Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine最新文献_第5页

CHARACTERISTICS OF BLOOD PLASMA PROTEOME IN THE HEALTHY HUMAN DURING A YEAR-LONG WINTERING ON THE ANTARCTIC STATION «VOSTOK» UNDER THE CONDITIONS OF HYPOBARIC HYPOXIA AND HYPOCAPNIA 健康人在南极“沃斯托克”站一年的低气压缺氧和低碳酸血症条件下的血浆蛋白质组特征

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2023-01-01 DOI: 10.21687/0233-528x-2023-57-4-49-57

I.M. Larina, D.N. Kashirina, L.Kh. Pastushkova, A.G. Goncharova, K.S. Korotaev, A.S. Kononikhin, A.G. Brzhozovsky, E.A. Ilyin, O.I. Orlov

引用次数: 0

PREVAILING PHENOMENA IN COSMONAUTS' COMMUNICATION WITHIN THE CREW – MISSION CONTROL CENTER COMMUNICATION SYSTEM AND WANTED MODIFICATIONS 航天员任务控制中心通信系统中航天员通信存在的普遍现象，需要改进

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2023-01-01 DOI: 10.21687/0233-528x-2023-57-4-20-25

N.S. Supolkina, D.M. Shved, A.K. Yusupova, V.I. Gushchin, О.О. Ryumin

引用次数: 0

STUDIES OF THE ACTIVITY OF THE CENTRAL RESPIRATORY MECHANISM IN LONG-TERM SPACE MISSIONS 长期太空任务中中枢呼吸机制活动的研究

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-3-5-11

V. Baranov, V. Katuntsev, G. Tarasenkov, E. P. Khudiakova, V. Sedelkova, I. Alferova, T. G. Shushunova

{"title":"STUDIES OF THE ACTIVITY OF THE CENTRAL RESPIRATORY MECHANISM IN LONG-TERM SPACE MISSIONS","authors":"V. Baranov, V. Katuntsev, G. Tarasenkov, E. P. Khudiakova, V. Sedelkova, I. Alferova, T. G. Shushunova","doi":"10.21687/0233-528x-2022-56-3-5-11","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-3-5-11","url":null,"abstract":"Interrelation between blood redistribution toward the upper part of the body in microgravity and changes in sensitivity of the central respiratory mechanism was studied with participation of 16 Russian members of the International space station crews (40-57 year-old males). Time of maximal voluntary breath-holding during inspiration (MVHins) and expiration (MVHexp) was measured prior to and following the 15-min low-body negative pressure test (LBNP, -25 mm Hg). Before launch, the baseline MVHins and MVHexp durations in the vertical position made up 61.9 ± 3.9 s and 24.5 ± 1.5 s, respectively. In the supine position, the parameters increased to 81.1 ± 5.6 s and 31.2 ± 1.9 s (p < 0.01), respectively. More significant increases of breath-holding were observed in space microgravity. On flight months 1-5, MVHins and MVHexp rose by 25–45.5 % and by 17.5–54.2 %, respectively. After return from space the initial values of the parameters were recovered. Comparison of the measurements made prior to and within 5-10 minutes after LBNP revealed a further gain in both MVHins and MVHexp. Breath-holding extension in the supine position (at 1 G) and in microgravity suggests attenuation of the respiratory center sensitivity to the physiological chemoreceptor stimuli, namely, increased РаСО2 and lowered РаО2. This attenuation is driven by the blood shift toward the upper part of the body that causes increase of the vascular pressure in the sinus carotid region and activation of baroreceptors. The conclusion results from the significantly greater time of breath-holding during LBNP in microgravity and supine position, as well as time reduction to the initial values on return from space mission.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67952718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VIRTUAL PROTOTYPING OF HELICOPTER-TYPE SPACECRAFT RADAR LANDING FOR UNDERSTANDING WHEN COSMONAUTS MAY TAKE A DECISION TO LAND A LUNAR MODULE MANUALLY 直升机型航天器雷达着陆的虚拟样机，以了解宇航员何时可能决定手动着陆登月舱

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-1-32-46

Y. Bubeev, V. Usov, B. Kryuchkov, A. A. Oboznov, M. Mikhaylyuk, V. I. Zhelonkin

引用次数: 0

UP-T0-DATE APPROACH TO IMPROVEMENT OF THE SYSTEM OF PROFESSIONAL PSYCHOLOGICAL SELECTION OF MILITARY TEST-PILOTS 军事试飞员职业心理选拔制度完善的最新途径

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-2-46-53

Yu.E. Pisarenko, А.О. Chulaevsky, M. Rybnikova

引用次数: 0

SPECIFIC FEATURES OF THE METHOD OF USING NOBLE GAS XENON WITH THE PURPOSE TO CORRECT STRESS-INDUCED DISORDERS IN PEOPLE OF DANGEROUS OCCUPATIONS 利用稀有气体氙气纠正危险职业人员应激性精神障碍的方法的具体特点

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-3-66-70

Y. Bubeev, А.V. Potapov, A. V. Ivanov

引用次数: 0

ВОЗМОЖНОСТЬ ПРИМЕНЕНИЯ КОМПЛЕКСНОГО МЕТОДА ЭКСПРЕСС-ОЦЕНКИ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ У КОСМОНАВТОВ 宇航员对中枢神经系统功能评估综合方法的可能性

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-5-51-59

М.А. Skedina, А.А. Kovaleva, M. Potapov

{"title":"ВОЗМОЖНОСТЬ ПРИМЕНЕНИЯ КОМПЛЕКСНОГО МЕТОДА ЭКСПРЕСС-ОЦЕНКИ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ У КОСМОНАВТОВ","authors":"М.А. Skedina, А.А. Kovaleva, M. Potapov","doi":"10.21687/0233-528x-2022-56-5-51-59","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-5-51-59","url":null,"abstract":"The ground-based studies with isolation (105- and 520-d isolation campaigns within the MARS-500 project) and modeled microgravity (5- and 21-d dry immersion) were aimed to test an integrated method of rapid assessment of the brain energy and electrical activities indicative of a current CNS status and adaptive changes. The method consists of synchronous recording electroencephalogram (EEG), constant potential level (CPL), and a number of psychophysiological tests. Analyzed parameters are a EEG pattern, relative power of EEG θ- (4–8 Hz), α- (8–13 Hz) and β-1- (13–25 Hz) waves, averaged CPL, ΔCPL values, and interhemispheric asymmetry. The method that measures CNS tension in response to psychological and physical stresses, adaptation to an unusual environment, fatigue and readaptation can be used to examine cosmonaut's CNS functioning prior to and after space mission, and in the period of post-mission recovery.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67956279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RELATIONSHIP AMONG THE LEVELS OF DOPAMINE, THYROID AND ANTISPERMAL ANTIBODIES IN POPULATIONS OF THE EUROPEAN AND ASIAN NORTH 欧洲和亚洲北部人群中多巴胺、甲状腺和抗精子抗体水平的关系

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-6-43-50

Е.V. Tipisova, V. Alikina, I. N. Molodovskaya, A. Elfimova, V. N. Zyabisheva

{"title":"RELATIONSHIP AMONG THE LEVELS OF DOPAMINE, THYROID AND ANTISPERMAL ANTIBODIES IN POPULATIONS OF THE EUROPEAN AND ASIAN NORTH","authors":"Е.V. Tipisova, V. Alikina, I. N. Molodovskaya, A. Elfimova, V. N. Zyabisheva","doi":"10.21687/0233-528x-2022-56-6-43-50","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-6-43-50","url":null,"abstract":"Autoantibodies to thyroglobulin (AntiTGs) and thyroperoxydase (AntiTPs) define in many ways the thyroid activity, whereas antispermal antibodies (ASABs) control the reproductive system. Most of these antibodies belong to immunoglobulin class G; dopamine is able to control the processes of antibody production. The aim was to demonstrate differences in contents of and relationship among dopamine, thyroid and thyroid and ASABs, thyroglobulin (TG) in male and female populations on the European and Asian North of the Russian Federation. We investigated 336 essentially healthy males and females at the age of 22 to 44 and 45 to 59 years respectively. Blood serum was analyzed for autoantibodies and plasma - for dopamine. High frequency of dopamine above the upper norm margin was observed in males; dopamine concentration was undetectable in females. Increased dopamine and decreased AntiTG combined with increased TG and ASABs in the Asian North population may suggest that dopamine inhibits AbtoTG synthesis and, therefore, stimulates the thyroid activity. In females, deviations in typically increased antithyroid antibodies and typically decreased TG were more often and could be connected with a higher occurrence of undetectable levels of dopamine that inhibits the autoantibodies production and contributes in autoimmunization. In addition to the dopamine and ASAB synergy effect on spermatozoids, negative correlations between their levels in the Asian and European North populations may also suggest an inhibitive effect of dopamine on ASAB. The dopamine effect on the autoimmune effect could be a building block for preventing the risk of autoimmune pathology among people living in the extreme North environment.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67957583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CONTRIBUTION OF mTORC1 AND GSK-3 TO THE REGULATION OF RIBOSOME BIOGENESIS IN RAT POSTURAL MUSCLE UNDER SIMULATED MICROGRAVITY mTORC1和GSK-3对模拟微重力下大鼠体位肌核糖体生物发生的调节作用

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-4-44-52

S. Rozhkov, K. Sharlo, B. Shenkman, Т.М. Mirzoev

{"title":"CONTRIBUTION OF mTORC1 AND GSK-3 TO THE REGULATION OF RIBOSOME BIOGENESIS IN RAT POSTURAL MUSCLE UNDER SIMULATED MICROGRAVITY","authors":"S. Rozhkov, K. Sharlo, B. Shenkman, Т.М. Mirzoev","doi":"10.21687/0233-528x-2022-56-4-44-52","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-4-44-52","url":null,"abstract":"The investigation was aimed to reveal a potential role of mechanistic target of rapamycin (mTORC1) and glycogen synthase kinase (GSK-3) in the regulation of ribosome biogenesis and protein synthesis in rat soleus muscle during simulated gravitational unloading. Wistar rats were subject to 7-day tail-suspension (hindlimb unloading) and treated with rapamycin (mTORC1 inhibitor) or AR-A014418 (GSK-3 inhibitor). Protein synthesis was measured with SUnSET. Phosphorylation of glycogen synthase-1 (GS-1) and ribosomal protein S6 (rpS6) was measured with the use of Western-blotting. Levels of 28S and 18S rRNA were determined using agarose gel electrophoresis. Expression of 47S pre-rRNA and c-Myc was assessed with RT-PCR. Gravitational unloading led to an increase in phosphorylation of GS-1 (a marker of GSK-3 activity) and inhibited phosphorylation of rpS6 (a marker of mTORC1 activity), expression of the ribosome biogenesis markers (total RNA РНК, 28S and 18S rRNA, 47S pre-rRNA, с-Myc) and protein synthesis in soleus muscle. GSK-3 inhibition prevented an increase in GS-1 phosphorylation and, partly, a reduction in the markers of both ribosomal biogenesis and protein synthesis. The mTORC1 inhibitor contributed to the phospho-rpS6 reduction but did not substantially influence the parameters of translational capacity and protein synthesis. To sum up, unlike mTORC1, an elevated GSK-3 activity can contribute to the inhibition of ribosome biogenesis and protein synthesis in rat soleus muscle under 7-day gravitational unloading.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67953923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECT OF SIMULATED GRAVITATIONAL UNLOADING ON M. SOLEUS SATELLITE CELLS 模拟重力卸载对比目鱼卫星细胞的影响

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-2-20-29

N. Vilchinskaya, S. Rozhkov, M. Komarova, R.B. Dmitrieva, B. Shenkman

引用次数: 2