BIO Web of Conferences最新文献

{"title":"Influence of the Natural and Geographical Environment on the Adaptation of the Deported People During the Great Patriotic War (on the Example of the Chechens)","authors":"S. Tsutsulaeva, Eliza Yangulbaeva","doi":"10.1051/bioconf/20236308002","DOIUrl":"https://doi.org/10.1051/bioconf/20236308002","url":null,"abstract":"The purpose of the article is to identify the mechanisms of reproduction and transformation of the mental and behavioral aspects of traditional ethno-social practices in extreme conditions of exile and ethnic deportation of the Chechen people.The question of the influence of the geographical environment on the socio-political processes and mores of society was raised by ancient authors, but the great geographical discoveries that caused the rapid economic and socio-political development of Europe served as the historical prerequisites for the emergence of an integral concept of geographical determinism.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86110276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study on aerosol inhalation of the human upper airway","authors":"Jianhe Liu, Wenzheng Li","doi":"10.1051/bioconf/20235903016","DOIUrl":"https://doi.org/10.1051/bioconf/20235903016","url":null,"abstract":"The study of aerosol deposition in the human upper respiratory tract is of great significance for understanding the impact of toxic aerosols on human health and improving the therapeutic effect of drug aerosol inhalation. 3D printing technology was used in the experimental model of the human upper airway. A laser particle size analyzer was used to study the deposition of aerosol particles with a particle size of 1-20 μm inhaled in the upper respiratory tract of the human body, and the particle deposition rules of the aerosol particles in the upper respiratory tract were analyzed. The experimental results show that aerosol particles remain more in the pharynx, larynx and position. For particles with a particle size of 1-5 μm, more deposition will occur in the trachea, and for particles with a particle size of 10-20 μm, most of them will be deposited in the mouth.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86183525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creation and Characterization of Mycolicibacterium Smegmatis mc2155 with Deletions in Genes Encoding Sterol Oxidation Enzymes","authors":"A. Byakov, M. Karpov, N. Strizhov, M. Donova","doi":"10.1051/bioconf/20235703004","DOIUrl":"https://doi.org/10.1051/bioconf/20235703004","url":null,"abstract":"The fast-growing saprotrophic strain Mycolicibacterium smegmatis mc2155 is capable of utilizing plant and animal sterols and can be used for creation of genetically engineered strains producing biologically active steroids. Oxidation of the 3β-hydroxyl group and Δ5(6)→Δ4(5) double bond isomerization followed by formation of stenones from sterols are considered as the initial stage of steroid catabolism in some actinobacteria. The study of the mechanism of steroid nucleus 3β-hydroxyl group oxidation is relevant for the creation of a method of the microbiological production of valuable 3β-hydroxy-5-en-steroids. A mutant strain of M. smegmatis with deletions in three genes (MSMEG_1604, MSMEG_5228 and MSMEG_5233) encoding known enzymes exhibiting 3β-hydroxysteroid dehydrogenase activity was constructed by homologous recombination coupled with double selection. The resulting mutant retained macromorphological properties and the ability to convert cholesterol. 3-Keto-4-en-steroids were found among the sterol catabolism intermediates. Experimentally obtained data indicate the presence of a previously undetected intracellular enzyme that performs the function of 3β-hydroxysteroid dehydrogenase/Δ5(6)→Δ4(5) isomerase.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86431658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Influence of Organic and Conventional Cultivation on Yield and Inner Quality in Spinach (Spinacia Oleracea L.)","authors":"Jinhua Bao, Cheng Wang, Xiangjun Shen, Defeng Zhuang, Eriko Sasakid","doi":"10.1051/bioconf/20236002001","DOIUrl":"https://doi.org/10.1051/bioconf/20236002001","url":null,"abstract":"This essay establishes three factors, i.e. organic fertilizer, chemical fertilizer and organic fertilizer with cow carbide. The purpose of the present study was to elucidate influence of organic fertilizer and chemical fertilizer on yield and inner quality in spinach with fifteen treatments at five levels. The results showed that the contents of reducing sugar and nitrate nitrogen of spinach in organic fertilizer handling area was less than those in chemical fertilizer. No significant difference was found among the fresh weight, total sugar content and vitamin C content by utilization of organic fertilizer or chemical fertilizer.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82942152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socio-psychological problems of children in migrant families and their solutions","authors":"Hasanboy Abdusamatov","doi":"10.1051/bioconf/20236506005","DOIUrl":"https://doi.org/10.1051/bioconf/20236506005","url":null,"abstract":"The article is devoted to socio-psychological characteristics of children in migrant families, and reveals their problems. It presents the research results of foreign and Uzbek scientists who conducted research on migrant families and their children. The article proves that growing up without a father or mother has a negative effect on the child’s psychology, and that family problems arise as a result of the increase in the number of migrants in the world, as a result of which family members do not see each other for a long time. The conflict in personal and family values, its impact on the upbringing system of Uzbek families, as well as methods of bringing up and educating the children of migrant families and providing psychological services to them in educational institutions are shown. Psychological recommendations are given to parents who have left their children in their homeland and become migrant workers in other countries.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86718847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms by Which Physical Activity Modulates the Wnt/β-catenin Pathway to Alleviate Anxiety-like Depression","authors":"Xiaofeng Jiang, Ziwei Ni, Q. Feng, Hongtao Guo, D. Fu, Junmian Wang, Hongtao Zhou, Xuefeng Liang, Cailian Ruan","doi":"10.1051/bioconf/20236101005","DOIUrl":"https://doi.org/10.1051/bioconf/20236101005","url":null,"abstract":"This study aimed to explore the effect of treadmill exercise on anxiety in rats. Thirty SPF male rats aged 2 months with a body mass of (225±25) g were randomly divided into control group (CG, n=10), chronic sleep deprivation group (CSD, n=10) and sleep deprivation exercise group (CSD+E, n=10) after adaptive feeding for 1 week. The CSD model of rats in CSD group and CSD+E group was made by multi platform water environment method. Sleep deprivation of 18 h per day (from 12:00 pm. to 6:00 am. the next day) for 8 weeks. The effect of running on the anxiety-like behaviour of CSD rats was examined in the open field test (OFT) and the elevated plus maze (EPM) experiment. Hematoxylin-eosin (HE) staining, Annexin V/PI flow cytometry, immunofluorescence staining, Western blot, RT-qPCR and other methods were used to detect the effects of treadmill exercise on the morphology of hippocampus, apoptosis related factors caspase-12, Bax, Bcl-1, inflammatory factors (IL-6, TNF-a), Wnt β- catenin, p- β-catenin. The results of HE staining showed that the brain tissue of the control rats was structurally intact, with thick layers of cone cells, relatively dense, neatly arranged and compact, the cell edge structures were intact and clearly visible, with no obvious abnormal changes. The cone cell layer of brain tissue in the chronic sleep deprivation group was thin, with relatively low cell density, disorganized and sparse arrangement, and blurred cell edges. The symptoms of the above pathological changes in brain tissue of rats in sleep deprivation exercise group gradually alleviated. OFT results showed that compared with CG group, the number of activities in the central region of CSD group was significantly reduced (P<0.01), and the total distance of exercise was significantly shortened (P<0.01). EPM results showed that compared with CG group, OT and CE in CSD group decreased significantly (P<0.01). CCK-8 results showed that compared with CG group, the activity of neurons in CA1 area of hippocampus in CSD group was significantly decreased (P<0.01), while that in CSD+E group was significantly increased (P<0.01); Annexin V/PI flow cytometry results showed that compared with CG group, the apoptosis of neurons in CA1 area of hippocampus in CSD group increased (P<0.01), and that in CSD+E group decreased significantly (P<0.01);Western blot results showed that caspase-12, Bax, IL-6, IL-1β and TNF-a were highly expressed and Bcl-1 was lowly expressed in hippocampal tissues of rats in the CSD group compared with the CG group (P<0.01), Wnt, β-catenin and p-β-catenin were lowly expressed in hippocampal tissues of rats in the CSD group, and Gsk-3βprotein expression was significantly higher (p<0.01). The results of RT-qPCR showed that caspase-12 mRNA, Bax mRNA, IL-6 mRNA, TNF-a mRNA and IL-1β mRNA were highly expressed and Bcl-1 mRNA was lowly expressed in hippocampal tissues of rats in the CSD group compared with the CG group (P<0.01). Compared with the CG group, Wnt mRNA and β","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":"144 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91454260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Melanoidin Contribution to Colour Characteristics of Brewing Products","authors":"Irina A. Gribkova, M. Eliseev, O. Kosareva, M. Zakharov, V. Zakharova","doi":"10.1051/bioconf/20235703001","DOIUrl":"https://doi.org/10.1051/bioconf/20235703001","url":null,"abstract":"The article focuses on the issue of melanoidin quantification and its influence on the color characteristics of brewing products. It is shown that the reaction conditions (100±2)°C, the processing time of 2 hours and a certain list of sugars and amino acids typical for brewing products are adequate to obtain linear dependencies for estimating the beer melanoidin content at 300 and 420 nm. The data on the total content of melanoidins in light beer in the range of 3.83-51.4 mg/dm3, and in dark beer – 6.82-145.94 mg/dm3 at the specified wavelengths are given. The authors found that the dependence between the color and the total beer melanoidin content is characterized by a correlation coefficient R = 0.624, which indicates the influence of other organic compounds of beer on the color intensity.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90167164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation, Assay and Stability Analysis of Curcumin-Polysaccharide Complexes","authors":"Yun Qiao","doi":"10.1051/bioconf/20236001012","DOIUrl":"https://doi.org/10.1051/bioconf/20236001012","url":null,"abstract":"Curcumin is a hydrophobic plant polyphenol with various functional properties such as antioxidant, antibacterial, anti-inflammatory, blood lipid regulator, hypotensive and anti-tumour, etc. However, it is sensitive to environmental factors such as light, oxygen and heat, and is prone to oxidative degradation and loss of biological activity during processing, storage and transportation, thus limiting its application. In this paper, chitosan and curcumin were used to form a complex to encapsulate and protect curcumin, and some modern assay techniques were used to examine the structural and functional properties of the complex and analyze its stability. RESULTS: Chitosan and curcumin could form a nanocomplex and the resistance of curcumin to light and heat was greatly enhanced after the formation of the complex. Significance: This study is of great importance to solve the problems of poor water dispersion, unstable physicochemical properties and difficult application of curcumin, and is of academic and practical significance for the future development and utilization of curcumin.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88912853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of mechanical channel in the proliferation and migration of colon cancer","authors":"Pin-Yu Wang","doi":"10.1051/bioconf/20236101024","DOIUrl":"https://doi.org/10.1051/bioconf/20236101024","url":null,"abstract":"Piezo channel is the first family of mechanically gated cation channels found in mammals and has been shown correlated with the proliferation and metastasis of tumors in recent years. In a variety of cancer tissues, colon cancer tissues are particularly affected by mechanical stimulation. In this paper, we reported that the role of piezo1 in the proliferation and migration of colon cancer. Firstly, bioinformatics indicated that high levels of piezo1 expression existed in CRC tissues and were associated with poor prognosis. In vitro experiments, SW1116 cells were cultured in DMSO solutions, and CCK-8 assay and transwell assay were separately performed. It turned out that the inhibition of PIEZO1 by Dooku1 resulted in diminished cell proliferation and metastasis, while the activation of PIEZO1 by Yoda1 led to enhanced proliferation and migration of colon cells. Collectively, these findings demonstrated the facilitation role of piezo1 in colon cancer proliferation and migration, suggesting that piezo1 has the potential as a novel therapeutic target for drug design and treatment of colon cancer.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83061533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The resistance of a number of indigenous species of shrubs and subshrubs of Sakhalin to a low-snow winter","authors":"V. V. Sheiko, D. M. Lebedev, V. Sorokopudov","doi":"10.1051/bioconf/20236601008","DOIUrl":"https://doi.org/10.1051/bioconf/20236601008","url":null,"abstract":"A negative reaction to the anomalous nature of the low-snow winter of 2018/19 was shown by representatives of 78% of the species of shrubs and subshrubs indigenous to Sakhalin island, studied in the botanical garden of the city of Yuzhno-Sakhalinsk, and 9% of species of foreign shrubs. Such a reaction of local plants can be associated with their adaptations to such factors as a thick snow cover, temperature stability in spruce-fir forests, weak soil freezing. The latter may be due to deep snow, high groundwater levels, or if the species is adapted to the warmer climate of the main part of the range.","PeriodicalId":8805,"journal":{"name":"BIO Web of Conferences","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80546844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}