{"title":"Histological diversity in hyperkeratotic flexural erythema-Beyond granular parakeratosis?","authors":"Anna Luo, Fergus Oliver, Harriet Kennedy","doi":"10.1111/ajd.14349","DOIUrl":"https://doi.org/10.1111/ajd.14349","url":null,"abstract":"<p><p>The term 'hyperkeratotic flexural erythema' (HFE) has been used synonymously with granular parakeratosis (GP), to describe a scaly, typically intertriginous rash associated with contact factors such as benzalkonium chloride. However, clinical HFE can occur without the classical GP histological pattern. We reviewed skin biopsies from 10 patients with clinically diagnosed HFE. A progression of histopathological features is suggested. The absence of histological GP should not exclude the clinical diagnosis of HFE when there is a high index of suspicion.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samantha Ting, Patricia Lowe, Annika Smith, Pablo Fernández-Peñas
{"title":"Biologic treatment sequences in moderate-to-severe psoriasis.","authors":"Samantha Ting, Patricia Lowe, Annika Smith, Pablo Fernández-Peñas","doi":"10.1111/ajd.14350","DOIUrl":"https://doi.org/10.1111/ajd.14350","url":null,"abstract":"<p><strong>Background: </strong>The advent of novel biologics has led to an increase in biologic-switching as patients and clinicians pursue improved clinical outcomes. However, guidance on treatment sequencing in an Australian setting is sparse. This study examines the patterns of care across two tertiary centres in Australia and characterizes the factors contributing to biologic-switching.</p><p><strong>Methods: </strong>A retrospective study of patients who attended the outpatient Dermatology biologic clinics across two tertiary hospitals was conducted. Data on treatment sequencing and patients' PASI at every visit from April 2006 to December 2020 were collected. Patterns of biologic-switching were examined. The speed of treatment response for each biologic was determined by the time to achieve PASI-90 and -100 for each treatment course.</p><p><strong>Results: </strong>A total of 440 treatment courses were analysed. Ustekinumab and adalimumab were the most frequently prescribed first-line biologics. The highest proportion of biologic-switching was observed among patients on TNF-α inhibitors (63.8%). After 2015, more patients were prescribed IL-12/23 and IL-17 inhibitors in favour of TNF-α inhibitors. IL-17 inhibitors demonstrated the most rapid treatment response and low PASI scores relative to other biologics. Patients who did not switch biologics had lower rates of psoriatic arthritis and lower BMI, compared to patients who switched biologics. The median PASI on discontinuation generally exceeded 3.0, while on continuation, it was less than 1.2, reflecting patients' and clinicians' thresholds for biologic-switching.</p><p><strong>Conclusions: </strong>This study demonstrates an increased uptake of more novel biologics as they become available, due to improved safety profiles and clinical outcomes.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful treatment of infantile refractory bullous pemphigoid with baricitinib.","authors":"Weinan Zhou, Yidong Tan, Xuanyi Chen, Wenqing Zhang, Zhe Sun, Yihang Shen, Zhirong Yao, Ruhong Cheng, Yan Gu","doi":"10.1111/ajd.14345","DOIUrl":"https://doi.org/10.1111/ajd.14345","url":null,"abstract":"<p><p>Infantile bullous pemphigoid (BP) is a rare autoantibody-mediated skin disorder. We report the effective treatment of a 6-month-old infant with BP using baricitinib, a Janus kinase (JAK) inhibitor, after failure with steroids and intravenous immunoglobulin. The patient achieved full remission and discontinued all medications without any relapses. To our knowledge, this is the first case of baricitinib used in an infant with BP.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141730958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling the clinical and epidemiological significance of Mycobacterium lepromatosis detection in a patient with severe lepra reaction from India.","authors":"Sukhdeep Singh, Itu Singh, Rucha Herlekar, Vinay Kumar Pathak, Debajyoti Chatterjee, Tarun Narang, Sunil Dogra","doi":"10.1111/ajd.14352","DOIUrl":"https://doi.org/10.1111/ajd.14352","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on 'Dupilumab for atopic dermatitis in metastatic cancer'.","authors":"Luca Potestio, Cataldo Patruno, Maddalena Napolitano","doi":"10.1111/ajd.14351","DOIUrl":"https://doi.org/10.1111/ajd.14351","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgina Harvey, Diana J Purvis, John M D Thompson, Libby Haskell, Harriet Kennedy, Karen Hoare, Stuart R Dalziel
{"title":"Childhood eczema prevalence in New Zealand using topical corticosteroid dispensing data.","authors":"Georgina Harvey, Diana J Purvis, John M D Thompson, Libby Haskell, Harriet Kennedy, Karen Hoare, Stuart R Dalziel","doi":"10.1111/ajd.14347","DOIUrl":"https://doi.org/10.1111/ajd.14347","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the prevalence of eczema among children in New Zealand.</p><p><strong>Methods: </strong>Population-based retrospective observational study utilising national pharmaceutical dispensing records for topical corticosteroids and emollients for all New Zealand children aged 0-14 years from 1st January 2006 to 31st December 2019. Data are reported using descriptive statistics, with comparisons between ethnicities and socioeconomic quintiles undertaken with rate ratios.</p><p><strong>Results: </strong>Based on dispensing data, the prevalence of eczema for New Zealand children aged 0-14 years in 2018 was 14.0% (95% CI 14.0%-14.1%), with prevalence decreasing in older age groups (children aged <1 year 26.0% (25.6%-26.4%); children aged 10-14 years 8.8% (8.7%-8.9%)). Prevalence was higher in Pacific children (23.6% (23.3%-24.0%)), but slightly lower in Māori children (13.2% (13.0%-13.3%)).</p><p><strong>Conclusion: </strong>Eczema is a common condition affecting a considerable proportion of children in New Zealand. This study provides nationwide paediatric prevalence data for New Zealand, and highlights the increased burden of eczema in Pacific children. Inequity in dispensing of topical corticosteroids is postulated to explain the reduced rates found for Māori children compared to previous studies. These results support the need for further research to determine factors contributing to differing eczema prevalence rates in New Zealand.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberto Fernandes Soares-Neto, Antônio Roberto de Oliveira Ramalho, Martha Débora Lira Tenório, Jonnia Maria Sherlock Araújo, Lana Luiza da Cruz Silva, Pedro Dantas Oliveira, Paulo Ricardo Martins-Filho, Fedro Menezes Portugal
{"title":"Anetoderma as an initial presentation of leprosy in a patient with prolonged steroid use.","authors":"Roberto Fernandes Soares-Neto, Antônio Roberto de Oliveira Ramalho, Martha Débora Lira Tenório, Jonnia Maria Sherlock Araújo, Lana Luiza da Cruz Silva, Pedro Dantas Oliveira, Paulo Ricardo Martins-Filho, Fedro Menezes Portugal","doi":"10.1111/ajd.14348","DOIUrl":"https://doi.org/10.1111/ajd.14348","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenjie Li, Zhongyun Deng, Ge Yang, Wei Liu, Zhen Rang, Tingting Wang, Mi Wang, Fan Cui
{"title":"Therapy of pemphigus foliaceous with prominent neutrophilic pustules with Acitretin: A case report and literature review.","authors":"Wenjie Li, Zhongyun Deng, Ge Yang, Wei Liu, Zhen Rang, Tingting Wang, Mi Wang, Fan Cui","doi":"10.1111/ajd.14346","DOIUrl":"https://doi.org/10.1111/ajd.14346","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}