compared to the no-substrate control (NSC). d-Allulose significantly increased the abundance of Anaerostipes hadrus and Lachnospiraceae_unclassified_species ( u _ s) at 48 h in healthy adults and adults with T2DM compared to the NSC. Erythritol significantly increased the abundance of Eubacteriaceae and Barnesiellaceae families at 48 h in healthy adults and adults with T2DM but had no significant effects on microbial species compared to the NSC. d-Allulose resulted in a larger increase in butyrate between 6-24 h whereas erythritol resulted in a larger increased butyrate between 24-48 h. The findings suggest prebiotic potential of d-allulose and erythritol worth of investigation in human clinical trials, as blending d-allulose and erythritol could be a promising strategy to reduce free sugar intakes and increase butyrate production in both healthy and T2DM individuals, resulting in beneficial effects on glycemic control.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-19"},"PeriodicalIF":3.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic Lacticaseibacillus paracasei from human gut microbiome against colistin-resistant Klebsiella pneumoniae: in vitro, in vivo and probiogenomic approaches.","authors":"Devika J Das, Vishnu Sunil Jaikumar, Karthika Suryaletha, Merin Paul, Aparna Shankar, Swapna R Nath, Sabu Thomas","doi":"10.1163/18762891-bja00065","DOIUrl":"https://doi.org/10.1163/18762891-bja00065","url":null,"abstract":"<p><p>Antibiotic treatment regimens fail to address Klebsiella pneumoniae exhibiting resistance to multiple drugs, including the last resort antibiotic, colistin. The use of probiotics as candidates for alternative antimicrobial therapy or as a source of new antibiotics is considered as an emerging trend in therapeutics. Rejuvenating the human gut with probiotics offers an intriguing therapeutic approach in various enteric diseases. However, the precise role of probiotics in non-enteric infections, particularly those caused by colistin-resistant Klebsiella pneumoniae remains unresolved, prompting further comprehensive research. Therefore, we propose an innovative prophylactic approach using Lacticaseibacilli of human gut origin against this pathogen. Probiotic characterisation like tolerance to acid, bile and sodium chloride were performed to evaluate its gastric survival. In vitro experiments revealed that non-neutralised cell-free supernatant (CFS) of Lacticaseibacillus has the potential to inhibit pathogenic K. pneumoniae. The observed growth reduction is suggestive of the cumulative effect of organic acids and other antimicrobial substances in CFS. The two Lacticaseibacillus paracasei isolates exhibited promising activity (with suspected proteinaceous heat labile molecules) against K. pneumoniae and those with better adhesion to CaCo-2 cell lines were selected for downstream studies. Scanning electron microscopic analysis of CFS treated pathogen cells revealed cell surface distortions and pore formations. The prophylactic potential of Lacticaseibacillus (live and heat-inactivated forms) in Balb/c mice model showed a reduction in histopathological and microbiological alterations caused by K. pneumoniae, when compared with untreated pathogen control. Whole genome analysis of the potential probiotic isolate revealed the genome is devoid of any antibiotic resistance genes and other virulence markers indicating its safety in vivo. Furthermore, the in vitro pathogen inhibition results were reinforced by antiSMASH and BAGEL analysis, which predicted the presence of putative bacteriocin genes. Hence, this multiapproach research study has revealed a promising prophylactic probiotic from human gut microbiome against multi-drug resistant K. pneumoniae.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-21"},"PeriodicalIF":3.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactiplantibacillus plantarum strains with enhanced animal growth promoting capabilities in well fed animals.","authors":"Maria Elena Martino, Martin Schwarzer, Pauline Joncour, Hugo Gervais, Stéphanie Geoffroy, Benjamin Gillet, Sandrine Hughes, François Leulier","doi":"10.1163/18762891-bja00070","DOIUrl":"https://doi.org/10.1163/18762891-bja00070","url":null,"abstract":"<p><p>The gut microbiota has a profound impact on animal physiology, improving organ function and promoting growth under different nutritional conditions. Complex mechanisms underlying growth-promotion by the gut microbiota have been described. In particular, strains of the same bacterial species within different genera exhibit strain-specific growth promotion. In a previous study, we used artificial selection on a poorly growth-promoting strain of Lactiplantibacillus plantarum (NIZO2877) and isolated evolved strains with enhanced growth-promoting capabilities in insects. However, it remains unclear to what extent existing growth-promoting strains can further optimise their benefits and whether these effects persist in well-fed mammals. Here, we experimentally evolved a Drosophila growth-promoting strain of L. plantarum (WJL) under conditions of nutrient deprivation. This strain had not undergone any prior evolutionary adaptation. Our aim was to maximize its growth-promoting benefits while evaluating the translation of this phenotype in different animal models. After artificial selection across ten Drosophila generations, we identified an evolved strain (L. plantarum IGFL1) that significantly improved Drosophila juvenile growth compared to the ancestral strain. Administration of IGFL1 to conventional C57Bl/6j male mice under both nutrient deprivation and normal dietary conditions significantly increased body length and weight growth rates compared to placebo-fed animals. These effects were comparable to those of the ancestral strain, suggesting a context-dependent phenotype. Genome sequencing of IGFL1 revealed the presence of four mutations that may be related to more effective utilization of nutrients. Our results demonstrate the high adaptive potential of L. plantarum, although functional improvements in promoting animal growth are strictly context-dependent. Despite this specificity in adaptation, both strains (the ancestral WJL and the evolved IGFL1) show transferable potential in terms of animal growth promotion, as they are both highly beneficial in flies and mice. These results pave the way for testing these strains to enhance the growth performance of agricultural target species.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-11"},"PeriodicalIF":3.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactobacillus taiwanensis BCRC17755 alleviates motor dysfunction and dopaminergic neuronal loss in mouse models of Parkinson's disease.","authors":"Y Choi, J G Choi, E Huh, H Eo, Y-J Shin, M G Park, D-H Kim, M S Oh","doi":"10.1163/18762891-bja00066","DOIUrl":"https://doi.org/10.1163/18762891-bja00066","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a complex progressive neurodegenerative disease characterized by both motor and nonmotor symptoms such as constipation and dyspepsia. Recently, growing evidence has suggested that a specific gut microbiome is associated with the pathophysiology of PD through the microbiota-gut-brain axis. We previously discovered that Proteus mirabilis induced motor impairment and brain dopaminergic neurodegeneration in normal mice. In this context, exploring beneficial microbe would be reasonable strategy to treat PD fundamentally. With that the current study aimed to evaluate whether Lactobacillus taiwanensis BCRC17755 (BCRC17755) could ameliorate PD pathologies induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and P. mirabilis in mice. To demonstrate this, we measured motor function by performing pole test and the rotarod test and conducted histological analysis to assess the changes of factors in both brain and the gut. As a result, BCRC17755 decreased faecal abundance of P. mirabilis, which was higher in both the MPTP and P. mirabilis-treated mice. Additionally, BCRC17755 improved the motor deficits and alleviated damage to nigrostriatal dopaminergic neurons observed in both MPTP and P. mirabilis-induced PD mice. Furthermore, BCRC17755 mitigated microglial hyperactivation triggered by MPTP and P. mirabilis in the substantia nigra pars compacta and striatum of mice. Similarly, the release of inflammatory cytokines, including interleukin-1 beta and tumor necrosis factor alpha, was suppressed following the administration of BCRC17755 in the colon. Taken together, all the results suggest that BCRC17755 is a beneficial microbe for the treatment of PD by inhibiting the P. mirabilis growth.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-11"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limosilactobacillus fermentum ACA-DC 179 oral administration attenuates atherosclerosis progression in apolipoprotein E-deficient mice through murine gut microbiota modulation.","authors":"I Ferrocino, G Zoumpopoulou, D Lali, R Anastasiou, A Agapaki, M Kazou, E Konstantakis, E Balafas, N P E Kadoglou, N Kostomitsopoulos, E Tsakalidou","doi":"10.1163/18762891-bja00064","DOIUrl":"https://doi.org/10.1163/18762891-bja00064","url":null,"abstract":"<p><p>Recent research findings have established a close relationship between gut microbiota and atherosclerosis development; hence, focus has shifted towards modifying gut microbiota through probiotics administration. We thereby investigated the impact of Limosilactobacillus fermentum ACA-DC 179 on the progression of atherosclerosis in apolipoprotein E-deficient (ApoE-/-) mice. Twelve-week-old ApoE-/- male and female mice were treated with low (106 CFU/mouse) or high (109 CFU/mouse) dose of L. fermentum ACA-DC 179 daily for 8 weeks. Microbiota of faeces during intervention and of gut content at study end was determined using classical microbiological and metataxonomic analyses. Additionally, blood serum biochemical markers and atherosclerotic lesions were evaluated in all animal groups. Classical microbiological analysis revealed high counts of Lactobacillus spp., Bifidobacterium spp. and Clostridium spp. for both male and female animals, regardless the treatment; however, at study end, L. fermentum ACA-DC 179 high dose managed to significantly increase Lactobacillus spp. counts of faeces of male mice. Metataxonomic analysis of faeces and gut content revealed significant differences among animal groups regarding either intestinal compartment, namely jejunum, ileum or colon, or probiotic treatment. A decrease in Lachnoclostridium and an increase in Erysipelatoclostridium were observed in faecal samples following probiotic treatment. This effect was consistent with the results obtained for all gut compartment samples of mice receiving the high dose of L. fermentum ACA-DC 179. Concerning main metabolism-related blood biomarkers, triglycerides decreased in animal groups of both sexes receiving L. fermentum ACA-DC 179. Moreover, L. fermentum ACA-DC 179 high dose significantly reduced atherosclerotic lesions in both male and female mice. Overall, our findings indicate that L. fermentum ACA-DC 179 administration attenuated the development of atherosclerosis in ApoE-/- mice supporting its beneficial potential in relevant human studies. Altered gut microbiota seems to play a significant role to this phenomenon and further studies should be conducted to elucidate underlying mechanisms.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-18"},"PeriodicalIF":3.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional fermented milk product from Zambia shifts the gut microbiota to healthier metabolism in a simulated SHIME® model system.","authors":"Anna I Alekseeva, Kun Ye, Johanna Mentani, Judith C M Wolkers-Rooijackers, Eddy J Smid, Sijmen E Schoustra","doi":"10.1163/18762891-bja00068","DOIUrl":"https://doi.org/10.1163/18762891-bja00068","url":null,"abstract":"<p><p>The human gut contains a complex and highly variable microbial ecosystem of which the composition is affected by the health condition, lifestyle and diet of the host. Fermented dairy products harbour microorganisms favourable to the human gut microbial community. Mabisi, a spontaneous fermented local dairy product from Zambia, carries a variety of potentially beneficial microorganisms. Using the gastrointestinal tract (GI-tract) model system, SHIME®, we tested how the administration of mabisi affects the composition and functionality of the human colon gut microbiota. After ten days of feeding mabisi into the GI-tract model system, the composition of the gut microbial community shifted towards a more even distribution of genera was similar to the community composition obtained by intervention with a standard prebiotic, fructooligosaccharide (FOS). This effect remained even when mabisi was heat-treated and all bacteria there were killed prior to the administration. Comparably to FOS, the microbial shift after mabisi treatment coincides with an increase in concentration of short chain fatty acids. Our findings suggest that mabisi carries important bioactive compounds with a prebiotic potential and might support and stabilize the gut microbial community.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-22"},"PeriodicalIF":3.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactobacillus acidophilus LA85 reverses experimental diabetic sensory neuropathy by restoring redox homeostasis in the spinal cord.","authors":"Max Denisson Maurı Cio Viana, Sthefane Silva Santos, Mariana Bastos de Souza, Luı Za Carolina França Opretzka, Dhara Leite Lopes, Milena Botelho Pereira Soares, Cristiane Flora Villarreal","doi":"10.1163/18762891-bja00069","DOIUrl":"https://doi.org/10.1163/18762891-bja00069","url":null,"abstract":"<p><p>Lactobacillus acidophilus (LA) ingestion has been previously shown to be beneficial for glycemic control and pain management, but not in diabetic neuropathy (DN). The present work was designed to evaluate the therapeutic potential of daily treatment with Lactobacillus acidophilus LA85 (LA85) strain in a model of streptozotocin (STZ)-induced painful DN in mice and characterize its mechanisms of action. Male C57BL/6 mice received a daily intraperitoneal administration of STZ (60 mg/kg, 3 days). After the establishment of sensory neuropathy, mice were daily treated with LA85 (1.0 × 107 or 1.0 × 109 CFU), vehicle, or gabapentin (isolated or associated with LA85) for 28 days. Nociceptive thresholds were assessed using von Frey and Hargreaves tests. Motor performance was evaluated in the rota-rod test. Glycaemic measurement was determined before and after induction in four different times. Gene expression profile, cytokine levels, and oxidative stress biomarkers in the spinal cord were evaluated by real-time PCR, ELISA, and biochemical assays, respectively. STZ-induced mice showed persistent hyperglycaemia and compatible behavioural signs of sensory neuropathy, such as mechanical allodynia and thermal hypoalgesia. Treatment with LA85, especially at 1.0 × 109 CFU, significantly reduced the neuropathy signs. No LA85-induced motor impairment was evidenced in the rota-rod test. LA85 treatment reduced levels of interleukin-1β, malondialdehyde, and nitrite, and modulated oxidative stress biomarkers in the spinal cord of diabetic mice. The long-lasting antinociceptive effect induced by Lactobacillus acidophilus LA85 during diabetic neuropathy may be associated with reestablishment of redox and immune homeostasis in the spinal cord.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fibre responses in microbiota reveal opportunity for disease-specific prebiotic approaches.","authors":"T Chen, T M Cantu-Jungles, B Zhang, T Yao, L Lamothe, M Shaikh, P A Engen, S J Green, A Keshavarzian, B R Hamaker","doi":"10.1163/18762891-bja00067","DOIUrl":"https://doi.org/10.1163/18762891-bja00067","url":null,"abstract":"<p><p>Prebiotics or fermentable dietary fibres are known for their potential to shape the gut microbial community and could be used as a tool in treating gut dysbiotic states found in a wide range of diseases. However, it remains unclear whether the microbiota of individuals with distinct diseases respond to fibre treatments in the same way as healthy individuals do. In this study, a mechanistic understanding of fibre responses across health conditions was performed through in vitro faecal fermentations with various dietary fibres and faecal microbial communities from healthy individuals (HC) as well as Crohn's disease (CD), ulcerative colitis (UC), and Parkinson's disease (PD). Production of short chain fatty acids (SCFAs) was measured, and microbial community structure shifts were assessed using 16S rRNA gene amplicon sequencing. All tested dietary fibres increased short chain fatty acid production upon fermentation, with variations based on both, disease state and fibre type. The magnitude of shifts in microbial community structure resulting from in vitro fermentation varied by condition; for example, samples from individuals with UC responded weakly to fibre fermentation, while those from individuals with PD underwent dramatic changes. Still, each health condition had distinct fibre types that were more effective in shifting the community structure and increasing SCFAs. Overall, these results suggest that the response to fibres on gut microbiota varies by disease. The selection of disease-specific prebiotics could be tailored according to health conditions for optimal desired gut microbiota responses.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antivirulence effects of lactic acid bacteria: pioneering new probiotic applications.","authors":"Yasmin Neves Vieira Sabino, Thaı S Costa de Almeida, Cinthia Alvim Faria, Sthefania Dalva da Cunha Rezende, Juliana Pereira Costa Miranda, Aline Dias Paiva, Alessandra Barbosa Ferreira Machado","doi":"10.1163/18762891-bja00063","DOIUrl":"https://doi.org/10.1163/18762891-bja00063","url":null,"abstract":"<p><p>Lactic acid bacteria are a group of microorganisms recognised for their health-promoting properties, with several strains being commercially utilised as probiotics. Probiotics offer numerous benefits, including modulation of the immune system, enhancement of nutrient absorption, regulation of intestinal microbiota, protection against intestinal pathogens, and strengthening of the intestinal barrier. However, the precise mechanisms by which probiotics exert their effects remain incompletely understood. In recent years, research into new therapeutic applications for probiotics has intensified, driven by the urgent need for strategies to combat antibiotic-resistant bacteria. Among the newly discovered properties of probiotics is their ability to produce antivirulence compounds. These compounds reduce the virulence of pathogens without inhibiting microbial growth, thereby imposing less selective pressure for the development of resistance compared to traditional antibiotics. Given the potential for these compounds in clinical settings, this study aims to provide a comprehensive review of the antivirulence activities of probiotics, with particular focus on lactic acid bacteria. It discusses their effects on two-component and quorum sensing systems, which regulate the simultaneous expression of various virulence genes, as well as their anti-adhesion, anti-biofilm, anti-toxin, and anti-enzymatic activities against a range of pathogens. Thus, this review offers insight into the novel mechanisms by which lactic acid bacteria contribute to health, potentially broadening their applications.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}