Actualidad medica最新文献_第3页

SARS-CoV-2 genome sequencing in Andalusia, methodology and study of variants 安达卢西亚SARS-CoV-2基因组测序、方法和变异研究

Actualidad medica Pub Date : 2022-01-01 DOI: 10.15568/am.2021.814.rev03

A. de Salazar, A. Fuentes-López, L. Viñuela, P. Camacho-Martínez, N. Chueca, L. Merino, J. Perez-Florido, C. Casimiro-Soriguer, J. Dopazo, N. Lorusso, F. García, J. A. Lepe

引用次数: 0

Psychosomatics aspects of the pathobiography of Alfonso X ‘The Wise’. 阿方索X的悲情传记《智者》的心理躯体方面。

Actualidad medica Pub Date : 2022-01-01 DOI: 10.15568/am.2021.814.hca01

E. Lupión-Cruz

引用次数: 0

Septo-optic dysplasia/ Morsier’s syndrome; a disease to be suspected 视隔发育不良/莫西尔综合征;一种值得怀疑的疾病

Actualidad medica Pub Date : 2022-01-01 DOI: 10.15568/am.2022.816.cc01

Sánchez Mellado, Montoro Moreno, Lacorzana, Caso Clínico, Alberto Sánchez Mellado

{"title":"Septo-optic dysplasia/ Morsier’s syndrome; a disease to be suspected","authors":"Sánchez Mellado, Montoro Moreno, Lacorzana, Caso Clínico, Alberto Sánchez Mellado","doi":"10.15568/am.2022.816.cc01","DOIUrl":"https://doi.org/10.15568/am.2022.816.cc01","url":null,"abstract":"Septo-optic dysplasia (SOD) or Morsier syndrome is a rare congenital malformation of infantile neurodevelopment with systemic anatomical and functional involvement. It is characterized by optic nerve hypoplasia, midline brain malformation, and hypothalamic-pituitary axis hypoplasia. The spectrum of clinical manifestations is very wide, from ophthalmological problems to endocrinological disorders that determine the severity and prognosis of these patients. The diagnosis is fundamentally clinical, based on an anamnesis and systematic clinical examination, supported by complementary tests for the study of hormonal deficits and imaging tests that objectify structural malformations. SOD has no cure; however, close follow-up focused on improving comorbidities through hormone replacement, neuropsychological support, and visual correction is necessary to improve the patient’s quality of life. Its low incidence and the breadth of forms of presentation require the knowledge and multidisciplinary approach of specialists in Pediatrics, Neurology, Endocrinology and Ophthalmology, among others. We present a descriptive case of this disease and its management.","PeriodicalId":86333,"journal":{"name":"Actualidad medica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67207741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Headache as a manifestation of Retinitis Pigmentosa and Idiopathic Intracranial Hypertension. A case report 头痛是色素性视网膜炎和特发性颅内高压的一种表现。病例报告

Actualidad medica Pub Date : 2022-01-01 DOI: 10.15568/am.2022.816.cc02

A. Sánchez Mellado, L. Alcaraz Clemente, A. A. Alfaro Juárez

引用次数: 0

Dexamethasone in outpatients with SARS-CoV-2 infection 地塞米松在门诊SARS-CoV-2感染患者中的应用

Actualidad medica Pub Date : 2022-01-01 DOI: 10.15568/am.2022.815.or04

M. Martínez-Zaldívar Moreno, E. Aguilera Maestre, P. Espinosa Barta, N. Navarro Ortiz, J. C. Callejas Rubio

{"title":"Dexamethasone in outpatients with SARS-CoV-2 infection","authors":"M. Martínez-Zaldívar Moreno, E. Aguilera Maestre, P. Espinosa Barta, N. Navarro Ortiz, J. C. Callejas Rubio","doi":"10.15568/am.2022.815.or04","DOIUrl":"https://doi.org/10.15568/am.2022.815.or04","url":null,"abstract":"Objective: To evaluate the clinical evolution of outpatients with SARS Cov-2 infection, who received dexamethasone in our Health Center. Methods: The medical records of the patients who were prescribed dexamethasone treatment from Primary Care, in the acute phase of the SARS-CoV-2 infection, were reviewed, without initial criteria of severity. We describe the clinical-demographic characteristics and the radiological and analytical data of the cytokine storm, as well as its final evolution. Results: a total of 9 patients were included, 6 women and 3 men with a mean age of 56.6 (34-74) years. The reason for consultation was fever in all cases, with a mean time of 4 (2-7) days from onset of symptoms to consultation. All patients presented a relationship between oxygen saturation and inspired oxygen fraction greater than 450. Out of these, 5 patients presented radiological findings compatible with COVID and no infiltrates were observed in 4. No patient had laboratory data for cytokine storm syndrome. The recommended dexamethasone dose was 6 mg/d for 7 days. In 3 cases, hospital admission was required, 2 on the third day and one on the fourth day after the start of dexamethasone. These patients resolved the in-hospital process with pulses of corticosteroids and antibiotics, without the need for high-flow oxygen therapy or mechanical ventilation. Conclusions: the use of dexamethasone in patients with SARS-CoV-2 infection without hospital admission criteria does not seem to prevent the risk of progression to more serious forms. In the absence of more data, the use of dexamethasone in these cases does not seem advisable, unless it is required for other reasons.","PeriodicalId":86333,"journal":{"name":"Actualidad medica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67208131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stem cells differenciate to human corneal endothelium. A literature review of published data 间充质干细胞分化为人角膜内皮。对已发表数据的文献综述

Actualidad medica Pub Date : 2022-01-01 DOI: 10.15568/am.2021.814.rev02

R. Martínez-Castillo, M. C. González-Gallardo, I. J. Garzón-Bello

{"title":"Mesenchymal stem cells differenciate to human corneal endothelium. A literature review of published data","authors":"R. Martínez-Castillo, M. C. González-Gallardo, I. J. Garzón-Bello","doi":"10.15568/am.2021.814.rev02","DOIUrl":"https://doi.org/10.15568/am.2021.814.rev02","url":null,"abstract":"Background and purpose: The main sources of mesenchymal stem cells used for the creation of artificial corneal endothelium or their uses such as regenerative therapy will be exposed in this review. Moreover, the different models of differentiation suggested by authors throughout the history just as cellular or physiological markers which have been used to typify defined cells will be described. Finally, it will also be described the translational potential of these cells to corneal endothelium diseases through the techniques which have been used to its implantation or transplant.\u0000Material and methods: Narrative review of publications on the differentiation of mesenchymal stem cells to human corneal endothelium or other applications of these cells as regenerative therapy in models of corneal endothelial damage.\u0000Results: A total of six studies used mesenchymal stem cells in differentiation or regeneration of corneal endothelium, of which four used cells from the umbilical cord. In four of these studies a different differentiation protocol was designed. The authors agreed on the differentiation markers ATP1A1, COL8A2, PITX2 and ZO-1.\u0000Conclusions: Although there are few published clinical trials on human corneal endothelium that use these cells; The regeneration and differentiation potential of MSCs and the development that Tissue Engineering has undergone, makes them postulate as the future of replacement therapy.","PeriodicalId":86333,"journal":{"name":"Actualidad medica","volume":"119 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41277187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Splenic rupture as a complication of an infectious mononucleosis 脾破裂是传染性单核细胞增多症的并发症

Actualidad medica Pub Date : 2022-01-01 DOI: 10.15568/am.2022.816.cc04

I. Morales- Hernández, M. García Castelblanque, E. Lou Calvo, S. Giner Ruiz, I.M. Estrada Lázaro

引用次数: 0

Neurodegeneation treatment in lysosomal diseases. An update 溶酶体疾病的神经退行性治疗。一个更新

Actualidad medica Pub Date : 2022-01-01 DOI: 10.15568/am.2022.816.rev01

S. Garcia-Navarrete, M. Gil-Campos

{"title":"Neurodegeneation treatment in lysosomal diseases. An update","authors":"S. Garcia-Navarrete, M. Gil-Campos","doi":"10.15568/am.2022.816.rev01","DOIUrl":"https://doi.org/10.15568/am.2022.816.rev01","url":null,"abstract":"Lysosomal diseases are a set of rare diseases where the genetic deficiency of certain enzymes gives rise to the accumulation of substrates at the multi-organ level. The treatment of these inborn errors of metabolism is still under continuous investigation since when they exist, they present limitations trying to increase the synthesis of the enzyme or decrease the deposit of substrate, without reaching the definitive solution, and therefore a cure. The progressive and limiting neurodegeneration that most of them produce from pediatric ages, is one of the greatest challenges. Hematopoietic cell transplantation and enzyme replacement therapy are accepted treatments for some of these diseases; however,its results on the control and progression of neurological symptoms often remain disappointing. Undoubtedly, crossing the blood-brain barrier is one of the obstacles that many clinical trials currently underway aim to overcome. Gene therapy and neurophysiological pathways triggered by the lack of partial or total degradation of molecules also constitute a new avenue of study whose main objective is also based on preventing progression in the deterioration of cognitive function. Therefore, the objective of this work is to carry out a review to know the approved therapies and the lines of research in progress in relation to the neurodegeneration of lysosomal diseases and It is essential to continue advancing in this field with further development of these approaches and the search new perspectives on therapies that can have a great impact on the quality of life of these patients.","PeriodicalId":86333,"journal":{"name":"Actualidad medica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67208445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current status of carbapenem resistance: epidemiology and microbiological aspects 碳青霉烯耐药现状:流行病学和微生物学方面

Actualidad medica Pub Date : 2022-01-01 DOI: 10.15568/am.2022.816.rev02

B. Calvo Bernal, M. A. López Rus

引用次数: 0

Colorectal polypectomy follow-up: an opportunity to establish protocols from the digestive endoscopy units 结直肠息肉切除术随访:从消化内窥镜单元建立方案的机会

Actualidad medica Pub Date : 2021-01-01 DOI: 10.15568/am.2021.812.cd02

M. M. Díaz-Alcázar, Adelina García-Robles, A. Maldonado

引用次数: 0