不同年龄血压正常大鼠心血管系统对气温、气压波动的适应性

Q4 Biochemistry, Genetics and Molecular Biology

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI:10.21687/0233-528x-2022-56-3-25-32

N. V. Kuzmenko, N. Rubanova, M. G. Pliss, V. Tsyrlin

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引用次数: 0

摘要

研究了不同年龄组正常血压Wistar大鼠血流动力学和心率变异性(HRV)的年龄相关性变化以及低温和气压波动对心血管功能的影响。在衰老大鼠中，收缩压(bp)的降低并不伴随着心率(HR)或HRV的显著变化。在所有年龄组中，短时间暴露于寒冷(0°С下30分钟)均未引起bp和HR的稳定变化;然而，22个月大鼠高频HRV谱的恢复比其他年龄组需要更多的时间。大气压波动(10-15 mmHg)对10个月大鼠的血流动力学没有显著影响。在22个月大鼠中，大气压力的增加和降低会增加bp。此外，低气压是本组心动过速和HRV高频频谱变窄的原因。这些数据证明了老年动物对外部环境刺激的迷走神经反应受到抑制，这可能使它们对气候变化敏感并损害血液动力学。

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ADAPTABILITY OF THE CARDIOVASCULAR SYSTEM IN NORMOTENSIVE RATS OF VARIOUS AGES AT FLUCTUATIONS OF AIR TEMPERATURE AND ATMOSPHERIC PRESSURE

Age-related changes in hemodynamics and heart rate variability (HRV) as well as effects of low temperature and atmospheric pressure fluctuations on the cardiovascular functioning were investigated in normotensive Wistar rats of different age groups. In aging rats, decrease of systolic blood pressure (BPs) was not accompanied by considerable changes in heart rate (HR) or HRV. In none of the age groups a short exposure to the cold (30 min at 0 °С) caused stable changes in BPs and HR; however, recovery of the high-frequency HRV spectrum in 22-mo old rats took more time than in the other age groups. Atmospheric pressure fluctuations (10–15 mmHg) did not influence hemodynamics in 10-mo rats substantially. In 22-mo old rats, atmospheric pressure growth and decrease increased BPs. Besides, low atmospheric pressure was the reason of tachicardia and narrowing of the HRV high-frequency spectrum in this group. These data witness to the inhibition of vagus reactions to external environment stimuli in aged animals that may make them sensitive to climatic variations and compromise hemodynamics.

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来源期刊

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

0.60

自引率

0.00%

发文量