Australasian Journal of Dermatology最新文献

{"title":"Real-World Outcomes of Rituximab in Pemphigus: An Australian Tertiary Cohort.","authors":"Pokphazz Christjaroon, Ali Abid, Orli Wargon, Paul Weller, Artiene Tatian","doi":"10.1111/ajd.70221","DOIUrl":"https://doi.org/10.1111/ajd.70221","url":null,"abstract":"<p><p>Rituximab is endorsed internationally as first-line therapy for moderate-to-severe pemphigus, but Australian guidelines position it as a rescue agent and local outcome data are limited. In this single-centre retrospective cohort, 24 adults with pemphigus vulgaris (n = 16) or pemphigus foliaceus (n = 8) received rituximab as part of routine care; median follow-up from first infusion was 24.9 months. Disease control was documented in all patients and complete remission in 20 (83%), of whom half subsequently relapsed despite most receiving more than one cycle. Adverse events occurred in eight patients (33%), predominantly mild infusion-related reactions, with one fatal pneumonia. These real-world data support planned maintenance after remission rather than single-course rescue use, and prospective multicentre study with standardised severity scoring.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid Rescue for Vision-Threatening Segmental Periocular Infantile Haemangioma in PHACE Syndrome When Propranolol Escalation Was Limited.","authors":"Ishana Dixit, Richard Webster, Alex Gooi, James Smith, Amber Seigel, Li-Chuen Wong","doi":"10.1111/ajd.70222","DOIUrl":"https://doi.org/10.1111/ajd.70222","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progestogen Hypersensitivity Mimicking Polymorphic Eruption of Pregnancy and Pemphigoid Gestationis Across Recurrent Pregnancies: A Case Report and Focused Review.","authors":"Weijia Yi, Matthew Verheyden, Sally de Zwaan","doi":"10.1111/ajd.70220","DOIUrl":"https://doi.org/10.1111/ajd.70220","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Location, Location, Location in Melanoma Biology.","authors":"Ewan A Langan","doi":"10.1111/ajd.70219","DOIUrl":"https://doi.org/10.1111/ajd.70219","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of NUDT15 in Azathioprine Toxicity: A Case of Recalcitrant Pityriasis Lichenoides Chronica.","authors":"Aleyna Akdemir, Lois Zhang, Jillian Wells","doi":"10.1111/ajd.70218","DOIUrl":"https://doi.org/10.1111/ajd.70218","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Variation in Skin Cancer Presentation in Primary Care Clinic in Parramatta, NSW.","authors":"Marjia Johns, Yagiz Aksoy, Gilberto Moreno Bonilla","doi":"10.1111/ajd.70213","DOIUrl":"https://doi.org/10.1111/ajd.70213","url":null,"abstract":"<p><strong>Background: </strong>Seasonal variation in melanoma and keratinocyte cancer (KC) diagnoses has been noted in the literature, predominantly from northern hemisphere populations, with summer peaks most commonly noted. There is limited contemporary literature from Australian data. This is the first study to our knowledge to examine both melanoma and KC presentations in Australia, and the first to investigate this in a primary care setting.</p><p><strong>Methods: </strong>A retrospective study was performed based on histopathological data taken from a primary care clinic in Parramatta NSW between March 2016 and March 2025. Inclusion criteria were basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. Multiple complementary analytical approaches were performed, including cosinor harmonic regression, negative binomial models, mixed-effects models, time series decomposition, and Bayesian inference. Multiple sensitivity analyses were also performed to assess the robustness of the findings.</p><p><strong>Results: </strong>9778 skin cancers were included over a nine-year period, which included BCC; (n = 5290; 54.1%), SCC; (n = 4041; 41.3%), and melanoma (n = 447; 4.6%). Seasonal differences were statistically significant; however, clinically negligible. Conversely, there was a demonstrated reduction in presentations at the onset of COVID-19, with sustained reduction in presentations through to 2024.</p><p><strong>Discussion: </strong>No clinically significant seasonal variation in skin cancer presentations was found, in direct contrast with literature from the northern hemisphere. This may reflect Australia's milder climate and relatively high annual ultraviolet index, effective public health messaging, and the accessibility of primary care services. Deficits in presentations throughout the year appear operation-dependent as opposed to biological seasonality. The significant and sustained impact of COVID-19 on skin cancer presentation raises concerns regarding the ongoing impact of delayed diagnoses of skin cancer in the Australian population.</p><p><strong>Conclusion: </strong>No clinically significant seasonal variation in skin cancer presentation was found in a large primary care skin cancer cohort in metropolitan Sydney; however, COVID-19 exerts a substantial and sustained impact. Vigilance regarding the long-term consequences of pandemic-related healthcare disruptions is warranted.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Malignant Melanoma and Sentinel Lymph Node Biopsy: Assessing the Impact of Teledermatology in an Eight-Year Cohort.","authors":"Sumir Chawla, Louise Fearfield","doi":"10.1111/ajd.70214","DOIUrl":"https://doi.org/10.1111/ajd.70214","url":null,"abstract":"<p><p>This eight-year retrospective cohort study of 285 patients with primary cutaneous malignant melanoma compared diagnostic pathways and oncological outcomes, demonstrating significantly lower mortality in patients diagnosed via teledermatology versus face-to-face appointments (5% vs. 23%; adjusted OR 8.1; p = 0.00009), despite comparable clinicopathological features. Sentinel lymph node biopsy positivity was independently associated with significantly higher odds of mortality (adjusted OR 13.9; p = 0.02), confirming its continued prognostic value in guiding adjuvant therapy selection.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab in Paediatric Netherton Syndrome: Two Case Reports and a Review of the Literature.","authors":"Jacqueline Tu, Paul Sun Woo Kim, Kelvin Truong, Gloria Fong, William Luu, Li-Chuen Wong","doi":"10.1111/ajd.70215","DOIUrl":"https://doi.org/10.1111/ajd.70215","url":null,"abstract":"<p><p>Netherton Syndrome (NS) is a rare genodermatosis characterised by a triad of ichthyosiform erythroderma, an atopic diathesis, and trichorrhexis invaginata, for which no effective management is currently approved in Australia. Dupilumab has demonstrated considerable effectiveness in the treatment of atopic conditions in the paediatric population. We conducted a literature review to identify trends in disease aspects and their responsiveness to dupilumab treatment, with only four reports having follow-up beyond 12 months. To address this gap and provide insights into the long-term trajectory of dupilumab treatment in this population, we report two cases of NS treated with dupilumab over 20 and 25 months. This paper demonstrates that dupilumab may be a relatively safe and potentially effective option for targeting Th2-mediated inflammation though its overall sustained effectiveness may be variable.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scabies Referrals to a New Zealand Dermatology Service: Recognition, Treatment and Persistent Symptoms.","authors":"Baraa Abuharbid, Karen Koch, Amanda Oakley","doi":"10.1111/ajd.70208","DOIUrl":"https://doi.org/10.1111/ajd.70208","url":null,"abstract":"<p><strong>Background: </strong>Scabies remains an important public health issue in New Zealand, particularly amongst socioeconomically disadvantaged populations. This study evaluated scabies-related referrals to a regional dermatology service, including treatment patterns, symptom persistence, and equity outcomes.</p><p><strong>Methods: </strong>A retrospective observational study was conducted of scabies-related referrals submitted to Waikato Dermatology between July 2024 and June 2025. Data was accessed through the Best Practice Advocacy Centre (BPAC) New Zealand database, with reference to clinical records and the New Zealand ePrescription Service (NZePS). Demographic characteristics, referral patterns, treatment before and after dermatology review, and persistent symptoms were reviewed. Diagnoses were categorised as dermatologist-diagnosed or possible scabies, based on specialist clinical assessment with reference to the International Alliance for the Control of Scabies (IACS) diagnostic criteria.</p><p><strong>Results: </strong>Over the 13-month period, 149 referrals were reviewed, of which 117 (78.5%) were dermatologist-confirmed or possible scabies. The median age was 30 years, and 35% identified as Māori. Referrers explicitly suspected scabies in 89 referrals (76.1%), while burrows were documented in only 18 referrals (15.4%). Following dermatology review, combined permethrin and ivermectin prescribing increased significantly, from 14 (12.0%) to 46 patients (39.3%) (McNemar p < 0.001). Persistent symptoms were reported in 63 patients (53.8%) and were significantly more common in dermatologist-diagnosed scabies than in possible scabies (odds ratio 6.0, 95% confidence interval (CI) 2.2-16.4; p < 0.001). Symptom persistence was significantly more common in Māori patients than New Zealand European patients (75.6% vs. 47.3%; odds ratio 3.5, 95% CI 1.4-84; p < 0.001).</p><p><strong>Conclusion: </strong>Most scabies-related referrals were clinically consistent with dermatologist-diagnosed or possible scabies, and clinical recognition by referrers was generally high, although classical supporting features were inconsistently documented. Persistent symptoms were common and likely multifactorial, more in keeping with treatment complexity, reinfestation, and socioeconomic barriers than true antiparasitic resistance.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Dupilumab Acceptability Requires Accounting for Treatment Discontinuation.","authors":"Fatih Kaplan","doi":"10.1111/ajd.70217","DOIUrl":"https://doi.org/10.1111/ajd.70217","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}