生物诱导的矛盾型银屑病脱发：系统综述。

IF 1.8 4区医学 Q2 DERMATOLOGY

Australasian Journal of Dermatology Pub Date : 2025-09-12 DOI:10.1111/ajd.14600

Yaron Gu, Deshan F Sebaratnam, Mani Makhija, Joshua Farrell

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引用次数: 0

摘要

一项系统综述完成了主要研究文章，报告了与生物治疗相关的矛盾银屑病性脱发的患者结局。除了我们自己的病例外，我们的搜索策略从45项研究中确定了96名患者。我们的回顾表明，在年轻女性患者中，悖论性银屑病脱发的患病率较高，最常见的继发于tnf - α抑制剂。与寻常型银屑病继发性脱发不同，观察到淋巴细胞、浆细胞和嗜酸性粒细胞混合炎症浸润。在大多数患者中观察到缓解，包括大约三分之一的患者继续进行生物治疗。试验注册：PROSPERO注册号：CRD42023471174。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biologic-Induced Paradoxical Psoriatic Alopecia: A Systematic Review.

A systemic review was completed of primary research articles reporting patient outcomes in paradoxical psoriatic alopecia in association with biologic therapy. Our search strategy identified 96 patients from 45 studies in addition to our own case. Our review indicates a higher prevalence of paradoxical psoriatic alopecia in younger female patients, most commonly secondary to TNF-alpha inhibitors. Unlike alopecia secondary to psoriasis vulgaris, a mixed inflammatory infiltrate featuring lymphocytes, plasma cells and eosinophils was observed. Remission was observed in most patients, including approximately a third of whom continued biologic therapy. Trial Registration: PROSPERO registration number: CRD42023471174.

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来源期刊

Australasian Journal of Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

5.00%

发文量

186

审稿时长

6-12 weeks

期刊介绍： Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.