Behavioral and Brain Functions最新文献

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Mediterranean natural extracts improved cognitive behavior in zebrafish and healthy rats and ameliorated lps-induced cognitive impairment in a sex dependent manner 地中海天然提取物改善斑马鱼和健康大鼠的认知行为,并以性别依赖的方式改善脂多糖诱导的认知障碍
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2022-02-25 DOI: 10.1186/s12993-022-00190-8
M. Pusceddu, Julia Hernandez-Baixauli, F. Puiggròs, L. Arola, A. Caimari, J. D. del Bas, Laura Baselga
{"title":"Mediterranean natural extracts improved cognitive behavior in zebrafish and healthy rats and ameliorated lps-induced cognitive impairment in a sex dependent manner","authors":"M. Pusceddu, Julia Hernandez-Baixauli, F. Puiggròs, L. Arola, A. Caimari, J. D. del Bas, Laura Baselga","doi":"10.1186/s12993-022-00190-8","DOIUrl":"https://doi.org/10.1186/s12993-022-00190-8","url":null,"abstract":"","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"18 1","pages":""},"PeriodicalIF":5.1,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65734894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Possible involvement of L-arginine-nitric oxide pathway in the antidepressant activity of Auraptene in mice. l -精氨酸-一氧化氮途径可能参与Auraptene小鼠抗抑郁活性。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2022-02-14 DOI: 10.1186/s12993-022-00189-1
Hossein Amini-Khoei, Shakiba Nasiri Boroujeni, Forough Maghsoudi, Mohammad Rahimi-Madiseh, Elham Bijad, Mohammadtaghi Moradi, Zahra Lorigooini
{"title":"Possible involvement of L-arginine-nitric oxide pathway in the antidepressant activity of Auraptene in mice.","authors":"Hossein Amini-Khoei,&nbsp;Shakiba Nasiri Boroujeni,&nbsp;Forough Maghsoudi,&nbsp;Mohammad Rahimi-Madiseh,&nbsp;Elham Bijad,&nbsp;Mohammadtaghi Moradi,&nbsp;Zahra Lorigooini","doi":"10.1186/s12993-022-00189-1","DOIUrl":"https://doi.org/10.1186/s12993-022-00189-1","url":null,"abstract":"<p><strong>Background: </strong>Depression is one of the most common mental illnesses worldwide. Nitric oxide (NO) is involved in the pathophysiology of depression. Auraptene (a coumarin derivative) has been shown to possess pharmacological effects on neurological diseases.</p><p><strong>Purpose: </strong>The present study aimed to investigate the possible role of the NO pathway in Auraptene antidepressant effects in male mice.</p><p><strong>Methods: </strong>Behavioral tests were used to assess depression-like behaviors. The mice received Auraptene at 10, 30, and 100 mg/kg, the combination of the sub-effective (ineffective) dose of Auraptene (10 mg/kg) and L-NAME, and the combination of the effective dose of Auraptene (30 mg/kg) and L-arginine. Finally, OFT, TST, FST, brain, serum MDA level, antioxidant capacity, hippocampus, and serum NO level were measured.</p><p><strong>Results: </strong>The data analysis showed that Auraptene (30 mg/kg) improved depression-like behaviors. Auraptene (30 mg/kg) also significantly reduced serum NO levels (P < 0.05) and significantly increased serum MDA (10 mg/kg, P < 0.05). Auraptene at 30 mg/kg also increased serum antioxidant capacity (P < 0.01). Co-administration of L-NAME and the sub-effective dose of Auraptene enhanced the effects of Auraptene. However, co-administration of the effective dose of Auraptene and L-arginine reduced the impacts of Auraptene.</p><p><strong>Conclusions: </strong>The results showed that Auraptene causes antidepressant effects in a dose-dependent manner and acts as a prooxidant at 100 mg/kg, and exacerbates oxidative stress. The antidepressant effects of this active molecule are exerted by reducing the NO level in the hippocampus and serum, increasing the antioxidant capacity, and reducing the MDA level in the serum.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":" ","pages":"4"},"PeriodicalIF":5.1,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39620726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Sleep EEG characteristics associated with total sleep time misperception in young adults: an exploratory study. 睡眠脑电图特征与年轻人总睡眠时间错误知觉相关:一项探索性研究。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2022-01-24 DOI: 10.1186/s12993-022-00188-2
Biyun Xu, Qinghao Cai, Runru Mai, Hailong Liang, Jiayu Huang, Zhimin Yang
{"title":"Sleep EEG characteristics associated with total sleep time misperception in young adults: an exploratory study.","authors":"Biyun Xu,&nbsp;Qinghao Cai,&nbsp;Runru Mai,&nbsp;Hailong Liang,&nbsp;Jiayu Huang,&nbsp;Zhimin Yang","doi":"10.1186/s12993-022-00188-2","DOIUrl":"https://doi.org/10.1186/s12993-022-00188-2","url":null,"abstract":"<p><strong>Background: </strong>Power spectral analysis (PSA) is one of the most commonly-used EEG markers of cortical hyperarousal, and can help to understand subjective-objective sleep discrepancy (SOD). Age is associated with decreased sleep EEG activity; however, the PSA of young adults is currently limited. Thus, this study aimed to examine the correlation of spectral EEG power with total sleep time (TST) misperception in young patients.</p><p><strong>Methods: </strong>Forty-seven young adults were recruited and underwent a polysomnography recording in a sleep laboratory. Clinical records and self-report questionnaires of all patients were collected, and were used to categorize patients into a good sleeper (GS) group (n = 10), insomnia with a low mismatch group (IWLM, n = 19) or participant with a high mismatch group (IWHM, n = 18). PSA was applied to the first 6 h of sleep.</p><p><strong>Results: </strong>IWHM patients exhibited a higher absolute power and relative beta/delta ratio in the frontal region compared to the GS group. No significant difference was observed between the IWLM and GS groups. No significant difference in the above parameters was observed between the IWHM and IWLM groups. Moreover, The SOD of TST was positively correlated with frontal absolute power and the relative beta/delta ratio (r = 0.363, P = 0.012; r = 0.363, P = 0.012), and absolute beta EEG spectral power (r = 0.313, P = 0.032) as well as the number of arousals.</p><p><strong>Conclusions: </strong>Increased frontal beta/delta ratio EEG power was found in young patients with a high mismatch but not in those with a low mismatch, compared with good sleepers. This suggests that there exists increased cortical activity in IWHM patients. In addition, the frontal beta/delta ratio and the number of arousals was positively correlated with the SOD of TST.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":" ","pages":"2"},"PeriodicalIF":5.1,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39856577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Algebra dissociates from arithmetic in the brain semantic network. 在大脑语义网络中,代数与算术分离。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2022-01-07 DOI: 10.1186/s12993-022-00186-4
Dazhi Cheng, Mengyi Li, Jiaxin Cui, Li Wang, Naiyi Wang, Liangyuan Ouyang, Xiaozhuang Wang, Xuejun Bai, Xinlin Zhou
{"title":"Algebra dissociates from arithmetic in the brain semantic network.","authors":"Dazhi Cheng,&nbsp;Mengyi Li,&nbsp;Jiaxin Cui,&nbsp;Li Wang,&nbsp;Naiyi Wang,&nbsp;Liangyuan Ouyang,&nbsp;Xiaozhuang Wang,&nbsp;Xuejun Bai,&nbsp;Xinlin Zhou","doi":"10.1186/s12993-022-00186-4","DOIUrl":"https://doi.org/10.1186/s12993-022-00186-4","url":null,"abstract":"<p><strong>Background: </strong>Mathematical expressions mainly include arithmetic (such as 8 - (1 + 3)) and algebra (such as a - (b + c)). Previous studies have shown that both algebraic processing and arithmetic involved the bilateral parietal brain regions. Although previous studies have revealed that algebra was dissociated from arithmetic, the neural bases of the dissociation between algebraic processing and arithmetic is still unclear. The present study uses functional magnetic resonance imaging (fMRI) to identify the specific brain networks for algebraic and arithmetic processing.</p><p><strong>Methods: </strong>Using fMRI, this study scanned 30 undergraduates and directly compared the brain activation during algebra and arithmetic. Brain activations, single-trial (item-wise) interindividual correlation and mean-trial interindividual correlation related to algebra processing were compared with those related to arithmetic. The functional connectivity was analyzed by a seed-based region of interest (ROI)-to-ROI analysis.</p><p><strong>Results: </strong>Brain activation analyses showed that algebra elicited greater activation in the angular gyrus and arithmetic elicited greater activation in the bilateral supplementary motor area, left insula, and left inferior parietal lobule. Interindividual single-trial brain-behavior correlation revealed significant brain-behavior correlations in the semantic network, including the middle temporal gyri, inferior frontal gyri, dorsomedial prefrontal cortices, and left angular gyrus, for algebra. For arithmetic, the significant brain-behavior correlations were located in the phonological network, including the precentral gyrus and supplementary motor area, and in the visuospatial network, including the bilateral superior parietal lobules. For algebra, significant positive functional connectivity was observed between the visuospatial network and semantic network, whereas for arithmetic, significant positive functional connectivity was observed only between the visuospatial network and phonological network.</p><p><strong>Conclusion: </strong>These findings suggest that algebra relies on the semantic network and conversely, arithmetic relies on the phonological and visuospatial networks.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":" ","pages":"1"},"PeriodicalIF":5.1,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39794438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
NLRP1 inflammasome involves in learning and memory impairments and neuronal damages during aging process in mice. NLRP1炎性体参与小鼠衰老过程中的学习记忆障碍和神经元损伤。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2021-12-17 DOI: 10.1186/s12993-021-00185-x
Dan Sun, Guofang Gao, Bihua Zhong, Han Zhang, Shixin Ding, Zhenghao Sun, Yaodong Zhang, Weizu Li
{"title":"NLRP1 inflammasome involves in learning and memory impairments and neuronal damages during aging process in mice.","authors":"Dan Sun,&nbsp;Guofang Gao,&nbsp;Bihua Zhong,&nbsp;Han Zhang,&nbsp;Shixin Ding,&nbsp;Zhenghao Sun,&nbsp;Yaodong Zhang,&nbsp;Weizu Li","doi":"10.1186/s12993-021-00185-x","DOIUrl":"https://doi.org/10.1186/s12993-021-00185-x","url":null,"abstract":"<p><strong>Background: </strong>Brain aging is an important risk factor in many human diseases, such as Alzheimer's disease (AD). The production of excess reactive oxygen species (ROS) mediated by nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) and the maturation of inflammatory cytokines caused by activation of the NOD-like receptor protein 1 (NLRP1) inflammasome play central roles in promoting brain aging. However, it is still unclear when and how the neuroinflammation appears in the brain during aging process.</p><p><strong>Methods: </strong>In this study, we observed the alterations of learning and memory impairments, neuronal damage, NLRP1 inflammasome activation, ROS production and NOX2 expression in the young 6-month-old (6 M) mice, presenile 16 M mice, and older 20 M and 24 M mice.</p><p><strong>Results: </strong>The results indicated that, compared to 6 M mice, the locomotor activity, learning and memory abilities were slightly decreased in 16 M mice, and were significantly decreased in 20 M and 24 M mice, especially in the 24 M mice. The pathological results also showed that there were no significant neuronal damages in 6 M and 16 M mice, while there were obvious neuronal damages in 20 M and 24 M mice, especially in the 24 M group. Consistent with the behavioral and histological changes in the older mice, the activity of β-galactosidase (β-gal), the levels of ROS and IL-1β, and the expressions of NLRP1, ASC, caspase-1, NOX2, p47phox and p22phox were significantly increased in the cortex and hippocampus in the older 20 M and 24 M mice.</p><p><strong>Conclusion: </strong>Our study suggested that NLRP1 inflammasome activation may be closely involved in aging-related neuronal damage and may be an important target for preventing brain aging.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"17 1","pages":"11"},"PeriodicalIF":5.1,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39735447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats. 新生儿黄体酮受体拮抗剂对大鼠幼年社交行为的性别特异性影响。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2021-11-05 DOI: 10.1186/s12993-021-00183-z
R M Forbes-Lorman
{"title":"Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats.","authors":"R M Forbes-Lorman","doi":"10.1186/s12993-021-00183-z","DOIUrl":"https://doi.org/10.1186/s12993-021-00183-z","url":null,"abstract":"<p><p>Developing mammals are exposed to progesterone through several sources; however, the role of progesterone in early development is not well understood. Males express more progestin receptors (PRs) than females within several brain regions during early postnatal life, suggesting that PRs may be important for the organization of the sex differences in the brain and behavior. Indeed, previous studies showed cognitive impairments in male rats treated neonatally with a PR antagonist. In the present study, we examined the role of PRs in organizing juvenile behaviors. Social play behavior and social discrimination were examined in juvenile male and female rats that had been treated with CDB, a PR antagonist, during the first week of postnatal life. Interestingly, neonatal PR antagonism altered different juvenile behaviors in males and females. A transient disruption in PR signaling during development had no effect on social discrimination but increased play initiation and pins in females. These data suggest that PRs play an important role in the organization of sex differences in some social behaviors.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"17 1","pages":"10"},"PeriodicalIF":5.1,"publicationDate":"2021-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39593759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats. Wistar大鼠穿孔通路齿状回(PP-DG)突触空间学习记忆和海马长时程增强的性别差异。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2021-11-01 DOI: 10.1186/s12993-021-00184-y
Samaneh Safari, Nesa Ahmadi, Reihaneh Mohammadkhani, Reza Ghahremani, Maryam Khajvand-Abedeni, Siamak Shahidi, Alireza Komaki, Iraj Salehi, Seyed Asaad Karimi
{"title":"Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats.","authors":"Samaneh Safari,&nbsp;Nesa Ahmadi,&nbsp;Reihaneh Mohammadkhani,&nbsp;Reza Ghahremani,&nbsp;Maryam Khajvand-Abedeni,&nbsp;Siamak Shahidi,&nbsp;Alireza Komaki,&nbsp;Iraj Salehi,&nbsp;Seyed Asaad Karimi","doi":"10.1186/s12993-021-00184-y","DOIUrl":"10.1186/s12993-021-00184-y","url":null,"abstract":"<p><strong>Background: </strong>Recent studies show that gender may have a significant impact on brain functions. However, the reports of sex effects on spatial ability and synaptic plasticity in rodents are divergent and controversial. Here spatial learning and memory was measured in male and female rats by using Morris water maze (MWM) task. Moreover, to assess sex difference in hippocampal synaptic plasticity we examined hippocampal long-term potentiation (LTP) at perforant pathway-dentate gyrus (PP-DG) synapses.</p><p><strong>Results: </strong>In MWM task, male rats outperformed female rats, as they had significantly shorter swim distance and escape latency to find the hidden platform during training days. During spatial reference memory test, female rats spent less time and traveled less distance in the target zone. Male rats also had larger LTP at PP-DG synapses, which was evident in the high magnitude of population spike (PS) potentiation and the field excitatory post synaptic potentials (fEPSP) slope.</p><p><strong>Conclusions: </strong>Taken together, our results suggest that sex differences in the LTP at PP-DG synapses, possibly contribute to the observed sex difference in spatial learning and memory.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"17 1","pages":"9"},"PeriodicalIF":5.1,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39848705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology. 神秘的耳廓神经回路及其在神经退行性病理学中作用的最新进展。
IF 4.7 2区 心理学
Behavioral and Brain Functions Pub Date : 2021-07-07 DOI: 10.1186/s12993-021-00181-1
Vladimir N Nikolenko, Negoriya A Rizaeva, Narasimha M Beeraka, Marine V Oganesyan, Valentina A Kudryashova, Alexandra A Dubovets, Irina D Borminskaya, Kirill V Bulygin, Mikhail Y Sinelnikov, Gjumrakch Aliev
{"title":"The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology.","authors":"Vladimir N Nikolenko, Negoriya A Rizaeva, Narasimha M Beeraka, Marine V Oganesyan, Valentina A Kudryashova, Alexandra A Dubovets, Irina D Borminskaya, Kirill V Bulygin, Mikhail Y Sinelnikov, Gjumrakch Aliev","doi":"10.1186/s12993-021-00181-1","DOIUrl":"10.1186/s12993-021-00181-1","url":null,"abstract":"<p><strong>Introduction: </strong>The claustrum is a structure involved in formation of several cortical and subcortical neural microcircuits which may be involved in such functions as conscious sensations and rewarding behavior. The claustrum is regarded as a multi-modal information processing network. Pathology of the claustrum is seen in certain neurological disorders. To date, there are not enough comprehensive studies that contain accurate information regarding involvement of the claustrum in development of neurological disorders.</p><p><strong>Objective: </strong>Our review aims to provide an update on claustrum anatomy, ontogenesis, cytoarchitecture, neural networks and their functional relation to the incidence of neurological diseases.</p><p><strong>Materials and methods: </strong>A literature review was conducted using the Google Scholar, PubMed, NCBI MedLine, and eLibrary databases.</p><p><strong>Results: </strong>Despite new methods that have made it possible to study the claustrum at the molecular, genetic and epigenetic levels, its functions and connectivity are still poorly understood. The anatomical location, relatively uniform cytoarchitecture, and vast network of connections suggest a divergent role of the claustrum in integration and processing of input information and formation of coherent perceptions. Several studies have shown changes in the appearance, structure and volume of the claustrum in neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), autism, schizophrenia, and depressive disorders. Taking into account the structure, ontogenesis, and functions of the claustrum, this literature review offers insight into understanding the crucial role of this structure in brain function and behavior.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"17 1","pages":"8"},"PeriodicalIF":4.7,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39162046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schizophrenia, the gut microbiota, and new opportunities from optogenetic manipulations of the gut-brain axis. 精神分裂症,肠道微生物群,以及肠-脑轴光遗传学操作的新机会。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2021-06-22 DOI: 10.1186/s12993-021-00180-2
Enrico Patrono, Jan Svoboda, Aleš Stuchlík
{"title":"Schizophrenia, the gut microbiota, and new opportunities from optogenetic manipulations of the gut-brain axis.","authors":"Enrico Patrono,&nbsp;Jan Svoboda,&nbsp;Aleš Stuchlík","doi":"10.1186/s12993-021-00180-2","DOIUrl":"https://doi.org/10.1186/s12993-021-00180-2","url":null,"abstract":"<p><p>Schizophrenia research arose in the twentieth century and is currently rapidly developing, focusing on many parallel research pathways and evaluating various concepts of disease etiology. Today, we have relatively good knowledge about the generation of positive and negative symptoms in patients with schizophrenia. However, the neural basis and pathophysiology of schizophrenia, especially cognitive symptoms, are still poorly understood. Finding new methods to uncover the physiological basis of the mental inabilities related to schizophrenia is an urgent task for modern neuroscience because of the lack of specific therapies for cognitive deficits in the disease. Researchers have begun investigating functional crosstalk between NMDARs and GABAergic neurons associated with schizophrenia at different resolutions. In another direction, the gut microbiota is getting increasing interest from neuroscientists. Recent findings have highlighted the role of a gut-brain axis, with the gut microbiota playing a crucial role in several psychopathologies, including schizophrenia and autism.There have also been investigations into potential therapies aimed at normalizing altered microbiota signaling to the enteric nervous system (ENS) and the central nervous system (CNS). Probiotics diets and fecal microbiota transplantation (FMT) are currently the most common therapies. Interestingly, in rodent models of binge feeding, optogenetic applications have been shown to affect gut colony sensitivity, thus increasing colonic transit. Here, we review recent findings on the gut microbiota-schizophrenia relationship using in vivo optogenetics. Moreover, we evaluate if manipulating actors in either the brain or the gut might improve potential treatment research. Such research and techniques will increase our knowledge of how the gut microbiota can manipulate GABA production, and therefore accompany changes in CNS GABAergic activity.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"17 1","pages":"7"},"PeriodicalIF":5.1,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-021-00180-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39096803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Molecular and cellular pathways contributing to brain aging. 导致大脑衰老的分子和细胞途径。
IF 5.1 2区 心理学
Behavioral and Brain Functions Pub Date : 2021-06-12 DOI: 10.1186/s12993-021-00179-9
Aliabbas Zia, Ali Mohammad Pourbagher-Shahri, Tahereh Farkhondeh, Saeed Samarghandian
{"title":"Molecular and cellular pathways contributing to brain aging.","authors":"Aliabbas Zia, Ali Mohammad Pourbagher-Shahri, Tahereh Farkhondeh, Saeed Samarghandian","doi":"10.1186/s12993-021-00179-9","DOIUrl":"10.1186/s12993-021-00179-9","url":null,"abstract":"<p><p>Aging is the leading risk factor for several age-associated diseases such as neurodegenerative diseases. Understanding the biology of aging mechanisms is essential to the pursuit of brain health. In this regard, brain aging is defined by a gradual decrease in neurophysiological functions, impaired adaptive neuroplasticity, dysregulation of neuronal Ca<sup>2+</sup> homeostasis, neuroinflammation, and oxidatively modified molecules and organelles. Numerous pathways lead to brain aging, including increased oxidative stress, inflammation, disturbances in energy metabolism such as deregulated autophagy, mitochondrial dysfunction, and IGF-1, mTOR, ROS, AMPK, SIRTs, and p53 as central modulators of the metabolic control, connecting aging to the pathways, which lead to neurodegenerative disorders. Also, calorie restriction (CR), physical exercise, and mental activities can extend lifespan and increase nervous system resistance to age-associated neurodegenerative diseases. The neuroprotective effect of CR involves increased protection against ROS generation, maintenance of cellular Ca<sup>2+</sup> homeostasis, and inhibition of apoptosis. The recent evidence about the modem molecular and cellular methods in neurobiology to brain aging is exhibiting a significant potential in brain cells for adaptation to aging and resistance to neurodegenerative disorders.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"17 1","pages":"6"},"PeriodicalIF":5.1,"publicationDate":"2021-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-021-00179-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39085337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 53
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