Biochimica et biophysica acta. Molecular and cell biology of lipids最新文献

{"title":"Loss of the acyltransferase TMEM68 leads to growth delay and dysregulation of triacylglycerol and glycerophospholipid homeostasis in the mouse brain","authors":"Chunyan Zhang ,&nbsp;Tingting Li ,&nbsp;Christoph Heier ,&nbsp;Huimin Pang ,&nbsp;Feifei Huang ,&nbsp;Xingxin Fu ,&nbsp;Pingan Chang","doi":"10.1016/j.bbalip.2025.159622","DOIUrl":"10.1016/j.bbalip.2025.159622","url":null,"abstract":"<div><div>Lipid droplets (LDs) are ubiquitous cellular storage organelles for triacylglycerol (TAG) that have recently been implicated in brain development and aging, and the progression of neurodegenerative diseases. However, the enzymes responsible for brain TAG synthesis are incompletely understood. Transmembrane protein 68 (TMEM68) catalyzes TAG synthesis independent of canonical diacylglycerol acyltransferase (DGAT) enzymes and is highly expressed in the brain. In the current study, we addressed the role of TMEM68 in murine brain TAG metabolism using a global <em>Tmem68</em> knockout mouse model. We found that loss of TMEM68 led to decreased TAG levels in the cerebral cortex and a concomitant increase in polyunsaturated glycerophospholipid species. These changes in lipid pattern were associated with perturbed expression of genes involved in fatty acid and glycerophospholipid metabolism. While brain size and morphology were largely unaffected, TMEM68 deficiency caused reductions in white adipose tissue mass, decreased insulin-like growth factor 1 levels, and retarded weight gain. In conclusion, our study identifies TMEM68 as regulator of TAG and glycerophospholipid homeostasis in the central nervous system and discloses a requirement of the enzyme for postnatal development and energy metabolism.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 5","pages":"Article 159622"},"PeriodicalIF":3.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous LC-PUFA biosynthetic capability in dwarf surf clam Mulinia lateralis: characterization and functional analysis of fatty acyl elongases and a desaturase","authors":"Zhenghua Zheng ,&nbsp;Na Liu ,&nbsp;Weiping Ren ,&nbsp;Mengjiao Liu ,&nbsp;Ao Wang ,&nbsp;Zujing Yang ,&nbsp;Jingjie Hu ,&nbsp;Zhenmin Bao ,&nbsp;Wenqian Jiao","doi":"10.1016/j.bbalip.2025.159623","DOIUrl":"10.1016/j.bbalip.2025.159623","url":null,"abstract":"<div><div>Elongases of very long-chain fatty acids (Elovls) and fatty acyl desaturases (Fads) are two key enzymes in the biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs). Here, we identified and characterized five <em>Elovl</em> genes (<em>MulElovl2/5</em>, <em>MulElovl4</em>, <em>MulElovlc</em>, <em>MulElovl7a</em>, and <em>MulElovl7b</em>) from the genome of <em>Mulinia lateralis</em>, a potential model bivalve. Expression analysis revealed that <em>MulElovl2/5</em>, <em>MulElovl4</em> and <em>MulElovlc</em> were highly expressed during the middle stage of embryonic development, whereas <em>MulElovl7a</em> and <em>MulElovl7b</em> peaked in mid-to-late development before declining. Tissue-specific expression showed that <em>MulElovl2/5</em> and <em>MulElovl4</em> were predominantly expressed in the digestive gland. Additionally, we examined the effects of dietary LC-PUFA composition on <em>MulElovls</em> expression by feeding <em>M. lateralis</em> two unialgal diets: <em>Chlorella pyrenoidosa</em> (Cp), rich in linoleic acid (LA, C18:2n-6) and α-linolenic acid (ALA, C18:3n-3), and <em>Platymonas helgolandica</em> (Ph), rich in eicosapentaenoic acid (EPA, C20:5n-3). Notably, <em>MulElovls</em> were significantly upregulated in most tissues of the Cp group, suggesting a compensatory mechanism under LC-PUFA-deficient conditions. Functional assays revealed distinct substrate specificities: MulElovl2/5 elongated C18 and C20 PUFAs, while MulElovl4 and MulElovlc efficiently converted C20 to C22 PUFAs. Additionally, MulFadsB exhibited Δ6 desaturase activity, enabling the conversion of C18 PUFAs. These findings demonstrate that <em>M. lateralis</em> possesses endogenous biosynthetic pathways for arachidonic acid (ARA) from LA via Δ6 desaturation, elongation, and Δ5 desaturation, as well as partial elongation of EPA to C22:5n-3. Our findings provide new insights into a comparison of endogenous LC-PUFAs synthetic capabilities in mollusks and highlight <em>M. lateralis</em> as a valuable model for investigating lipid metabolism in marine bivalves.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 5","pages":"Article 159623"},"PeriodicalIF":3.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipidome plasticity in medium- and long-chain fatty acid oxidation disorders: Insights from dried blood spot lipidomics","authors":"Inês M.S. Guerra ,&nbsp;Hugo Rocha ,&nbsp;Sónia Moreira ,&nbsp;Ana Gaspar ,&nbsp;Ana C. Ferreira ,&nbsp;Helena Santos ,&nbsp;Esmeralda Rodrigues ,&nbsp;Paulo Castro-Chaves ,&nbsp;Tânia Melo ,&nbsp;Laura Goracci ,&nbsp;Pedro Domingues ,&nbsp;Ana S.P. Moreira ,&nbsp;M. Rosário Domingues","doi":"10.1016/j.bbalip.2025.159621","DOIUrl":"10.1016/j.bbalip.2025.159621","url":null,"abstract":"<div><div>Fatty acid (FA) oxidation disorders (FAOD) are characterized by accumulation of specific acylcarnitines (CAR) and FA and can lead to potentially severe complications. In this study, dried blood spots (DBS) combined with LC-MS lipidomics analysis were used to assess lipidome plasticity in medium-chain acyl-CoA dehydrogenase deficiency (MCADD), long-chain hydroxyacyl-CoA dehydrogenase deficiency (LCHADD), and very long-chain acyl-CoA dehydrogenase deficiency (VLCADD), compared to control (CT) individuals, for screening potential prognostic biomarkers.</div><div>Statistically significant variations were found in CAR, biomarkers for FAOD diagnosis, but other lipid species showed variations depending on the FAOD. Common changes in all FAOD included a few phosphatidylcholine (PC) lipid species, notably an up-regulation of LPC 16:1, possibly associated with a higher risk of cardiovascular disease (CVD). In LCHADD and VLCADD, an up-regulation of odd-chain PC (PC 33:0, PC 35:4 and PC 37:4) was observed. VLCADD exhibited higher levels of odd-chain TG, while LCHADD showed an up-regulation of ceramide (Cer 41:2;O2). The increase in the Cer class has been found to be associated with neurodegeneration and may contribute to the risk of developing this condition in LCHADD. An upregulation of ether-linked PC lipid species, including plasmenyl (known as endogenous antioxidants), was observed in MCADD, possibly as a response to increased oxidative stress reported in this disorder.</div><div>Overall, DBS combined with lipidomics effectively pinpoints the lipid plasticity in FAOD, highlighting potential specific biomarkers for disease prognosis that warrant further validation for their association with the development of FAOD comorbidities.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 5","pages":"Article 159621"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luteolin, as a bidirectional ROS regulator, elevates mouse beige adipocyte browning","authors":"Zhixin Zhang ,&nbsp;Linli Zhao ,&nbsp;Jiahui Wang ,&nbsp;Hao Chen ,&nbsp;Yan Lin ,&nbsp;Fangbin Wang ,&nbsp;Lu Wang ,&nbsp;Juan Chen ,&nbsp;Jian Liu ,&nbsp;Xian Zhang","doi":"10.1016/j.bbalip.2025.159620","DOIUrl":"10.1016/j.bbalip.2025.159620","url":null,"abstract":"<div><div>In beige adipocytes, UCP1-dependent thermogenesis can be driven by intracellular reactive oxygen species (ROS) generation. While ROS elevation also induces mast cell activation, serotonin synthesis and release from mast cells inhibits beige progenitor cell proliferation and browning. As a natural antioxidant and mast cell stabilizer, luteolin promotes adipocyte thermogenesis and inhibits mast cell activation. Thus, to activate adipocyte thermogenesis, how luteolin regulates ROS level in beige adipocytes and mast cells needs to be further investigated. In this study, mouse subcutaneous stromal vascular fraction (SVF) cells are induced to differentiate into beige adipocytes, and mouse bone marrow-derived mast cells (BMMCs) are activated with hydrogen peroxide (H₂O₂). Intracellular ROS level is augmented in differentiated beige adipocytes and H₂O₂-activated BMMCs, and H₂O₂-activated BMMCs inhibited brown differentiation of SVF cells and thermogenesis of beige adipocytes. In beige adipocytes, unlike synthetic antioxidant <em>N</em>-acetylcysteine (NAC), luteolin elevates the expression of thermogenic and beige-selective marker genes and intracellular ROS generation. Contrarily, luteolin inhibits H₂O₂-induced mast cell activation and ROS generation. Further, luteolin partially reverses the inhibitory effects of H₂O₂-activated BMMCs on the brown differentiation of SVF cells and the thermogenesis of beige adipocytes. Molecular mechanistic studies demonstrate that luteolin regulates intracellular ROS level in beige adipocytes and mast cells via the nuclear factor erythroid 2-related factor 2 (Nrf2)/Catalase pathway. Altogether, as a ROS regulator, luteolin contrarily affects intracellular ROS generation in beige adipocytes and mast cells, and hence elevates adipocyte browning.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 5","pages":"Article 159620"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in carotenoid absorption, distribution, and elimination","authors":"Wafa'a Hajeer ,&nbsp;Amparo Blanco ,&nbsp;Anthony P. Miller ,&nbsp;Jaume Amengual","doi":"10.1016/j.bbalip.2025.159619","DOIUrl":"10.1016/j.bbalip.2025.159619","url":null,"abstract":"<div><div>Carotenoids are a class of pigments with antioxidant properties synthesized by photosynthetic and heterotrophic organisms. Humans can store carotenoids in their intact form or cleave them enzymatically to apocarotenoids such as vitamin A, a hormone-like nutrient with crucial roles in gene expression and vision. Clinical and preclinical studies suggest that the consumption of diets rich in carotenoids attenuate cardiometabolic diseases, some types of cancer, neurodegenerative disorders, and inflammatory conditions. The bioactive properties of carotenoids depend, at least in part, on their accumulation in target tissues. However, the pathways that drive carotenoid absorption, delivery, and accumulation in tissues remain largely uncharacterized. This review provides a critical overview of the experimental models utilized to monitor carotenoid homeostasis in mammals. We also delve into recent findings concerning carotenoid intestinal uptake, bodily distribution, cellular uptake, and intracellular trafficking. Finally, we discuss the physiological relevance of a fecal carotenoid elimination pathway that operates independently of carotenoid enzymatic cleavage. Establishing the players governing carotenoid biodistribution and elimination is essential to maximize the bioactive properties of carotenoids in humans to prevent chronic diseases.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 5","pages":"Article 159619"},"PeriodicalIF":3.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OTUD7B controls oxLDL uptake by stabilizing Lox-1 in THP-1 and U937 cells","authors":"Yanbiao Rao ,&nbsp;Feng Li ,&nbsp;Chao Wan,&nbsp;Shanshan Tong,&nbsp;Yandong Fu,&nbsp;Yongsheng Li","doi":"10.1016/j.bbalip.2025.159618","DOIUrl":"10.1016/j.bbalip.2025.159618","url":null,"abstract":"<div><h3>Background</h3><div>The scavenger receptor Lox-1 plays a crucial role in mediating the uptake of oxidized low-density lipoprotein (oxLDL) by macrophages, thereby promoting foam cell formation and the development of atherosclerosis. Recent studies have suggested that ubiquitination plays a role in accelerating the degradation of Lox-1. However, the specific mechanisms underlying how the ubiquitin-proteasome system regulates the stability and function of Lox-1 remain poorly understood.</div></div><div><h3>Results</h3><div>In our study, we identified OTUD7B, a deubiquitinase, as a potent stabilizer of Lox-1 in THP-1 and U937 cells. Knockdown of OTUD7B significantly reduced the level of Lox-1 and impaired the uptake of oxLDL by these cells. Furthermore, we found that OTUD7B interacts with Lox-1 and deubiquitinates it, thereby promoting its degradation. Importantly, overexpression of Lox-1 effectively rescued oxLDL uptake by OTUD7B-deficient THP-1 and U937 cells.</div></div><div><h3>Conclusions</h3><div>Our findings indicate that OTUD7B plays a crucial role in controlling oxLDL uptake by enhancing the stability of Lox-1. This highlights the potential significance of targeting the OTUD7B-Lox-1 axis as a therapeutic strategy for atherosclerosis.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 5","pages":"Article 159618"},"PeriodicalIF":3.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methyl-end desaturases determine the capability for de novo biosynthesis of polyunsaturated fatty acids in bivalves","authors":"Naoki Kabeya ,&nbsp;Marc Ramos-Llorens ,&nbsp;Yo Nakano ,&nbsp;André Gomes-dos-Santos ,&nbsp;Amílcar Teixeira ,&nbsp;Megumu Fujibayashi ,&nbsp;Juan G. Haro ,&nbsp;Juan C. Navarro ,&nbsp;L. Filipe C. Castro ,&nbsp;Yutaka Haga ,&nbsp;Óscar Monroig","doi":"10.1016/j.bbalip.2025.159617","DOIUrl":"10.1016/j.bbalip.2025.159617","url":null,"abstract":"<div><div>Recent studies have shown that many invertebrate species possess methyl-end desaturases (herein referred to as ‘ωx’), enabling biosynthesis of polyunsaturated fatty acids (PUFA). However, the phylogenetic distribution of these enzymes across the animal kingdom remains puzzling, possibly due to horizontal gene transfer (HGT) and/or independent large-scale gene loss in certain invertebrate lineages. In molluscs, ωx genes have been identified in various cephalopods and gastropods but remain barely explored in bivalves. The increasing availability of genomic and transcriptomic resources enables a comprehensive exploration of the ωx gene repertoire in bivalves. To elucidate the distribution of ωx in bivalves, we conducted a broad homology search across existing genome and transcriptome assemblies, followed by functional characterisation of ωx in lineage representative species. Our results revealed no ωx-like sequences in any of the 65 Pteriomorphia species, suggesting gene loss in this clade. However, ωx-like sequences were found in Protobranchia, Palaeoheterodonta and Imparidentia. We analysed ωx from <em>Solemya pusilla</em> (Protobranchia), <em>Lanceolaria oxyrhyncha</em> and <em>Margaritifera margaritifera</em> (Palaeoheterodonta), and <em>Ruditapes philippinarum</em> and <em>Tridacna crocea</em> (Imparidentia). Except for <em>M. margaritifera</em>, which had two ωx genes, each species had a single ωx gene. Functional analysis showed Δ15Δ17Δ19 desaturase activity in the <em>R. philippinarum</em> and <em>T. crocea</em> ωx, while the L. <em>oxyrhyncha</em> ωx exhibited Δ15Δ17 activity but not Δ19. Both ωx from <em>M. margaritifera</em> showed no detectable activity in yeast. Interestingly, the <em>S. pusilla</em> ωx exhibited Δ12 desaturase activity. These findings highlight the diversity of ωx desaturation capabilities in bivalves, with significant gene loss in Pteriomorphia.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 5","pages":"Article 159617"},"PeriodicalIF":3.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calpain-1 is required for abnormality of liver function and metabolism in apolipoprotein E knockout mouse evaluated noninvasively by small animal MRI and PET-CT","authors":"MOHAMED ALI AWAD ,&nbsp;Wenjiao Gu ,&nbsp;Shuangyi Li ,&nbsp;Yujie Wei ,&nbsp;Yu Tang ,&nbsp;Youming Shi ,&nbsp;HAVYARIMANA JUVENAL ,&nbsp;Ying Jiang ,&nbsp;Ting Liu ,&nbsp;Limei Shuai ,&nbsp;Zhiming Wang ,&nbsp;Bofan Wu ,&nbsp;Xiaochun Zhou ,&nbsp;Futian Tang","doi":"10.1016/j.bbalip.2025.159616","DOIUrl":"10.1016/j.bbalip.2025.159616","url":null,"abstract":"<div><div>We previously reported that calpain-1 knockout (KO) improved liver dysfunction in C57 mouse fed with high-fat diet (HFD). In the present study, Apolipoprotein E KO (ApoE KO) mouse was hybridized with calpain-1 KO mouse to obtain ApoE/calpain-1 double KO (A × C DKO) mouse to investigate role of calpain-1 in abnormality of liver function and metabolism evaluated noninvasively with MRI and PET<img>CT. Mice were divided into C57 mice fed with standard diet (C57 + SD group) and C57 + HFD, calpain-1 KO + HFD, ApoE KO + HFD and A × C DKO + HFD groups fed with HFD. Contents of albumin (ALB), activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in serum and/or liver were measured. Fat fraction (FF) in liver was evaluated using MRI. Liver metabolism was measured using PET<img>CT after injection of ¹⁸F-Fluorodeoxyglucose (FDG). The results showed that levels of ALB, AST, ALT, TNF-α, and IL-6 in calpain-1 KO + HFD and A × C DKO + HFD mice were decreased compared with that of the matched C57 + HFD and ApoE KO + HFD mice, respectively. In addition, calpain-1 KO improved FDG metabolism in the liver. However, calpain-1 KO did not affect lipid profiles in serum and liver and FF in liver. The results suggested that calpain-1 deficiency improves dyslipidemia-induced abnormality of liver function and metabolism through inhibition of inflammation. In addition, small animal MRI and PET<img>CT are ideal approaches for noninvasively evaluating lipid deposition and substance metabolism in liver of mice.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 5","pages":"Article 159616"},"PeriodicalIF":3.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphatidylinositol 4-phosphate; A minor lipid with multiple personalities","authors":"Tamas Balla","doi":"10.1016/j.bbalip.2025.159615","DOIUrl":"10.1016/j.bbalip.2025.159615","url":null,"abstract":"<div><div>Phosphorylated products of phosphatidylinositol (PI), named Diphosphoinositide (DPI) and triphosphoinositide (TPI) were identified long time ago and found to exhibit high turnover rates based on their rapid ³²P-phosphate labeling. The PI kinase activities that were responsible for their production were subsequently identified and found to be associated with different organelle membranes, including the plasma membrane. These activities were then linked with a certain group of cell surface receptors that activated phospholipase C enzymes to hydrolyze PI and used calcium or cGMP as a second messenger. This visionary concept was introduced in the seminal BBA review written by Robert Michell, exactly 50 years ago. The enzymology and functional diversity of PI 4-phosphate (PI4P) (the term that has replaced DPI) has since underwent an expansion that could not have been foreseen. In this review I will attempt to revisit this expansion with some historical reflections celebrating the 50th anniversary of the Michell review.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 5","pages":"Article 159615"},"PeriodicalIF":3.9,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of skin carotenoids and their association with diseases: a narrative review","authors":"Akira Obana","doi":"10.1016/j.bbalip.2025.159612","DOIUrl":"10.1016/j.bbalip.2025.159612","url":null,"abstract":"<div><div>Skin carotenoids are highly correlated with blood carotenoid concentrations and can be measured noninvasively using optical methods. Skin carotenoid levels are widely used in nutritional education as indicators of fruit and vegetable intake; however, research on their use as biomarkers for disease prevention is limited. This narrative review outlines methods for measuring skin carotenoid levels and describes the diseases in which the relationship between skin carotenoids and diseases has been examined, including atherosclerotic cardiovascular disease, metabolic syndrome, pediatric asthma, age-related macular degeneration, and cognitive impairment.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 5","pages":"Article 159612"},"PeriodicalIF":3.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}