Biochemistry Research International最新文献

{"title":"In Vitro Study on the Regulation of Annexin IV and VEGF by hCG in the Human Endometrium.","authors":"Shaoyuan Xu,&nbsp;Jie Li,&nbsp;Xiaoyan Chen,&nbsp;Beiyu Liu","doi":"10.1155/2020/8892930","DOIUrl":"https://doi.org/10.1155/2020/8892930","url":null,"abstract":"<p><strong>Objective: </strong>Whether changes in vascular endothelial growth factor (VEGF) and annexin IV during implantation are regulated through the LH/hCG-R needs further research. To investigate the mechanism of hCG on the expression of annexin IV and VEGF in human endometrial cells.</p><p><strong>Methods: </strong>Endometrial cells were isolated and identified from human specimens. The proportion of glandular and epithelial cells was analyzed. Annexin IV and VEGF were analyzed by qRT-PCR (mRNA), western blot (proteins), and immunohistochemistry (proteins). Protein location was identified by immunohistochemistry. The cells were cultured with hCG, hCG/PD98059 (a MAPK inhibitor), or no treatment (control).</p><p><strong>Results: </strong>The proportions between the glandular epithelial cells and stromal cells at inoculation and when adding hCG were 25.8 ± 0.2% and 27.8 ± 0.04%, respectively (<i>P</i> > 0.05). LH/hCG-R, annexin IV, and VEGF were found in the cytoplasm of endometrial cells. After 2, 6, 12, and 24 h of hCG treatment, compared with 1 h, VEGF mRNA was increased by 1.25-fold, 3.19-fold, 4.21-fold, and 4.86-fold and annexin IV by 2.23-fold, 3.37-fold, 5.14-fold, and 5.02-fold. Compared with the control group, annexin IV mRNA and protein were increased in the hCG and hCG/PD98059 groups (mRNA/protein: 1.99-fold/1.80-fold and 2.33-fold/1.93-fold, <i>P</i> < 0.05). Compared with the control group, VEGF mRNA and protein were increased in the hCG group (mRNA/protein: 2.30-fold/1.86-fold), but not in the hCG/PD98059 group.</p><p><strong>Conclusion: </strong>hCG could upregulate the mRNA and protein expression of annexin IV and VEGF. The upregulation of annexin IV by hCG could not be inhibited by PD98059, but the upregulation of VEGF by hCG could.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"8892930"},"PeriodicalIF":3.0,"publicationDate":"2020-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8892930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38569394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive-Enhancing, <i>Ex Vivo</i> Antilipid Peroxidation and Qualitative Phytochemical Evaluation of the Aqueous and Methanolic Stem Bark Extracts of <i>Lonchocarpus eriocalyx</i> (Harms.).","authors":"Gervason Moriasi, Anthony Ireri, Mathew Ngugi","doi":"10.1155/2020/8819045","DOIUrl":"10.1155/2020/8819045","url":null,"abstract":"<p><p>Over 50 million persons are living with cognitive deficits worldwide, with over 80% of these individuals living in the developing world. The number of affected persons is projected to go over 152 million by the year 2050. Current drugs used for cognitive impairment are debatably ineffective, costly, inaccessible, and associated with undesirable events that call for the search for alternative and complementary approaches. Plants are arguably affordable, accessible, and efficacious. However, despite the reported healing claims, scientific data validating these claims are lacking. <i>L. eriocalyx</i> is traditionally used for the management of various conditions, including cognitive impairment but has not been scientifically explored. In this study, the Morris Water Maze (MWM) method was used to evaluate <i>in vivo</i> cognitive-enhancing effects of studied extracts of <i>L. eriocalyx.</i> Furthermore, following MWM experiments, brains were dissected and processed, and malondialdehyde profiles were determined. Qualitative phytochemical profiles of the studied plant extracts were also determined. The results showed that mice that were treated with the studied plant extracts took significantly shorter transfer latencies, navigation distances, and significantly longer latencies in the target quadrant (NW) (<i>p</i> < 0.05) compared with the negative control mice, indicating cognitive-enhancing activities. Furthermore, cognitively impaired mice that received the studied plant extracts had significantly lower MDA profiles compared with the MDA profile of the negative control group mice (<i>p</i> < 0.05). The cognitive-enhancing and MDA profile lowering effects were attributed to the presence of antioxidant phytoconstituents that ought to have modulated the redox state, thereby attenuating brain damage. These extracts can be, therefore, used for the management of cognitive deficits. Further studies leading to isolation and characterization of active molecules for cognitive impairment are recommended. Furthermore, the precise mechanism(s) through which these extracts exert their pharmacologic activity should be established.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"8819045"},"PeriodicalIF":3.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8819045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39079631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic Content, Antioxidant Activity, Anti-Inflammatory Potential, and Acute Toxicity Study of <i>Thymus leptobotrys</i> Murb. Extracts.","authors":"Asmaa Oubihi,&nbsp;Hanae Hosni,&nbsp;Issmail Nounah,&nbsp;Abdessamad Ettouil,&nbsp;Hicham Harhar,&nbsp;Katim Alaoui,&nbsp;Mohammed Ouhssine,&nbsp;Zineb Guessous","doi":"10.1155/2020/8823209","DOIUrl":"https://doi.org/10.1155/2020/8823209","url":null,"abstract":"<p><p><i>Thymus leptobotrys</i> is a medicinal plant belonging to the Lamiaceae family, endemic in Morocco, and used in traditional medicine. The present work aims to study the phenolic compounds, the antioxidant activity, the anti-inflammatory effect, and the toxicity of two ethanolic and methanolic extracts of <i>Thymus leptobotrys</i> aerial part. The yield of the methanolic extraction (22.2%) is higher than that of the ethanolic extraction (15.8%) and is characterized by higher contents of polyphenols 243.08 mg/g GAE (mg/g of gallic acid), flavonoids 179.28 mg/g RE (mg/g of rutin), and tannins 39.31 mg/g CE (mg/g of catechin). The <i>in vitro</i> measurement of antioxidant activity with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical reduction test and Trolox equivalent antioxidant capacity (TEAC) test demonstrates the higher performance of the methanolic extract. The evaluation of the anti-inflammatory effect <i>in vivo</i> on adult Wistar female rats leads to a very significant decrease in the inflammation of the edema compared to the standard drug (indomethacin) and the control group. The toxicity test reveals that both extracts showed no toxicity within an LD50 above 2000 mg/kg body weight of the rats.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"8823209"},"PeriodicalIF":3.0,"publicationDate":"2020-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8823209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38452350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiochemical, Insecticidal, and Antidiabetic Activities of <i>Senna occidentalis</i> Linn Root.","authors":"Tahani Osman Issa,&nbsp;Ahmed Ibrahim Mohamed Ahmed,&nbsp;Yahya Sulieman Mohamed,&nbsp;Sakina Yagi,&nbsp;Abdelrafie Mohamed Makhawi,&nbsp;Tarig Osman Khider","doi":"10.1155/2020/8810744","DOIUrl":"https://doi.org/10.1155/2020/8810744","url":null,"abstract":"<p><p>The present study aimed to investigate the physiochemical activities of <i>Senna occidentalis</i> (Linn) roots and phytochemicals as insecticidal (ethyl acetate and methanol) and antidiabetic (ethanolic extract) activities. Physicochemical properties were carried out by using Association of Official Analytical Chemist methods; thin layer chromatography was carried out according to the Stahl method. Larvicidal activity and LD₅₀ were studied against the third instar of <i>Culex quinquefasciatus</i> mosquito larvae to detect and extract toxicity. The ethanolic extracts of the roots were orally tested at the dose 200 mg/kg for the hypoglycemic effect on induced hyperglycemia in normal rats, assessed in the ethanol extract, and were compared with diabetic control and standards glibenclamide 10 mg/kg. Physiochemical parameters showed high rate in the nitrogen-free extract (69.6%), curd fiber (14.5%), crude proteins (8.15%), ether extract (3.75%), and both ash and moisture (2%), and high concentrations values were found in potassium (43 mg/l) followed by phosphorous (28.5 mg/l), calcium (15 mg/l), sodium (3.65 mg/l), and magnesium (0.145 mg/l). In this part, phytochemical compounds showed high amount of alkaloids, triterpene, flavonoids, tannins, sugars, and few amount of anthraquinone glycosides. Thin-layer chromatography (TLC) studies different colored phytochemical constituted with different Rf values. All the spots are colored under UV light, but some are localized colorless after spaying. The ethyl acetate (EtAc) extract showed eight spots, and the methanol (MeOH) extract showed thirteen spots. The larvicidal activity showed that the ethyl acetate extract was safe against mosquito larvae with an LD₅₀ value 1412.54 (<i>p</i> < 0.05), and the methanol extract had moderate larvicidal activity against mosquito larvae with an LD₅₀ value 257.54 (<i>p</i> < 0.05), while the ethanolic extract of <i>Senna occidentalis</i> (L.) causes a favorable hypoglycemic activity when compared to control significant reduction by [53.15%, 32.87%, and 20.94%], respectively, as well as standard glibenclamide. Based on the various data of the physicochemical parameters, TLC spots, and phytochemical compounds of <i>Senna occidentalis</i> root, they could be used as references standards for manufacturing units of <i>Senna occidentalis</i> root larvicidal and antidiabetic drugs.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"8810744"},"PeriodicalIF":3.0,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8810744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38452349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between Conventional Decalcification and a Microwave-Assisted Method in Bone Tissue Affected with Mycetoma.","authors":"Magdi Mansour Salih","doi":"10.1155/2020/6561980","DOIUrl":"https://doi.org/10.1155/2020/6561980","url":null,"abstract":"<p><p>Mycetoma is a lifelong granulomatous disease of subcutaneous tissues and bones. Histopathology is a substantiated indicative method based on the assumption of a definitive diagnosis of mycetoma. It requires efficient processing of tissues including bone decalcification. The decalcification process must ensure complete removal of calcium and also a proper preservation of tissue and microorganisms' staining ability. <i>Objectives</i>. To compare the conventional method used in decalcification with the microwave method using different decalcification solutions. Different characteristics were tested, including the speed of decalcification and morphological and fungal preservation in bone tissue affected with mycetoma. <i>Materials and Methods</i>. Three decalcification solutions were employed to remove calcium from 50 bone tissue samples affected with mycetoma, including 10% neutral buffered EDTA (pH 7.4), 5% nitric acid, and 5% hydrochloric acid. Conventional and microwave methods were used. Haematoxylin-eosin (HE) stain, Gridley's stain, and Grocott hexamine-silver stain were employed to evaluate the bone and fungi morphologies. <i>Results</i>. The decalcification time of the conventional method compared with the microwave method with 10% EDTA (pH 7.4) took 120 hours and 29 hours, while 5% hydrochloric acid and 5% nitric acid took 8 hours and 3 hours, separately. Also, 10% EDTA is the best decalcifying agent for HE staining and fungal stains. 5% hydrochloric acid and 5% nitric acid can be used for fungal staining. <i>Conclusion</i>. The current study investigated the effects of different decalcifying agents as well as two decalcification procedures on the preservation of the bone structure and fungal staining, which will help to develop suitable protocols for the analyses of the bone tissue affected with mycetoma infection.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"6561980"},"PeriodicalIF":3.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6561980","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38300684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Liquid Culture Condition of a Novel Fungus <i>Hygrophoropsis</i> sp. and Antioxidant Activity of Extracts.","authors":"Liang Huang,&nbsp;Chunxia Li,&nbsp;Ning Sun,&nbsp;Yu Wang,&nbsp;Hongpeng Yang,&nbsp;Yiting Li,&nbsp;Litong Ban","doi":"10.1155/2020/7403257","DOIUrl":"https://doi.org/10.1155/2020/7403257","url":null,"abstract":"<p><p>To evaluate pharmacological activities of a novel fungus <i>Hygrophoropsis</i> sp., the influence of aeration rate on the production of mycelial biomass, exopolysaccharides (EPS), and intrapolysaccharides (IPS) in the fungus <i>Hygrophoropsis</i> sp. was investigated. And the water extracts of cultured <i>Hygrophoropsis</i> sp. mycelia and the fermentation broth were analyzed for their antioxidation activity by using four different assay methods such as hydroxyl radical scavenging, superoxide radical scavenging, hydrogen peroxide scavenging, and reducing power. The <i>Hygrophoropsis</i> sp. was cultivated under various aeration rates in a 7 l bioreactor. The highest mycelial biomass (3.98 mg/mL) and IPS production (19.63 mg/g) were obtained at aeration rate 4.5 v.v.m. The results showed that <i>Hygrophoropsis</i> sp., in general, possesses a strong antioxidation activity in all assays tested. The deproteinized extracts had stronger antioxidation activity as compared to the un-deproteinized extracts by using superoxide radical scavenging, hydrogen peroxide scavenging, and reducing power. Besides, the un-deproteinized extracts had stronger antioxidation activity as compared to the deproteinized extracts by using hydroxyl radical scavenging. Thus, the polysaccharide extractions from the <i>Hygrophoropsis</i> sp. studied have antioxidant activities <i>in vitro</i>, which may be a good source of natural antioxidants or further investigation as potential natural antioxidants.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"7403257"},"PeriodicalIF":3.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7403257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38300685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and Investigation of MicroRNA-mRNA Regulatory Network of Gastric Cancer with <i>Helicobacter pylori</i> Infection.","authors":"Ping Yang,&nbsp;Junjie Liu,&nbsp;Tianci Yang,&nbsp;Lei Zhang,&nbsp;Peiyou Gong,&nbsp;Boqing Li,&nbsp;Xiuzhi Zhou","doi":"10.1155/2020/6285987","DOIUrl":"https://doi.org/10.1155/2020/6285987","url":null,"abstract":"<p><strong>Background: </strong><i>Helicobacter pylori</i> (<i>H. pylori</i>) is a common human pathogen, which is closely correlated with gastric cancer (GC). However, the mechanism of <i>H. pylori</i>-related GC has not been elucidated. This study aimed to explore the role of <i>H. pylori</i> infection in GC and find biomarkers for early diagnosis of <i>H. pylori</i>-related GC.</p><p><strong>Methods: </strong>We identified differentially expressed microRNAs (DEMs) and genes (DEGs) from the Gene Expression Omnibus (GEO) dataset, constructed microRNA-(miRNA-)mRNA expression networks, analyzed the function and signal pathway of cross-genes, analyzed the relations between cross-genes and GC prognosis with the Cancer Genome Atlas (TCGA) data, and verified the expression of cross-genes in patients with <i>H. pylor</i>i infection.</p><p><strong>Results: </strong>22 DEMs and 68 DEGs were identified in GSE197694 and GSE27411 dataset. 16 miRNAs and 509 genes were involved in the expression network, while the cross-genes of the network were mainly enriched in MAP kinase (MAPK) signaling pathway and TGF-beta signaling pathway. Patients with higher expression of hsa-miR-196b-3p, CALML4, or SMAD6 or lower expression of PITX2 or TGFB2 had better outcomes than those with lower expression of hsa-miR-196b-3p, CALML4, or SMAD6 or higher expression of PITX2 or TGFB2 (<i>P</i> < 0.05). Patients with <i>H. pylori</i> infection had a higher expression of hsa-miR-196b-3p and CALML4 than those without <i>H. pylori</i> infection (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The study of miRNA-mRNA expression network would provide molecular support for early diagnosis and treatment of <i>H. pylori</i>-related GC.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"6285987"},"PeriodicalIF":3.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6285987","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38269456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency.","authors":"Linman Li,&nbsp;Li Zhong,&nbsp;Xiaoya Zheng,&nbsp;Wenyi You,&nbsp;Yunting Wang,&nbsp;Jihui Yu,&nbsp;Xun Wu,&nbsp;Wei Ren,&nbsp;Gangyi Yang","doi":"10.1155/2020/5079625","DOIUrl":"https://doi.org/10.1155/2020/5079625","url":null,"abstract":"<p><strong>Aim: </strong>Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures. The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. In this study, we sought to investigate the relationship between various parameters of body composition and bone mineral density (BMD) as well as determine the role of visceral fat in determining the bone mass in patients with AGHD.</p><p><strong>Methods: </strong>We conducted a cross-sectional study on 57 patients with AGHD. Anthropometry, biochemistry, and analysis of body composition and BMD were performed according to standard protocols. Male and female patients were classified into those with osteoporosis and those without osteoporosis (normal subjects and patients with osteopenia). Further, we analyzed the correlation between the BMD and measurements obtained for various body composition parameters in male and female AGHD patients.</p><p><strong>Results: </strong>Our findings indicated that among female AGHD patients, those with osteoporosis had a significantly higher levels of fat mass (FM) and visceral adipose tissue mass (VATM) (both, <i>P</i> < 0.05) than those without osteoporosis. Further, Pearson correlation analysis showed that the values of age, body mass index (BMI), FM, and VATM correlated negatively with BMD in women with AGHD (all <i>P</i> < 0.05); however, this association was not noted in men. After adjusting for the other covariates, VATM was found to be independently correlated with the BMD in female patients with AGHD.</p><p><strong>Conclusions: </strong>A close correlation was noted between VATM and BMD in female patients with AGHD.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"5079625"},"PeriodicalIF":3.0,"publicationDate":"2020-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5079625","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and Antibacterial Activities of the Essential Oil of Moroccan <i>Tetraclinis articulata</i> (Vahl) Masters.","authors":"Halima Rabib,&nbsp;Chaimaa Elagdi,&nbsp;Mohammed Hsaine,&nbsp;Hassan Fougrach,&nbsp;Tayeb Koussa,&nbsp;Wadi Badri","doi":"10.1155/2020/9638548","DOIUrl":"https://doi.org/10.1155/2020/9638548","url":null,"abstract":"<p><p>The purpose of this study is to evaluate and compare the antioxidant and antibacterial activities of essential oil isolated from <i>Tetraclinis articulata</i> (Vahl) leaves, Masters originating in Morocco (Benslimane Region, Atlantic-influenced plain). The analysis of the major compounds of essential oil was performed by gas chromatography and mass spectrometry, and this oil is dominated by bornyl acetate (35.05%), camphor (11.17%), and <i>α</i>-pinene (10.84%). The antioxidant properties were evaluated by the test of the radical trap 2,2-diphényl-1-picrylhydrazyl (DPPH), and the antimicrobial activity of <i>T</i>. <i>articulata</i> essential oil was tested against clinical isolates of <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Escherichia coli</i> which have been inhibited from the 25 <i>μ</i>g/mL.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"9638548"},"PeriodicalIF":3.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9638548","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38185264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan.","authors":"Chih-Chiang Hung,&nbsp;Youngsen Yang,&nbsp;I-Chen Tsai,&nbsp;Chiann-Yi Hsu,&nbsp;Chia-Hua Liu,&nbsp;Jie-Ru Yang","doi":"10.1155/2020/5729389","DOIUrl":"https://doi.org/10.1155/2020/5729389","url":null,"abstract":"<p><p>Breast cancer is a global issue regarding women's health, and high incident rates remain in the Taiwanese female population. Chemotherapy, using anthracycline-based chemotherapeutic agents in neoadjuvant settings, has been introduced as a promising new therapeutic option for treatment of invasive breast cancer. Set apart from conventional anthracycline regimens such as epirubicin, pegylated liposomal doxorubicin (Lipo-Dox®, PLD) was introduced for providing a justifiable treatment effect, while offering a favorable toxicity profile for breast cancer patients in a metastatic setting. However, the efficacy of PLD in neoadjuvant settings for breast cancer patients has not yet been sufficiently reported. This study aims to investigate the efficacy of PLD-based neoadjuvant chemotherapy in breast cancer patients using a retrospective matched case-control study. A total of 183 PLD cases and 183 epirubicin-based controls were included after a 1 : 1 ratio case-control matching procedure was held, according to the matching criteria. These criteria included the patient's preoperative clinical stage, molecular subtype, chemotherapy regimen with taxanes prior to surgery, and histological grade. All data were collected according to an institutional review board approved protocol. The study results reported that the PLD and epirubicin groups both obtained similar outcomes in pathologic complete response (pCR), recurrence, and overall survival rate with no statistically significant differences. Overall, the study results demonstrate that PLD-based neoadjuvant chemotherapy offers a similar effect of treatment with a favorable toxicity profile within the study follow-up duration, when compared with conventional epirubicin-based neoadjuvant chemotherapy.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"5729389"},"PeriodicalIF":3.0,"publicationDate":"2020-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5729389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37927098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}