Basic and Clinical Neuroscience最新文献

{"title":"The Effect of a Structured and Progressive Rhythmiccognitive Dual-task Exercise Program on Impulsivity in Children With ADHD.","authors":"Behzad Amini, Seyed Ali Hosini, Ebrahim Pishyareh, Enayatollah Bakhshi","doi":"10.32598/bcn.2025.7630.1","DOIUrl":"10.32598/bcn.2025.7630.1","url":null,"abstract":"<p><strong>Introduction: </strong>Impulsivity is a core diagnostic feature of attention-deficit/hyperactivity disorder (ADHD) in children. Deficits in inhibitory control can lead to behavioral issues and difficulties in interpersonal communication. Due to the limited use of medication at early ages and the broad impact of impulsivity on developmental domains, there is an increasing need for effective interventional approaches. This study aimed to evaluate the effectiveness of a structured dual-task exercise program that incorporates rhythmic movements preferred by children, along with visual and auditory cues, in reducing impulsivity and its related symptoms.</p><p><strong>Methods: </strong>This randomized clinical trial was conducted in 60 children aged 6 to 12 years who were diagnosed with ADHD. Participants were allocated equally into the intervention (dual-task) and control groups using covariate adaptive randomization. Both groups received 18 45-minute intervention sessions over a period of 6 weeks. Evaluations were performed at baseline, immediately after the intervention, and one month after the intervention to assess the sustainability of outcomes using the integrated visual and auditory continuous performance test and the Cambridge neuropsychological testing automated battery (CANTAB) assessments.</p><p><strong>Results: </strong>Significant improvements were found in the intervention group in all response control and prudence measures, including auditory and visual subdomains (P<0.001). Reaction time indicators also demonstrated significant between-group differences (P<0.001). At the one-month follow-up, response control and auditory response control measures showed no significant differences; however, other outcomes continued to show significant improvements.</p><p><strong>Conclusion: </strong>The findings suggest that a rhythmic-cognitive dual-task training program can have a positive impact on symptoms of impulsivity and enhance inhibitory control in children with ADHD.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 5","pages":"949-964"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subthalamic Nucleus Deep Brain Stimulation in Early-onset Parkinson's Disease: Clinical Outcomes in LRRK2 Mutation Carriers Compared to Non-Carriers.","authors":"Hicham El Otmani, Mohamed Daghi, Maha Abdallaoui, Bouchra El Moutawakil, Mohammed Abdoh Rafai, Nadia Tahiri Jouti, Suzanne Lesage, Abdelhakim Lakhdar","doi":"10.32598/bcn.2025.7579.1","DOIUrl":"10.32598/bcn.2025.7579.1","url":null,"abstract":"<p><strong>Introduction: </strong>Subthalamic nucleus deep brain stimulation (STN-DBS) is an established treatment for early-onset Parkinson's disease (EOPD). While the effect of STN-DBS on patients with <i>LRRK2 G2019S</i> mutation has been largely investigated, data specific to EOPD patients with this mutation remain scarce. This study examines the impact of the <i>LRRK2 G2019S</i> mutation on STN-DBS outcomes in EOPD patients in Morocco, a developing country where such treatment is challenging to provide.</p><p><strong>Methods: </strong>A prospective cohort study was conducted at the University Hospital of Ibn Rochd in Casablanca. Genomic DNA was analyzed for the <i>LRRK2 G2019S</i> mutation, and clinical data were collected before and after surgery. Motor outcomes, including dyskinesia, motor fluctuations, and reduction in levodopa equivalent daily dose (LEDD), were assessed one year post-DBS.</p><p><strong>Results: </strong>Seventeen EOPD patients who underwent STN-DBS were included, with 10(58.8%) being carriers of the <i>LRRK2 G2019S</i> mutation. The mean age of participants was 57.2±8.4 years, with a mean age at onset of 37.9±6.2 years. Motor fluctuations were present in 88.2% of patients, and 94.1% experienced dyskinesia. Following DBS, both mutation carriers and non-carriers demonstrated significant improvements in motor symptoms, with a mean improvement of 61.3% in the unified PD rating scale (UPDRS) III. Dyskinesia and motor fluctuations, as measured by specific UPDRS IV items, improved by 77.1% and 83.8%, respectively, with a mean LEDD reduction of 60.6%. Improvements were comparable between <i>LRRK2 G2019S</i> carriers and non-carriers. All patients were satisfied with the treatment, though one patient had a hardware-related infection.</p><p><strong>Conclusion: </strong>STN-DBS is effective in managing motor symptoms and reducing medication needs in EOPD patients, regardless of <i>LRRK2 G2019S</i> mutation status.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 5","pages":"941-948"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an Automated Training Device for Macaque Monkeys.","authors":"Jalaledin Noroozi, Mahsa Ahmadi, Atlas Shahamati, Ehsan Rezayat, Mohammad-Reza A Dehaqani","doi":"10.32598/bcn.2024.1191.1","DOIUrl":"10.32598/bcn.2024.1191.1","url":null,"abstract":"<p><strong>Introduction: </strong>Training macaques for cognitive and behavioral tasks is often time-consuming, stressful, and requires extensive human involvement. Traditional chair-based methods may take weeks or months and can negatively affect animal welfare. To address these challenges, we developed an automated, cage-based training device.</p><p><strong>Methods: </strong>Two adult male rhesus macaques were trained using the device step-by-step on working memory, delayed match-to-sample, starting from simple screen touches and progressing to the full task.</p><p><strong>Results: </strong>The monkeys interacted well with the device, and the system reduced stress by eliminating the need for chair restraint. Training time was shortened, and both monkeys successfully learned the task within 30-33 days.</p><p><strong>Conclusion: </strong>This automated training device provides an efficient, cost-effective, and welfare-friendly alternative to conventional training methods for monkeys. It shortens training duration, improves task acquisition, and enhances enrichment, offering a promising tool for neuroscience research with non-human primates.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 5","pages":"845-856"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy and Safety of Dual Versus Single Antiplatelet Therapy in Lacunar Stroke.","authors":"Sandhya Manorenj, Srikant Jawalkar","doi":"10.32598/bcn.2025.2973.1","DOIUrl":"10.32598/bcn.2025.2973.1","url":null,"abstract":"<p><strong>Introduction: </strong>Lacunar stroke, comprising 18% of ischemic stroke, is the second most common subtype of stroke in India. Available data on the effect of dual antiplatelet treatment with aspirin plus clopidogrel versus single antiplatelet therapy with aspirin alone, and their doses in lacunar stroke, are very limited. Our study aimed to investigate the efficacy, safety, and tolerability of dual versus single antiplatelet therapy in patients with a recent occurrence of lacunar stroke.</p><p><strong>Methods: </strong>This research was a prospective, single-center study conducted at the Department of Neurology. Patients with recent occurrence of lacunar stroke were randomly divided into 4 groups to receive aspirin 150 mg (group 1), aspirin 150 mg plus clopidogrel 75 mg (group 2), aspirin 75 mg plus clopidogrel 75 mg (group 3), and aspirin 75 mg (group 4) once daily. They were then closely monitored for 90 days.</p><p><strong>Results: </strong>A total of 360 patients were recruited and followed up for 90 days. The mean age of the patients was 57.8±14.1 years. Also, 188 patients (52.2%) were male. Recurrence of ischemic stroke occurred highest in group 4(22%), with no recurrence in group 2. Comparisons of recurrence of ischemic stroke between group 1 and group 4 (95% CI, 2.6829%, 31.73551%) and between group 3 and group 4 (95% CI, 3.9439%, 32.1542%) were significant (P<0.05). Haemorrhagic events occurred among recipients on dual antiplatelet therapy (DAPT).</p><p><strong>Conclusion: </strong>Efficacy-wise, group 2, which received 150 mg of aspirin plus 75 mg of clopidogrel, was found to be superior to the other groups in preventing lacunar stroke. Groups with DAPT manifested a worrisome trend of bleeding events.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 5","pages":"965-974"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Report of Lumbar Disk Herniation Treatment Outcomes: Percutaneous Laser Disk Decompression vs Open Microdiscectomy.","authors":"Masoud Khadivi, Ali Ahmadzadeh Amiri, Navid Moghadam, Amir Ahmadzadeh Amiri, Mohammad Eslamian, Mohammad Zarei, Mersad Moosavi, Milad Shafizadeh, Alireza Borghei, Ramin Kordi, Mohsen Rostami","doi":"10.32598/bcn.2023.3845.2","DOIUrl":"10.32598/bcn.2023.3845.2","url":null,"abstract":"<p><strong>Introduction: </strong>Lumbar disk herniation (LDH) is one of the most common pathologies leading to radiculopathy. Open microdiscectomy is the gold standard of LDH treatment. However, minimally invasive techniques such as percutaneous laser disk decompression (PLDD) are gaining growing attention. In this study, we retrospectively reviewed the clinical outcomes of patients who underwent PLDD and compared them with those of a group of patients who underwent open microdiscectomy.</p><p><strong>Methods: </strong>Our report included patients diagnosed with protruded LDH with severe refractory pain for at least 6 to 8 weeks who underwent the interventions. Baseline outcome parameters were recorded before the procedures, and questionnaires were completed at two follow-up sessions. Pain intensity was measured using the visual analog scale (VAS). Additionally, patients were asked to complete the 36-item short-form health survey (SF-36) to report their quality of life. Finally, we used the Oswestry disability index (ODI) to obtain information about patients' daily functional status.</p><p><strong>Results: </strong>A total of 165 patients were enrolled in the study. At the final follow-up, there was no statistically significant difference in the VAS level between the groups. However, the differences between the two groups regarding the SF-36 and ODI were statistically significant.</p><p><strong>Conclusion: </strong>Our study report showed that both methods significantly improved the clinical outcomes of the patients with protruded disk herniation.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 5","pages":"869-878"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlighting the Role of Neurofilament Light and Medium Polypeptides in Peripheral Diabetic Neuropathy.","authors":"Vahid Mansouri, Mostafa Rezaei-Tavirani, Farshad Okhovatian","doi":"10.32598/bcn.2021.946.1","DOIUrl":"10.32598/bcn.2021.946.1","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus is a chronic disease caused by insulin uptake or deficiency. Side effects of diabetes are numerous, according to the severity of the disease. Diabetes could harm the peripheral nerves, with chronic pain leading to nerve damage known as diabetic neuropathy (DN). Signs and symptoms of DN are sharp pains, numbness, and tingling. Distal symmetric polyneuropathy is the most common nerve injury during DN. Accordingly, this study screens candidate genes related to sural nerve DN (SDN) to find the critical ones.</p><p><strong>Methods: </strong>Gene expression data from diabetic patients with and without progressive sural nerve neuropathy (GSE24290) were included in the analysis. GEO2R was applied to the first step analysis to find the significantly differentially expressed genes (DEGs). The queried significant DEGs, along with their first 100 neighbors, were included in a network using the Cytoscape software. The network was analyzed using the Cytoscape network analysis application, and the central nodes were identified.</p><p><strong>Results: </strong>A total of 26 significant DEGs that were extracted from the gene expression profiles, plus 100 first neighbors, were interacted to form the network. <i>INS</i>, <i>ALB</i>, <i>AKT1</i>, <i>APP</i>, <i>SNAP25</i>, <i>NEFL</i>, <i>GFAP</i>, <i>IL6</i>, <i>NEFM</i>, <i>TNF</i>, <i>MAPT</i>, <i>GAP43</i>, and <i>MBP</i> were identified as 13 hubs of the network. <i>NEFL</i> and <i>NEFM</i> were highlighted as the queried hub genes. Insulin, as the top hub node, was determined among all interacted genes (the queried and added genes).</p><p><strong>Conclusion: </strong><i>INS</i>, <i>NEFL</i>, and <i>NEFM</i> are key genes in DN, which are involved in metabolism regulation and intracellular transportation into axons and dendrites, respectively.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 4","pages":"691-700"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated MATLAB Toolbox for fMRI Visualization and Data Conversion.","authors":"Hussain A Jaber, Hadeel K Aljobouri, Orhan M Koçak, Oktay Algin, Ilyas Çankaya","doi":"10.32598/bcn.2021.1694.1","DOIUrl":"10.32598/bcn.2021.1694.1","url":null,"abstract":"<p><strong>Introduction: </strong>Working with functional magnetic resonance imaging (fMRI) often involves engaging with multiple file formats and complex viewers. In this study, we developed a novel platform as a visualization and conversion fMRI (VCfMRI) MATLAB toolbox for fMRI data.</p><p><strong>Methods: </strong>The VCfMRI was developed to read and write 3D fMRI volumes in DICOM, NIfTI, ANALYZE, and MAT formats and convert between them, on a single user-friendly platform. It includes 62 functions across seven graphical user interface modules for conversion, batch read/write, and orthogonal viewing (sagittal, coronal, horizontal). This toolbox also supports overlaying statistical maps on anatomical images with adjustable thresholds. We built and tested VCfMRI using real datasets from a scanner (3T, Siemens Co.) at UMRAM, Bilkent University.</p><p><strong>Results: </strong>VCfMRI successfully converted and visualized all supported formats in one environment, enabling synchronized 3D views and functional overlays with interactive threshold control, streamlining previously fragmented steps.</p><p><strong>Conclusion: </strong>The VCfMRI toolbox provides a simple and efficient solution for fMRI data conversion and visualization. It simplifies the handling of fMRI datasets across different formats, which is especially beneficial for physicians, healthcare specialists, and researchers who face challenges in processing and visualizing multi-format neuroimaging data.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 4","pages":"701-714"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural MRI Biomarkers Related to Cognitive Recovery and Resistance to Recovery Using the Penalized Mixture Cure Model.","authors":"Vida Pahlevani, Farzad Eskanadri, Mostafa Almasi-Dooghaee, Ebrahim Hajizadeh","doi":"10.32598/bcn.2025.7352.1","DOIUrl":"10.32598/bcn.2025.7352.1","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive trajectories in individuals with a baseline clinical dementia rating (CDR) score of 0.5 vary widely, ranging from recovery (stable reverse migration) to resistance to recovery. Identifying predictors of these trajectories is essential for targeted interventions. This study aimed to investigate baseline structural magnetic resonance imaging (MRI) features and clinical factors associated with the rate of recovery and the likelihood of resistance to it, using a penalized mixture cure model (MCM).</p><p><strong>Methods: </strong>Data from 185 individuals with a baseline CDR of 0.5 in the OASIS-3 database were analyzed. OASIS-3 is a retrospective compilation of data for 1378 participants that were collected across several ongoing projects through the WUSTL Knight ADRC over 30 years. Structural MRI features and clinical measures were assessed using the latency and incidence components of an MCM. The latency component evaluated factors influencing recovery rates, while the incidence component identified predictors of resistance.</p><p><strong>Results: </strong>The latency component revealed that increasing right rostral middle frontal thickness (hazard ratio [HR]=2.06) was linked to faster recovery, while right frontal pole thickness (HR=0.48) predicted slower recovery. The cure component identified left bankssts volume (odds ratio [OR]=2.21) as a key predictor of resistance, whereas left pars orbitalis thickness (OR=0.56) was protective. Notably, right supramarginal thickness was paradoxically associated with both faster recovery (HR=1.24) and increased resistance (OR=1.48), potentially acting as a proxy for both compensatory mechanisms and maladaptive changes.</p><p><strong>Conclusion: </strong>The MCM revealed complex, context-dependent roles of structural MRI features in recovery and resistance trajectories, with frontal and temporal regions pivotal to cognitive outcomes. These findings highlight the value of MCM in advancing personalized therapeutic strategies and understanding recovery dynamics.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 4","pages":"787-804"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulatory Effects of CB1 Receptors on Cognitive Performance in Rat Model of Empathic Pain.","authors":"Fatemeh Rahimi Shourmasti, Raheleh Rafaiee, Seyedeh Masoumeh Seyedhosseini Tamijani, Mehdi Khodamoradi, Mohammad Shabani, Hamed Ghazvini","doi":"10.32598/bcn.2025.2297.2","DOIUrl":"10.32598/bcn.2025.2297.2","url":null,"abstract":"<p><strong>Introduction: </strong>Cannabinoid receptor type 1 (CB1) is extensively distributed across brain regions that are crucial for emotional processing, social cognition, and anxiety, including the prefrontal cortex, amygdala, and hippocampus. Dysregulation of CB1 receptors (CB1Rs) has been associated with several disorders characterized by impaired empathy, social behavior, and anxiety. Accordingly, this study investigates the modulatory role of CB1Rs in social interaction and anxiety in an empathic pain model in rats.</p><p><strong>Methods: </strong>A total of 48 adult male Wistar rats were used (n=8 for each group). One sibling received formalin injection into the hind paw five times within nine days (demonstrator), and the other siblings reported pain (observer) while being treated with dimethyl sulfoxide (DMSO), the CB1R agonist WIN 55,212-2 (WIN; 3 mg/kg, intraperitoneal), or the CB1R antagonist rimonabant (1 mg/kg intraperitoneal). Treatments were administered intraperitoneally 30 min before behavioral tests conducted on day 10, which were used to assess social behavior and anxiety.</p><p><strong>Results: </strong>Empathic pain can impair social behavior and elicit anxiety-like effects. Rimonabant was effective in ameliorating deficits induced by empathic pain; conversely, WIN did not have a significant effect.</p><p><strong>Conclusion: </strong>CB1Rs play a modulatory role in social contagion. This modulation may provide new therapeutic targets for conditions, such as autism spectrum disorder, schizophrenia, and other psychological disorders characterized by impaired empathy and dysregulated social behavior associated with the CB1 signaling pathway.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 4","pages":"715-726"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of Center of Pressure Measures in Chronic Stroke Survivors: Influence of Motor and Cognitive Dual-tasking.","authors":"Mitra Parsa, Iraj Abdollahi, Hossein Negahban, Mohammad Ali Sanjari, Enayatollah Bakhshi, Haniyeh Fakur Haddadiyan","doi":"10.32598/bcn.2025.6958.1","DOIUrl":"10.32598/bcn.2025.6958.1","url":null,"abstract":"<p><strong>Introduction: </strong>Reliable balance measures are crucial for effective stroke rehabilitation. This study examines the between-day and within-day reliabilities of the center of pressure (CoP) measures in chronic stroke survivors in different standing positions under the influence of motor and cognitive dual-tasking.</p><p><strong>Methods: </strong>Sixteen people (49.31±15.5 years, 5 females) with chronic stroke were assessed in two sessions, 48 hours apart. Participants completed three balance control conditions: Single-task, motor dual-task, and cognitive dual-task. They performed three trials of open-eye quiet standing and semi-tandem standing. Three trials of closed-eye quiet standing were conducted in the single-task condition. A 2-way random model of the intraclass correlation coefficient (ICC), standard error of measurement (SEM), and minimal detectable change (MDC) were calculated for CoP mean velocity, anterior-posterior (AP) and medial-lateral (ML) mean velocity, the standard deviation (SD) of AP and ML velocity, and sway area.</p><p><strong>Results: </strong>Within-day ICC values were higher than between-day values (ICC: 0.78-0.96). Mean velocity and Mean±SD of velocity in the AP direction showed the highest relative and absolute reliabilities in an open-eye quiet standing position (ICC: 0.82-0.92, SEM: 0.67-1.24). Dual-tasking could increase the reliability of the CoP measures, except for the sway area (ICC: 0.53-0.93 changed to 0.84-0.96). MDCs ranged from 1.03 to 7.77 mm/s for velocity-based variables.</p><p><strong>Conclusion: </strong>Assessing the postural control system during dual-task conditions provides more reliable CoP measures, especially in a semi-tandem standing position. These findings can provide clinicians with valuable insights into detecting specific balance problems that post-stroke individuals encounter.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 4","pages":"763-776"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}