Australasian Journal of Dermatology最新文献

{"title":"Dupilumab for atopic dermatitis in metastatic cancer","authors":"Jessica McClatchy BBiomed MD,&nbsp;Gayle Ross MBBS (Hons) FACD","doi":"10.1111/ajd.14296","DOIUrl":"10.1111/ajd.14296","url":null,"abstract":"<p>We present a case of a 47-year-old male with severe atopic dermatitis and metastatic renal cell carcinoma managed successfully with dupilumab. This case further supports the safety of dupilumab in patients with active malignancy, an area currently with limited data.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140837381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescription retinoid and contraception use in women in Australia: A population-based study","authors":"Laura Gerhardy BBNSc, MBBS, GCertBiostat, FRANZCOG, CMFM, DDU,&nbsp;Natasha Nassar PhD MPH BEc,&nbsp;Melisa Litchfield BAppSc, MPH(Hons),&nbsp;Debra Kennedy MBBS, FRACP, MBioth, HGSA (Clin Genetics),&nbsp;Annika Smith MBBS (HONS1) MPHTM FRACP FACD,&nbsp;Malcolm B. Gillies BSc(Hons) PhD MBiostat,&nbsp;Sallie-Anne Pearson PhD,&nbsp;Helga Zoega BA, MA, PhD,&nbsp;Antonia Shand FRANZCOG,M.Med (Clin Epi)","doi":"10.1111/ajd.14294","DOIUrl":"10.1111/ajd.14294","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background/Obectives</h3>\u0000 \u0000 <p>Oral retinoids are teratogenic, and pregnancy avoidance is an important part of retinoid prescribing. Australia does not have a standardised pregnancy prevention programme for women using oral retinoids, and the contraception strategies for women who use oral retinoids are not well understood.</p>\u0000 \u0000 <p>The objectives were to determine trends in the use of prescription retinoids among Australian reproductive-aged women and whether women dispensed oral retinoids used contraception concomitantly.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a population-based study using Australian Pharmaceutical Benefits (PBS) dispensing claims for a random 10% sample of 15-44-year-old Australian women, 2013 - 2021. We described rates and annual trends in dispensing claims for PBS-listed retinoids and contraceptives. We also estimated concomitant oral retinoid and contraceptive use on the day of each retinoid dispensing and determined if there was a period of contraceptive treatment that overlapped. Estimates were then extrapolated to the national level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 1,545,800 retinoid dispensings to reproductive-aged women; 57.1% were oral retinoids. The rate of retinoid dispensing to reproductive-aged women increased annually, from 28 dispensings per 1000 population in 2013 to 41 per 1000 in 2021. The rate of oral retinoid dispensing doubled over the study period, from 14 dispensings per 1000 population in 2013 to 28 per 1000 in 2021, while topical retinoid dispensing did not change. Only 25% of oral retinoid dispensings had evidence of concomitant contraceptive use in 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Rates of oral retinoid dispensing have doubled among reproductive-aged women over the past decade. A large percentage of oral retinoid use does not appear to have concomitant contraception use, posing a risk of teratogenic effects in pregnancies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140837386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normolipemic xanthoma associated with folliculotropic mycosis fungoides","authors":"Shunsuke Takahagi MD, PhD,&nbsp;Toshihisa Hamada MD, PhD,&nbsp;Daiki Matsubara MD, PhD","doi":"10.1111/ajd.14300","DOIUrl":"10.1111/ajd.14300","url":null,"abstract":"<p>Folliculotropic mycosis fungoides (fMF), a variant of mycosis fungoides, is characterized by infiltration of atypical T cells into the follicular epithelium.<span>¹</span> Follicular damage caused by lymphoma cell invasion leads to cyst formation, alopecia and follicular mucinosis. While xanthoma formation within fMF is rare,<span>^{2, 3}</span> its underlying mechanism remains unclear. Additionally, dense histiocytic infiltration may hinder fMF diagnosis.</p><p>A 60-year-old Japanese man presented with a 4-year history of multiple yellowish masses with patchy alopecia on the frontal and parietal scalp (Figure 1a–b). Follicular papules were observed on the trunk and extremities (Figure S1a). Trichoscopy of the patchy alopecia margin showed scaling and crusting at the hair shafts and follicles and milky white structures in the perifollicular region (Figure 1c). In the alopecic area, dilated follicles lacking hair were surrounded by yellowish white structures (Figure 1d). Histologically, a scalp specimen from the alopecia margin revealed mucin deposition and lymphocyte and eosinophil infiltrations within the follicles (Figure 2a–c). The perifollicular region displayed a diffuse infiltration of histiocytes mixed with eosinophils and lymphocytes (Figure 2a, d). In the alopecic area, follicles dilated with keratin plugs had lymphocytic and eosinophilic infiltration (Figure 2e, f). The dermis showed a diffuse and dense infiltration of foamy histiocytes, eosinophils and lymphocytes (Figure 2e, g). The infiltrating lymphocytes showed mild to moderate atypia, CD3 positivity and predominant CD4 over CD8 expression (Figure S1b). Histiocytes exhibited CD68⁺ S-100− CD1a− phenotype (Figure 2h). The patient had normal serum lipid levels, sIL-2R 723 U/mL and negative anti-human T-cell lymphotropic virus type 1 antibodies, with no evidence of lymph node or visceral involvement. Despite the obscured lymphomatous features due to dense inflammatory infiltrates with histiocytes, the combination of lymphocytic atypia, clonal T-cell receptor gene rearrangement detected by polymerase chain reaction and characteristic extrascalp skin lesions supported the diagnosis of fMF (stage IIB) with xanthoma. Local radiotherapy, narrow-band ultraviolet B, systemic etretinate and intravenous interferon-gamma helped reduce the scalp masses, leaving xanthoma.</p><p>Kurihara et al.<span>²</span> observed lymphoma regression after treatment, with subsequent xanthoma formation, suggesting that foamy histiocytes aggregate to ingest destroyed tumour cells. In contrast, in the cases reported by Viedma-Martinez et al.<span>³</span> and ours, xanthomatous lesions were present before treatment. In our case, non-lipid-laden histiocytes infiltrated early lesions at the alopecia margin, whereas lipid-laden foamy histiocytes emerged concurrently with follicular destruction in the alopecic area. This implies that the tumour microenvironment fir","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140837785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining labelling guidelines for AI-based software as a medical device: A review and analysis of dermatology mobile applications in Australia","authors":"Ayooluwatomiwa Oloruntoba,&nbsp;Åsa Ingvar MD, PhD,&nbsp;Maithili Sashindranath PhD,&nbsp;Ojochonu Anthony MD,&nbsp;Lisa Abbott MBBS, FACD,&nbsp;Pascale Guitera MD, PhD, FACD,&nbsp;Tony Caccetta MBBS (Hons), FACD,&nbsp;Monika Janda PhD,&nbsp;H. Peter Soyer MD, FACD,&nbsp;Victoria Mar MBBS, PhD, FACD","doi":"10.1111/ajd.14269","DOIUrl":"10.1111/ajd.14269","url":null,"abstract":"<p>In recent years, there has been a surge in the development of AI-based Software as a Medical Device (SaMD), particularly in visual specialties such as dermatology. In Australia, the Therapeutic Goods Administration (TGA) regulates AI-based SaMD to ensure its safe use. Proper labelling of these devices is crucial to ensure that healthcare professionals and the general public understand how to use them and interpret results accurately. However, guidelines for labelling AI-based SaMD in dermatology are lacking, which may result in products failing to provide essential information about algorithm development and performance metrics. This review examines existing labelling guidelines for AI-based SaMD across visual medical specialties, with a specific focus on dermatology. Common recommendations for labelling are identified and applied to currently available dermatology AI-based SaMD mobile applications to determine usage of these labels. Of the 21 AI-based SaMD mobile applications identified, none fully comply with common labelling recommendations. Results highlight the need for standardized labelling guidelines. Ensuring transparency and accessibility of information is essential for the safe integration of AI into health care and preventing potential risks associated with inaccurate clinical decisions.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140837387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of recurrent generalized pustular psoriasis of pregnancy with ixekizumab: A case report","authors":"İrem Özdemir MD,&nbsp;Mehmet Gülengül MD,&nbsp;Muhammed Kaan Temirkaynak MD,&nbsp;Burcu Beksaç MD,&nbsp;Esra Adışen MD","doi":"10.1111/ajd.14297","DOIUrl":"10.1111/ajd.14297","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140837463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A photo-distributed rash and eczematous eruptions in two siblings—A diagnostic conundrum","authors":"Kittu Malhi MD,&nbsp;Akash Mustari MD,&nbsp;Sukhdeep Singh MD,&nbsp;Anoop Kumar BS MS,&nbsp;Pandiarajan Vignesh MD, DM,&nbsp;Dipankar De MD,&nbsp;Sanjeev Handa MD,&nbsp;Rahul Mahajan MD","doi":"10.1111/ajd.14295","DOIUrl":"10.1111/ajd.14295","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140677015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of bone scan in diagnosing calciphylaxis in practice—A retrospective case series of patients who were clinically managed for calciphylaxis despite resulting negative on initial biopsy","authors":"Emilee Herringshaw MBA,&nbsp;Maximilian Kinne MS,&nbsp;Renee Joyce BS,&nbsp;Fnu Nutan MD","doi":"10.1111/ajd.14263","DOIUrl":"10.1111/ajd.14263","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab for chronic actinic dermatitis: A case series and review of the literature","authors":"Zachary Holmes MB, BCh, BAO, MA, MSc, MRCPI,&nbsp;Peter Foley MBBS, BMedSc, MD, FACD,&nbsp;Chris Baker MBBS, FACD,&nbsp;Benjamin S. Daniel MBBS, BA, BCom, MMed (Clin Epi), FACD","doi":"10.1111/ajd.14293","DOIUrl":"10.1111/ajd.14293","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140610757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of biologics for psoriasis in solid organ transplant recipients","authors":"Marta Costa Blasco,&nbsp;Claire Doyle,&nbsp;Sophie Diong,&nbsp;Siona Ni Raghallaigh","doi":"10.1111/ajd.14292","DOIUrl":"10.1111/ajd.14292","url":null,"abstract":"<p>Biologics have significantly advanced the treatment of inflammatory disorders, including psoriasis. However, their use in immunosuppressed patients, such as those with solid-organ transplants, is less understood. These patients often face dermatological issues, but inflammatory skin diseases are rare due to their immunosuppressive treatments. Our study aims to assess biologics' effectiveness in such immunocompromised patients. We report a case from our institution of a 29-year-old man with a history of psoriasis, who underwent a kidney transplant and later developed erythroderma. He did not respond to traditional treatments and was successfully treated with adalimumab, leading to the discontinuation of MMF. We also reviewed literature in solid organ transplant patients with psoriasis. Our findings, based on 10 articles, indicate a cautious approach to using biologics in this group, with further research needed for efficacy and safety.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140580667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatitis and prolonged dysesthesia from the poisonous wood nettle, Dendrocnide meyeniana (Urticaceae)","authors":"Johannes F. Dayrit MD,&nbsp;Bryan Edgar K. Guevara MD,&nbsp;Lunardi Bintanjoyo MD,&nbsp;Scott A. Norton MD, MPH, MSc","doi":"10.1111/ajd.14252","DOIUrl":"10.1111/ajd.14252","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140580758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}