Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine最新文献_第6页

PSYCHOPHYSIOLOGICAL ASPECTS OF EXECUTING SUPERMANEUVER FLIGHTS 执行超机动飞行的心理生理方面

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-2-39-45

A.V. Zatsepilin, A. V. Khomenko, V.N. Filatov, S. D. Chistov, V.V. Simukhin, Yu.Yu. Kisliakov

引用次数: 0

HYGIENIC ASPECTS OF THE NOISE GENERATED BY AERODROME FACILITIES 机场设施所产生噪音的卫生方面

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-2-85-89

S. K. Soldatov, S. P. Dragan, A. Bogomolov, M. Pirozhkov, S.Yu. Skriabin, O.V. Gorodenko, I.A. Sinelnikov

引用次数: 0

EVALUATION OF THE UHF-ENERGY STERILIZING EFFECT ON ATMOSPHERIC MOISTURE CONDENSATE 超能灭菌对大气冷凝水灭菌效果的评价

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-3-61-65

S. I. Klimarev, Yu E Siniak, G. V. Kanatova

引用次数: 0

ПОТЕНЦИАЛ К ДИФФЕРЕНЦИРОВКЕ МЕЗЕНХИМАЛЬНЫХ СТРОМАЛЬНЫХ КЛЕТОК ПРИ РЕПЛИКАТИВНОМ СТАРЕНИИ 复制衰老中间质基质细胞分化的潜力

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-4-64-69

A.Yu. Ratushnyy, L. B. Buravkova

{"title":"ПОТЕНЦИАЛ К ДИФФЕРЕНЦИРОВКЕ МЕЗЕНХИМАЛЬНЫХ СТРОМАЛЬНЫХ КЛЕТОК ПРИ РЕПЛИКАТИВНОМ СТАРЕНИИ","authors":"A.Yu. Ratushnyy, L. B. Buravkova","doi":"10.21687/0233-528x-2022-56-4-64-69","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-4-64-69","url":null,"abstract":"Mesenchymal stromal/stem cells (MSCs) are capable of multilinear differentiation and participate in tissue homeostasis including the remodeling and reparation processes. With aging these cells more and more often activatesenescence (cell aging) that alters cell functions and microenvironment which can be the reason for age-related pathologies. One of the features of senescent MSCs is thought to be a decline of multipotency that may limit their reparative functions in tissues. The paper presents a study of the MSCs osteogenic and adipogenic potential during replicative senescence. A decline of the MSCs adipogenic potential was associated with downregulation of PPARG,(a key transcription regulator of adipogenesis). There was evidence of reciprocal increasing of the osteogenic potential even though the several positive osteogenesis regulators (BMP2, BMP6, IGF1, IL1B) were downregulated. Besides, during differentiation matrix calcification was enhanced and osteoprotegerin concentration increased that can be an issue in context of atherosclerotic plaques calcification in elder people. Expression of key osteogenesis regulator RUNX2 and markers SPARC, SPP1, COL1A1, BGLAP remained stable during replicative senescence of MSCs.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67953864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ADAPTABILITY OF THE CARDIOVASCULAR SYSTEM IN NORMOTENSIVE RATS OF VARIOUS AGES AT FLUCTUATIONS OF AIR TEMPERATURE AND ATMOSPHERIC PRESSURE 不同年龄血压正常大鼠心血管系统对气温、气压波动的适应性

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-3-25-32

N. V. Kuzmenko, N. Rubanova, M. G. Pliss, V. Tsyrlin

{"title":"ADAPTABILITY OF THE CARDIOVASCULAR SYSTEM IN NORMOTENSIVE RATS OF VARIOUS AGES AT FLUCTUATIONS OF AIR TEMPERATURE AND ATMOSPHERIC PRESSURE","authors":"N. V. Kuzmenko, N. Rubanova, M. G. Pliss, V. Tsyrlin","doi":"10.21687/0233-528x-2022-56-3-25-32","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-3-25-32","url":null,"abstract":"Age-related changes in hemodynamics and heart rate variability (HRV) as well as effects of low temperature and atmospheric pressure fluctuations on the cardiovascular functioning were investigated in normotensive Wistar rats of different age groups. In aging rats, decrease of systolic blood pressure (BPs) was not accompanied by considerable changes in heart rate (HR) or HRV. In none of the age groups a short exposure to the cold (30 min at 0 °С) caused stable changes in BPs and HR; however, recovery of the high-frequency HRV spectrum in 22-mo old rats took more time than in the other age groups. Atmospheric pressure fluctuations (10–15 mmHg) did not influence hemodynamics in 10-mo rats substantially. In 22-mo old rats, atmospheric pressure growth and decrease increased BPs. Besides, low atmospheric pressure was the reason of tachicardia and narrowing of the HRV high-frequency spectrum in this group. These data witness to the inhibition of vagus reactions to external environment stimuli in aged animals that may make them sensitive to climatic variations and compromise hemodynamics.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67953010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MOLECULAR, NEUROPHYSIOLOGICAL AND INTEGRATIVE EFFECTS OF THE COMBINED EXPOSURE TO TAIL-SUSPENSION AND IONIZING RADIATION IN RATS 尾悬液和电离辐射联合暴露对大鼠的分子、神经生理和综合影响

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-2-30-38

K. Lebedeva-Georgievskaya, A. Perevezentsev, O. Kuznetsova, V. Kudrin, V. Pikalov, O. Mitrofanova, A. A. Masanova, A. Shtemberg

{"title":"MOLECULAR, NEUROPHYSIOLOGICAL AND INTEGRATIVE EFFECTS OF THE COMBINED EXPOSURE TO TAIL-SUSPENSION AND IONIZING RADIATION IN RATS","authors":"K. Lebedeva-Georgievskaya, A. Perevezentsev, O. Kuznetsova, V. Kudrin, V. Pikalov, O. Mitrofanova, A. A. Masanova, A. Shtemberg","doi":"10.21687/0233-528x-2022-56-2-30-38","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-2-30-38","url":null,"abstract":"Molecular mechanisms of the neurobiological effects of 10-d suspension combined with daily exposure to ᵞ-radiation and carbon ions were studied in rats. Analysis of the molecular changes in hippocamp dopamine receptors revealed changes in irradiated rats including, specifically, intensive expression of monoamine oxidase А, substrates for which are serotonin, adrenalin, noradrenaline and histamine. The EEG spectral and amplitude-frequency characteristics were analyzed. Comparison of primary EEG data regardless of rhythms brought to light a downward trend in the alpha frequencies. A similar trend was observed in the center frequencies and amplitudes of the most expressed peak, and the center frequency and amplitude of the delta highest peak. More anxious behavior and a somewhat quicker learning to fulfill the Morris tests and conditioned response of active avoidance in the shuttle chamber were in harmony with changes in metabolites of hippocamp dopamine and serotonin.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67951259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MANAGERIAL PROFESSIONALLY IMPORTANT QUALITIES OF THE INTERPLANETARY CREW COMMANDER: STRUCTURE, ASSESSMENT, DEVELOPMENT 星际机组指挥员管理专业的重要素质:结构、考核、发展

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-2-5-10

O. Ryumin, А.М. Voitenko

引用次数: 0

SCHEDULE OF ASCENT TO THE SURFACE AFTER SATURATION DIVE ON HELIOX MIXTURE TO 500 METERS 使用螺旋混合气饱和潜水至500米后上升到地面进度表

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-3-19-24

V. P. Nikolaev

引用次数: 0

MICROBIAL STATUS OF DEEP DIVERS 深海潜水员的微生物状况

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-6-37-42

V. Ilyin, L. Starkova

引用次数: 0

MOLECULAR MECHANISMS OF BACILLUS PUMILUS 25 SUPER RESISTANCE TO ANTIBIOTICS AND OXIDATIVE STRESS 短小芽孢杆菌25对抗生素和氧化应激超抗性的分子机制

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-6-70-78

P.D. Osipova, D. Karpov, A. Domashin, N. Polyakov, A. Soloviev, M. Zubasheva, V. Zhukhovitsky, S. Poddubko

{"title":"MOLECULAR MECHANISMS OF BACILLUS PUMILUS 25 SUPER RESISTANCE TO ANTIBIOTICS AND OXIDATIVE STRESS","authors":"P.D. Osipova, D. Karpov, A. Domashin, N. Polyakov, A. Soloviev, M. Zubasheva, V. Zhukhovitsky, S. Poddubko","doi":"10.21687/0233-528x-2022-56-6-70-78","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-6-70-78","url":null,"abstract":"Spore-forming bacteria are residents on the International space station (ISS) and can act as potential biodistructors of structural materials with a consequent disturbance of equipment operation. These bacteria demonstrate high resistance to many stress factors. Molecular mechanisms of this resistance are poorly understood. Sanitary/hygienic monitoring resulted in detection and isolation of strain Bacillus pumilus 25. The investigation was aimed to test B. pumilus 25 resistance to oxidative agents, antibiotics, and to analyze expression of genes associated with the cell response to DNA damage and hydrogen sulfide production. The strain was identified by sequencing 16S RNA and MALDI-TOF analysis. Resistance to stresses and antibiotics was tested with the use of standard microbiological methods. Level of mRNA genes was determined with the real-time polymerase chain reaction. Our results evidence for heightened B. pumilus 25 resistance to the oxidative stress and majority of the antibiotics used in the investigation. This resistance seems to be associated with high expression of the ku-ligD operon genes, and elevated production of hydrogen sulfide.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67957433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0