Baylor University Medical Center Proceedings最新文献

{"title":"Biodegradable temporizing matrix utilization on a pediatric burn following an exploratory laparotomy.","authors":"Namratha Mohan, Shruti Patel, Genesy Aickareth, John A Griswold, Alan Pang","doi":"10.1080/08998280.2025.2458984","DOIUrl":"10.1080/08998280.2025.2458984","url":null,"abstract":"<p><p>Biodegradable temporizing matrix (BTM) is a synthetic polymer used to promote new tissue growth in full-thickness wounds by providing a framework for additional tissue coverage of a new fascial closure, demonstrating its potential for use in recent incision closure and wound healing. While a case study on a pediatric patient with deep soft tissue friction burns exists, there are no reports on BTM utilization immediately following the closure of a surgical excision. This case report describes the successful use of BTM in promoting wound healing and skin graft incorporation in a 19-month-old female patient with severe scalding burns and a recent exploratory laparotomy. Following an excision of the burn wounds and closure of the surgical incision, BTM was secured over the incision site, and a split-thickness skin graft was applied using the RECELL system. Despite the initially limited blood flow around the incision, the BTM facilitated additional tissue coverage of a new fascial abdominal closure and vascularization, thus enabling successful graft incorporation and incision healing. This case highlights the untapped potential of BTM in supporting wound healing and skin grafting over recently closed incisions, expanding its application beyond traditional use in full-thickness wounds.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 4","pages":"564-566"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials.","authors":"Alaa Abdrabou Abouelmagd, Amro Mamdouh Abdelrehim, Mohamed Nabih Bashir, Fares Abdelsalam, Ahmed Marey, Yousef Tanas, Duha Milad Abuklish, Mohamed Mohamed Belal","doi":"10.1080/08998280.2025.2456441","DOIUrl":"https://doi.org/10.1080/08998280.2025.2456441","url":null,"abstract":"<p><strong>Background: </strong>Retatrutide is a novel triple agonist targeting the receptors of glucagon-like peptide 1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon. We sought to assess the efficacy and safety of retatrutide in obese patients with or without diabetes.</p><p><strong>Methods: </strong>PubMed, Scopus, Web of Science, and Cochrane databases were searched from inception until May 2024. Eligible studies comprised randomized controlled trials that compared retatrutide with placebo in obese patients. We excluded studies on healthy populations, non-English texts, single-arm studies, animal studies, and abstracts. RevMan software (version 5.4) was used for analysis, with subgroup evaluation by dose (4 mg, 8 mg, 12 mg).</p><p><strong>Results: </strong>Three randomized controlled trials, encompassing 878 patients, satisfied our inclusion criteria. Retatrutide significantly reduced body weight (mean difference [MD]: -14.33%), body mass index (MD: -5.38), waist circumference (MD: -10.51 cm), fasting plasma glucose (MD: -23.51 mg/dL), hemoglobin A1c (MD: -0.91%), and systolic and diastolic blood pressure (MD: -9.88 mm Hg and -3.88 mm Hg, respectively), all with <i>P</i> values < 0.00001. No significant difference in adverse events was observed between the groups (relative risk: 1.11, <i>P</i> = 0.24).</p><p><strong>Conclusion: </strong>Retatrutide demonstrated significant improvements in body weight and metabolic outcomes among adults with obesity and had an appropriate safety profile. However, additional large and long-term trials are required to establish these results.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"291-303"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplant program utilization of donation after circulatory death liver grafts by procurement technique and storage modality: a survey of US liver transplant surgical directors.","authors":"Nazokat Otajonova, Eric J Martinez, Amar Gupta, Johanna Bayer, Giuliano Testa, Anji E Wall","doi":"10.1080/08998280.2025.2457899","DOIUrl":"https://doi.org/10.1080/08998280.2025.2457899","url":null,"abstract":"<p><strong>Introduction: </strong>Donation after circulatory death (DCD) increased in the US over the past decade. However, 30% of DCD liver grafts procured for transplantation are not utilized. Barriers to DCD liver utilization include quality concerns, particularly the risk of ischemic cholangiopathy and retransplantation, and costs associated with DCD organ acquisition. This study investigated the attitudes of the liver transplantation community in the US toward DCD and identified barriers to DCD liver utilization.</p><p><strong>Methods: </strong>RedCap survey of liver transplantation surgical directors in the US.</p><p><strong>Results: </strong>Of 101 liver transplantation surgical directors, 24 responded to the survey, and 96% of respondents accepted DCD donors. Most programs accepted livers from thoracoabdominal normothermic regional perfusion with cold storage (96%), while substantially fewer accepted liver grafts from rapid recovery DCD donors with cold storage (67%). Sixty-five percent of transplant centers' functional warm ischemic time started when oxygen saturation or systolic blood pressure was <80%/mm Hg; 13% started at extubation, 17.4% started at systolic blood pressure <80 mm Hg, and 4.3% used a systolic blood pressure <50 mm Hg.</p><p><strong>Conclusion: </strong>We found variability among transplant programs in DCD liver graft acceptance based on procuring surgeon, procurement technique, and storage modality. Quality and cost are two main barriers to DCD liver utilization, with the main tradeoffs being between rapid recovery with static cold storage (lower cost, lower quality) and machine perfusion/normothermic regional perfusion (higher cost, better quality).</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"253-258"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences after PCI are not explained by comorbidities.","authors":"Cara East","doi":"10.1080/08998280.2025.2454183","DOIUrl":"https://doi.org/10.1080/08998280.2025.2454183","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 2","pages":"170"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aseptic osteonecrosis of the jaw in a patient with HIV on tenofovir.","authors":"Shraddha Bhattarai, Shashank Bhattarai, Lavanya Dondapati, Eric Macapinlac, Victor Kolade","doi":"10.1080/08998280.2025.2457077","DOIUrl":"10.1080/08998280.2025.2457077","url":null,"abstract":"<p><p>The introduction of antiretroviral therapy has improved survival of people with HIV (PWH). However, morbidities that accompany aging and the added burden of antiretroviral therapy on bone metabolism are growing concerns with treatment and improved survival. While a few studies have been done among PWH examining bone density and risk of fractures, the association with osteonecrosis is less studied. PWH have been reported to have osteonecrosis involving the hip joint, shoulder joint, knees, and ankles. Most cases of osteonecrosis associated with HIV infection involve the femoral head, but the involvement of the jaw is rare. We report a case of osteonecrosis of the jaw in a patient who has had HIV for more than 10 years.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 4","pages":"561-563"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From toasted skin to tumors: a retrospective nationwide case-control analysis investigating the link between erythema ab igne and various skin cancers.","authors":"Kritin K Verma, Maitreyi Dhavala, Jalyn Vo, Tejas P Joshi, Ida F Orengo, Michelle B Tarbox, Daniel P Friedmann, Zeena Y Nawas","doi":"10.1080/08998280.2025.2458993","DOIUrl":"10.1080/08998280.2025.2458993","url":null,"abstract":"<p><p>This study investigated erythema ab igne (EAI) and comorbid skin cancers. Each EAI case, searched by ICD-10-CM code L59.0 in the All of Us database, was compared to four controls, matched by sex at birth, age, and self-identified race/ethnicity. Demographics and skin cancer comorbidities were assessed with odds ratios (ORs) and 95% confidence intervals (CIs) using Wald's method. EAI was most prevalent between 60 and 70 years of age. A female-to-male ratio of 1:1 was observed between ages 40 and 50. EAI patients had a statistically significant increased risk of basal cell carcinoma (OR, 10.67; 95% CI, 2.76-41.30; <i>P</i> < 0.001), squamous cell carcinoma (OR, 27.84; 95% CI, 1.42-545.59; <i>P</i> = 0.03), and melanoma (OR, 8.00; 95% CI, 1.43-44.60; <i>P</i> = 0.02). Additional tumors were analyzed, but insufficient case/control data was obtained from the database. In conclusion, EAI is positively correlated with skin cancers. Awareness and prevention of EAI is warranted.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 2","pages":"210-212"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention.","authors":"Jackeline P Vajta Gomez, Dae Yong Park, Maxwell D Eder, Seokyung An, Angela Lowenstern, Michelle D Kelsey, Jennifer A Rymer, Pamela S Douglas, Michael G Nanna","doi":"10.1080/08998280.2025.2452113","DOIUrl":"10.1080/08998280.2025.2452113","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have reported worse outcomes in women following percutaneous coronary intervention (PCI), but contemporary studies examining sex differences in in-hospital outcomes and 90-day readmission risk are lacking. Therefore, we sought to compare 90-day readmission rates and in-hospital adverse outcomes after PCI.</p><p><strong>Methods: </strong>We used the United States National Readmissions Database to stratify all inpatient PCIs from 2017 to 2018 by sex. We then performed propensity score matching of the two groups based on demographics, medical history, hospital characteristics, clinical presentation, socioeconomic status, and procedures. The primary outcome of interest was 90-day readmission to the hospital. Secondary outcomes included 30-day readmission, in-hospital mortality, and additional in-hospital outcomes. We performed Cox proportional-hazards modeling to compare the hazard of readmission between women and men and logistic regression to calculate odds ratios for the secondary outcomes of interest.</p><p><strong>Results: </strong>After propensity score matching, 206,556 women and 205,134 men were included. At index hospitalization, women experienced higher odds of in-hospital mortality, hypovolemic shock, and need of blood transfusion, while men experienced higher odds of cardiac arrest, intracranial hemorrhage, and acute kidney injury. Women had a higher hazard of 30-day readmission (hazard ratio 1.16, 95% confidence interval 1.14-1.18, <i>P</i> < 0.01) and 90-day readmission (hazard ratio 1.14, 95% confidence interval 1.12-1.15), with the greatest difference seen among younger women <45 years of age. Findings were similar after stratification into different age groups and clinical presentations.</p><p><strong>Conclusion: </strong>Substantial sex differences in outcomes after PCI persist, with variable sex differences in in-hospital complications, and women at higher risk of 30- and 90-day readmission to the hospital. Given the clinical and reimbursement implications of readmissions to patients and health systems, urgent efforts are needed to close these gaps.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 2","pages":"159-169"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should handheld ultrasound replace the stethoscope for the cardiologist in the bedside cardiac examination?","authors":"Barry Silverman, Ifeoma Onuorah","doi":"10.1080/08998280.2025.2456396","DOIUrl":"https://doi.org/10.1080/08998280.2025.2456396","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"368-369"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of preoperative blood pressure on postoperative bleeding complications following Mohs micrographic surgery.","authors":"Riyad N H Seervai, Sarah K Friske, Emily Powell, Ida F Orengo, Ikue Shimizu, Suzanne Alkul","doi":"10.1080/08998280.2025.2452119","DOIUrl":"https://doi.org/10.1080/08998280.2025.2452119","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a common comorbidity in patients undergoing Mohs micrographic surgery (MMS). Evidence in other surgical fields has suggested that high blood pressure increases the risk of perioperative bleeding, predisposing patients to complications such as hematomas, dehiscence, wound infection, and necrosis.</p><p><strong>Methods: </strong>We reviewed medical charts of all 530 patients who underwent MMS at our institution in one calendar year to identify whether an association exists between preoperative blood pressure and bleeding outcomes in patients undergoing MMS.</p><p><strong>Results: </strong>Perioperative variables, including history of diagnosed hypertension, preoperative systolic blood pressure >160 mm Hg, systolic blood pressure >180 mm Hg, anticoagulation/antiplatelet therapy, tumor type, and number of stages did not significantly increase the risk of overall postoperative complications, including intra- and postoperative bleeding.</p><p><strong>Conclusion: </strong>Hypertensive patients and those on anticoagulation/antiplatelet therapy are not at significantly increased risk of bleeding or other complications following MMS.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"274-276"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The silent struggle: how chronic hip pain shapes adolescent lives.","authors":"Evan J Hernandez, Adam Yasin, Kyle Messer","doi":"10.1080/08998280.2025.2456407","DOIUrl":"https://doi.org/10.1080/08998280.2025.2456407","url":null,"abstract":"<p><p>Adolescence is a critical stage of development marked by physical growth, social exploration, and academic pursuits. Chronic hip pain, which is often overlooked due to its physical effects, can significantly impact the psychosocial well-being of affected adolescents. This vulnerable group faces various challenges, including disruptions in their education, feelings of social isolation, and emotional distress, highlighting an urgent need for comprehensive interdisciplinary interventions. By addressing both the psychosocial factors and the physical treatment of chronic hip pain, we can help adolescents navigate their developmental years with resilience and hope.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"370-371"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}