The South Dakota journal of medicine and pharmacy最新文献

{"title":"Transcriptome - wide bioinformatics analysis of the binding sites of RNA - binding proteins and their putative role in mendelian diseases","authors":"Thu Phan Nguyen Anh, M. Floris, M. Laura Idda, Bach Nguyen Hoang","doi":"10.34071/jmp.2022.7.11","DOIUrl":"https://doi.org/10.34071/jmp.2022.7.11","url":null,"abstract":"Background: Post-transcriptional regulation is the control of gene expression at the RNA level. After produced, the stability and distribution of the different transcripts are regulated by means of RNA-binding proteins (RBPs). Mutations in RNA-binding proteins can cause Mendelian diseases - prominently neuromuscular disorders and cancers. This study determines the interaction between RBPs and target-RNA complexes from public data of the ENCODE project and identifies mutations associated with Mendelian diseases that could disrupt the RBP-RNA interactions. Materials and methods: we performed a transcriptome - wide bioinformatics prediction of the binding sites of RBPs in the human transcriptome from public\u0000data of the ENCODE project. Results: The majority (54%) of pathogenic mutation putatively affecting the binding sites of RBPs are located in protein - coding genes and are mainly classified as loss - of - function mutations. Mutations located in the binding sites of RBPs related to RNA processing. For 13 diseases, Familial hypercholesterolemia is the most significant disease with about 40% of mutations in ClinVar database located into the binding sites of RBPs (p=2.3e-65), but congenital hypogonadotropic hypogonadism is the disease with the highest percentage of mutations affecting the binding sites of RBPs (98%, p=2.7e-25). The RBPs most involved in human Mendelian diseases by binding sites-disrupting mutations are YBX3, AQR and PRPF8. Conclusions: A large number of Mendelian diseases are potentially mediated by disease - causing variants\u0000that potentially disrupt the binding sites of RBPs. This will provide insight sharper on post - transcriptional mechanisms. Besides, it is useful to know the role of protein - RNA interactome networks in pathologies, thereby serving the treatment of diseases. \u0000Key words: bioinformatics analysis, ENCODE project, ClinVar, RNA-binding proteins, Mendelian diseases","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"14 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72477217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of antibiotic resistance and genotyping of Helicobacter pylori isolates in patients with gastroduodenal disease","authors":"Linh Nguyen Thi Khanh, Hoa Tran Thi Nhu, Thang Phan Van Bao, Nam Phan Trung, B. Paglietti, A. Le Van","doi":"10.34071/jmp.2022.7.5","DOIUrl":"https://doi.org/10.34071/jmp.2022.7.5","url":null,"abstract":"Background: In this study, we assessed the status of antibiotic resistance of H. pylori isolates to antimicrobial agents at Hospital of Hue University of Medicine and Pharmacy in Central Vietnam and identified the underlying molecular mechanisms related to tetracycline and amoxicillin resistance. In addition, the cagA, cagE, cagT, vacA, iceA genotypes of H. pylori strains were investigated to predict clinical outcomes. Materials\u0000and methods: H. pylori was successfully cultured in 52 patients with different gastrointestinal disorders at the Hospital of Hue University of Medicine and Pharmacy in Central Vietnam. The minimum inhibitory concentrations (MICs) of five antimicrobials; clarithromycin (CLR), metronidazole (MTZ), levofloxacin (LE), amoxicillin (AMX) and tetracycline (TE) were determined by the E-test method. Genetic determinants of AMX\u0000and TE resistance were identified with the polymerase chain reaction (PCR), followed by sequencing and gene analysis. Allelic variants of cagA, cagE, cagT, vacA, iceA were identified by the PCR. Results: The resistance to CLR, MTZ, LE, AMX, and TE were 90.4%, 86.5%, 65.4%, 40.4% and 0%, respectively. Multidrug resistance was observed in 88.5% of the isolates investigated. Several known AMX resistance mutations were identified in PBP1A (A369T, V374L, S543R, T556S, N562Y), whereas a known mutation in 16S rRNA (A926G) was detected in strains with higher MIC level (TE MICs of 0.25 and 0.5 mg/L). The cagA, cagE and cagT genotypes were found together in 46 isolates (88.5%), vacAs- region genotype in 51 (98.1%, predominantly vacAs1), vacAmregion genotype in all strains studied (vacAm1 - 51.9%, vacAm2 - 40.4%, vacAm1 and vacAm2 - 7.7%), iceA1 in 22 (42.3%) and iceA2 in 20 (38.5%) of strains. The allelic variant vacAs1m1 was prominent (57.4%), and vacAs1m2 (42.6%). Conclusion: Overall, resistance rates to CLR, MTZ, LE and AMX were high in H. pylori from Central Vietnam, except for TE, which serves as a foundation for developing local guidelines for more effective therapeutic strategies. Neither the single genes nor the combination of genes was significantly helpful in predicting the clinical outcome of H. pylori infection in patients in our study. \u0000Key words: H. pylori, antibiotic resistance, genotype.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85987703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overall agreement between eGFR estimates obtained with the CKDEPI, MDRD and CG formulae in patients with advanced HIV diseases","authors":"Dat Vu Quoc, Phuc Nguyen Dinh Hong, Thang Ba Dinh","doi":"10.34071/jmp.2022.7.17","DOIUrl":"https://doi.org/10.34071/jmp.2022.7.17","url":null,"abstract":"Background: Traditional CKD risk factors as well as HIV-related factors are major determinants of the prevalence of renal diseases among HIV patients. Few equations have been used in clinical practice for calculating creatinine clearance, however, the accuracy of these formulae in HIV patients has been different. Our goal was to evaluate the reliability of all three equations (Chronic Kidney Disease Epidemiology Collaboration, Modification of Diet in Renal Disease, and Cockcroft-Gault) to estimate GFR in HIV-infected patients. Materials and method: We conduct a retrospective, observational cohort study of patients with\u0000HIV infection who are first time in care at selected HIV OPCs in Vietnam. Results: In 1108 patients eligible for analysis, a major patient was in HIV clinical stage 3 and 4 with a median age of 36, and median serum creatinine of 0.89 mg/dL. eGFR calculated by CG equation was lower than CKD-EPI formulae in overall except overweight patients (p<0.05, paired t-test) while the similar results were observed in both CKD-EPI and MRDR (p=0.144, paired t-test). Conclusion: There was a substantial agreement between CKD-EPI and MDRD eGFR, agreement percentage of 90.1 and MDRD was reliable as CKD-EPI to calculate eGFR in the HIV population.\u0000Key words: HIV, eGFR, CKD-EPI, MRDR, CG.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82811318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Map of perforators of the posterior tibial artery and peroneal artery using handheld doppler ultrasound evaluating clinical outcome of perforator flaps which cover soft tissue defects of the lower leg and foot","authors":"Phuc Le Hong, Nhan Le Nghi Thanh","doi":"10.34071/jmp.2022.7.18","DOIUrl":"https://doi.org/10.34071/jmp.2022.7.18","url":null,"abstract":"Background: Soft tissue defects of the lower leg and foot are complicated injuries with numerous causes including trauma, ulcers, and Gout. Widespread treatment of these defects has been effectively applied with perforator flaps of the peroneal artery and posterior tibial artery. Objectives: 1. Construct a map of the perforators of the peroneal artery and posterior tibial artery using a handheld Doppler ultrasound. 2. Evaluate the clinical outcome of perforator flaps to cover soft tissue defects in the lower leg and foot. Materials and method: Cross-sectional study of 34 volunteers with no previous history of vascular diseases and the prospective study of 31 patients with soft tissue defects treated with peroneal artery perforator flap\u0000and posterior tibial artery perforator flap. Results: There are, on average, 4.7 peroneal perforating arteries. From the lateral malleolus to the fibula’s head, the percentage of perforating arteries in the 2/10 and 6/10 segments is 85.3% and 97%, respectively. In the 2-3/10 segment, 94.1% have perforator arteries. There are, on average, 3.3 posterior tibial artery perforators. From the medial malleolus to the medial tibial plateau, it was found that 100% of volunteers had perforating arteries in the 3-4/10 segments and 61.7% in the 5/10 segment. Evaluation of postoperative results in 31 patients: 77.49% showed the right flap. The most common complications were edge necrosis (12.9%), partial necrosis (6.44%), and infection (3.23%). The donor sites showed good survival in 96.4% of patients, while partial necrosis resulted in 3.6%. A follow-up examination revealed that 90.32% of flaps had a good result, 9.68% had an average result, and no poor results were\u0000shown. 100% of donor sites had good results. Conclusion: An average of 4.7 perforators of the peroneal artery is detected by handheld Doppler ultrasound. Also, there are 1-2 relatively constant perforators in segments 2/10 and 5-6/10 from the lateral malleolus. On average, there are 3.3 perforators of the posterior tibial artery, primarily in the 3-4/10 and 5/10 segments proximally from the medial malleolus. 90.32% of the flap had good results. \u0000Key words: Perforator flap, Soft tissue defect, Lower leg, Foot, Reconstruction.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84792206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serotype distribution and antibiotic resistance of Streptococcus agalactiae isolated from patients in Hue Central Hospital","authors":"Anh Nguyen Thi Chau, Thuy Ung Thi, Tuyen Nguyen Thi, Hung Nguyen Phi, Nhi Vo Thi Phuong, Tuan Mai Van, A. Le Van","doi":"10.34071/jmp.2022.7.7","DOIUrl":"https://doi.org/10.34071/jmp.2022.7.7","url":null,"abstract":"Group B streptococcus (GBS) infections are still the leading cause of invasive infections in neonates, specically they also seriously cause mortality and morbidity with underlying diseases in adults. Curently, there are ten GBS serotypes (Ia, Ib, and II-IX) and the resistance characteristic of GBS is important to clinical treatment. Objectives and methods: 30 clinical isolates of GBS were obtained from patients in Hue Central Hospital, Vietnam, from January 2016 until Jun 2019. Then the isolated GBS was conducted antimicrobial susceptibility test to determine the antibiotic resistance and serotypes by a multiplex PCR method. Results: GBS strains were resistant to tetracycline (100%), azithromycin (82.6%), erythromycin (80%) and clindamycin (80%). Resistance rates were lower with levofloxacin (45%), chloramphenicol (52.6%) and ceftriaxone (6.7%) whereas resistance was not observed in ampicillin, vancomycin and penicillin G. The distribution rate of serotype V (66.67%) was higher than type I (33.33%). Conclusions: Antibiotic resistance characteristics of GBS in samples are mostly familiar with other studies: β -lactams and vancomycin were the most susceptible antibiotics to GBS, the resistance rate in second line drug like clindamycin and erythromycin were high but there were large differences between studies. This study determined two GBS serotypes of Ia and V among isolated strains. \u0000Key words: Streptococcus agalactiae, GBS, antibiotic resistance, serotype.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75176499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Situation of plastic waste management and health conditions of people in Hai Duong coastal community of Thua Thien Hue province in 2020","authors":"Trí Tôn Thất Cảnh, Nhan Nguyen Van Thanh, Nguyen Nguyen Le Hanh, Minh Hoang Thi Binh, Long Nguyen Dac Hoang, Thu Dang Thi Anh","doi":"10.34071/jmp.2022.7.15","DOIUrl":"https://doi.org/10.34071/jmp.2022.7.15","url":null,"abstract":"Background: Unmanaged plastic waste will affect the environment and human health. The study was conducted to describe the current situation of plastic waste management and the health conditions related to plastic waste of people in Hai Duong commune, Central Vietnam, in 2020. Methodology: A cross-sectional descriptive study using a structured questionnaire was carried out on 291 people over 18 years old in Hai Duong commune, Huong Tra town, from September to October, 2020. Results: The amount of plastic waste accounted for 16.5% of the total volume of collected waste. The main forms of plastic waste treatment included collecting at gathering places (87.3%), selling scrap (60.8%), or burning (19.9%). In most cases,\u0000plastic bags were collected at the gathering place (90.4%), washed for reuse (45.4%), and burned (14.8%). The notable weakness of garbage collection and transportation was that residents did not sort out different types of garbage (29.6%), and littered indiscriminately in public places with little traffic at night (11.3%). Health conditions related to over-plastic waste use included headache (9.6%), rash (4.8%), cardiovascular disease (5.2%), and gastrointestinal disease (3.4%). Conclusion: The management of plastic waste in general and plastic bags in particular is still inadequate. It could be seen that if a lot of plastic products were used and the waste was not handled properly, it would cause much harm to human health. Therefore, appropriate policies need to be implemented to improve local management of plastic waste as well as awareness and\u0000effective practices regarding garbage disposal.\u0000Key words: Plastic waste, nylon bags, health conditions, Hai Duong commune","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75569468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of bacterial pathogens from clinical samples using 16S rRNA sequencing","authors":"Bach Nguyen Hoang, Nhi Mai Thi Thao, Thuy Ung Thi, Linh Nguyen Thi Khanh","doi":"10.34071/jmp.2022.7.9","DOIUrl":"https://doi.org/10.34071/jmp.2022.7.9","url":null,"abstract":"Introduction: Bacterial infections have a substantial impact on global health and can become serious if misdiagnosed with several diseases related to the central nervous, cardiovascular, and respiratory systems. The prognosis in patients with infectious disease strongly depends on early diagnosis and appropriate antibiotic therapy. We aimed to compare the accuracy of genus and species-level identification bacteria using biochemical testing and 16S rRNA sequence analysis. Material and methods: 50 clinical samples were isolated and identified the pathogenic bacteria by routine laboratory methods. In parallel, DNA was extracted from isolate’s colonies and amplified the 16S rRNA gene by using specific primers. The PCR products were evaluated by agarose gel electrophoresis and direct sequencing by the Sanger method. The sequence data\u0000were manipulated by Geneious Prime software. The sequence data matching the Prokaryotic 16S Ribosomal RNA database with a similarity score of ≥ 98% were selected. Results: Total of 50 clinical samples were isolated and identified the pathogenic bacteria with common biochemical test and API® Microbial Identification. The sequencing data showed that almost species identified by 16S rRNA sequencing matched the biochemical test method. There are 3 species (6%) were identified as different species with the routine methods. Conclusions: 16S rRNA gene sequencing is more sensitive, easier to manage, more accurate and especially for bacteria that are difficult to identify. 16S rRNA sequencing is considered an effective method to early identify pathogens in clinical samples, and this technique is increasingly being used in microbiology laboratories \u0000Key words: 16S rRNA gene, Sanger sequencing, bacterial identification, misdiagnosed","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74007144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer assessment approach to promote clinical communication skills in a blended learning course of early clinical exposure","authors":"Anh Le Ho Thi Quynh, Cuc Nguyen Thi, Huyen Nguyen Thi Thanh, Hien Ho Anh, Toan Vo Duc, Tam Nguyen Minh, Chi Le Van","doi":"10.34071/jmp.2022.7.10","DOIUrl":"https://doi.org/10.34071/jmp.2022.7.10","url":null,"abstract":"Background: Blended learning offers opportunities for the complexity of learning in clinical education. Student peer assessment is widely used as a form of formative assessment in early clinical exposure programs, especially clinical communication skills training. This study aimed to describe clinical communication skills competencies of second-year students and to identify the relationships between peer and faculty assessment of communication skills in a blended learning program format. Methods: A total of 474 second-year general medical students and dental students participated in the study. Peer and lecturer assessment forms with a 5-point Likert scale according to the Calgary-Cambridge guide format were used to evaluate students’ performance of basic communication skills, relationship building, and history taking. Pearson’s correlation coefficients and paired t-test were applied. A p-value < 0.05 was considered statistically significant. Results: Most of students were rated at distinction level (score at 7-8.4) in communication skills. Mean of the overall score by peer and faculty assessment were 7.46 ± 1.03 and 7.17 ± 0.68, respectively. Peers rarely provided negative ratings on subcategories of communication skills. Skills of understanding the patient’s perspectives and gathering information were the most reported skills needed to improve among students. Significant positive correlations were found between peer and faculty evaluations for building relationship, establishing initial rapport, and gathering information domains (p < 0.01). Students tended to grade their colleagues higher for building relationship (3.88 ± 0.62) and establishing initial rapport domains (3.72 ± 0.61) than other\u0000domains, meanwhile, teachers tended to grade building relationship (3.80 ± 0.55) and gathering information domains (3.64 ± 0.38) higher than other domains. Conclusion: The findings suggest that student peer evaluation can be valuable for clinical education. As part of a formative assessment, it can be also used for faculty to evaluate students’ clinical communication skills performance in innovative medical education programs.\u0000Key words: peer assessment, clinical communication skills, practice of medicine, early clinical practice, blended learning.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79006955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characterization of alpha globin and beta globin genes in patients with hemoglobinopathies in Central Vietnam","authors":"Quynh Le Phan Tuong, Thi Ha Thi Minh, Nga Tran Thi Nhu, Triet Le Phan Minh, Tri Ton That Minh, Sang Dong Si, Hoa Phan Thi Thuy, Linh Le Tuan","doi":"10.34071/jmp.2022.7.4","DOIUrl":"https://doi.org/10.34071/jmp.2022.7.4","url":null,"abstract":"Background: Hemoglobinopathy is the most common monogenic disease worldwide. The aims of the current study were: (1) to investigate some hematological characteristics of patients with hemoglobinopathies; and (2) to detect the mutation of α-globin and β-globin genes, as well as the association between genotype and degree of anemia. Materials and method: 251 patients with hemoglobinopathies were examined for the α-globin or β-globin gene mutations. Results: 51% were the carriers, and 49% were thalassemia intermedia or thalassemia major. Hematological characteristics were suitable for α-thalassemia or β-thalassemia. Elevenβ-globin gene mutations were observed. The β0/βA, βE/βA, βE/βE, βE/β+, β+/β+ genotypes were only found\u0000in β-thalassemia intermedia individuals; the β0/β0 genotype was limited to β-thalassemia major patients; the β+/β0 and βE/β0 genotypes were seen in both types. Four α-globin gene mutations were observed. All α-thalassemia patients were intermedia, the most common genotype was --SEA/-α3.7. Conclusion: There were differences in anemia degree between β-globin genotypes\u0000Key words: hemoglobinopathies, α-globin, β-globin.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78804292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Hepatitis B Core Antibody: Significance and Clinical practice","authors":"Giang Phan Thi Hang, Hua Le Ba, Thanh Phan Ngoc Dan, Huyen Trang Nguyen Thi, Anh Tran Long, Ngoc Tran Thi Bich, Phuong Truong Thi Bich, Phuoc Nguyen Thi, Phuong Phan Thi Minh","doi":"10.34071/jmp.2022.7.1","DOIUrl":"https://doi.org/10.34071/jmp.2022.7.1","url":null,"abstract":"Hepatitis B infection remains a global health problem, with progression to acute-chronic hepatitis, severe liver failure, and death making hepatitis B one of the most serious infections worldwide. The disease is most widely transmitted from an infected mother to her baby, after exposure to infected blood or body fluids or unsafe sexual contact. Pregnant women, adolescents, and all adults at high risk for chronic infection are recommended to be screened for hepatitis B. Serological tests allow the distinction between acute and chronic hepatitis. Meanwhile, the molecular tests performed provide detection and quantification of viral DNA, genotyping, drug resistance, and pre-core/core mutation analysis to confirm infection and follow monitoring disease progression in patients with chronic hepatitis B. Because, the current treatment is only based on nucleotide analogs and pegylated interferons that save lives by decreasing liver cancer death, liver transplant, slowing or reversing the progression of liver disease as well as the virus infectivity. In this review, we clearly light the role of Hepatitis B Core Antibody, therefore clinicians understand the need to screen for hepatitis B core antigen (Anti-HBc), proper interpretation of HBV biomarkers, and that “anti-HBc only” indicates HBV exposure, lifelong persistence of cccDNA with incomplete infection control, and potential risk for reactivation.\u0000\u0000Key words: Hepatitis B virus (HBV), Hepatitis B Core Antibody (Anti-HBc/HbcAb).","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85866528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}