Biochemical Journal最新文献_第8页

Insights into the mechanisms driven by H3K4 KMTs in pancreatic cancer. 洞察胰腺癌中 H3K4 KMTs 的驱动机制。

IF 4.4 3区生物学

Biochemical Journal Pub Date : 2024-08-07 DOI: 10.1042/BCJ20230374

Kayla C LaRue-Nolan, Glancis Luzeena Raja Arul, Ashley N Sigafoos, Jiaqi Shi, Martin E Fernandez-Zapico

{"title":"Insights into the mechanisms driven by H3K4 KMTs in pancreatic cancer.","authors":"Kayla C LaRue-Nolan, Glancis Luzeena Raja Arul, Ashley N Sigafoos, Jiaqi Shi, Martin E Fernandez-Zapico","doi":"10.1042/BCJ20230374","DOIUrl":"10.1042/BCJ20230374","url":null,"abstract":"Pancreatic cancer is a malignancy arising from the endocrine or exocrine compartment of this organ. Tumors from exocrine origin comprise over 90% of all pancreatic cancers diagnosed. Of these, pancreatic ductal adenocarcinoma (PDAC) is the most common histological subtype. The five-year survival rate for PDAC ranged between 5 and 9% for over four decades, and only recently saw a modest increase to ∼12-13%, making this a severe and lethal disease. Like other cancers, PDAC initiation stems from genetic changes. However, therapeutic targeting of PDAC genetic drivers has remained relatively unsuccessful, thus the focus in recent years has expanded to the non-genetic factors underlying the disease pathogenesis. Specifically, it has been proposed that dynamic changes in the epigenetic landscape promote tumor growth and metastasis. Emphasis has been given to the re-organization of enhancers, essential regulatory elements controlling oncogenic gene expression, commonly marked my histone 3 lysine 4 monomethylation (H3K4me1). H3K4me1 is typically deposited by histone lysine methyltransferases (KMTs). While well characterized as oncogenes in other cancer types, recent work has expanded the role of KMTs as tumor suppressor in pancreatic cancer. Here, we review the role and translational significance for PDAC development and therapeutics of KMTs.","PeriodicalId":8825,"journal":{"name":"Biochemical Journal","volume":"481 15","pages":"983-997"},"PeriodicalIF":4.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing. 温度调节转录组学：温度依赖性替代剪接的分子基础和生物学意义。

IF 4.4 3区生物学

Biochemical Journal Pub Date : 2024-08-07 DOI: 10.1042/BCJ20230410

Tom Haltenhof, Marco Preußner, Florian Heyd

{"title":"Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing.","authors":"Tom Haltenhof, Marco Preußner, Florian Heyd","doi":"10.1042/BCJ20230410","DOIUrl":"10.1042/BCJ20230410","url":null,"abstract":"Temperature-dependent alternative splicing (AS) is a crucial mechanism for organisms to adapt to varying environmental temperatures. In mammals, even slight fluctuations in body temperature are sufficient to drive significant AS changes in a concerted manner. This dynamic regulation allows organisms to finely tune gene expression and protein isoform diversity in response to temperature cues, ensuring proper cellular function and physiological adaptation. Understanding the molecular mechanisms underlying temperature-dependent AS thus provides valuable insights into the intricate interplay between environmental stimuli and gene expression regulation. In this review, we provide an overview of recent advances in understanding temperature-regulated AS across various biological processes and systems. We will discuss the machinery sensing and translating temperature cues into changed AS patterns, the adaptation of the splicing regulatory machinery to extreme temperatures, the role of temperature-dependent AS in shaping the transcriptome, functional implications and the development of potential therapeutics targeting temperature-sensitive AS pathways.","PeriodicalId":8825,"journal":{"name":"Biochemical Journal","volume":"481 15","pages":"999-1013"},"PeriodicalIF":4.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Rubisco activity by interaction with chloroplast metabolites. 通过与叶绿体代谢物的相互作用调节 Rubisco 的活性。

IF 4.4 3区生物学

Biochemical Journal Pub Date : 2024-08-07 DOI: 10.1042/BCJ20240209

Ana K M Lobo, Douglas J Orr, Elizabete Carmo-Silva

{"title":"Regulation of Rubisco activity by interaction with chloroplast metabolites.","authors":"Ana K M Lobo, Douglas J Orr, Elizabete Carmo-Silva","doi":"10.1042/BCJ20240209","DOIUrl":"10.1042/BCJ20240209","url":null,"abstract":"Rubisco activity is highly regulated and frequently limits carbon assimilation in crop plants. In the chloroplast, various metabolites can inhibit or modulate Rubisco activity by binding to its catalytic or allosteric sites, but this regulation is complex and still poorly understood. Using rice Rubisco, we characterised the impact of various chloroplast metabolites which could interact with Rubisco and modulate its activity, including photorespiratory intermediates, carbohydrates, amino acids; as well as specific sugar-phosphates known to inhibit Rubisco activity - CABP (2-carboxy-d-arabinitol 1,5-bisphosphate) and CA1P (2-carboxy-d-arabinitol 1-phosphate) through in vitro enzymatic assays and molecular docking analysis. Most metabolites did not directly affect Rubisco in vitro activity under both saturating and limiting concentrations of Rubisco substrates, CO2 and RuBP (ribulose-1,5-bisphosphate). As expected, Rubisco activity was strongly inhibited in the presence of CABP and CA1P. High physiologically relevant concentrations of the carboxylation product 3-PGA (3-phosphoglyceric acid) decreased Rubisco activity by up to 30%. High concentrations of the photosynthetically derived hexose phosphates fructose 6-phosphate (F6P) and glucose 6-phosphate (G6P) slightly reduced Rubisco activity under limiting CO2 and RuBP concentrations. Biochemical measurements of the apparent Vmax and Km for CO2 and RuBP (at atmospheric O2 concentration) and docking interactions analysis suggest that CABP/CA1P and 3-PGA inhibit Rubisco activity by binding tightly and loosely, respectively, to its catalytic sites (i.e. competing with the substrate RuBP). These findings will aid the design and biochemical modelling of new strategies to improve the regulation of Rubisco activity and enhance the efficiency and sustainability of carbon assimilation in rice.","PeriodicalId":8825,"journal":{"name":"Biochemical Journal","volume":" ","pages":"1043-1056"},"PeriodicalIF":4.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution and maintenance of mtDNA gene content across eukaryotes. 真核生物中 mtDNA 基因含量的进化和保持。

IF 4.4 3区生物学

Biochemical Journal Pub Date : 2024-08-07 DOI: 10.1042/BCJ20230415

Shibani Veeraragavan, Maria Johansen, Iain G Johnston

{"title":"Evolution and maintenance of mtDNA gene content across eukaryotes.","authors":"Shibani Veeraragavan, Maria Johansen, Iain G Johnston","doi":"10.1042/BCJ20230415","DOIUrl":"10.1042/BCJ20230415","url":null,"abstract":"Across eukaryotes, most genes required for mitochondrial function have been transferred to, or otherwise acquired by, the nucleus. Encoding genes in the nucleus has many advantages. So why do mitochondria retain any genes at all? Why does the set of mtDNA genes vary so much across different species? And how do species maintain functionality in the mtDNA genes they do retain? In this review, we will discuss some possible answers to these questions, attempting a broad perspective across eukaryotes. We hope to cover some interesting features which may be less familiar from the perspective of particular species, including the ubiquity of recombination outside bilaterian animals, encrypted chainmail-like mtDNA, single genes split over multiple mtDNA chromosomes, triparental inheritance, gene transfer by grafting, gain of mtDNA recombination factors, social networks of mitochondria, and the role of mtDNA dysfunction in feeding the world. We will discuss a unifying picture where organismal ecology and gene-specific features together influence whether organism X retains mtDNA gene Y, and where ecology and development together determine which strategies, importantly including recombination, are used to maintain the mtDNA genes that are retained.","PeriodicalId":8825,"journal":{"name":"Biochemical Journal","volume":"481 15","pages":"1015-1042"},"PeriodicalIF":4.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease. E3 连接酶：DNA 修复、DNA 复制和人类疾病之间无处不在的联系。

IF 4.4 3区生物学

Biochemical Journal Pub Date : 2024-07-17 DOI: 10.1042/BCJ20240124

Anoop S Chauhan, Satpal S Jhujh, Grant S Stewart

{"title":"E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease.","authors":"Anoop S Chauhan, Satpal S Jhujh, Grant S Stewart","doi":"10.1042/BCJ20240124","DOIUrl":"10.1042/BCJ20240124","url":null,"abstract":"Maintenance of genome stability is of paramount importance for the survival of an organism. However, genomic integrity is constantly being challenged by various endogenous and exogenous processes that damage DNA. Therefore, cells are heavily reliant on DNA repair pathways that have evolved to deal with every type of genotoxic insult that threatens to compromise genome stability. Notably, inherited mutations in genes encoding proteins involved in these protective pathways trigger the onset of disease that is driven by chromosome instability e.g. neurodevelopmental abnormalities, neurodegeneration, premature ageing, immunodeficiency and cancer development. The ability of cells to regulate the recruitment of specific DNA repair proteins to sites of DNA damage is extremely complex but is primarily mediated by protein post-translational modifications (PTMs). Ubiquitylation is one such PTM, which controls genome stability by regulating protein localisation, protein turnover, protein-protein interactions and intra-cellular signalling. Over the past two decades, numerous ubiquitin (Ub) E3 ligases have been identified to play a crucial role not only in the initiation of DNA replication and DNA damage repair but also in the efficient termination of these processes. In this review, we discuss our current understanding of how different Ub E3 ligases (RNF168, TRAIP, HUWE1, TRIP12, FANCL, BRCA1, RFWD3) function to regulate DNA repair and replication and the pathological consequences arising from inheriting deleterious mutations that compromise the Ub-dependent DNA damage response.","PeriodicalId":8825,"journal":{"name":"Biochemical Journal","volume":"481 14","pages":"923-944"},"PeriodicalIF":4.4,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biophysical and structural analyses of the interaction between the SHANK1 PDZ domain and an internal SLiM. SHANK1 PDZ 域与内部 SLiM 之间相互作用的生物物理和结构分析。

IF 4.4 3区生物学

Biochemical Journal Pub Date : 2024-07-17 DOI: 10.1042/BCJ20240126

Yue Li, Chi H Trinh, Amanda Acevedo-Jake, Diana Gimenez, Stuart L Warriner, Andrew J Wilson

{"title":"Biophysical and structural analyses of the interaction between the SHANK1 PDZ domain and an internal SLiM.","authors":"Yue Li, Chi H Trinh, Amanda Acevedo-Jake, Diana Gimenez, Stuart L Warriner, Andrew J Wilson","doi":"10.1042/BCJ20240126","DOIUrl":"10.1042/BCJ20240126","url":null,"abstract":"The PDZ (Postsynaptic density protein-95[PSD-95]/Discs-large) domain, prevalent as a recognition module, has attracted significant attention given its ability to specifically recognize ligands with consensus motifs (also termed PDZ binding motifs [PBMs]). PBMs typically bear a C-terminal carboxylate as a recognition handle and have been extensively characterized, whilst internal ligands are less well known. Here we characterize a short linear motif (SLiM) - EESTSFQGP - as an internal PBM based on its strong binding affinity towards the SHANK1 PDZ domain (SHANK1656-762 hereafter referred to as SHANK1). Using the acetylated analogue Ac-EESTSFQGP-CONH2 as a competitor for the interaction of SHANK1 with FAM-Ahx-EESTSFQGP-CONH2 or a typical fluorophore-labelled C-terminal PBM - GKAP - FITC-Ahx-EAQTRL-COOH - the internal SLiM was demonstrated to show comparable low-micromolar IC50 by competition fluorescent anisotropy. To gain further insight into the internal ligand interaction at the molecular level, we obtained the X-ray co-crystal structure of the Ac-EESTSFQGP-CONH2/SHANK1 complex and compared this to the Ac-EAQTRL-COOH/SHANK1 complex. The crystallographic studies reveal that the SHANK1 backbones for the two interactions overlap significantly. The main structural differences were shown to result from the flexible loops which reorganize to accommodate the two PBMs with distinct lengths and terminal groups. In addition, the two C-terminal residues Gly and Pro in Ac-EESTSFQGP-CONH2 were shown not to participate in interaction with the target protein, implying further truncation and structural modification using peptidomimetic approaches on this sequence may be feasible. Taken together, the SLiM Ac-EESTSFQGP-CONH2 holds potential as an internal ligand for targeting SHANK1.","PeriodicalId":8825,"journal":{"name":"Biochemical Journal","volume":" ","pages":"945-955"},"PeriodicalIF":4.4,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death. Bcl-2 家族蛋白的 C 端序列介导着调节细胞死亡的相互作用。

IF 4.4 3区生物学

Biochemical Journal Pub Date : 2024-07-17 DOI: 10.1042/BCJ20210352

Dang Nguyen, Elizabeth Osterlund, Justin Kale, David W Andrews

引用次数: 0

Charting the importance of filamin A posttranslational modifications. 描绘丝胺 A 翻译后修饰的重要性。

IF 4.4 3区生物学

Biochemical Journal Pub Date : 2024-07-03 DOI: 10.1042/BCJ20240121

Kyle D Shead, Veneta Salyahetdinova, George S Baillie

{"title":"Charting the importance of filamin A posttranslational modifications.","authors":"Kyle D Shead, Veneta Salyahetdinova, George S Baillie","doi":"10.1042/BCJ20240121","DOIUrl":"10.1042/BCJ20240121","url":null,"abstract":"Filamin A is an essential protein in the cell cytoskeleton because of its actin binding properties and unique homodimer rod-shaped structure, which organises actin into three-dimensional orthogonal networks imperative to cell motility, spreading and adhesion. Filamin A is subject to extensive posttranslational modification (PTM) which serves to co-ordinate cellular architecture and to modulate its large protein-protein interaction network which is key to the protein's role as a cellular signalling hub. Characterised PTMs include phosphorylation, irreversible cleavage, ubiquitin mediated degradation, hydroxylation and O-GlcNAcylation, with preliminary evidence of tyrosylation, carbonylation and acetylation. Each modification and its relation to filamin A function will be described here. These modifications are often aberrantly applied in a range of diseases including, but not limited to, cancer, cardiovascular disease and neurological disease and we discuss the concept of target specific PTMs with novel therapeutic modalities. In summary, our review represents a topical 'one-stop-shop' that enables understanding of filamin A function in cell homeostasis and provides insight into how a variety of modifications add an extra level of Filamin A control.","PeriodicalId":8825,"journal":{"name":"Biochemical Journal","volume":"481 13","pages":"865-881"},"PeriodicalIF":4.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pepper catalase: a broad analysis of its modulation during fruit ripening and by nitric oxide. 辣椒过氧化氢酶：果实成熟期一氧化氮对其调节作用的广泛分析。

IF 4.4 3区生物学

Biochemical Journal Pub Date : 2024-07-03 DOI: 10.1042/BCJ20240247

Salvador González-Gordo, Javier López-Jaramillo, Marta Rodríguez-Ruiz, Jorge Taboada, José M Palma, Francisco J Corpas

{"title":"Pepper catalase: a broad analysis of its modulation during fruit ripening and by nitric oxide.","authors":"Salvador González-Gordo, Javier López-Jaramillo, Marta Rodríguez-Ruiz, Jorge Taboada, José M Palma, Francisco J Corpas","doi":"10.1042/BCJ20240247","DOIUrl":"10.1042/BCJ20240247","url":null,"abstract":"Catalase is a major antioxidant enzyme located in plant peroxisomes that catalyzes the decomposition of H2O2. Based on our previous transcriptomic (RNA-Seq) and proteomic (iTRAQ) data at different stages of pepper (Capsicum annuum L.) fruit ripening and after exposure to nitric oxide (NO) enriched atmosphere, a broad analysis has allowed us to characterize the functioning of this enzyme. Three genes were identified, and their expression was differentially modulated during ripening and by NO gas treatment. A dissimilar behavior was observed in the protein expression of the encoded protein catalases (CaCat1-CaCat3). Total catalase activity was down-regulated by 50% in ripe (red) fruits concerning immature green fruits. This was corroborated by non-denaturing polyacrylamide gel electrophoresis, where only a single catalase isozyme was identified. In vitro analyses of the recombinant CaCat3 protein exposed to peroxynitrite (ONOO-) confirmed, by immunoblot assay, that catalase underwent a nitration process. Mass spectrometric analysis identified that Tyr348 and Tyr360 were nitrated by ONOO-, occurring near the active center of catalase. The data indicate the complex regulation at gene and protein levels of catalase during the ripening of pepper fruits, with activity significantly down-regulated in ripe fruits. Nitration seems to play a key role in this down-regulation, favoring an increase in H2O2 content during ripening. This pattern can be reversed by the exogenous NO application. While plant catalases are generally reported to be tetrameric, the analysis of the protein structure supports that pepper catalase has a favored quaternary homodimer nature. Taken together, data show that pepper catalase is down-regulated during fruit ripening, becoming a target of tyrosine nitration, which provokes its inhibition.","PeriodicalId":8825,"journal":{"name":"Biochemical Journal","volume":" ","pages":"883-901"},"PeriodicalIF":4.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery. 将细菌分子遗传学与化学生物学相结合，重新发现抗菌药物。

IF 4.4 3区生物学

Biochemical Journal Pub Date : 2024-07-03 DOI: 10.1042/BCJ20220062

Susannah L Parkhill, Eachan O Johnson

{"title":"Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery.","authors":"Susannah L Parkhill, Eachan O Johnson","doi":"10.1042/BCJ20220062","DOIUrl":"10.1042/BCJ20220062","url":null,"abstract":"The application of dyes to understanding the aetiology of infection inspired antimicrobial chemotherapy and the first wave of antibacterial drugs. The second wave of antibacterial drug discovery was driven by rapid discovery of natural products, now making up 69% of current antibacterial drugs. But now with the most prevalent natural products already discovered, ∼107 new soil-dwelling bacterial species must be screened to discover one new class of natural product. Therefore, instead of a third wave of antibacterial drug discovery, there is now a discovery bottleneck. Unlike natural products which are curated by billions of years of microbial antagonism, the vast synthetic chemical space still requires artificial curation through the therapeutics science of antibacterial drugs - a systematic understanding of how small molecules interact with bacterial physiology, effect desired phenotypes, and benefit the host. Bacterial molecular genetics can elucidate pathogen biology relevant to therapeutics development, but it can also be applied directly to understanding mechanisms and liabilities of new chemical agents with new mechanisms of action. Therefore, the next phase of antibacterial drug discovery could be enabled by integrating chemical expertise with systematic dissection of bacterial infection biology. Facing the ambitious endeavour to find new molecules from nature or new-to-nature which cure bacterial infections, the capabilities furnished by modern chemical biology and molecular genetics can be applied to prospecting for chemical modulators of new targets which circumvent prevalent resistance mechanisms.","PeriodicalId":8825,"journal":{"name":"Biochemical Journal","volume":"481 13","pages":"839-864"},"PeriodicalIF":4.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0