R Cascio Ingurgio, A Alfano, L Gargiulo, L Ibba, A Narcisi, F Satgé, M Stark, A Costanzo, D F Murrell
{"title":"Using Biologics to Reduce Long-Term Corticosteroid Use in Pyoderma Gangrenosum: Real-World Evidence From Two Centres.","authors":"R Cascio Ingurgio, A Alfano, L Gargiulo, L Ibba, A Narcisi, F Satgé, M Stark, A Costanzo, D F Murrell","doi":"10.1111/ajd.14532","DOIUrl":"10.1111/ajd.14532","url":null,"abstract":"<p><strong>Background: </strong>Pyoderma gangrenosum (PG) is a challenging inflammatory skin disorder. While corticosteroids offer a rapid response, their long-term risks necessitate alternative treatments.</p><p><strong>Objective: </strong>To compare the long-term effectiveness of biologic therapies versus systemic corticosteroids in PG management.</p><p><strong>Methods: </strong>A retrospective analysis of 15 PG patients from two centres (Sydney, Australia, and Milan, Italy) was conducted. Patients received either biologic therapies (n = 8) or corticosteroids (n = 7), with ulcer healing outcomes assessed at weeks 16, 28-32 and 54.</p><p><strong>Results: </strong>At week 16, corticosteroids led to faster ulcer reduction and re-epithelialisation. However, biologic-treated patients showed sustained improvement over time, supporting their role in long-term PG management.</p><p><strong>Conclusion: </strong>While corticosteroids provide an initial advantage, biologics demonstrate gradual and sustained efficacy, suggesting a long-term therapeutic role in PG treatment.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kelvin Truong, James Elhindi, Raquel Ruiz Araujo, Maria Jones-Caballero, Charmaine Chamberlin, Jillian Wells, Pablo Fernandez-Penas
{"title":"Asynchronous 3D Photography Is a Reliable Tool for the Assessment of Mycosis Fungoides Clinical Severity","authors":"Kelvin Truong, James Elhindi, Raquel Ruiz Araujo, Maria Jones-Caballero, Charmaine Chamberlin, Jillian Wells, Pablo Fernandez-Penas","doi":"10.1111/ajd.14531","DOIUrl":"10.1111/ajd.14531","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mycosis fungoides (MF) requires accurate clinical assessment for staging and management. Teledermatology aids remote evaluations, but there is limited data on the use of 3D total body photography (TBP) in assessing MF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study evaluates the accuracy and reliability of assessing a patient with MF using 3D TBP compared to in-person review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirteen MF patients were evaluated in-person using the modified Severity Weighted Assessment Tool (mSWAT) by two dermatologists, and then had 3D TBP taken. 8 weeks later, the dermatologists evaluated the virtual images. Three independent dermatologists reviewed the virtual images twice, 8 weeks apart. Intraclass correlation coefficients (ICC) assessed agreement between in-person and virtual assessments and test–retest reliability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There was moderate agreement (ICC = 0.71) for intra-rater in-person and virtual assessments. Test–retest reliability of virtual assessment was good (ICC = 0.79). Evaluating inter-rater agreement between in-person and virtual assessments indicated good agreement (ICC = 0.80).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Limitations</h3>\u0000 \u0000 <p>3D TBP could not capture skin on the scalp, beneath clothing and on the soles of the feet, limiting complete assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Clinical assessment of mSWAT using 3D TBP is as reliable as in-person mSWAT, suggesting its potential in teledermatology. Further studies are needed to validate these findings in larger cohorts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 6","pages":"344-349"},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14531","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caterina Mariarosaria Giorgio, Gaetano Licata, Eugenia Veronica Di Brizzi, Giulia Briatico, Elvira Moscarella, Camila Scharf, Maria Maddalena Nicoletti, Giuseppe Argenziano, Gabriella Brancaccio
{"title":"Neoadjuvant Intralesional Methotrexate for Infiltrating Squamous Cell Carcinoma of the Head: A Case Series of 19 Patients.","authors":"Caterina Mariarosaria Giorgio, Gaetano Licata, Eugenia Veronica Di Brizzi, Giulia Briatico, Elvira Moscarella, Camila Scharf, Maria Maddalena Nicoletti, Giuseppe Argenziano, Gabriella Brancaccio","doi":"10.1111/ajd.14529","DOIUrl":"https://doi.org/10.1111/ajd.14529","url":null,"abstract":"<p><p>Squamous cell carcinoma (SCC) of the head presents a significant challenge in achieving complete surgical excision while preserving function and aesthetics. Neoadjuvant intralesional methotrexate (MTX) has emerged as a potential strategy to reduce tumour burden preoperatively, facilitating more conservative surgical excisions. The results demonstrated significant lesion shrinkage, with a mean tumour size reduction of 68%, enabling less invasive surgical interventions.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pablo Fernandez-Peñas, Samantha Ting, Patricia Lowe
{"title":"A Reply to: ‘Drug Survival of Biologics in Psoriasis: An Australian Multicentre Retrospective Study’","authors":"Pablo Fernandez-Peñas, Samantha Ting, Patricia Lowe","doi":"10.1111/ajd.14483","DOIUrl":"10.1111/ajd.14483","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 6","pages":"e376-e377"},"PeriodicalIF":1.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case Report: The Use of Methotrexate After the Diagnosis of Primary Tumoral Melanosis Without Metastatic Disease","authors":"Niyaz Mostafa, Tevi Wain, Erin Mullan","doi":"10.1111/ajd.14521","DOIUrl":"10.1111/ajd.14521","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 4","pages":"e245-e246"},"PeriodicalIF":2.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rodney Sinclair, Samantha Eisman, Carol M. Y. Lee, Maureen Hitschfeld, Komal Kapoor, Budhaditya Goswami, David Witcombe, Candida da Fonseca Pereira
{"title":"Psychosocial and Occupational Burden on Caregivers of Adolescents With Alopecia Areata in Australia","authors":"Rodney Sinclair, Samantha Eisman, Carol M. Y. Lee, Maureen Hitschfeld, Komal Kapoor, Budhaditya Goswami, David Witcombe, Candida da Fonseca Pereira","doi":"10.1111/ajd.14519","DOIUrl":"10.1111/ajd.14519","url":null,"abstract":"<p>We conducted a noninterventional, cross-sectional online survey in Australia from April to July 2023 to investigate the impact of alopecia areata (AA) on psychosocial well-being, work productivity and quality of life among caregivers of adolescent patients with AA living in Australia. The survey results revealed a substantial psychosocial and occupational burden and impairment on mental and emotional well-being among caregivers of adolescents with AA. These findings highlight the importance of recognising the AA-related burden that extends beyond the individual patient.</p><p><b>Trial Registration:</b> Australian New Zealand Clinical Trials Registry: ACTRN12623000158662</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 4","pages":"e235-e240"},"PeriodicalIF":2.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14519","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}