Asia-Pacific journal of clinical oncology最新文献

{"title":"Understanding and Addressing Clinical Variation in Rectal Cancer Care: Application of an Analytic Framework.","authors":"Bernadette Bea Brown, Daniel Steffens, Michael Solomon, Cherry Koh, Jane Young","doi":"10.1111/ajco.14207","DOIUrl":"https://doi.org/10.1111/ajco.14207","url":null,"abstract":"<p><strong>Aim: </strong>There is substantial, protracted clinical variation in the use of neoadjuvant radiotherapy (with/without chemotherapy) prior to surgical resection for high-risk rectal cancer. In New South Wales (NSW), Australia, in 2018, this ranged from 25% to 59% across health districts. This study aimed to describe specialist clinicians' views about: the amount of clinical variation explained by patient factors and preference (warranted clinical variation) reasons for observed clinical variation solutions to address unwarranted clinical variation METHODS: A study-specific questionnaire was mailed to all rectal cancer specialists in NSW. Quantitative responses were summarized using descriptive statistics. Open-ended responses were analyzed thematically. Follow-up semi-structured interviews were conducted with a subset of participants. Proposed reasons were categorized against the Sutherland and Levesque analytic framework to assess if the observed clinical variation is warranted or unwarranted.</p><p><strong>Results: </strong>A total of 75 of 210 eligible specialists (36%) completed questionnaires. The majority strongly supported the use of neoadjuvant radiotherapy, with no evidence of equipoise. The maximum difference in the proportion of patients receiving neoadjuvant radiotherapy explained by patient factors or preference was estimated at 10%-20%, substantially less than reported. Proposed reasons for observed clinical variation were largely unwarranted and centered on five main themes: Multidisciplinary team (MDT)-related issues (capacity) Imaging-related issues (capacity) Workforce and practice patterns (capacity) Surgeon treatment preferences (agency) Data quality (evidence) CONCLUSIONS: Improving the consistency of MDT processes, uniform access to high-quality imaging, and improving data quality for performance reporting are focus areas with the potential to reduce unwarranted clinical variation in rectal cancer care.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":"e14207"},"PeriodicalIF":1.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Current Status of Circulating Tumor DNA Utilization in Australasia: A Survey of Thoracic Oncology Group Australasia Members.","authors":"Yifei Zhu, Danyon Lo, Deme Karikos, Malinda Itchins, Annie Wong","doi":"10.1111/ajco.14215","DOIUrl":"https://doi.org/10.1111/ajco.14215","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the current status of circulating tumor DNA (ctDNA) utilization for non-small cell lung cancer (NSCLC) among members of the Thoracic Oncology Group Australasia (TOGA), and to identify barriers to its implementation in clinical practice across Australia and New Zealand (ANZ).</p><p><strong>Methods: </strong>A 31-item electronic survey was distributed to TOGA members between December 2023 and August 2024. Responses were analysed descriptively to assess access, usage patterns, perceived barriers, and clinician attitudes toward ctDNA testing.</p><p><strong>Results: </strong>Thirty complete responses were analysed. Most respondents were medical oncologists working in metropolitan academic or public hospitals. While respondents estimated 83% of patients have access to molecular testing, only 12% were believed to have access to ctDNA testing. Only 33% reported routine ctDNA use, primarily in advanced disease settings. If more accessible, 83% indicated they would adopt ctDNA in advanced NSCLC. Key barriers to ctDNA utilization included cost (93%), logistical challenges (63%), limited knowledge (50%), and assay confidence (40%). Although over half of clinicians had patients inquire about ctDNA, fewer than 40% routinely discussed it. Most preferred are in-person or virtual workshops for education. Notably, 30% lacked access to a Molecular Tumor Board, and 70% did not provide pre-test counselling regarding incidental germline findings.</p><p><strong>Conclusion: </strong>Despite limited current use, there is strong interest in ctDNA testing for NSCLC in ANZ. Addressing funding, logistical barriers, and clinician education is essential to enabling equitable, widespread adoption of ctDNA into standard lung cancer care.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":"e14215"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Real-World Evaluation of a Statewide Mainstream Model of Germline Genetic Testing for BRCA1/2 and Mismatch Repair Gene Variants (Lynch Syndrome).","authors":"Cally A Jennings, Kathryn Cornthwaite, Michael Osborn, Ganessan Kichenadasse, Eryn Dow","doi":"10.1111/ajco.14210","DOIUrl":"https://doi.org/10.1111/ajco.14210","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and evaluate an evidence-based mainstream germline genetic testing model to support cancer treatment including the BRCA1/BRCA2 and mismatch repair (MMR) genes across South Australia.</p><p><strong>Methods: </strong>Participatory action research (PAR) and implementation science principles were used to guide the development of the statewide mainstream pathway. To support the implementation of the mainstream pathway, genetic testing packages for clinicians and consumer support materials have been developed, and an education program has been delivered to clinicians. This quality improvement study used an independent sample t-test to compare the average number of monthly tests completed via mainstream and traditional pathways during two nonconsecutive 6-month periods. Acceptability among patients and clinicians and clinician knowledge, confidence, and experience measures were assessed.</p><p><strong>Results: </strong>The total number of BRCA1/2 tests did not increase from pre- to post-pathway implementation. However, there was a significant increase in both the number of tests ordered through the mainstream pathway (pre: mean 3.5, SD 2.07; post: mean 7, SD 2.53) and the proportion of total tests ordered via mainstreaming (pre: mean 14%, SD 9.25%; post: mean 25.0%, SD 5.48%). There were no changes in MMR gene testing patterns, with no mainstream tests ordered. Among clinicians (n = 20) who responded to the post-implementation survey, positive levels of acceptability were reported.</p><p><strong>Conclusion: </strong>This study showed that the implementation of a statewide mainstream genetic testing pathway in a public health system improved the uptake of mainstream testing for BRCA1/2. Further understanding of the barriers to uptake across settings is needed to support effective utilization.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":"e14210"},"PeriodicalIF":1.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing Teletrials to Improve Equity of Access for Regional Patients With Cancer: Report From the Victorian Teletrial Collaborative.","authors":"Craig Underhill, A Woollett, Mark Buzza, Jessica Freeman, Will Evans, Jacqui McBurnie, Sam Harris, Kate Burbury, Kylie Shackleton, Linda Brown, Simonne Neil, Donna Long","doi":"10.1111/ajco.14209","DOIUrl":"https://doi.org/10.1111/ajco.14209","url":null,"abstract":"<p><strong>Aim: </strong>The uptake of telehealth, including for clinical trials (teletrials), accelerated during the pandemic and helps address inequity of access for underserved populations. This report discusses the work of experts in Victoria to implement teletrials in cancer clinical trials but has learnings for other jurisdictions and in other disease types.</p><p><strong>Methods: </strong>Three funded programs in Victoria (the Regional Trials Network Victoria, Trial Hub Alfred, and the Victorian Comprehensive Cancer Centre Alliance), each tasked with improving access to clinical trials for regional patients, formed the Victorian Teletrial Collaborative. In addition, they coordinated work with the Australian Teletrial Program and Safer Care Victoria. The Collaborative, backed with a Memorandum of Understanding and using a collective impact framework, held a workshop and developed a workplan and program logic. It met monthly to make progress against the workplan, which had four main themes: governance/logistics, education/training, advocacy/awareness, and operational Processes.</p><p><strong>Results: </strong>The Collaborative developed operational templates, toolkits for consumers and clinicians, education and training modules, and discussion papers to help overcome barriers to the implementation of teletrials. It conducted a workshop of national experts to consider barriers and enablers for the implementation of teletrials in early-phase clinical trials and developed a masterclass for clinicians. Future work plans focus on advocacy and communication about teletrials.</p><p><strong>Conclusion: </strong>The Victorian Teletrial Collaborative has utilized an evidence-based approach to develop a series of toolkits and recommendations aimed at facilitating the sustainable uptake of teletrials in our jurisdiction and elsewhere.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":"e14209"},"PeriodicalIF":1.4,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Survivorship Care for People Affected by Advanced or Metastatic Cancer: A Clinical Oncology Society of Australia Endorsement of the Joint Multinational Association of Supportive Care in Cancer and American Society of Clinical Oncology Care Standards and Practice Recommendations.","authors":"Nicolas H Hart, Michael Jefford, Bogda Koczwara, Larissa Nekhlyudov, Julia Lai-Kwon, Sarah Heynemann, Jasmine Yee, Gregory B Crawford, Andrea L Smith, Darren Haywood, Meera R Agar, Raymond J Chan","doi":"10.1111/ajco.14214","DOIUrl":"https://doi.org/10.1111/ajco.14214","url":null,"abstract":"","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":"e14214"},"PeriodicalIF":1.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Digital Mental Health Interventions for Breast Cancer Survivors: Insights and Future Directions.","authors":"Pei-Chen Li, Lien-Chung Wei","doi":"10.1111/ajco.14213","DOIUrl":"https://doi.org/10.1111/ajco.14213","url":null,"abstract":"","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":"e14213"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Longitudinal Observation of Lenvatinib-associated Adverse Events in Patients With Unresectable Radioiodine-refractory Differentiated Thyroid Cancer.","authors":"Yuka Aida, Toshio Suzuki, Yusuke Watanabe, Sachie Hashimoto, Emika Ichioka, Akiko Iguchi-Manaka, Joichi Usui, Masato Homma, Hisato Hara, Ikuo Sekine","doi":"10.1111/ajco.14211","DOIUrl":"https://doi.org/10.1111/ajco.14211","url":null,"abstract":"<p><strong>Aim: </strong>To characterize the long-term adverse events (AEs) observed in patients who received lenvatinib.</p><p><strong>Methods: </strong>We longitudinally assessed long-term AEs in patients with advanced or metastatic radioiodine-refractory differentiated thyroid cancer who had received lenvatinib for more than 1 year. AEs were graded according to the National Cancer Institute Common Terminology Criteria for AEs. Grade 2 AEs were defined as intolerable if a patient complained of distress.</p><p><strong>Results: </strong>Seventeen patients were treated for more than 1 year. The median age was 69 years. The median duration of lenvatinib treatment was 40 months. Notable intolerable grade 2 and 3 AEs were developed in the following order: hypertension (median day 18; range, day 1-131), diarrhea (median, day 27; range, day 4-1205), hand-foot skin reaction (median, day 33; range, day 20-582), platelet decrease (median, day 57; range, day 15-427), proteinuria (median, day 72; range, day 18-1772), anorexia (median, day 319; range, day 57-1541), and chronic kidney disease (CKD) (median, day 715; range, day 274-1296). After 2 years of administration, the decrease in estimated glomerular filtration rate became remarkable. Grade 3 hypertension occurred in 94.1% (16/17) of patients, of whom 66.8% (11/16) developed intolerable grade 2 proteinuria at a median interval of 35 days. Of these patients, 54.5% (6/11) developed intolerable grade 2 CKD at a median interval of 245 days.</p><p><strong>Conclusions: </strong>This longitudinal study revealed which AEs appeared and when. The findings provide useful information about when and which AEs we should be attentive to during daily practice.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":"e14211"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multicenter Real-World Study of Outcomes in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma Treated with a Polatuzumab Vedotin-Based Regimen in a Compassionate Use Program in Malaysia.","authors":"S Fadilah Abdul Wahid, Nor Asiah Muhamad, Nor Azimah Ismail, Izzah Athirah Rosli, Chiang Su Kien, Soo Min Lim, Lee Ping Chew, Kirubamoorthy Kamini, Veena Selvaratnam, Ahlam Naila Kori, Teh Hiok Seng, Soo-Chin Ng","doi":"10.1111/ajco.14208","DOIUrl":"https://doi.org/10.1111/ajco.14208","url":null,"abstract":"<p><strong>Background: </strong>Polatuzumab vedotin + bendamustine + rituximab (Pola-BR) was recently approved in Malaysia for treating relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). A multicenter retrospective study was conducted to assess the effectiveness of this regimen among patients in a compassionate use program.</p><p><strong>Objective: </strong>To determine treatment response and survival rates for R/R DLBCL patients treated with Pola-BR in Malaysia.</p><p><strong>Methodology: </strong>Safety and efficacy data of 23 adults with R/R DLBCL treated with Pola-BR at nine centers in Malaysia (September 2019-February 2021) were used. Of the 23 patients, 13 received six cycles of Pola-BR. The median follow-up was 10 months (1-37 months). The primary endpoint was complete response (CR) rate; secondary endpoints were overall survival (OS), progression-free survival (PFS), and adverse events (AEs).</p><p><strong>Results: </strong>The overall response rate was 56.5%, with 34.8% achieving CR. The 1-, 2-, and 3-year OS rates were 51.6%, 51.6%, and 44.2%, respectively, with a median OS of 27 months. The 1- and 2-year PFS rates were 48.2% and 41.3%, respectively, with a median PFS of 10 months; 60% of the nonresponders had progressive disease. Cox proportional hazard regression analysis showed that bulky disease was a significant hazard for disease progression. A total of 42 AEs were recorded, of which 66.7% were grade ≥ 3 AEs; 90.5% of the AEs were hematological and resolved with treatment; only one patient succumbed to neutropenic sepsis.</p><p><strong>Conclusions: </strong>Pola-BR has a favorable safety profile for R/R DLBCL treatment in Malaysia, although larger sample sizes and longer follow-ups are needed to confirm these results.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":"e14208"},"PeriodicalIF":1.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Impact of Synchronous and Metachronous Second Primary Cancers in Laryngeal Cancer Patients Treated With Radiotherapy: Variable With Time-Varying Effects and Cox Proportional Hazard Analyses.","authors":"Akikazu Kobori, Chiyoko Makita, Osamu Tanaka, Sunaho Okada, Yuichi Kajiura, Nansei Yamada, Masayuki Matsuo","doi":"10.1111/ajco.14206","DOIUrl":"https://doi.org/10.1111/ajco.14206","url":null,"abstract":"<p><strong>Aims: </strong>Patients with laryngeal and other head and neck cancers face a high risk of developing second primary cancers. This retrospective cohort study evaluated the prognostic value of second primary cancers in laryngeal cancer patients treated with radiotherapy.</p><p><strong>Methods: </strong>We retrospectively investigated patients with laryngeal cancer who underwent radiotherapy, and evaluated the incidence and relative risk of synchronous and metachronous second primary cancers in a single-institution cohort.</p><p><strong>Results: </strong>Between January 2007 and December 2021, 138 patients with laryngeal cancer were analyzed. The median follow-up period was 5.2 years. The 5-year overall survival rate was 82.4% and the progression-free survival rate was 71.9%. Synchronous and metachronous second primary cancers were observed in 15 (10.9%) and 38 (27.5%) patients, respectively, during the follow-up period. The cumulative incidence of metachronous second primary cancers was 23.3% at 5 years. Moreover, deaths from laryngeal cancer, other cancers, and noncancer illnesses accounted for 3.6% (5 patients), 12.3% (17 patients), and 10.9% (17 patients), respectively, with most deaths from causes other than laryngeal cancer occurring after the first 5 years. Synchronous second primary cancer was a significant prognostic factor of poor outcomes (hazard ratio, 4.42; 95% confidence interval, 1.93-10.13) on time-independent multivariate analysis, and metachronous second primary cancer was a significant prognostic factor of poor outcomes (hazard ratio, 4.55; 95% confidence interval, 2.09-9.91) in the time-dependent Cox proportional hazards model.</p><p><strong>Conclusion: </strong>Synchronous and metachronous second primary cancers are significant prognostic factors for patients with laryngeal cancer treated with radiotherapy.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":"e14206"},"PeriodicalIF":1.4,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation-Based Prognostication in Extensive-Stage Small Cell Lung Cancer in the First-Line Setting: The Advanced Lung Inflammation Index and the Others.","authors":"Erdoğan Selçuk Şeber, Ömer Faruk Elçiçek, Eyyüp Çavdar, Özge Yalıcı, Yıldız Garip Bilen, İlker Karaduman, Ezel Gedik, Okan Avcı","doi":"10.1111/ajco.14200","DOIUrl":"https://doi.org/10.1111/ajco.14200","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the prognostic significance of inflammatory indices, including the advanced lung inflammation index (ALI), in extensive-stage small cell lung cancer (ES-SCLC) patients receiving first-line platinum-etoposide chemotherapy.</p><p><strong>Methods: </strong>The study included 167 ES-SCLC patients. Patients with confirmed ES-SCLC histology who had completed at least 2 months of first-line treatment (platinum etoposide chemotherapy regimen without immunotherapy) were included. Demographic information, clinicopathological characteristics, and blood parameters (blood test results between Days 1 and 7 before the first chemotherapy) of the patients before the first treatment were recorded from the electronic record system.</p><p><strong>Results: </strong>Median age was 62 years (range: 40-88 years). A total of 163 (97.6%) patients had died of cancer-related causes. For all patients, the median OS (mOS) was 9 (95% CI: 8-10) months. In univariate analysis, gender, age, smoking, BMI, brain metastasis status, bone metastasis status, PCI (prophylactic cranial irradiation), and SVCSS (superior vena cava syndrome) were not associated with survival. Poor performance status (p = 0.036), low C-reactive protein-albumin-lymphocyte index (CALLY) (p = 0.030), high systemic immune inflammation index (SII) (p = 0.042), and low ion index (ALI) (p = 0.016) were predictive of poor survival on univariate analysis. Factors found to be prognostic in univariate analysis were evaluated in multivariate analysis. In the established model, only ALI (HR = 0.68, 95% CI: 0.49-0.93, p = 0.016) were found to be an independent prognostic factor for OS. The corresponding mOS according to CALLY, SII, ALI, and ECOG (Eastern Cooperative Oncology Group - Performance score) performance status were 8 versus 10 months (p = 0.020), 10 versus 8 months (p = 0.030), 8 versus 9 months (p = 0.010), and 9 versus 8 months (p = 0.025), respectively, with significant difference.</p><p><strong>Conclusion: </strong>CALLY, SII, ALI, and ECOG performance status could be useful prognostic markers for clinicians in patients with ES-SCLC receiving chemotherapy, with ALI emerging as the strongest prognostic factor. These readily accessible and easily computed markers can facilitate cost-effective follow-up and treatment decision-making by providing clinicians with a real-time assessment of the dynamic balance between host immunity and tumor-associated inflammation.</p>","PeriodicalId":8633,"journal":{"name":"Asia-Pacific journal of clinical oncology","volume":" ","pages":"e14200"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}