Behavioral and Brain Functions最新文献

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Age and cognitive status dependent differences in blood steroid and thyroid hormone concentrations in intact male rats. 完整雄性大鼠血液类固醇和甲状腺激素浓度的年龄和认知状态依赖性差异。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2019-06-30 DOI: 10.1186/s12993-019-0161-3
Jovana Maliković, Daniel Daba Feyissa, Predrag Kalaba, Babak Saber Marouf, Harald Höger, Michaela F Hartmann, Stefan A Wudy, Gerhard Schuler, Gert Lubec, Jana Aradska, Volker Korz
{"title":"Age and cognitive status dependent differences in blood steroid and thyroid hormone concentrations in intact male rats.","authors":"Jovana Maliković,&nbsp;Daniel Daba Feyissa,&nbsp;Predrag Kalaba,&nbsp;Babak Saber Marouf,&nbsp;Harald Höger,&nbsp;Michaela F Hartmann,&nbsp;Stefan A Wudy,&nbsp;Gerhard Schuler,&nbsp;Gert Lubec,&nbsp;Jana Aradska,&nbsp;Volker Korz","doi":"10.1186/s12993-019-0161-3","DOIUrl":"https://doi.org/10.1186/s12993-019-0161-3","url":null,"abstract":"<p><strong>Background: </strong>Age-dependent alterations of hormonal states have been considered to be involved in age related decline of cognitive abilities. Most of the studies in animal models are based on hormonal substitution in adrenal- and/or gonadectomized rodents or infusion of steroid hormones in intact rats. Moreover, the manipulations have been done timely, closely related to test procedures, thus reflecting short-term hormonal mechanisms in the regulation of learning and memory. Here we studied whether more general states of steroid and thyroid hormone profiles, independent from acute experiences, may possibly reflect long-term learning capacity. A large cohort of aged (17-18 months) intact male rats were tested in a spatial hole-board learning task and a subset of inferior and superior learners was included into the analysis. Young male adult rats (16 weeks of age) were also tested. Four to 8 weeks after testing blood plasma samples were taken and hormone concentrations of a variety of steroid hormones were measured by gas chromatography-tandem mass spectrometry or radioimmunoassay (17β-estradiol, thyroid hormones).</p><p><strong>Results: </strong>Aged good learners were similar to young rats in the behavioral task. Aged poor learners but not good learners showed higher levels of triiodothyronine (T3) as compared to young rats. Aged good learners had higher levels of thyroid stimulating hormone (TSH) than aged poor learning and young rats. Both aged good and poor learners showed significantly reduced levels of testosterone (T), 4-androstenedione (4A), androstanediol-3α,17β (AD), dihydrotestosterone (DHT), 17-hydroxyprogesterone (17OHP), higher levels of progesterone (Prog) and similar levels of 17β-estradiol (E2) as compared to young rats. The learning, but not the memory indices of all rats were significantly and positively correlated with levels of dihydrotestosterone, androstanediol-3α,17β and thyroxine (T4), when the impacts of age and cognitive division were eliminated by partial correlation analyses.</p><p><strong>Conclusion: </strong>The correlation of hormone concentrations of individuals with individual behavior revealed a possible specific role of these androgen and thyroid hormones in a state of general preparedness to learn.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"15 1","pages":"10"},"PeriodicalIF":5.1,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-019-0161-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37375864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Neuroprotective effects of Withania somnifera in BPA induced-cognitive dysfunction and oxidative stress in mice. 睡茄对双酚 A 诱导的小鼠认知功能障碍和氧化应激的神经保护作用
IF 4.7 2区 心理学
Behavioral and Brain Functions Pub Date : 2019-05-07 DOI: 10.1186/s12993-019-0160-4
Hareram Birla, Chetan Keswani, Sachchida Nand Rai, Saumitra Sen Singh, Walia Zahra, Hagera Dilnashin, Aaina Singh Rathore, Surya Pratap Singh
{"title":"Neuroprotective effects of Withania somnifera in BPA induced-cognitive dysfunction and oxidative stress in mice.","authors":"Hareram Birla, Chetan Keswani, Sachchida Nand Rai, Saumitra Sen Singh, Walia Zahra, Hagera Dilnashin, Aaina Singh Rathore, Surya Pratap Singh","doi":"10.1186/s12993-019-0160-4","DOIUrl":"10.1186/s12993-019-0160-4","url":null,"abstract":"<p><strong>Background: </strong>Bisphenol A (BPA), a major endocrine disruptor and a xenobiotic compound is used abundantly in the production of polycarbonate plastics and epoxy resins. Human exposure to this compound is primarily via its leaching from the protective internal epoxy resin coatings of containers into the food and beverages. In addition, the plastics used in dental prostheses and sealants also contain considerable amount of BPA and have a high risk of human exposure. Since it is a well-known endocrine disruptor and closely mimics the molecular structure of human estrogen thereby impairing learning and memory. Withania somnifera (Ws), commonly known as Ashwagandha is known for its varied therapeutic uses in Ayurvedic system of medicine. The present study was undertaken to demonstrate the impairment induced by BPA on the spatial learning, working memory and its alleviation by Ws in Swiss albino mice. The study was conducted on thirty Swiss albino mice, randomly distributed among three groups: control, BPA and BPA + Ws. The behavioral recovery after treatment with Ws was investigated using the Y-maize and Morris water maize test. Whereas, for the estimation of recovery of NMDA receptor which is related to learning and memory in hippocampus region by western blot and immunohistochemistry. Furthermore, the oxidative stress and antioxidant level was assessed by biochemical tests like MDA, SOD and catalase.</p><p><strong>Results: </strong>The study revealed that administration of Ws alleviated the behavioral deficits induced by BPA. Alongside, Ws treatment reinstated the number of NMDA receptors in hippocampus region and showed anti-oxidative property while ameliorating the endogenous anti-oxidant level in the brain.</p><p><strong>Conclusion: </strong>These findings suggest that Ws significantly ameliorates the level of BPA intoxicated oxidative stress thereby potentially treating cognitive dysfunction which acts as the primary symptom in a number of neurodegenerative diseases.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"15 1","pages":"9"},"PeriodicalIF":4.7,"publicationDate":"2019-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37217971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebellar activation associated with model-based estimation of tool-use consequences. 与基于模型的工具使用后果估计相关的小脑激活。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2019-04-16 DOI: 10.1186/s12993-019-0158-y
Sayako Ueda, Hiroyuki Sakai, Kenichi Ueno, Kang Cheng, Takatsune Kumada
{"title":"Cerebellar activation associated with model-based estimation of tool-use consequences.","authors":"Sayako Ueda,&nbsp;Hiroyuki Sakai,&nbsp;Kenichi Ueno,&nbsp;Kang Cheng,&nbsp;Takatsune Kumada","doi":"10.1186/s12993-019-0158-y","DOIUrl":"https://doi.org/10.1186/s12993-019-0158-y","url":null,"abstract":"<p><strong>Background: </strong>Dexterous tool use is considered to be underpinned by model-based control relying on acquired internal models of tools. In particular, this is the case in situations where available sensory feedback regarding the consequences of tool use is restricted. In the present study, we conducted an fMRI study to identify cerebellar involvement in model-based estimation of tool-use consequences using tracking tasks with different levels of visual feedback.</p><p><strong>Methods: </strong>Twenty healthy right-handed adults participated in this study. These participants tracked a moving target on a screen with a cursor controlled by a joystick using their right hand during fMRI scanning. For each trial, the level of visual feedback for cursor position was randomly selected from three task conditions, namely, Precise, Obscure, and No conditions.</p><p><strong>Results: </strong>A conjunction analysis across all task conditions found extensive activation of the right cerebellum, covering the anterior lobe (lobule V) and inferior posterior lobe (lobule VIII). Also, contrasts among the three task conditions revealed additional significant activation of the left superior posterior lobe (Crus I) in the No compared to the Precise condition. Furthermore, a post hoc psychophysiological interaction analysis revealed conditional modulation of functional coupling between the right, but not the left, cerebellar region and right frontoparietal regions that are involved in self-body perception.</p><p><strong>Conclusions: </strong>Our data show that the left Crus I is the only region that was more active in a condition where no visual feedback for cursor position was available. This suggests that the left Crus I region plays a role in model-based estimation of tool-use consequences based on an acquired internal model of tools.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"15 1","pages":"8"},"PeriodicalIF":5.1,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-019-0158-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37160627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'. 在“大数据”时代,利用黑腹果蝇研究酒精使用障碍。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2019-04-16 DOI: 10.1186/s12993-019-0159-x
Gregory L Engel, Kreager Taber, Elizabeth Vinton, Amanda J Crocker
{"title":"Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'.","authors":"Gregory L Engel,&nbsp;Kreager Taber,&nbsp;Elizabeth Vinton,&nbsp;Amanda J Crocker","doi":"10.1186/s12993-019-0159-x","DOIUrl":"10.1186/s12993-019-0159-x","url":null,"abstract":"<p><p>Our understanding of the networks of genes and protein functions involved in Alcohol Use Disorder (AUD) remains incomplete, as do the mechanisms by which these networks lead to AUD phenotypes. The fruit fly (Drosophila melanogaster) is an efficient model for functional and mechanistic characterization of the genes involved in alcohol behavior. The fly offers many advantages as a model organism for investigating the molecular and cellular mechanisms of alcohol-related behaviors, and for understanding the underlying neural circuitry driving behaviors, such as locomotor stimulation, sedation, tolerance, and appetitive (reward) learning and memory. Fly researchers are able to use an extensive variety of tools for functional characterization of gene products. To understand how the fly can guide our understanding of AUD in the era of Big Data we will explore these tools, and review some of the gene networks identified in the fly through their use, including chromatin-remodeling, glial, cellular stress, and innate immunity genes. These networks hold great potential as translational drug targets, making it prudent to conduct further research into how these gene mechanisms are involved in alcohol behavior.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"15 1","pages":"7"},"PeriodicalIF":5.1,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-019-0159-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37321896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Consequences of multilingualism for neural architecture. 多语言对神经结构的影响。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2019-03-25 DOI: 10.1186/s12993-019-0157-z
Sayuri Hayakawa, Viorica Marian
{"title":"Consequences of multilingualism for neural architecture.","authors":"Sayuri Hayakawa,&nbsp;Viorica Marian","doi":"10.1186/s12993-019-0157-z","DOIUrl":"https://doi.org/10.1186/s12993-019-0157-z","url":null,"abstract":"<p><p>Language has the power to shape cognition, behavior, and even the form and function of the brain. Technological and scientific developments have recently yielded an increasingly diverse set of tools with which to study the way language changes neural structures and processes. Here, we review research investigating the consequences of multilingualism as revealed by brain imaging. A key feature of multilingual cognition is that two or more languages can become activated at the same time, requiring mechanisms to control interference. Consequently, extensive experience managing multiple languages can influence cognitive processes as well as their neural correlates. We begin with a brief discussion of how bilinguals activate language, and of the brain regions implicated in resolving language conflict. We then review evidence for the pervasive impact of bilingual experience on the function and structure of neural networks that support linguistic and non-linguistic cognitive control, speech processing and production, and language learning. We conclude that even seemingly distinct effects of language on cognitive operations likely arise from interdependent functions, and that future work directly exploring the interactions between multiple levels of processing could offer a more comprehensive view of how language molds the mind.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"15 1","pages":"6"},"PeriodicalIF":5.1,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-019-0157-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37264799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Motor cortex and pain control: exploring the descending relay analgesic pathways and spinal nociceptive neurons in healthy conscious rats. 运动皮质与疼痛控制:健康意识大鼠下行中继镇痛通路和脊髓痛觉神经元的探索。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2019-03-25 DOI: 10.1186/s12993-019-0156-0
Patrícia Sanae Souza Lopes, Ana Carolina Pinheiro Campos, Erich Talamoni Fonoff, Luiz Roberto Giorgetti Britto, Rosana Lima Pagano
{"title":"Motor cortex and pain control: exploring the descending relay analgesic pathways and spinal nociceptive neurons in healthy conscious rats.","authors":"Patrícia Sanae Souza Lopes,&nbsp;Ana Carolina Pinheiro Campos,&nbsp;Erich Talamoni Fonoff,&nbsp;Luiz Roberto Giorgetti Britto,&nbsp;Rosana Lima Pagano","doi":"10.1186/s12993-019-0156-0","DOIUrl":"https://doi.org/10.1186/s12993-019-0156-0","url":null,"abstract":"<p><p>Motor cortex stimulation (MCS) is an effective therapy for refractory neuropathic pain. MCS increases the nociceptive threshold in healthy rats via endogenous opioids, inhibiting thalamic nuclei and activating the periaqueductal gray. It remains unclear how the motor cortex induces top-down modulation of pain in the absence of persistent pain. Here, we investigated the main nuclei involved in the descending analgesic pathways and the spinal nociceptive neurons in rats that underwent one session of MCS and were evaluated with the paw pressure nociceptive test. The pattern of neuronal activation in the dorsal raphe nucleus (DRN), nucleus raphe magnus (NRM), locus coeruleus (LC), and dorsal horn of the spinal cord (DHSC) was assessed by immunoreactivity (IR) for Egr-1 (a marker of activated neuronal nuclei). IR for serotonin (5HT) in the DRN and NRM, tyrosine hydroxylase (TH) in the LC, and substance P (SP) and enkephalin (ENK) in the DHSC was also evaluated. MCS increased the nociceptive threshold of the animals; this increase was accompanied by activation of the NRM, while DRN activation was unchanged. However, cortical stimulation induced an increase in 5HT-IR in both serotonergic nuclei. MCS did not change the activation pattern or TH-IR in the LC, and it inhibited neuronal activation in the DHSC without altering SP or ENK-IR. Taken together, our results suggest that MCS induces the activation of serotonergic nuclei as well as the inhibition of spinal neurons, and such effects may contribute to the elevation of the nociceptive threshold in healthy rats. These results allow a better understanding of the circuitry involved in the antinociceptive top-down effect induced by MCS under basal conditions, reinforcing the role of primary motor cortex in pain control.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"15 1","pages":"5"},"PeriodicalIF":5.1,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-019-0156-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37264794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Anticipation of difficult tasks: neural correlates of negative emotions and emotion regulation. 对困难任务的预期:负面情绪和情绪调节的神经关联。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2019-03-18 DOI: 10.1186/s12993-019-0155-1
Elise Klein, Silke M Bieck, Johannes Bloechle, Stefan Huber, Julia Bahnmueller, Klaus Willmes, Korbinian Moeller
{"title":"Anticipation of difficult tasks: neural correlates of negative emotions and emotion regulation.","authors":"Elise Klein,&nbsp;Silke M Bieck,&nbsp;Johannes Bloechle,&nbsp;Stefan Huber,&nbsp;Julia Bahnmueller,&nbsp;Klaus Willmes,&nbsp;Korbinian Moeller","doi":"10.1186/s12993-019-0155-1","DOIUrl":"https://doi.org/10.1186/s12993-019-0155-1","url":null,"abstract":"<p><strong>Background: </strong>Difficult cognitive tasks are often associated with negative feelings. This can be already the case for the mere anticipation of having to do a difficult task. For the case of difficult math tasks, it was recently suggested that such a negative emotional response may be exclusive to highly math-anxious individuals. However, it is also conceivable that negative emotional responses simply reflect that math is perceived as difficult. Here we investigated whether non-math-anxious individuals also experience negative emotional responses when anticipating to do difficult math tasks.</p><p><strong>Methods: </strong>We compared brain activation following the presentation of a numerical cue indicating either difficult or easy upcoming proportion magnitude comparison tasks.</p><p><strong>Results: </strong>Comparable to previous results for highly math-anxious individuals we observed a network associated with negative emotions to be activated in non-math-anxious individuals when facing cues indicating a difficult upcoming task. Importantly, however, math anxiety scores did not predict the neural response. Furthermore, we observed activation in areas associated with processes of cognitive control areas such as anterior cingulate cortex, which were suggested to play a key role in emotion regulation.</p><p><strong>Conclusion: </strong>Activation in the emotion processing network was observed when anticipating an upcoming difficult (math) task. However, this activation was not predicted by individual' degree of math anxiety. Therefore, we suggest that negative emotional responses to difficult math tasks might be a rather common reaction not specific to math-anxious individuals. Whether or not this initial negative response impairs math performance, however, might depend on the ability to regulate those emotions effectively.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"15 1","pages":"4"},"PeriodicalIF":5.1,"publicationDate":"2019-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-019-0155-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37069077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Age-related changes in neuroinflammation and prepulse inhibition in offspring of rats treated with Poly I:C in early gestation. Poly I:C在妊娠早期处理大鼠后代神经炎症和脉前抑制的年龄相关变化。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2019-03-05 DOI: 10.1186/s12993-019-0154-2
Shuang Ding, Yunqing Hu, Binbin Luo, Yaqi Cai, Keke Hao, Yongfeng Yang, Yan Zhang, Xiujuan Wang, Minli Ding, Hongxing Zhang, Wenqiang Li, Luxian Lv
{"title":"Age-related changes in neuroinflammation and prepulse inhibition in offspring of rats treated with Poly I:C in early gestation.","authors":"Shuang Ding,&nbsp;Yunqing Hu,&nbsp;Binbin Luo,&nbsp;Yaqi Cai,&nbsp;Keke Hao,&nbsp;Yongfeng Yang,&nbsp;Yan Zhang,&nbsp;Xiujuan Wang,&nbsp;Minli Ding,&nbsp;Hongxing Zhang,&nbsp;Wenqiang Li,&nbsp;Luxian Lv","doi":"10.1186/s12993-019-0154-2","DOIUrl":"https://doi.org/10.1186/s12993-019-0154-2","url":null,"abstract":"<p><strong>Background: </strong>Maternal immune activation (MIA) during gestation can increase the later risk of schizophrenia in adult offspring. Neuroinflammation is believed to underlie this process. Postmortem brain studies have found changes in the neuroimmune systems of patients with schizophrenia. However, little is known about the dynamic changes in cerebral inflammation and behavior during the course of the disease.</p><p><strong>Methods: </strong>Here, the prepulse inhibition (PPI) test was conducted in adolescent and adult Sprague-Dawley rats prenatally challenged with polyriboinosinic-polyribocytidylic acid (Poly I:C) on gestational day 9 to determine the behavioral trajectory triggered by early exposure to Poly I:C. Brain immune changes were determined in the prefrontal cortex (PFC) and hippocampus (HC) at both ages. The status of the microglia and astrocytes was determined with immunohistochemical staining. The levels of IL-6, IL-1β, and TNF-α in both brain regions were evaluated with enzyme-linked immunosorbent assays.</p><p><strong>Results: </strong>Disrupted PPI, the core phenotype of schizophrenia, only emerged in adulthood. Behavioral changes during puberty and adulthood were both accompanied by the activation of microglia (PFC and HC). Astrocytes were only activated at PN60. The levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) in the offspring of the Poly I:C-exposed mothers differed with brain region and time, with more cytokines elevated during periadolescence than during adulthood.</p><p><strong>Conclusions: </strong>Our findings indicate that immune activation emerged before symptom manifestation in the offspring of MIA rats. We conclude that early prenatal Poly I:C challenge can lead to age-related behavioral and neuroinflammatory changes. These data provide new insight into the neuroinflammatory and neuropathological mechanisms underlying the development of schizophrenia. They also suggest that periadolescence could be more important than adulthood in the prevention and treatment of schizophrenia.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"15 1","pages":"3"},"PeriodicalIF":5.1,"publicationDate":"2019-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-019-0154-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37025929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Behavioral models in psychopathology: epistemic and semantic considerations. 精神病理学中的行为模型:认识论和语义考虑。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2019-03-01 DOI: 10.1186/s12993-019-0152-4
Caio Maximino, Franz Josef van der Staay
{"title":"Behavioral models in psychopathology: epistemic and semantic considerations.","authors":"Caio Maximino,&nbsp;Franz Josef van der Staay","doi":"10.1186/s12993-019-0152-4","DOIUrl":"https://doi.org/10.1186/s12993-019-0152-4","url":null,"abstract":"<p><p>The use of animals in neurosciences has a long history. It is considered indispensable in areas in which \"translational\" research is deemed invaluable, such as behavioral pharmacology and comparative psychology. Animal models are being used in pharmacology and genetics to screen for treatment targets, and in the field of experimental psychopathology to understand the neurobehavioral underpinnings of a disorder and of its putative treatment. The centrality of behavioral models betrays the complexity of the epistemic and semantic considerations which are needed to understand what a model is. In this review, such considerations are made, and the breadth of model building and evaluation approaches is extended to include theoretical considerations on the etiology of mental disorders. This expansion is expected to help improve the validity of behavioral models and to increase their translational value. Moreover, the role of theory in improving construct validity creates the need for behavioral scientists to fully engage this process.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"15 1","pages":"1"},"PeriodicalIF":5.1,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-019-0152-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37015379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos. 毒死蜱对成年C57Bl6/J小鼠先天和条件性社会行为的影响
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2019-03-01 DOI: 10.1186/s12993-019-0153-3
Anat Lan, Daniel Stein, Miguel Portillo, Debra Toiber, Ora Kofman
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引用次数: 24
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