Behavioral and Brain Functions最新文献

{"title":"Relations between family cohesion and adolescent-parent's neural synchrony in response to emotional stimulations.","authors":"Xinmei Deng,&nbsp;Mingping Lin,&nbsp;Lin Zhang,&nbsp;Xiaoqing Li,&nbsp;Qiufeng Gao","doi":"10.1186/s12993-022-00197-1","DOIUrl":"https://doi.org/10.1186/s12993-022-00197-1","url":null,"abstract":"<p><strong>Background: </strong>The interaction between parent and adolescent is more challenging than in other age periods. Family cohesion seriously impacts parent-adolescent emotional interactions. However, the underlying neural mechanism has not been fully examined. This study examined the differences in the neural synchrony in response to emotional film clips between high and low family cohesion adolescent-parent dyads by using the electroencephalograph (EEG) hyperscanning.</p><p><strong>Results: </strong>Simultaneously electroencephalograph (EEG) was recorded while 15 low family cohesion parent-adolescent dyads (LFCs)and 14 high family cohesion parent-adolescent dyads (HFCs)received different emotional induction when viewing film clips. Interbrain phase-locking-value (PLV) in gamma band was used to calculate parent-adolescent dyads' interbrain synchrony. Results showed that higher gamma interbrain synchrony was observed in the HFCs than the LFCs in the positive conditions. However, there was no significant difference between the HFCs and LFCs in other conditions. Also, the HFCs had significantly higher gamma interbrain synchrony in the positive conditions than in the negative conditions.</p><p><strong>Conclusion: </strong>Interbrain synchrony may represent an underlying neural mechanism of the parent-adolescent emotional bonding, which is the core of family cohesion.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":" ","pages":"11"},"PeriodicalIF":5.1,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40377807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing allocation of visual attention with emotional cues presented in two sensory modalities.","authors":"Ulrike Zimmer,&nbsp;Mike Wendt,&nbsp;Marlene Pacharra","doi":"10.1186/s12993-022-00195-3","DOIUrl":"https://doi.org/10.1186/s12993-022-00195-3","url":null,"abstract":"<p><strong>Background: </strong>Responses to a visual target stimulus in an exogenous spatial cueing paradigm are usually faster if cue and target occur in the same rather than in different locations (i.e., valid vs. invalid), although perceptual conditions for cue and target processing are otherwise equivalent. This cueing validity effect can be increased by adding emotional (task-unrelated) content to the cue. In contrast, adding a secondary non-emotional sensory modality to the cue (bimodal), has not consistently yielded increased cueing effects in previous studies. Here, we examined the interplay of bimodally presented cue content (i.e., emotional vs. neutral), by using combined visual-auditory cues. Specifically, the current ERP-study investigated whether bimodal presentation of fear-related content amplifies deployment of spatial attention to the cued location.</p><p><strong>Results: </strong>A behavioral cueing validity effect occurred selectively in trials in which both aspects of the cue (i.e., face and voice) were related to fear. Likewise, the posterior contra-ipsilateral P1-activity in valid trials was significantly larger when both cues were fear-related than in all other cue conditions. Although the P3a component appeared uniformly increased in invalidly cued trials, regardless of cue content, a positive LPC deflection, starting about 450 ms after target onset, was, again, maximal for the validity contrast in trials associated with bimodal presentation of fear-related cues.</p><p><strong>Conclusions: </strong>Simultaneous presentation of fear-related stimulus information in the visual and auditory modality appears to increase sustained visual attention (impairing disengagement of attention from the cued location) and to affect relatively late stages of target processing.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":" ","pages":"10"},"PeriodicalIF":5.1,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33471014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended functional connectivity of convergent structural alterations among individuals with PTSD: a neuroimaging meta-analysis.","authors":"Brianna S Pankey,&nbsp;Michael C Riedel,&nbsp;Isis Cowan,&nbsp;Jessica E Bartley,&nbsp;Rosario Pintos Lobo,&nbsp;Lauren D Hill-Bowen,&nbsp;Taylor Salo,&nbsp;Erica D Musser,&nbsp;Matthew T Sutherland,&nbsp;Angela R Laird","doi":"10.1186/s12993-022-00196-2","DOIUrl":"https://doi.org/10.1186/s12993-022-00196-2","url":null,"abstract":"<p><strong>Background: </strong>Post-traumatic stress disorder (PTSD) is a debilitating disorder defined by the onset of intrusive, avoidant, negative cognitive or affective, and/or hyperarousal symptoms after witnessing or experiencing a traumatic event. Previous voxel-based morphometry studies have provided insight into structural brain alterations associated with PTSD with notable heterogeneity across these studies. Furthermore, how structural alterations may be associated with brain function, as measured by task-free and task-based functional connectivity, remains to be elucidated.</p><p><strong>Methods: </strong>Using emergent meta-analytic techniques, we sought to first identify a consensus of structural alterations in PTSD using the anatomical likelihood estimation (ALE) approach. Next, we generated functional profiles of identified convergent structural regions utilizing resting-state functional connectivity (rsFC) and meta-analytic co-activation modeling (MACM) methods. Finally, we performed functional decoding to examine mental functions associated with our ALE, rsFC, and MACM brain characterizations.</p><p><strong>Results: </strong>We observed convergent structural alterations in a single region located in the medial prefrontal cortex. The resultant rsFC and MACM maps identified functional connectivity across a widespread, whole-brain network that included frontoparietal and limbic regions. Functional decoding revealed overlapping associations with attention, memory, and emotion processes.</p><p><strong>Conclusions: </strong>Consensus-based functional connectivity was observed in regions of the default mode, salience, and central executive networks, which play a role in the tripartite model of psychopathology. Taken together, these findings have important implications for understanding the neurobiological mechanisms associated with PTSD.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":" ","pages":"9"},"PeriodicalIF":5.1,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33465939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the administration of Elovl5-dependent fatty acids on a spino-cerebellar ataxia 38 mouse model.","authors":"Ilaria Balbo,&nbsp;Francesca Montarolo,&nbsp;Federica Genovese,&nbsp;Filippo Tempia,&nbsp;Eriola Hoxha","doi":"10.1186/s12993-022-00194-4","DOIUrl":"https://doi.org/10.1186/s12993-022-00194-4","url":null,"abstract":"<p><strong>Background: </strong>Spinocerebellar ataxia 38 (SCA38) is a rare autosomal neurological disorder characterized by ataxia and cerebellar atrophy. SCA38 is caused by mutations of ELOVL5 gene. ELOVL5 gene encodes a protein, which elongates long chain polyunsaturated fatty acids (PUFAs). Knockout mice lacking Elovl5 recapitulate SCA38 symptoms, including motor coordination impairment and disruption of cerebellar architecture. We asked whether, in Elovl5 knockout mice (Elovl5^-/-), a diet with both ω3 and ω6 PUFAs downstream Elovl5 can prevent the development of SCA38 symptoms, and at which age such treatment is more effective. Elovl5^-/- mice were fed either with a diet without or containing PUFAs downstream the Elovl5 enzyme, starting at different ages. Motor behavior was assessed by the balance beam test and cerebellar structure by morphometric analysis.</p><p><strong>Results: </strong>The administration from birth of the diet containing PUFAs downstream Elovl5 led to a significant amelioration of the motor performance in the beam test of Elovl5^-/- mice, with a reduction of foot slip errors at 6 months from 2.2 ± 0.3 to 1.3 ± 0.2 and at 8 months from 3.1 ± 0.5 to 1.9 ± 0.3. On the contrary, administration at 1 month of age or later had no effect on the motor impairment. The cerebellar Purkinje cell layer and the white matter area of Elovl5^{-/ -}mice were not rescued even by the administration of diet from birth, suggesting that the improvement of motor performance in the beam test was due to a functional recovery of the cerebellar circuitry.</p><p><strong>Conclusions: </strong>These results suggest that the dietary intervention in SCA38, whenever possible, should be started from birth or as early as possible.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":" ","pages":"8"},"PeriodicalIF":5.1,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40590006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment.","authors":"Anna Delprato, Emily Xiao, Devika Manoj","doi":"10.1186/s12993-022-00191-7","DOIUrl":"10.1186/s12993-022-00191-7","url":null,"abstract":"<p><p>Genetic variants of DCX, COMT and FMR1 have been linked to neurodevelopmental disorders related to intellectual disability and social behavior. In this systematic review we examine the roles of the DCX, COMT and FMR1 genes in the context of hippocampal neurogenesis with respect to these disorders with the aim of identifying important hubs and signaling pathways that may bridge these conditions. Taken together our findings indicate that factors connecting DCX, COMT, and FMR1 in intellectual disability and social behavior may converge at Wnt signaling, neuron migration, and axon and dendrite morphogenesis. Data derived from genomic research has identified a multitude of genes that are linked to brain disorders and developmental differences. Information about where and how these genes function and cooperate is lagging behind. The approach used here may help to shed light on the biological underpinnings in which key genes interface and may prove useful for the testing of specific hypotheses.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"18 1","pages":"7"},"PeriodicalIF":4.7,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65734908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The shifting role of the cerebellum in executive, emotional and social processing across the lifespan","authors":"P. Beuriat, Irene Cristofori, B. Gordon, J. Grafman","doi":"10.1186/s12993-022-00193-5","DOIUrl":"https://doi.org/10.1186/s12993-022-00193-5","url":null,"abstract":"","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"18 1","pages":""},"PeriodicalIF":5.1,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65734917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean natural extracts improved cognitive behavior in zebrafish and healthy rats and ameliorated lps-induced cognitive impairment in a sex dependent manner","authors":"M. Pusceddu, Julia Hernandez-Baixauli, F. Puiggròs, L. Arola, A. Caimari, J. D. del Bas, Laura Baselga","doi":"10.1186/s12993-022-00190-8","DOIUrl":"https://doi.org/10.1186/s12993-022-00190-8","url":null,"abstract":"","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"18 1","pages":""},"PeriodicalIF":5.1,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65734894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible involvement of L-arginine-nitric oxide pathway in the antidepressant activity of Auraptene in mice.","authors":"Hossein Amini-Khoei,&nbsp;Shakiba Nasiri Boroujeni,&nbsp;Forough Maghsoudi,&nbsp;Mohammad Rahimi-Madiseh,&nbsp;Elham Bijad,&nbsp;Mohammadtaghi Moradi,&nbsp;Zahra Lorigooini","doi":"10.1186/s12993-022-00189-1","DOIUrl":"https://doi.org/10.1186/s12993-022-00189-1","url":null,"abstract":"<p><strong>Background: </strong>Depression is one of the most common mental illnesses worldwide. Nitric oxide (NO) is involved in the pathophysiology of depression. Auraptene (a coumarin derivative) has been shown to possess pharmacological effects on neurological diseases.</p><p><strong>Purpose: </strong>The present study aimed to investigate the possible role of the NO pathway in Auraptene antidepressant effects in male mice.</p><p><strong>Methods: </strong>Behavioral tests were used to assess depression-like behaviors. The mice received Auraptene at 10, 30, and 100 mg/kg, the combination of the sub-effective (ineffective) dose of Auraptene (10 mg/kg) and L-NAME, and the combination of the effective dose of Auraptene (30 mg/kg) and L-arginine. Finally, OFT, TST, FST, brain, serum MDA level, antioxidant capacity, hippocampus, and serum NO level were measured.</p><p><strong>Results: </strong>The data analysis showed that Auraptene (30 mg/kg) improved depression-like behaviors. Auraptene (30 mg/kg) also significantly reduced serum NO levels (P < 0.05) and significantly increased serum MDA (10 mg/kg, P < 0.05). Auraptene at 30 mg/kg also increased serum antioxidant capacity (P < 0.01). Co-administration of L-NAME and the sub-effective dose of Auraptene enhanced the effects of Auraptene. However, co-administration of the effective dose of Auraptene and L-arginine reduced the impacts of Auraptene.</p><p><strong>Conclusions: </strong>The results showed that Auraptene causes antidepressant effects in a dose-dependent manner and acts as a prooxidant at 100 mg/kg, and exacerbates oxidative stress. The antidepressant effects of this active molecule are exerted by reducing the NO level in the hippocampus and serum, increasing the antioxidant capacity, and reducing the MDA level in the serum.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":" ","pages":"4"},"PeriodicalIF":5.1,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39620726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep EEG characteristics associated with total sleep time misperception in young adults: an exploratory study.","authors":"Biyun Xu,&nbsp;Qinghao Cai,&nbsp;Runru Mai,&nbsp;Hailong Liang,&nbsp;Jiayu Huang,&nbsp;Zhimin Yang","doi":"10.1186/s12993-022-00188-2","DOIUrl":"https://doi.org/10.1186/s12993-022-00188-2","url":null,"abstract":"<p><strong>Background: </strong>Power spectral analysis (PSA) is one of the most commonly-used EEG markers of cortical hyperarousal, and can help to understand subjective-objective sleep discrepancy (SOD). Age is associated with decreased sleep EEG activity; however, the PSA of young adults is currently limited. Thus, this study aimed to examine the correlation of spectral EEG power with total sleep time (TST) misperception in young patients.</p><p><strong>Methods: </strong>Forty-seven young adults were recruited and underwent a polysomnography recording in a sleep laboratory. Clinical records and self-report questionnaires of all patients were collected, and were used to categorize patients into a good sleeper (GS) group (n = 10), insomnia with a low mismatch group (IWLM, n = 19) or participant with a high mismatch group (IWHM, n = 18). PSA was applied to the first 6 h of sleep.</p><p><strong>Results: </strong>IWHM patients exhibited a higher absolute power and relative beta/delta ratio in the frontal region compared to the GS group. No significant difference was observed between the IWLM and GS groups. No significant difference in the above parameters was observed between the IWHM and IWLM groups. Moreover, The SOD of TST was positively correlated with frontal absolute power and the relative beta/delta ratio (r = 0.363, P = 0.012; r = 0.363, P = 0.012), and absolute beta EEG spectral power (r = 0.313, P = 0.032) as well as the number of arousals.</p><p><strong>Conclusions: </strong>Increased frontal beta/delta ratio EEG power was found in young patients with a high mismatch but not in those with a low mismatch, compared with good sleepers. This suggests that there exists increased cortical activity in IWHM patients. In addition, the frontal beta/delta ratio and the number of arousals was positively correlated with the SOD of TST.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":" ","pages":"2"},"PeriodicalIF":5.1,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39856577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algebra dissociates from arithmetic in the brain semantic network.","authors":"Dazhi Cheng,&nbsp;Mengyi Li,&nbsp;Jiaxin Cui,&nbsp;Li Wang,&nbsp;Naiyi Wang,&nbsp;Liangyuan Ouyang,&nbsp;Xiaozhuang Wang,&nbsp;Xuejun Bai,&nbsp;Xinlin Zhou","doi":"10.1186/s12993-022-00186-4","DOIUrl":"https://doi.org/10.1186/s12993-022-00186-4","url":null,"abstract":"<p><strong>Background: </strong>Mathematical expressions mainly include arithmetic (such as 8 - (1 + 3)) and algebra (such as a - (b + c)). Previous studies have shown that both algebraic processing and arithmetic involved the bilateral parietal brain regions. Although previous studies have revealed that algebra was dissociated from arithmetic, the neural bases of the dissociation between algebraic processing and arithmetic is still unclear. The present study uses functional magnetic resonance imaging (fMRI) to identify the specific brain networks for algebraic and arithmetic processing.</p><p><strong>Methods: </strong>Using fMRI, this study scanned 30 undergraduates and directly compared the brain activation during algebra and arithmetic. Brain activations, single-trial (item-wise) interindividual correlation and mean-trial interindividual correlation related to algebra processing were compared with those related to arithmetic. The functional connectivity was analyzed by a seed-based region of interest (ROI)-to-ROI analysis.</p><p><strong>Results: </strong>Brain activation analyses showed that algebra elicited greater activation in the angular gyrus and arithmetic elicited greater activation in the bilateral supplementary motor area, left insula, and left inferior parietal lobule. Interindividual single-trial brain-behavior correlation revealed significant brain-behavior correlations in the semantic network, including the middle temporal gyri, inferior frontal gyri, dorsomedial prefrontal cortices, and left angular gyrus, for algebra. For arithmetic, the significant brain-behavior correlations were located in the phonological network, including the precentral gyrus and supplementary motor area, and in the visuospatial network, including the bilateral superior parietal lobules. For algebra, significant positive functional connectivity was observed between the visuospatial network and semantic network, whereas for arithmetic, significant positive functional connectivity was observed only between the visuospatial network and phonological network.</p><p><strong>Conclusion: </strong>These findings suggest that algebra relies on the semantic network and conversely, arithmetic relies on the phonological and visuospatial networks.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":" ","pages":"1"},"PeriodicalIF":5.1,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39794438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}