Atherosclerosis最新文献

{"title":"Common and distinct genetic features of three atherosclerotic cardiovascular diseases","authors":"Ling Li ,&nbsp;Rainer Malik ,&nbsp;Carla Abrahamian ,&nbsp;Moritz von Scheidt ,&nbsp;Zhifen Chen ,&nbsp;Thorsten Kessler ,&nbsp;Martin Dichgans ,&nbsp;Heribert Schunkert","doi":"10.1016/j.atherosclerosis.2026.120733","DOIUrl":"10.1016/j.atherosclerosis.2026.120733","url":null,"abstract":"<div><h3>Background and aims</h3><div>Coronary artery disease (CAD), peripheral arterial disease (PAD), and ischemic stroke (IS) are the principal manifestations of atherosclerotic cardiovascular diseases (ASCVDs). Here we systematically explored the shared and distinct genetic underpinnings of these ASCVDs.</div></div><div><h3>Methods</h3><div>SNP-based heritability estimates were calculated using GCTA-GREML in a subset of the UK Biobank, where 8000 controls and equally sized cases were randomly selected for the three ASCVDs separately. Genetic correlations and causal relations were analyzed among three ASCVDs, 13 risk factors and three comorbid conditions using summary data of respective genome-wide association studies (GWASs). Cross-trait meta-analyses and pathway analyses were conducted to investigate shared and distinct risk loci, as well as pathway activities.</div></div><div><h3>Results</h3><div>Overall, CAD showed the highest SNP-based heritability estimate (23.7 ± 3.3%), which was significantly higher than that of PAD (15.1 ± 2.3%) and IS (9.1 ± 2.8%). Genetic correlations were modest, being largest for CAD-PAD (<em>r</em>_<em>g</em> = 0.65), and similar for CAD-IS (<em>r</em>_<em>g</em> = 0.47) and PAD-IS (<em>r</em>_<em>g</em> = 0.48). Of 233 significant risk loci, 71 (30.5%) were shared by three, and 159 (68.2%) by at least two ASCVDs. Analyses of genetic correlations, Mendelian randomization, and pathway enrichment revealed significant differences between respective ASCVDs. Specially, lipid traits were more strongly associated with CAD and PAD than IS; diabetes mellitus and lifestyle factors affected predominantly PAD, while blood coagulation/clotting pathways and atrial fibrillation were predominantly associated with IS. Interestingly, pathways related to vascular remodeling and inflammation were significantly enriched by genes affecting all ASCVD.</div></div><div><h3>Conclusions</h3><div>The genetic foundation of the three ASCVDs varies substantially, including genetically-mediated effects of associated risk factors and pathways, suggesting commonalities but also differences in the pathogenesis of atherosclerosis in respective arterial beds. Shared genetic features of ASCVDs may be particularly informative for drug target identification.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"416 ","pages":"Article 120733"},"PeriodicalIF":5.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the residual SYNTAX score on clinical outcomes in patients with acute coronary syndrome","authors":"Taito Arai ,&nbsp;Koshiro Sakai ,&nbsp;Hiroyoshi Mori ,&nbsp;Takuya Mizukami ,&nbsp;Seita Kondo ,&nbsp;Teruo Sekimoto ,&nbsp;Rikuo Sakai ,&nbsp;Kengo Suzuki ,&nbsp;Masamichi Takano ,&nbsp;Nobuaki Kobayashi ,&nbsp;Kohei Wakabayashi ,&nbsp;Myong Hwa Yamamoto ,&nbsp;Sakiko Yasuhara ,&nbsp;Tsunekazu Kakuta ,&nbsp;Sunao Nakamura ,&nbsp;Tomoyo Sugiyama ,&nbsp;Taishi Yonetsu ,&nbsp;Tomotaka Dohi ,&nbsp;Jun Yamashita ,&nbsp;Junichi Yamaguchi ,&nbsp;Toshiro Shinke","doi":"10.1016/j.atherosclerosis.2026.120689","DOIUrl":"10.1016/j.atherosclerosis.2026.120689","url":null,"abstract":"<div><h3>Background</h3><div>The residual SYNTAX score (rSS) quantifies coronary artery disease extent following percutaneous coronary intervention (PCI) and predicts adverse outcomes. However, its relationship with plaque morphology in acute coronary syndrome (ACS) remains unclear.</div></div><div><h3>Objective</h3><div>To investigate associations between rSS and optical coherence tomography (OCT)-defined culprit lesion morphology and assess rSS prognostic impact on 1-year outcomes in ACS patients.</div></div><div><h3>Methods</h3><div>This pre-specified subanalysis of the TACTICS registry enrolled 611 ACS patients with plaque rupture (PR), plaque erosion (PE), or calcified nodule (CN) undergoing OCT-guided emergency PCI. Patients were stratified by rSS: 0, 0 &lt; rSS ≤5, 5 &lt; rSS ≤10, and rSS &gt;10. The primary outcome was major adverse cardiac events (MACE): cardiovascular death, myocardial infarction, heart failure, or ischemia-driven revascularization.</div></div><div><h3>Results</h3><div>PR was most common (66.5%), followed by PE (31.0%) and CN (2.6%). Median rSS was significantly higher in CN than PR and PE (p &lt; 0.001). At 1 year, MACE occurred in 8.0%, 15.0%, 11.8%, and 18.8% of patients with rSS = 0, 0 &lt; rSS ≤5, 5 &lt; rSS ≤10, and rSS &gt;10, respectively (p = 0.016). Higher rSS associated with lower PE probability (OR: 0.95; 95% CI: 0.92–0.98; p = 0.002) and higher CN probability (OR: 1.10; 95% CI: 1.05–1.14; p &lt; 0.001). CN (HR: 4.44; p = 0.022) and rSS (HR: 1.04; p = 0.015) independently predicted adverse outcomes.</div></div><div><h3>Conclusion</h3><div>Higher residual SYNTAX scores were associated with CN morphology and worse clinical outcomes in ACS patients, suggesting that combined anatomical and morphological assessment may enhance post-PCI risk stratification.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"416 ","pages":"Article 120689"},"PeriodicalIF":5.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term trends in dyslipidemia prevalence, awareness, treatment, and control in the Middle East and North Africa: a meta-analysis of 116 representative surveys","authors":"Ehsaneh Taheri ,&nbsp;Shirin Esmaeili ,&nbsp;Saeed Hamidizadeh ,&nbsp;Niloofar Seighali ,&nbsp;Amirhossein Mehrpour ,&nbsp;Maryam Beiky ,&nbsp;Alireza Khodayari Javazm ,&nbsp;Hedie Soltani ,&nbsp;Ali Ahmadi ,&nbsp;Erfan Basirat ,&nbsp;Shirin Djalalinia ,&nbsp;Kiavash Semnani ,&nbsp;Gerald F. Watts ,&nbsp;Mostafa Qorbani","doi":"10.1016/j.atherosclerosis.2026.120725","DOIUrl":"10.1016/j.atherosclerosis.2026.120725","url":null,"abstract":"<div><h3>Background and aims</h3><div>Dyslipidemia is a major risk factor for cardiovascular disease. Trends in dyslipidemia prevalence have been poorly described in the Middle East and North Africa region (MENA). We evaluated the prevalence of dyslipidemia, temporal trends, and reports on awareness, treatment, and control.</div></div><div><h3>Methods</h3><div>MEDLINE, Scopus, and Web of Science were searched for population-representative studies –supplemented by WHO STEPS reports. Prevalence of dyslipidemia (hypercholesterolemia, hypertriglyceridemia, low HDL, and elevated LDL) was pooled via random-effects meta-analysis. Average Annual Percentage Changes (AAPC) in the prevalence of dyslipidemia were calculated using joinpoint regression. Temporal trends were visualized via Locally Estimated Scatterplot Smoothing.</div></div><div><h3>Results</h3><div>116 studies (628,134 individuals) were included in meta-analysis. Nominal pooled proportions were 0.69 (95% CI: 0.63–0.74; 95%PI: 0.38-0.92) for dyslipidemia, 0.33 (95%CI: 0.30–0.36) for hypertriglyceridemia, 0.35 (95%CI 0.31– 0.38) for hypercholesterolemia, 0.29 (95%CI: 0.24–0.35) for high LDL, and 0.50 (95%CI: 0.45–0.55) for Low HDL – all subject to substantial heterogeneity. A temporal decrease in hypercholesterolemia (AAPC 1982-2023: –1.52, 95%CI: –2.80––0.23) was noted without significant changes in other components. A higher proportion of women (0.72, 95%CI: 0.66–0.77 vs. 0.65, 95%CI: 0.59–0.70) had dyslipidemia. Awareness (9.2–28.5%) and treatment (3.0–28.6%) varied widely across studies.</div></div><div><h3>Conclusions</h3><div>Although dyslipidemia remains prevalent in MENA, awareness and treatment in most areas are low. Estimates vary substantially across different areas. Effective prevention, detection, and management strategies adopted to local needs are needed. Further research into determinants, and associations with other modifiable risk factors are also required.</div></div><div><h3>Protocol registration</h3><div>PROSPERO, ID: CRD420251114986.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"416 ","pages":"Article 120725"},"PeriodicalIF":5.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to correspondence: MASLD and revascularized coronary events: a cautious reading of the data.","authors":"Hee-Taik Kang","doi":"10.1016/j.atherosclerosis.2026.120751","DOIUrl":"https://doi.org/10.1016/j.atherosclerosis.2026.120751","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":" ","pages":"120751"},"PeriodicalIF":5.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced risk for recurrent adverse cardiovascular events in homozygous carriers of the T-allele of CD40 SNP rs1883832.","authors":"Mark Colin Gissler, Johannes Neumann, Linlin Guo, Patrick Malcolm Siegel, Timoteo Marchini, Hauke Horstmann, Sophie Hansen, Hanna Wolf, Virgina K Haacke, Debora Ehrhardt, Juana Dominguez, Daniela Stallmann, Ana Sophia Burkard, Xiaowei Li, Xin Gu, Ingo Hilgendorf, Thorsten Kessler, Panagiotis Antiochos, Holger Winkels, Lucas Bacmeister, Nils A Sörensen, Paul M Haller, Betül Toprak, Jonas Lehmacher, Andreas Zirlik, Constantin von Zur Mühlen, Raphael Twerenbold, Dirk Westermann, Diana Lindner, Dennis Wolf","doi":"10.1016/j.atherosclerosis.2026.120761","DOIUrl":"https://doi.org/10.1016/j.atherosclerosis.2026.120761","url":null,"abstract":"<p><strong>Background and aims: </strong>The co-stimulatory signaling dyad of CD40 and CD40L is a potent inducer of cardiovascular inflammation and vulnerability of atherosclerotic plaques. A cytosine-to-thymidine transition (-1C > T) in the Kozak sequence of the CD40 gene (rs1883832) lowers CD40 protein expression. Here, we interrogate whether this CD40 gene variant correlates with recurrent cardiovascular events after acute coronary syndromes.</p><p><strong>Methods: </strong>The Biomarkers in Acute Cardiac Care (BACC) cohort prospectively enrolled patients presenting to the emergency department with acute chest pain and suspected myocardial infarction. Genotype status (homozygous C/C or T/T, heterozygous: C/T) was determined by a TaqMan assay in 1298 patients with either confirmation of or ruled out acute myocardial infarction (AMI). The CD40 genotype-adjusted risk for major adverse cardiovascular events (MACE) during a median follow-up time of 5.2 years was studied by multivariate Cox regression.</p><p><strong>Results: </strong>Relative abundances of the genotypes among all participants were 55.8% for C/C, 37.1% for C/T, and 7.2% for T/T. None of the genotype variants was associated with diabetes, hypertension, hyperlipoproteinemia, or a history of coronary artery disease (CAD). T/T carriers showed a strong trend towards an increased sex- and age-adjusted risk for AMI at admission (OR 1.58, 95% CI 0.95-2.64, p = 0.078) in logistic regression analysis. MACE occurred more often in patients with the T/T genotype (HR 1.46, 95% CI 1.01-2.11, p = 0.046) compared to C/T (HR 0.96, 95% CI 0.77-1.19, p = 0.70) and C/C (HR 0.94, 95% CI 0.76-1.16, p = 0.54) carriers. This effect was independent of age, sex, diabetes mellitus, hyperlipoproteinemia, arterial hypertension, smoking status and left ventricular ejection fraction in multivariable regression.</p><p><strong>Conclusions: </strong>Our data indicate that - unexpectedly - the T/T genotype of rs1883832 is associated with an enhanced risk for myocardial infarction and subsequent MACE. As this SNP impedes effective CD40 translation, our findings suggest a potentially protective role of CD40 in high-risk patients.</p>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":" ","pages":"120761"},"PeriodicalIF":5.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence on: Impact of coronary artery disease patterns assessed with pullback pressure gradient on clinical outcomes: Meta-analysis.","authors":"Artur Dziewierz, Barbara Zdzierak, Stanisław Bartuś, Wojciech Zasada","doi":"10.1016/j.atherosclerosis.2026.120752","DOIUrl":"https://doi.org/10.1016/j.atherosclerosis.2026.120752","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":" ","pages":"120752"},"PeriodicalIF":5.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological and clinical considerations in a Japanese cohort study of familial hypercholesterolemia and stroke.","authors":"Yining Hui, Gang Tian","doi":"10.1016/j.atherosclerosis.2026.120753","DOIUrl":"https://doi.org/10.1016/j.atherosclerosis.2026.120753","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":" ","pages":"120753"},"PeriodicalIF":5.7,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of atherosclerotic lesion by optical coherence tomography with cholesterol efflux capacity by immobilized liposome-bound gel beads method.","authors":"Tsunehiro Miyakoshi, Yuna Horiuchi, Makoto Araki, Taishi Yonetsu, Mei Watanabe, Takahiro Kameda, Akira Yoshimoto, Naoya Ichimura, Shuji Tohda, Minoru Tozuka, Tetsuo Sasano, Ryunosuke Ohkawa","doi":"10.1016/j.atherosclerosis.2026.120724","DOIUrl":"https://doi.org/10.1016/j.atherosclerosis.2026.120724","url":null,"abstract":"<p><strong>Background and aims: </strong>Cholesterol efflux capacity (CEC) is robust biomarker for atherosclerotic cardiovascular disease (ASCVD). However, cell-based CEC assays require complex procedures that limit clinical use. The immobilized liposome-bound gel beads (ILG) method, a newly developed cell-free CEC assay, demonstrates sufficient performance for clinical application. This study investigated the clinical significance of CEC measured by the ILG method in relation to HDL subclasses and coronary artery plaque characteristics.</p><p><strong>Methods: </strong>We analyzed CEC and HDL parameters, including the ratio of apolipoprotein E (apoE)-HDL-C to HDL-C (%apoE) and HDL₃-C/HDL₂-C, in 61 patients who underwent coronary angiography or percutaneous coronary intervention. Coronary artery plaques were assessed by optical coherence tomography (OCT). A large lipid-rich plaque was defined as lipid length >5 mm and lipid arc >180°.</p><p><strong>Results: </strong>CEC correlated positively with HDL-C and %apoE. Among the patients, 26 (42.6%) exhibited large lipid-rich plaques on OCT. Univariable analysis showed that CEC was significantly lower in patients with large lipid-rich plaques compared to those without. While this association did not reach statistical significance after multivariable adjustment (p = 0.109), the addition of CEC to traditional risk factors improved the model's explanatory power (Nagelkerke R²: 0.346 to 0.381) and discriminatory ability (AUC: 0.775 to 0.805) for large lipid-rich plaques.</p><p><strong>Conclusions: </strong>CEC measured using the ILG method reflects HDL subclass features and is associated with the burden of lipid-rich coronary artery plaques. These findings suggest the significance of CEC evaluated using the ILG method, supporting its potential for enhanced ASCVD risk assessment and further clinical applications.</p>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":" ","pages":"120724"},"PeriodicalIF":5.7,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the bidirectional relationship between breast cancer and cardiovascular disease.","authors":"Anna Abou-Raya, Suzan Abou-Raya","doi":"10.1016/j.atherosclerosis.2026.120728","DOIUrl":"https://doi.org/10.1016/j.atherosclerosis.2026.120728","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":" ","pages":"120728"},"PeriodicalIF":5.7,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCSK9 switches partner inside the vascular wall: from LDL receptor to LRP1.","authors":"Marco Crescenzio, Nicola Ferri","doi":"10.1016/j.atherosclerosis.2026.120726","DOIUrl":"https://doi.org/10.1016/j.atherosclerosis.2026.120726","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":" ","pages":"120726"},"PeriodicalIF":5.7,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}