Asia-Pacific journal of clinical oncology最新文献

{"title":"Management Strategies and Outcomes of Tumor Thrombus in Extremity Osteosarcoma.","authors":"Ashik A Bary, Karthigaiselvi Murugesan, Chandra Kumar Krishnan, Shirley SunderSingh, Anand Raja","doi":"10.1111/ajco.14190","DOIUrl":"https://doi.org/10.1111/ajco.14190","url":null,"abstract":"<p><p>Osteosarcoma, accounting for 2.4% of all childhood malignancies and about 20% of primary bone cancers, primarily affects young adults, with 60% of cases occurring before age 25. Tumor thrombus (TT) formation, a type of cancer-associated thrombosis, is a rare but critical complication in osteosarcoma, leading to increased morbidity and mortality. TT is characterized by the direct extension of the tumor into adjacent vessels, displaying similar imaging characteristics and contrast enhancement as the primary tumor. Our study is a case series of five cases of extremity osteosarcoma where the presence of tumor thrombus has been diagnosed, highlighting diagnostic challenges and management strategies. Preoperative identification of TT remains difficult and is often diagnosed postoperatively or at autopsy. Advanced imaging techniques such as Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography can aid in the detection of TT, although they are not definitive. Surgical resection combined with thrombectomy is recommended, improving prognosis. Anticoagulation therapy aims to prevent bland thrombus formation rather than resolving TT, as the latter increases the risk of embolization. This study underscores the need for heightened suspicion and comprehensive preoperative imaging to improve outcomes in osteosarcoma patients with TT, advocating for multidisciplinary management including vascular surgeons during limb salvage procedures. Further research is essential to optimize anticoagulation protocols and validate these findings in larger cohorts.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the Incidence of Early-Onset Adenocarcinomas in Aotearoa New Zealand Increasing?","authors":"Raymond Phang, Oliver Waddell, William Dixon, John Pearson, Andrew McCombie, Frank Frizelle","doi":"10.1111/ajco.14184","DOIUrl":"https://doi.org/10.1111/ajco.14184","url":null,"abstract":"<p><strong>Aim: </strong>The incidence of certain cancers in those under 50 years old (early-onset cancers) has been rising in many countries. This increase is generally unexplained and has significant implications for health policies and treatment. We wish to understand if this trend is occurring in Aotearoa New Zealand and whether it is across the spectrum of adenocarcinomas or site (cancer location)-specific. Differences in patterns between sites would suggest different possible etiologies for any increase in incidence and hence differences in how this trend might be managed.</p><p><strong>Method: </strong>The change in incidence of esophageal, gastric, colorectal, pancreatic, breast, lung, uterine, ovarian, and prostate adenocarcinomas from 2000 to 2020 in Aotearoa New Zealand was analyzed. Data was extracted from the New Zealand Cancer Registry. All new cases of relevant adenocarcinomas were analyzed to calculate the crude incidence, incidence rate ratios (IRRs), and age-standardized incidence. Trends were estimated by age and ethnicity, focusing on early-onset adenocarcinomas.</p><p><strong>Results: </strong>There was evidence for increases in early-onset colorectal (IRR 1.23, p < 0.01), breast (IRR 1.08, p < 0.01), uterine (IRR 1.73, p < 0.01), and prostate adenocarcinomas (IRR 1.14, p < 0.05). In Māori, there was evidence for significant increases in colorectal (IRR 1.42, p < 0.01), uterine (IRR 1.98, p < 0.01), and lung adenocarcinomas (IRR 1.23, p < 0.05).</p><p><strong>Conclusion: </strong>From 2000 to 2020, there were increases in multiple early-onset adenocarcinomas. This is site-specific, namely colorectal, breast, uterine, and prostate. Ongoing research is needed to investigate possible causes and develop strategies to address the increase in site-specific early-onset adenocarcinoma incidence.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary Implementation of Neoadjuvant Therapy for Early Breast Cancer in a Middle-income Country-Real-world Challenges in Malaysia.","authors":"Nur Aishah Mohd Taib, Nur Fadhlina Abdul Satar, Adibah Ali, Chun Sen Lim, Rohaizak Muhammad, Navarasi S Raja Gopal, Yueh Ni Lim, Shantini Arasaratnam, Juliana Abdul Latiff, Anita Baghawi, Char Hong Ng, Mastura Md Yusof","doi":"10.1111/ajco.14185","DOIUrl":"https://doi.org/10.1111/ajco.14185","url":null,"abstract":"<p><strong>Aim: </strong>Neoadjuvant therapy (NAT) is not widely employed for the management of patients with early breast cancer (EBC) in Malaysia. We sought to identify barriers to NAT and explore solutions for improving equitable, safe, and timely access to NAT in these patients.</p><p><strong>Methods: </strong>We used deliberative stakeholder consultation, a descriptive qualitative study design, for data collection. Sixteen breast cancer specialists (seven breast surgeons, seven clinical oncologists, one radiologist, and one pathologist) from 11 tertiary centers in Malaysia were purposively recruited. Deliberations were recorded, transcribed, and thematically analyzed to generate analytical and deliberative outputs. A literature search was performed to ensure that consensus statements were aligned with scientific evidence and clinical practice guidelines.</p><p><strong>Results: </strong>Four barrier themes affecting NAT implementation were derived: (1) diagnostic delays, (2) lack of access to oncology services, (3) patient low acceptance of NAT, and (4) high treatment costs. We highlighted potential solutions to address each barrier. Seven key areas for improvement were identified across the EBC care pathway: (1) rational use of imaging modalities, (2) biopsy sampling technique, (3) standardized histopathological reporting, (4) patient selection for NAT, (5) marker clip insertion, (6) monitoring during NAT, and (7) surgical axillary management. Expert recommendations for practice-change interventions were in alignment with published international, national, and institutional guidelines.</p><p><strong>Conclusion: </strong>Barriers to NAT in Malaysia are multifactorial. This study draws on a multidisciplinary stakeholder perspective to define real-world challenges faced by breast cancer specialists and provides recommendations for implementing guideline-recommended practices for NAT utilization in the local healthcare setting.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Toxicity in Older Patients Receiving Anticancer Agents: A Retrospective Analysis of Australian Patients.","authors":"Joseph S Taylor, Cassandra White, Larissa Collins, Benjamin Moran, Craig Kukard","doi":"10.1111/ajco.14186","DOIUrl":"https://doi.org/10.1111/ajco.14186","url":null,"abstract":"<p><p>The number of older adults being treated for cancer is increasing. Despite this, older patients are under-represented in clinical trials. Those who are included are unlikely to be an accurate reflection of real-world patients as many are excluded based on performance status and comorbidities. There is a paucity of data examining the toxicity, and effectiveness, of systemic therapy in this group; particularly in a regional Australian cohort. Retrospective data from patients ≥75 years, on treatment for a solid organ malignancy in an Australian regional center was collected to assess the toxicity, and effectiveness, of immunotherapy and chemotherapy. Ninety-two patients were included. The mean age was 81. There was no significant difference in overall survival based on; age, Eastern Cooperative Oncology Group score, or number of comorbidities. Only 27% of treatments were ceased due to toxicity. 35% of patients on chemotherapy had had a dose reduction during treatment. Grade ≥3 toxicity was experienced by 32% of patients who received chemotherapy-containing regimens and 22% who received immunotherapy-containing regimens. To our knowledge, this is the first study providing real-world data on the effectiveness, and safety, of anti-cancer agents in older patients in a regional Australian center across multiple tumor streams. In older adults otherwise well enough for treatment, outcomes from treatment were not greatly affected by age. Other factors, rather than age and comorbidities alone, may predict outcomes. The use of screening tools may help select patients for comprehensive geriatric assessment.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Lung Cancer Patient Journey in Singapore: Challenges and Recommendations.","authors":"Lynette Teo, Mariko Siyue Koh, Kevin Lee Min Chua, Lowell Leow, Chong Hee Lim, Darren Wan-Teck Lim, Hong Liang Lim, Hwai Loong Kong, Gideon Ooi, Jens Samol, Chee Seng Tan, Ross A Soo","doi":"10.1111/ajco.14180","DOIUrl":"https://doi.org/10.1111/ajco.14180","url":null,"abstract":"<p><p>Early detection of lung cancer is crucial for improving survival rates because it allows for potentially curative treatments; however, most lung cancer cases in Singapore are diagnosed at advanced stages. This review article provides an overview of current practices in the management of early-stage non-small-cell lung cancer (stages I-IIIA) in Singapore (i.e., screening, diagnosis, treatment, and follow-up) while identifying and addressing the associated challenges. Implementing a locally adapted, subsidized national screening program with awareness campaigns can facilitate lung cancer screening uptake. Improving the accessibility and affordability of diagnostic tests and treatments, establishing clear referral pathways and diagnostic workup, adopting multidisciplinary teams, and utilizing cost-effective treatments are critical to timely and effective management of early-stage lung cancers. Establishment of local guidelines for follow-up care, integrating digital technologies and artificial intelligence, and expanding patient assistance programs for follow-up procedures are vital to improving long-term outcomes. Overall, improving the management of early-stage lung cancer necessitates collaboration among healthcare professionals, medical societies, policymakers, patient advocacy groups, and the general public.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survivorship Needs and Experiences of Survivors of Head and Neck Cancer in Rural Australia: A Qualitative Study.","authors":"Poorva Pradhan, Helen Hughes, Ashleigh R Sharman, Judith Lacey, Patrick Dwyer, Jacques Hill, Kimberley J Davis, Steven Craig, Raymond Wu, Bruce Ashford, Jenny Mitchell, Jonathan R Clark, Michael Elliott, Carsten E Palme, Rebecca L Venchiarutti","doi":"10.1111/ajco.14179","DOIUrl":"https://doi.org/10.1111/ajco.14179","url":null,"abstract":"<p><strong>Aim: </strong>Head and neck cancer (HNC) survivors experience complex survivorship needs compared to other cancer types. This is exacerbated for people living in regional and remote (rural) areas of Australia, who experience poorer outcomes, higher physical and psychological needs, and poorer quality of life compared to their metropolitan counterparts. Little is known about the general survivorship experiences of rural HNC survivors in New South Wales (NSW), Australia. This study aims to explore the general survivorship experiences of people living with HNC in rural areas of NSW, Australia.</p><p><strong>Methods: </strong>HNC survivors living in rural NSW were recruited, and semi-structured interviews were conducted to explore their general survivorship experiences. The interviews were recorded, transcribed, and analyzed using a qualitative thematic analysis approach until saturation of themes was reached.</p><p><strong>Results: </strong>Semi-structured interviews were conducted with 17 participants, with a mean age of 65 years. The most common diagnoses were oral cavity (41%) and oropharyngeal cancers (29%). Six key themes emerged around general survivorship experiences among participants: 1) financial impacts, 2) physical effects, 3) psychosocial effects, 4) clinical management, 5) information and support needs, and 6) access.</p><p><strong>Conclusions: </strong>Rural cancer survivors face unique survivorship concerns, exacerbated by living further from specialist care. The unmet needs of people living in rural areas include financial reimbursement, psychosocial services and support, and access to survivorship care closer to home. Understanding cancer survivors' experiences throughout the care journey can identify unmet needs. By recognizing these needs, they can be more readily addressed by government policy and other interventions.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Literature Review on the Burden of Human Papillomavirus Infection and Related Diseases in India.","authors":"De Partha, Rambhad Gautam S, Wu Ying Hui, Sukarom Isaya","doi":"10.1111/ajco.14181","DOIUrl":"https://doi.org/10.1111/ajco.14181","url":null,"abstract":"<p><p>Human papillomavirus (HPV)-related diseases pose public health concerns for both genders, yet their understanding remains limited in India. This review outlines HPV incidence and prevalence, genotype distribution, and attribution rates across different HPV-related disease types. A comprehensive literature search was performed to identify observational studies on individuals aged 15 years and older, and a total of 3702 publications were identified. A total of 139 studies were included in this review, involving 607,425 subjects aged 15.8-82.2 years, with a gender distribution of 38.13% males and 61.86% females. The prevalence of HPV infection in the anogenital area among healthy males and females was 41.07% and between 0.4% and 41.8%, respectively. Among individuals with HPV-related diseases, HPV infection prevalence was 26.1%-100% in unhealthy cervixes and cervical lesions, 3.1%-41% in anal lesions, 71.4% in vulva and vaginal lesions, and 0%-92.3% in head and neck cancer. The review highlights the variability in HPV prevalence across genders and age groups in India, likely due to population heterogeneity and testing differences. This study highlights the need for rigorous and uniform studies in India on the HPV disease burden and the importance of gathering evidence with a special focus on males.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer Awareness and the Practice of Self Breast Examination Among Undergraduate Students in Karachi, Pakistan.","authors":"Mubashir Zafar, Tafazzul Hyder Zaidi, Nadira Hyder Zaidi, Amber Ilyas, Syeda Ruqaya Neha Majeed, Iqra Manzoor, Tooba Sajid, Saadia Akram, Kiran Mehtab, Rahat Naz, Ayesha Mubbashir","doi":"10.1111/ajco.14182","DOIUrl":"https://doi.org/10.1111/ajco.14182","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer remains one of the most prevalent malignancies affecting women worldwide, and breast self-examination (BSE) is acknowledged as a sensitive method for its early detection. This study aimed to assess the level of awareness regarding both breast cancer and BSE among undergraduate students in Karachi, Pakistan.</p><p><strong>Methodology: </strong>A cross-sectional survey was conducted at a public-sector university in Karachi. A total of 328 female students were selected using multistage stratified cluster sampling. The Chi-square test was employed to evaluate differences in awareness levels across various socio-demographic characteristics, with a p value of less than 0.05 considered statistically significant. All ethical guidelines were strictly adhered to throughout the study.</p><p><strong>Results: </strong>The mean age of the participants was 22 years. The study revealed that younger age groups (18-22 years), first-year students from various colleges, and students enrolled in business programs exhibited significantly lower levels of awareness regarding both breast cancer and BSE (p value <0.005). Overall, appropriate levels of awareness were reported by 45.1% of the participants for breast cancer and 47.3% for BSE.</p><p><strong>Conclusion: </strong>The findings indicate that the awareness levels regarding breast cancer and BSE are inadequate, particularly among first-year students and those pursuing business-related studies. These results underscore the need for targeted educational interventions to enhance awareness and promote the early detection and effective management of breast cancer through the practice of BSE.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting the Benchmark: Patterns of Care and Outcomes for Early-stage Non-small Cell Lung Cancer in Queensland, Australia, 2011-2017.","authors":"Bryan A Chan, Danny R Youlden, Tracey Guan, Margot Lehman, Morgan Windsor, Alison Bolton, Nathan Dunn, Danica Cossio, Shoni Philpot, Jasotha Sanmugarajah","doi":"10.1111/ajco.14177","DOIUrl":"https://doi.org/10.1111/ajco.14177","url":null,"abstract":"<p><strong>Aim: </strong>Treatment paradigms for early-stage non-small cell lung cancer (NSCLC) are evolving rapidly. Our aim was to document baseline patterns of care and outcomes at the population level immediately prior to the introduction of immunotherapy.</p><p><strong>Methods: </strong>Data were obtained from the Queensland Oncology Repository. The study cohort comprised Queensland residents diagnosed with a non-metastatic primary NSCLC between 2011 and 2017, with follow-up on treatment and mortality to December 31, 2022. Poisson regression was used to determine patient and clinical characteristics associated with receiving different treatment modalities within 1 year of diagnosis. Variations in 5-year observed survival were assessed using flexible parametric modelling.</p><p><strong>Results: </strong>A total of 4445 people were included, of whom 30% were treated with surgery only, 15% with surgery plus chemotherapy and/or radiotherapy and 44% with chemotherapy and/or radiotherapy only. The remaining 10% did not receive any recorded treatment. People in outer regional/remote areas had lower rates of radiotherapy (relative likelihood [RL] = 0.87, 95% confidence interval [CI] 0.78-0.97) and chemotherapy (RL = 0.89, 95% CI 0.81-0.98) than those in major cities, but there were no significant differences by First Nations status or socio-economic status. Five-year observed survival varied from 63% (95% CI 60%-65%) for stage I to 41% (38%-45%) for stage II and 20% (18%-22%) for stage III. The treatment modality significantly affected survival irrespective of stage at diagnosis (all p < 0.001).</p><p><strong>Conclusion: </strong>Monitoring treatment outcomes for early-stage NSCLC at the population level is crucial for optimizing patient care, resource allocation and informing consumer choice. Emerging approaches involving immunotherapy are expected to further improve outcomes.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Lobular Breast Cancer: Outcomes of Patients Treated at a Single Tertiary Institution.","authors":"Ek Leone Oh, Elizabeth Steinepreis, Chia Len, Hilary Martin","doi":"10.1111/ajco.14175","DOIUrl":"https://doi.org/10.1111/ajco.14175","url":null,"abstract":"<p><strong>Background: </strong>Management for lobular breast cancer is generally extrapolated from trials comprised predominantly of ductal breast cancer patients. However, lobular cancers are biologically distinct with associated treatment implications, but despite this, prospective trial data focusing on lobular cancers is lacking.</p><p><strong>Methods: </strong>We conducted a retrospective review of patients diagnosed with metastatic lobular breast cancer at our cancer service. We collected data on clinical characteristics and analysed treatment outcomes following various lines of systemic therapies.</p><p><strong>Results: </strong>Between January 2017 and April 2023, 21 patients with metastatic lobular breast cancer were identified. As expected, most (76.2%) patients had a hormone-receptor-positive HER2-negative (HR+HER2-) disease. The mean age at diagnosis of metastatic disease was 60.61 years, and the mean time to progression from early to metastatic disease was 8.45 years. Responses to systemic treatments given for metastatic disease varied significantly. For patients with HR+HER2- disease, the highest clinical benefit rate was observed with capecitabine, followed by a CDK4/6 inhibitor plus a non-steroidal aromatase inhibitor.</p><p><strong>Conclusion: </strong>This study aligns with existing literature in terms of the clinical characteristics of early lobular breast cancers. For metastatic disease, HR+HER2- lobular breast cancer treated with CDK4/6 inhibitors and non-steroidal aromatase inhibitors had a similar progression-free survival compared to the registration trial data supporting its use for lobular cancer. There were also some responses to chemotherapy, with all patients who received capecitabine obtaining clinical benefit. Patients with HER2+ disease had excellent outcomes, while outcomes were poor for triple-negative lobular breast cancer, though the small number of patients in our study limits interpretation.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}