{"title":"Estimating health risk from exposure to 1,4-dioxane in Japan.","authors":"Ryoji Makino, Hajime Kawasaki, Atsuo Kishimoto, Masashi Gamo, Junko Nakanishi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Exposure to 1,4-dioxane from the atmosphere around high-emission plants and from consumer products used in daily life that contain the substance may have adverse health effects; however, its emission into the atmosphere is not regulated. In this study, the health risk posed by 1,4-dioxane is assessed to investigate whether measures should be undertaken to reduce exposure to 1,4-dioxane. The notion of the margin of exposure (MOE), given by the ratio of no observed adverse effect level (NOAEL) to actual or projected exposure level, is used to assess risk. In exposure assessment, two types of exposure channel are considered: (a) the use of consumer products that contain 1,4-dioxane and (b) the inhalation of air around high-emission plants. To estimate exposure via channel (a), we measured the concentration of 1,4-dioxane in consumer products and estimated the interindividual variability of exposure by Monte Carlo simulation that reflects the measured data. To estimate exposure via channel (b), we employed a local-level atmospheric dispersion model to estimate the concentration of 1,4-dioxane immediately around high-emission plants. For hazard assessment, we derived the inhalatory and oral NOAELs for liver adenomas and carcinomas and the uncertainty factor. The results suggest that measures are not needed to reduce exposure to 1,4-dioxane from consumer products. As for inhalation exposure around high-emission plants, some residents may be exposed to health risks if certain conservative analytical conditions are assumed. Even in this case, we conclude that it is not necessary for Plant A to stop the use of 1,4-dioxane immediately and that medium- to long-term emission reduction measures should be sufficient.</p>","PeriodicalId":87178,"journal":{"name":"Environmental sciences : an international journal of environmental physiology and toxicology","volume":"13 1","pages":"43-58"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26011384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Production of sepedonin by Sepedonium chrysospermum NT-1 in submerged culture.","authors":"Kazutaka Nagao, Naho Yoshida, Kazufumi Iwai, Takashi Sakai, Mitsuo Tanaka, Toshiro Miyahara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Strains of Sepedonium chrysospermum and the anamorph strain of Hypomyces chrysospermus (congruent with Apiocrea chrysosperma) were isolated and purified from parasitic filamentous fungi on the fruiting bodies of Boletaceae, such as the Gyroponus and Suillus genera in Japan, and identified from formations of conidia and chlamydospores. It is known that these strains produce sepedonin. S. chrysospermum NT-1 strain was selected from these strains and isolated. As the optimum medium (CY-1 medium), 0.1% yeast extract was added to the fruiting-body-forming medium (C medium) of Schizophyllum commune. After 8 days of growth on CY-1 medium, the yield of sepedonin was about 34 mg per 2 g of glucose added. This sepedonin seemed to inhibit the growth of various gram-positive and gram-negative bacteria, yeasts and molds.</p>","PeriodicalId":87178,"journal":{"name":"Environmental sciences : an international journal of environmental physiology and toxicology","volume":"13 5","pages":"251-6"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26356383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Direct analysis of diesel exhaust particles by fragmentation-free mass spectrometry using ion attachment mass spectrometry.","authors":"Hiroyuki Masaki, Lei Chen, Takashi Korenaga","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We analyzed diesel exhaust particles immediately by fragmentation-free mass spectrometry using ion attachment mass spectrometry (IA-MS). IA-MS can be used to measure labile organic compounds without any fragmentation. Ionization without fragmentation can be performed because a neutral molecule becomes an adduct ion by the attachment of Li(+) with a small amount of energy by the Coulomb force. A third-body gas, such as 100 Pa N(2), removes any excess energy of the adduct ion and makes it stable. The aim is to be able to measure the preprocessing of the sample promptly using this analysis. In a direct analysis of diesel exhaust particles using IA-MS, many compounds (including some unknown chemicals) were detected. In the mass spectrum consisting of the ion peaks of many compounds, it is possible that the source and load factor to the environment are considered as one index.</p>","PeriodicalId":87178,"journal":{"name":"Environmental sciences : an international journal of environmental physiology and toxicology","volume":"13 6","pages":"347-52"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26530292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimation of aggregate population cancer risk from dichloromethane for Japanese using atmospheric dispersion model.","authors":"Kazuya Inoue, Haruyuki Higashino, Hiroshi Yoshikado, Junko Nakanishi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aggregate population cancer risk from dichloromethane exposure for each prefecture and for all of Japan was estimated using an atmospheric dispersion model and by considering the population within each calculation mesh (about 5 x 5 km). Indoor dichloromethane exposure was also taken into consideration. The number of lifetime dichloromethane-exposure-induced cancer cases for all of Japan was estimated to be only 1.3 (of 125 million people) using a most recently reported unit risk value. It was also found that the average ratio of the contribution to the aggregate population cancer risk attributable to outdoor emission sources (industrial factories) to the total emission sources was no more than 40% for all of Japan. From these results, it is believed that further reductions in dichloromethane emissions from industrial factories on a prefectural or a nationwide scale would not be effective in reducing cancer risk. It was also revealed that the average ambient concentration of dichloromethane measured at monitoring stations for hazardous air pollutants in each prefecture is a good measure of the average ambient dichloromethane concentration to which people in that prefecture are exposed. Therefore, it was suggested that the aggregate population cancer risk from dichloromethane exposure can be effectively estimated for entire Japan by simply using the average ambient concentration measured at monitoring stations in all of Japan taking into consideration indoor dichloromethane exposure.</p>","PeriodicalId":87178,"journal":{"name":"Environmental sciences : an international journal of environmental physiology and toxicology","volume":"13 1","pages":"59-74"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26011385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Masculinization of female gastropod mollusks induced by organotin compounds, focusing on mechanism of actions of tributyltin and triphenyltin for development of imposex.","authors":"Toshihiro Horiguchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Imposex, the superimposition of male-type genital organs (penis and vas deferens) on female gastropods, is cause-specific and induced by low concentrations of certain organotins, such as tributyltin (TBT) and triphenyltin (TPT) from antifouling paints. Reproductive failure may be observed at severely affected stages. The history of imposex study and the legislation of organotins are summarized. The present statuses of gastropod imposex and organotin pollution in Japan, together with endocrine disruption observed in abalones, are also summarized, on the basis of the results of the field studies of the rock shell (Thais clavigera) conducted at 174 locations along the Japan coast between January 1999 and November 2001, the histopathological and analytical chemical studies of the ivory shell (Babylonia japonica), and both field and laboratory studies of the abalone (Haliotis madaka and H. gigantea). The fundamental knowledge of the endocrinology of gastropod mollusks is briefly described. Four hypotheses, such as that of aromatase-inhibition, regarding the induction mechanism of imposex induced by organotins in gastropods are reviewed. Finally, a new hypothesis that states that retinoid X receptor (RXR) plays an important role in inducing the development of imposex, i.e., the differentiation and growth of male-type genital organs in female gastropods, is reviewed and discussed to clarify the entire mode of action of TBT or TPT in the development of imposex in gastropods.</p>","PeriodicalId":87178,"journal":{"name":"Environmental sciences : an international journal of environmental physiology and toxicology","volume":"13 2","pages":"77-87"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26100609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formaldehyde uptake by Methylobacterium sp. MF1 and Acidomonas methanolica MB 58 with the different formaldehyde assimilation pathways.","authors":"Ryoji Mitsui, Hideaki Kitazawa, Takayuki Sato, Mitsuo Tanaka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Methylobacterium sp. MF1 (an obligate methylotrophic bacterium isolated newly by the authors) and Acidomonas methanolica MB58 (a facultative methylotrophic bacterium) uptake formaldehyde similarly. It was found that the former assimilated formaldehyde via the serine pathway whereas the latter did so via the ribulose-monophosphate pathway from the measurement of the key enzyme activities in each assimilation pathway. That is, hydroxy pyruvate reductase was detected in only the above-mentioned MF1 strain, but hexulose phosphate synthase (HPS) was not. The efficiencies of formaldehyde consumption by both strains under a continuous chemostat cultivation in the steady state were almost the same in spite of their different assimilation pathways. That is, the consumption efficiencies of the MF strain and the MB58 strain were ca. 1.2 g/L/d and ca. 1.8 g/L/d, respectively, under the experimental conditions. In the future, optimal continuous operating conditions will be investigated.</p>","PeriodicalId":87178,"journal":{"name":"Environmental sciences : an international journal of environmental physiology and toxicology","volume":"13 4","pages":"185-92"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26356485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel method to identify illegal diesel fuel, I: use of adamantane or [1, 2-D2] n-tetradecane as chemical marker.","authors":"Yaeko Suzuki, Shintaro Ishioka, Takashi Korenaga, Yoshito Chikaraishi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this study, we demonstrated a new identification method of illegal diesel fuel using adamantane (tricyclo[3,3,1,1,(3,7)]decane) or [1, 2-D(2)] n-tetradecane as a potential chemical marker instead of coumarin. In a mixing system of diesel fuel with marker-labeled kerosene, the concentration of kerosene in the mixed oil is quantitatively determined using specific ion fragments of the markers using GC/MS analysis, in which the detection limit is 12.5 ng/microl for adamantane or 7.1 ng/microl for [1, 2-D(2)] n-tetradecane. Coumarin, the currently used chemical marker, can be easily removed by sulfuric acid treatment, which is a primal cause of environmental pollution due to the illicit disposal of the strong acidic by-product. However, adamantane and [1, 2-D(2)] n-tetradecane cannot be removed by sulfuric acid treatment. Thus, although the detection limit of adamantane and [1, 2-D(2)] n-tetradecane is higher by approximately one or two orders of magnitude than that of coumarin, they cannot be removed by sulfuric acid treatment. Therefore, adamantane and [1, 2-D(2)] n-tetradecane are strong candidates as potential markers instead of coumarin, leading to the prevention of the production of illegal diesel fuel and a reduction in environmental pollution.</p>","PeriodicalId":87178,"journal":{"name":"Environmental sciences : an international journal of environmental physiology and toxicology","volume":"13 4","pages":"207-12"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26356488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stability of cellular foam generated from amphoteric surfactant aqueous solution.","authors":"Kae Fujita, Tamiya Kishimoto, Kazutaka Nagao, Toshiro Miyahara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experiments were carried out to investigate the stability of cellular foam generated from an amphoteric surfactant aqueous solution in a standard bubble column. A typical growth and collapse process were found, and the cellular foam became stable with increasing pH of the solution under both acidic and basic conditions. The critical film thickness calculated from the thinning equation, the well-known Reynolds equation, was between 100 to 400 nm. Of particular note is that the cellular foam was not observed at pH=7 of the liquid.</p>","PeriodicalId":87178,"journal":{"name":"Environmental sciences : an international journal of environmental physiology and toxicology","volume":"13 5","pages":"243-9"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26356382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A simple fluorometric method for the determination of sulfur dioxide in ambient air with a passive sampler.","authors":"Wei Chang, Miwako Okamoto, Takashi Korenaga","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A simple and rapid fluorescence detection method was used for the determination of sulfur dioxide (SO(2)) in ambient air collected by a passive sampler. Gaseous SO(2) was absorbed as sulfite ions into an absorbing solution of triethanolamine (TEA) contained in an adsorbent sheet and reacted with N-(9-acridinyl)maleimide (NAM), which was used as a fluorescent reagent. TEA was also used as a buffer solution in this study. The calibration curve of SO(2) showed a linear correlation R(2)=0.992, and the relative standard deviation (RSD) was 2.4% for 50 ppb SO(2) with six repeated measurements. It was satisfactory to apply this method to determine the SO(2) level for simultaneous multipoint monitoring.</p>","PeriodicalId":87178,"journal":{"name":"Environmental sciences : an international journal of environmental physiology and toxicology","volume":"13 5","pages":"257-62"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26356384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Volatilization and recovery of mercury from mercury-polluted soils and wastewaters using mercury-resistant Acidithiobacillus ferrooxidans strains SUG 2-2 and MON-1.","authors":"Fumiaki Takeuchi, Tsuyoshi Sugio","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Iron-oxidizing bacterium, Acidithiobacillus ferrooxidans, is one of the most important bacteria for the bioleaching of copper and gold ores. In order to use the mercury reducing activity of A. ferrooxidans for the bioremediation of mercury, mercury-resistant A. ferrooxidans strains SUG 2-2 and MON-1 were screened among 150 strains of iron-oxidizing bacteria isolated from natural environments. It was found that strains SUG 2-2 and MON-1 have a novel ferrous iron-dependent mercury volatilization activity as well as an NADPH-dependent mercury reductase activity. Strain MON-1 has an organomercurial lyase-like activity and grew most rapidly in an iron medium with 0.1 microM p-chloromercuribenzoic acid among 11 A. ferrooxidans strains tested. Nearly 100% of the total mercury in mercury-polluted soil or mercury wastewater was volatilized and recovered by incubating SUG 2-2 or MON-1 cells in 20 ml of an acidified water (pH 2.5) with ferrous iron, suggesting that these mercury-resistant strains can be used for the bioremediation of inorganic and organic mercurial compounds. We show for the first time that MON-1 cells immobilized in polyvinyl alcohol (PVA) resins could efficiently volatilize mercury from 2 L of a synthetic mercury-polluted wastewater (pH 2.5) containing 40 microM Hg(2+) and ferrous iron. The MON-1-immobilized PVA resins were used repeatedly.</p>","PeriodicalId":87178,"journal":{"name":"Environmental sciences : an international journal of environmental physiology and toxicology","volume":"13 6","pages":"305-16"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26530288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}