Australasian Journal of Dermatology最新文献

{"title":"Idiopathic Facial Aseptic Granuloma and Infantile Acne: A Case Report of an Overlapping Entity.","authors":"James Gaston, Alexander Pritchard, David Orchard","doi":"10.1111/ajd.14489","DOIUrl":"https://doi.org/10.1111/ajd.14489","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Non-Steroidal Topical Aryl Hydrocarbon Receptor Agonists for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.","authors":"Martin Cevallos-Cueva, Carlos Alberto Monteiro Leitão Neto, Devanie Martani, Laura Ghanem, Camila Almeida Sardinha, Daniela Lucía Mendoza-Millán, Cristina Sicorschi Gutu, Victor Barreiros Pungirum, Peter Chien","doi":"10.1111/ajd.14485","DOIUrl":"https://doi.org/10.1111/ajd.14485","url":null,"abstract":"<p><strong>Background: </strong>Current first-line topical treatments for atopic dermatitis (AD) are often limited by concerns related to age, systemic absorption, especially when applied to large body surface areas or under maximal usage conditions and undesirable adverse events (AEs), highlighting the need for alternative therapies.</p><p><strong>Methods: </strong>We performed a systematic review and meta-analysis of seven randomised controlled trials (RCT) comparing topical aryl hydrocarbon receptor agonists (TAHRA), including tapinarof and benvitimod cream, to vehicle at different concentrations and application frequencies in patients with AD, which evaluated outcomes such as Investigator Global Assessment (IGA) scores/Validated Investigator's Global Assessment (vIGA), the Eczema Area and Severity Index (EASI-75), change from baseline in body surface area (BSA) and pruritus score (PS) and safety profiles.</p><p><strong>Results: </strong>A total of 1631 patients, 1086 received TAHRA, while 545 received vehicle. Overall, TAHRA led to a significant improvement in the IGA/vIGA scores (RR 2.38; 95% CI 1.68 to 3.37; p < 0.0001), EASI-75 (RR 2.94; 95% CI 2.07 to 4.17; p < 0.00001). Similar findings were observed for mean change from baseline in BSA% (MD -6.08; 95% CI -8.00 to -4.16; p < 0.00001), and PS (Std MD -0.90; 95% CI -1.41 to -0.39; p = 0.0006). The incidence of AE was significantly higher in the TAHRA group (RR 1.48; 95% CI: 1.19-1.85; p = 0.0005). We found no significant difference in the incidence of serious adverse events (SAEs) (RR of 1.51; 95% CI: 0.34-6.64; p = 0.59). Treatment-emergent adverse events (TEAEs), such as folliculitis, were more frequent in the TAHRA group (RR 8.06; 95% CI: 2.75-23.60; p = 0.0001).</p><p><strong>Conclusion: </strong>Our findings support the efficacy of TAHRA among different metrics with minimal and tolerable AEs and its use as a valuable new non-steroidal option for the treatment of AD.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wolf's Isotopic Response: A Rare Case of Terra Firma-Forme Dermatosis on Resolved Psoriatic Plaques.","authors":"Conor Larney, Peter A Foley, Senhong Lee","doi":"10.1111/ajd.14488","DOIUrl":"https://doi.org/10.1111/ajd.14488","url":null,"abstract":"<p><p>Terra firma-forme dermatosis is a benign condition characterised by asymptomatic hyperkeratotic, dark papules or plaques. The diagnosis may be confirmed by firmly rubbing the lesions with 70% isopropyl alcohol, resulting in resolution of the lesions. Wolf's isotopic response refers to the development of a new dermatosis in the same location that a previous, healed, unrelated skin condition occupied. We report the case of a patient developing Terra firma-forme dermatosis at the site of resolved psoriatic plaques.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report of Dermatomyositis With Features of the Wong Variant Developing Post-Trastuzumab Therapy for Breast Cancer.","authors":"Lauren C LaMonica, Margaret E Lang Houser, Paul W Harms, Frank Wang","doi":"10.1111/ajd.14456","DOIUrl":"https://doi.org/10.1111/ajd.14456","url":null,"abstract":"<p><p>Drug-induced dermatomyositis can be challenging to distinguish from paraneoplastic dermatomyositis. Rarely, antibodies directed against human epidermal growth factor receptor 2 (HER-2), such as trastuzumab, may trigger dermatomyositis, and immune checkpoint inhibitors may incite the Wong variant of dermatomyositis, characterised by clinical and histopathologic features of pityriasis rubra pilaris, including monomorphic keratotic papules. We present an unusual case of dermatomyositis with features of the Wong variant occurring in a 51-year-old female with a history of breast cancer after completion of adjuvant therapy with trastuzumab.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systemic Review of Large Language Models and Their Implications in Dermatology.","authors":"Miłosz Lewandowski, Julia Kropidłowska, Alexandra Kvinen, Wioletta Barańska-Rybak","doi":"10.1111/ajd.14484","DOIUrl":"https://doi.org/10.1111/ajd.14484","url":null,"abstract":"<p><p>In computational linguistics, large language models have reached a significant turning point. They have quickly spread throughout several sectors, including the medical field. By integrating demographics, clinical photos, medical interviews, or genetic data where appropriate, these technologies may offer deeper insights into patient data in dermatology. They may also offer recommendations for suitable diagnosis and treatment. Their work in dermatology may influence patient education and interactions with doctors by addressing patients' questions or developing patient education materials, in addition to enhancing diagnostic procedures and treatment schedule planning. Through a thorough systematic evaluation of the publicly accessible big language model applications in dermatology, the paper seeks to close the current gap by highlighting previously published research, identifying important obstacles, and investigating potential future directions.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Challenges in the Management of VEXAS Syndrome: A Case Report.","authors":"Georgia Kelly, Yolanka Lobo, Amanda Godbolt","doi":"10.1111/ajd.14478","DOIUrl":"https://doi.org/10.1111/ajd.14478","url":null,"abstract":"<p><p>VEXAS syndrome is a newly described autoinflammatory and haematologic condition that has variable cutaneous and systemic presentations. We present a case of VEXAS syndrome in a 63-year-old male with treatment refractory pyoderma gangrenosum and a complex dermatologic and systemic history. We hope it informs and encourages dermatologists to consider early diagnostic testing for VEXAS syndrome in any male over 50 years of age with a neutrophilic dermatosis and unexplained autoinflammation.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Surgical and Aesthetic Complications of Mohs Micrographic Surgery in an Australian Cohort.","authors":"Joshua Farrell, Thomas Stewart, Eleni Yiasemides","doi":"10.1111/ajd.14482","DOIUrl":"https://doi.org/10.1111/ajd.14482","url":null,"abstract":"<p><p>Australian research on the complications of Mohs micrographic surgery (MMS) is scarce. We reviewed our MMS cases for patient, tumour, and treatment factors, as well as surgical complications and aesthetic dissatisfaction. Our results reaffirm international data showing that MMS in Australia has low complication rates (≤ 2%). Smoking, anticoagulant use, tumour anatomic site, defect size, and repair method may affect the risk of surgical complications, and patient age and sex may influence the risk of aesthetic dissatisfaction.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising Actinic Cheilitis Management: Balancing Efficacy, Safety, and Patient Adherence With Topical Tirbanibulin.","authors":"Alvaro Prados-Carmona, Francisco M Almazán-Fernández, Pablo Velasco-Amador, Ricardo Ruiz-Villaverde","doi":"10.1111/ajd.14480","DOIUrl":"https://doi.org/10.1111/ajd.14480","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upadacinib for the Treatment of Refractory Morphea.","authors":"Vincenzo Maione, Sara Rovaris, Carola Romanò, Stefano Bighetti, Iacopo Ghini, Luca Bettolini","doi":"10.1111/ajd.14481","DOIUrl":"https://doi.org/10.1111/ajd.14481","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Impact of Guselkumab and Risankizumab on Psoriasis in HIV-Positive Patients: Insights From Four Italian Centers.","authors":"V Maione, S Rovaris, C Romanó, S Bighetti, M Arisi, C G Carrera, F Bellinato, P Gisondi, Z Fratton, E Errichetti, L Bettolini","doi":"10.1111/ajd.14467","DOIUrl":"https://doi.org/10.1111/ajd.14467","url":null,"abstract":"<p><p>HIV-positive patients with psoriasis often face delays in accessing biologic therapies due to their exclusion from clinical trials and concerns about the impact of immunomodulatory drugs on viral replication. Anti-IL-23 therapies, such as risankizumab and guselkumab, have shown great promise thanks to their strong efficacy and favourable safety profiles. A case series from four Italian centres reported sustained effectiveness of these drugs, with no observed effects on viral replication or immune parameters in HIV-positive patients. Although the number of cases is limited, these therapies appear to be a compelling option for patients with extensive or treatment-resistant psoriasis.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}