RELATIONSHIP AMONG THE LEVELS OF DOPAMINE, THYROID AND ANTISPERMAL ANTIBODIES IN POPULATIONS OF THE EUROPEAN AND ASIAN NORTH

Abstract

Autoantibodies to thyroglobulin (AntiTGs) and thyroperoxydase (AntiTPs) define in many ways the thyroid activity, whereas antispermal antibodies (ASABs) control the reproductive system. Most of these antibodies belong to immunoglobulin class G; dopamine is able to control the processes of antibody production. The aim was to demonstrate differences in contents of and relationship among dopamine, thyroid and thyroid and ASABs, thyroglobulin (TG) in male and female populations on the European and Asian North of the Russian Federation. We investigated 336 essentially healthy males and females at the age of 22 to 44 and 45 to 59 years respectively. Blood serum was analyzed for autoantibodies and plasma - for dopamine. High frequency of dopamine above the upper norm margin was observed in males; dopamine concentration was undetectable in females. Increased dopamine and decreased AntiTG combined with increased TG and ASABs in the Asian North population may suggest that dopamine inhibits AbtoTG synthesis and, therefore, stimulates the thyroid activity. In females, deviations in typically increased antithyroid antibodies and typically decreased TG were more often and could be connected with a higher occurrence of undetectable levels of dopamine that inhibits the autoantibodies production and contributes in autoimmunization. In addition to the dopamine and ASAB synergy effect on spermatozoids, negative correlations between their levels in the Asian and European North populations may also suggest an inhibitive effect of dopamine on ASAB. The dopamine effect on the autoimmune effect could be a building block for preventing the risk of autoimmune pathology among people living in the extreme North environment.