Behavior Genetics最新文献_第4页

The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder. 多重多基因评分在预测重度抑郁障碍及其与酒精使用障碍共病的倾向中的作用

IF 2.4 4区医学

Behavior Genetics Pub Date : 2026-03-01 Epub Date: 2026-04-10 DOI: 10.1007/s10519-026-10263-3

Jonathan L Wells, Jill A Rabinowitz, Brion S Maher, Amanda E Gentry, James B Burch, Elizabeth C Prom-Wormley

{"title":"The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder.","authors":"Jonathan L Wells, Jill A Rabinowitz, Brion S Maher, Amanda E Gentry, James B Burch, Elizabeth C Prom-Wormley","doi":"10.1007/s10519-026-10263-3","DOIUrl":"10.1007/s10519-026-10263-3","url":null,"abstract":"The inclusion of polygenic scores (PGS) from genetically correlated traits such as Major Depressive Disorder (MDD) and alcohol use disorder (AUD) may improve the prediction of these outcomes and their comorbidity. Despite the importance of this work, few studies have evaluated the efficacy of this possibility. The current study evaluates the use of MDD and AUD PGS individually and together to improve the prediction of MDD, AUD, and comorbid MDD-AUD using a sample of European, African, or Admixed American Ancestry participants from the National Longitudinal Study of Adolescent to Adult Health (N = 7,965). Cross-ancestry MDD and AUD PGS were created using PRS-CSx. The best fitting model of comorbid MDD-AUD in the whole sample included PGS for MDD and AUD (PGSMDD OR: 1.26, 95% CI 1.16-1.35, p = 2.69 × 10- 6; PGSAUD OR: 1.77, 95% CI 1.66-1.87, p = 3.49 × 10- 28), explaining an additional 4.88% of variance compared to a model only including sociodemographic covariates. For MDD, the best fitting model included the MDD PGS (OR: 1.25, 95% CI 1.17-1.33, p = 2.05 × 10- 8), explaining an additional 0.65% of variance. For AUD, the best fitting model included the AUD PGS (OR: 1.37, 95% CI 1.32-1.43, p = 1.25 × 10-28), which explained an additional 1.52% of variance. Inclusion of both PGS did not significantly improve the prediction of individual MDD or AUD. Inclusion of PGS for MDD and AUD significantly improved prediction for comorbid MDD-AUD, but not in MDD or AUD. These results help clarify the role of utilizing genetically correlated PGS in improving prediction of MDD, AUD, and comorbid MDD-AUD.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"80-98"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability and Change in Wellbeing Throughout Adolescence and Its Relationship with Life Events: A Longitudinal Twin Study. 青春期幸福感的稳定性和变化及其与生活事件的关系：一项纵向双胞胎研究。

IF 2.4 4区医学

Behavior Genetics Pub Date : 2026-03-01 Epub Date: 2026-04-11 DOI: 10.1007/s10519-026-10262-4

Eirunn Skaug, Trine Waaktaar, Svenn Torgersen

{"title":"Stability and Change in Wellbeing Throughout Adolescence and Its Relationship with Life Events: A Longitudinal Twin Study.","authors":"Eirunn Skaug, Trine Waaktaar, Svenn Torgersen","doi":"10.1007/s10519-026-10262-4","DOIUrl":"10.1007/s10519-026-10262-4","url":null,"abstract":"Wellbeing-the balance of positive and negative affect and life satisfaction-is closely tied to mental health. However, the sources of stability and change and how life events shape wellbeing are not well understood. Data from the Oslo University Adolescent and Young Adult Project (2,879 individuals from 1,483 families) provided wellbeing and life‑event data across three waves ~ 2 years apart (ages 12-18 at Wave 1). We used a trivariate Cholesky decomposition to estimate genetic and environmental contributions to wellbeing, and genetically informative random intercept cross‑lagged panel models (RI‑CLPMs) to test prospective effects of life events on wellbeing. Wellbeing showed moderate stability, predominantly driven by genetic influences (81%). Cross-sectional heritability was about 50% at Waves 1-2 and declined to 26% at Wave 3. Negative life events were correlated with lower wellbeing (concurrent r = - 0.34 to - 0.28; 2-year r = - 0.26 to - 0.19; 4-year r = - 0.22 to - 0.12). However, RI‑CLPMs indicated minimal longitudinal effects of life events on wellbeing after accounting for genetics and trait stability: negative dependent life events explained 1% of change from Wave 1 to Wave 2 and ≈ 0% (non-significant) from Wave 2 to Wave 3. Genetic factors primarily account for stability in wellbeing, while measured life events showed limited prospective influence on wellbeing levels. Future research should combine richer genetically informed longitudinal designs (e.g., measured genotypes and GxE models) and examine biological pathways and person-level processes (e.g., neural and epigenetic mechanisms) to clarify pathways influencing wellbeing and inform interventions.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"99-109"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and Environmental Influences on Singing Self-Evaluation and its Relationship with Singing Ability: An Australian Twin Study. 遗传和环境对歌唱自我评价的影响及其与歌唱能力的关系：一项澳大利亚双胞胎研究。

IF 2.4 4区医学

Behavior Genetics Pub Date : 2026-03-01 Epub Date: 2026-02-09 DOI: 10.1007/s10519-026-10254-4

Daniel Yeom, Kendall S Stead, Yi Ting Tan, Gary E McPherson, Miriam A Mosing, Sarah J Wilson

{"title":"Genetic and Environmental Influences on Singing Self-Evaluation and its Relationship with Singing Ability: An Australian Twin Study.","authors":"Daniel Yeom, Kendall S Stead, Yi Ting Tan, Gary E McPherson, Miriam A Mosing, Sarah J Wilson","doi":"10.1007/s10519-026-10254-4","DOIUrl":"10.1007/s10519-026-10254-4","url":null,"abstract":"People evaluate their singing ability to varying degrees of accuracy, but why these individual differences occur is largely unknown. Objectively evaluated, everyday singing ability is influenced by both genetic and environmental factors. Since singing self-evaluation (SSE) strongly correlates with everyday singing ability, it is possible that the same factors might influence both. Using a classical twin design, we estimated genetic and environmental influences on SSE and its phenotypic relationship with everyday singing ability in Australian twins (N = 996). Two validated measures of SSE were used: a single self-report item assessing overall singing ability (SSE-Single) and a four-item composite measure (SSE-Factor). Both measures showed significant genetic (SSE-Single A = 42%; SSE-Factor A = 53%) and unshared environmental influences (both E = 29%). Phenotypic correlations between the SSE measures and everyday singing ability ranged from rp = 0.67 - 0.68 and were significantly influenced by genetic, shared and unshared environmental factors (SSE-Single A = 41%, C = 51%, E = 8%; SSE-Factor A = 37%, C = 52%, E = 11%). Strong genetic correlations (rg = 0.63 - 0.64) were observed between SSE measures and everyday singing ability, as well as between both SSE measures (rg = 0.82), suggesting shared underlying genes. Taken together, our findings indicate that both genes and environments affect how individuals evaluate their own singing ability and how accurate these evaluations are compared to their actual ability.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"66-79"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Genetic and Environmental Influences on Age at Initiation of Gaming. 遗传和环境对游戏开始年龄影响的性别差异。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-02-28 DOI: 10.1007/s10519-026-10253-5

Yubin Kim, Yoon-Mi Hur

{"title":"Sex Differences in Genetic and Environmental Influences on Age at Initiation of Gaming.","authors":"Yubin Kim, Yoon-Mi Hur","doi":"10.1007/s10519-026-10253-5","DOIUrl":"https://doi.org/10.1007/s10519-026-10253-5","url":null,"abstract":"The link between age at initiation of gaming (AAIG) and gaming addiction (GA) is well established, but the genetic and environmental etiology of AAIG remains poorly understood due to the scarcity of genetically informative studies. This study investigated genetic and environmental influences on AAIG using data from 1,394 South Korean adult twins (mean age = 23.0 ± 2.6 years; range = 19 to 30 years). Tetrachoric correlations for AAIG were 0.96 (95% CI = 0.92, 0.98) for monozygotic (MZ) male, 0.84 (95%CI = 0.69, 0.92) for dizygotic (DZ) male, 0.80 (95%CI = 0.73, 0.85) for MZ female, 0.56 (95% CI = 0.38, 0.70) for DZ female, and 0.54 (95% CI = 0.36, 0.68) for opposite-sex DZ twins. Model-fitting analysis incorporating sex differences revealed that shared environmental factors dominated (71%; 95% CI = 39%, 89%), with a smaller but significant genetic component (24%; 95% CI = 6%, 57%) in males, whereas genetic factors played a larger role (59%; 95% CI = 37%, 77%), while shared environmental (21%; 95% CI = 5%, 41%) and non-shared environmental influences (20%; 95% CI = 15%, 27%) were also significant in females. Our findings highlight sex differences in genetic and shared environmental influences in the etiology of AAIG. Effective prevention and intervention strategies for GA should consider genetic vulnerability to AAIG and family exposures, incorporating sex-specific approaches.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public Perception of Genetic Research on Sexual Orientation and Gender Identity. 公众对性取向和性别认同基因研究的认知。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-02-28 DOI: 10.1007/s10519-026-10257-1

Briana L Kunstman, Allison M Woosley, Jaime Derringer

{"title":"Public Perception of Genetic Research on Sexual Orientation and Gender Identity.","authors":"Briana L Kunstman, Allison M Woosley, Jaime Derringer","doi":"10.1007/s10519-026-10257-1","DOIUrl":"https://doi.org/10.1007/s10519-026-10257-1","url":null,"abstract":"Genetic research on sexual orientation and gender identity (SOGI) receives disproportionate public attention compared to the limited depth of existing research. However, newer genetically informative datasets include more detailed measures of SOGI than were previously available, establishing the potential for rapid expansion of research in this area. Prior research on the relationship between genetic knowledge and social attitudes related to genetics research suggests the potential to both reduce stigma and reify genetic determinism, highlighting the need to explore stakeholder opinions regarding the impacts of genetics research. We explored public attitudes toward and anticipated risks and benefits of SOGI genetic research. Survey responses from 338 participants were collected via social media. In regression analyses, higher scores on genetic knowledge were related to more negative attitudes toward SOGI genetics research (β = -0.16) and participants who held sexual and/or gender minority (SGM) identities had more negative attitudes toward SOGI genetic research than non-SGM participants (β = -0.17). In qualitative analysis of responses to open-ended questions, participants expressing a diverse range of formal scientific training and political attitudes consistently questioned the usefulness of SOGI genetic research. Ethical concerns were described as unresolvable, both in broad terms and concerning specific applications that are currently plausible, especially related to data privacy and politicizing research results, regardless of the content. We discuss public attitudes toward SOGI genetic research in the context of the broader literature on the social, legal, and ethical implications of behavior genetics research and provide recommendations for planning and communicating SOGI genetics research.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the Danish Twin Registry into its Third Century: Secular Trends in Twin Births and Survival. 扩展丹麦双胞胎登记进入第三个世纪：双胞胎出生和生存的长期趋势。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-02-18 DOI: 10.1007/s10519-026-10255-3

Kaare Christensen, Lisbeth Aagaard Larsen, Dorthe Almind Pedersen, Jacob von Bornemann Hjelmborg, Kirsten Ohm Kyvik, Marianne Nygaard

{"title":"Expanding the Danish Twin Registry into its Third Century: Secular Trends in Twin Births and Survival.","authors":"Kaare Christensen, Lisbeth Aagaard Larsen, Dorthe Almind Pedersen, Jacob von Bornemann Hjelmborg, Kirsten Ohm Kyvik, Marianne Nygaard","doi":"10.1007/s10519-026-10255-3","DOIUrl":"https://doi.org/10.1007/s10519-026-10255-3","url":null,"abstract":"The Danish Twin Registry has been expanded several times since its establishment in 1954. Here we describe the inclusion of the Danish 2001-2021 twin birth cohorts and the merging with the Danish 1870-2000 twin birth cohorts that enabled us to analyze changes in both twin birth frequency and survival over three centuries. Through Danish nationwide registers, 22,680 twin pairs born in Denmark in the period 2001-2021 were identified and contacted. Response to an electronic questionnaire including similarity questions for zygosity classification was obtained from 15,005 pairs (66.2%). Genetic markers for a subsample revealed a zygosity misclassification rate of 5.3%. From the mid-19th to the mid-20th century, twinning rate was relatively stable followed by an unexplained one third reduction from 1950 to 1970. A doubling occurred from the 1980s to the 2000s due to increasing maternal age at birth and, most importantly, Medically Assisted Reproduction (MAR). Changes in MAR procedures have since resulted in a marked decline, bringing the contemporary twinning rate back to the level of the 19th century. In the 19th century, 43% of twins died before age 6; in the 1970s, the number was 5.4% and in the most recent 21st century cohorts, it was 2.0%. In all three centuries studied, the twin mortality before age 6 was 2-5 times higher in twins compared to singletons. However, large studies of the Danish and other Scandinavian twin cohorts suggest that twin-singleton differences generally vanish with age and, for more recent birth cohorts, are few and generally small after childhood.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-twin Control Analyses Reveal Genetic Contributions to SES Influences in Mean Level and Longitudinal Change in Physical Aging. 双胞对照分析揭示SES对生理衰老平均水平和纵向变化的遗传影响。

IF 2.4 4区医学

Behavior Genetics Pub Date : 2026-02-18 DOI: 10.1007/s10519-026-10256-2

Deborah Finkel, Brian K Finch, Margaret Gatz, Ida K Karlsson, Chandra A Reynolds, Miriam Mosing, Sneha Nimmagadda, Malin Ericsson

{"title":"Co-twin Control Analyses Reveal Genetic Contributions to SES Influences in Mean Level and Longitudinal Change in Physical Aging.","authors":"Deborah Finkel, Brian K Finch, Margaret Gatz, Ida K Karlsson, Chandra A Reynolds, Miriam Mosing, Sneha Nimmagadda, Malin Ericsson","doi":"10.1007/s10519-026-10256-2","DOIUrl":"10.1007/s10519-026-10256-2","url":null,"abstract":"Socioeconomic status (SES) predicts age-related changes in health status; however, the source of SES-health associations is heavily debated. Twin studies allow tests of causal hypotheses by modeling within and between twin pair differences in longitudinal latent growth curve models (LGCM) of physical aging, examining level of functioning and rate of change with age. Three longitudinal twin studies of aging (mean age at baseline = 71.36, SD = 10.7) from the Swedish Twin Registry (N = 1369) included up to 27 years of follow-up on a Functional Aging Index (FAI) consisting of lung function, grip strength, walking speed, and self-report sensory functioning. SES indicators included education, financial strain, and occupation-based socioeconomic position. Pair means (between family effect) and within pair differences (within family effect) for SES were included as covariates of both intercept and slopes in a two-slope LGCM (intercept at age 75); models were corrected for sex and parental SES. LGCM results were compared across the full sample, then separately for both monozygotic and dizygotic twin pairs. Results indicated genetic confounding in the associations between multiple SES indicators and the FAI intercept. Additionally, the relationship between education longitudinal change in physical aging up to age 75 was subject to genetic confounding. These patterns were replicated among men. In contrast, findings for women pointed to shared environmental influences rather than genetic confounding, although statistical power was reduced in sex-stratified analyses. Results highlight the importance of considering the timing of socioeconomic exposures and gendered life-course trajectories when examining health inequalities in aging.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing and Teaching Curriculum to Reduce Genetic Essentialism in University Classrooms. 减少大学课堂遗传本质主义的课程开发与教学。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-02-16 DOI: 10.1007/s10519-026-10251-7

Kathryn Fiuza Malerbi, Andrew Brubaker, Monica Weindling, Katherine N Thompson, Christine Miriam Habib, Yeongmi Jeong, Brian M Donovan, Robbee Wedow

{"title":"Developing and Teaching Curriculum to Reduce Genetic Essentialism in University Classrooms.","authors":"Kathryn Fiuza Malerbi, Andrew Brubaker, Monica Weindling, Katherine N Thompson, Christine Miriam Habib, Yeongmi Jeong, Brian M Donovan, Robbee Wedow","doi":"10.1007/s10519-026-10251-7","DOIUrl":"10.1007/s10519-026-10251-7","url":null,"abstract":"Genetic essentialism is a social-cognitive prejudice involving the belief that people of the same race share genes that make them behaviorally, physically, and cognitively uniform and also genetically distinct from other other races, despite the fact that race and ethnicity are socially constructed categories that lack any biological basis. It can be exacerbated by a basic, Mendelian-based genetics and biology education. To combat this phenomenon, the Humane Genomics Literacy (HGL) curriculum was developed and has been highly effective in both increasing students' understanding of genetics and reducing students' belief in genetic essentialism. In this article, we focus on how to teach the HGL curriculum in the classroom. We carefully describe the original HGL curriculum in terms of content and the unique pedagogical practices that the curriculum includes. Next, we discuss how to adapt the curriculum for the university classroom. In doing so, we allow readers to see inside the HGL curriculum for the first time and to gain a better understanding of how each instructional support and each conceptual understanding are built from lesson to lesson. We aim to provide a guide for genetics educators who are interested in using HGL in their own university classrooms.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics. 从基因组到对话：精神病学遗传学的拓展和参与。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-02-05 DOI: 10.1007/s10519-025-10246-w

Helena L Davies, Niamh M Ryan, Kylie K Reed, Natasha Berthold, Jared G Maina, Ruth McNulty, Abigail R Ter Kuile, Ofure A Ubah, Eva Trujillo-ChiVacuan, Eva C Schulte, Jessica Mei Kay Yang, Melanie M de Wit, Estela Maria Bruxel, Joseph D Deak, Maria Koromina, Thomas Sollie, Alice Braun, Cynthia M Bulik, Cathryn M Lewis, Danielle M Dick, Jerry Guintivano, Howard J Edenberg

{"title":"From Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics.","authors":"Helena L Davies, Niamh M Ryan, Kylie K Reed, Natasha Berthold, Jared G Maina, Ruth McNulty, Abigail R Ter Kuile, Ofure A Ubah, Eva Trujillo-ChiVacuan, Eva C Schulte, Jessica Mei Kay Yang, Melanie M de Wit, Estela Maria Bruxel, Joseph D Deak, Maria Koromina, Thomas Sollie, Alice Braun, Cynthia M Bulik, Cathryn M Lewis, Danielle M Dick, Jerry Guintivano, Howard J Edenberg","doi":"10.1007/s10519-025-10246-w","DOIUrl":"https://doi.org/10.1007/s10519-025-10246-w","url":null,"abstract":"Outreach in psychiatric genetics bridges the gaps across research advancements, clinical practice, and public understanding. Effective communication with a range of audiences faces multiple challenges, including the complex nature of psychiatric disorders and of genetic findings, the chronicled and ongoing misuse of genetic data, and the rapid growth of direct-to-consumer genetic testing. This is particularly true in the internet and social media era, which has accelerated the spread of inaccurate information with serious consequences, including perpetuating stigma and increasing shame. Yet a significant gap remains in outreach: a recent survey found that only 51% of psychiatric genetics researchers participate in outreach, largely attributed to their perceived lack of skill and support. The Psychiatric Genomics Consortium (PGC) developed an Outreach Committee to organize and catalyze initiatives including: the Worldwide Lab, an online seminar series covering new and important approaches that is then posted on YouTube; the PGC Video Textbook, which has resources for clinicians, researchers, educators, and the broader public; patient and family engagement programs; and social media campaigns designed to inform both researchers and affected communities about new developments in psychiatric genetics. These initiatives were developed to demystify psychiatric genetics research and empower broad audiences with reliable, actionable information. Along with research and traditional teaching, the psychiatric genomics community should continue to prioritize and recognize engagement as a core component of our academic mission and values.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imputing Parental Genotypes Through Mendelian Imputation: Ethical and Legal Considerations. 通过孟德尔归算推断亲代基因型：伦理和法律考虑。

IF 2.4 4区医学

Behavior Genetics Pub Date : 2026-01-08 DOI: 10.1007/s10519-025-10250-0

Margot P van de Weijer, Emily Bassett, Paul S Appelbaum, Evan J Giangrande, Lucas J Matthews

{"title":"Imputing Parental Genotypes Through Mendelian Imputation: Ethical and Legal Considerations.","authors":"Margot P van de Weijer, Emily Bassett, Paul S Appelbaum, Evan J Giangrande, Lucas J Matthews","doi":"10.1007/s10519-025-10250-0","DOIUrl":"10.1007/s10519-025-10250-0","url":null,"abstract":"Mendelian imputation is a promising method for imputing missing parental genotypes and estimating direct and indirect genetic effects. While the method has clear scientific benefits, so far there has been little reflection on its legal and ethical implications. In this perspective, we discuss these considerations and provide recommendations on transparent use of this method. We argue that imputed genotypes should be considered identifiable, personal data, and that using these data requires informed consent. We distinguish different scenarios where consent may be missing, such as an individual previously not having been contacted for consent, or a person who was contacted but did not reply or did not wish to participate. Informed consent is important across all these scenarios as it allows individuals to decide whether they want to participate in a study. In addition, transparent communication on how people's data are used is important for public perception of science, and a failure to communicate this may contribute to mistrust. We discuss potential harmful applications of Mendelian imputation, and how robust regulatory frameworks guiding Institutional Review Boards on novel advanced methods such as Mendelian imputation are currently missing. This complicates decision making, especially when researchers argue for public interest as a lawful basis for foregoing consent. We end with a set of recommendations for (1) future genetic research projects for which Mendelian imputation will be possible; (2) research that has already been conducted using this method; and (3) the inclusion of ethical considerations in the publication of novel techniques/analyses.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0