AtherosclerosisPub Date : 2024-12-01DOI: 10.1016/j.atherosclerosis.2024.118663
Madeeha Khan Ms., Prof Fouzia Sadiq, Quratul Ain Ms, Dr Hijab Batool, Prof Mohammad Iqbal Khan, Prof Muhammad Qasim Hayat
{"title":"FAMILIAL HYPERCHOLESTEROLEMIA AMONG PEDIATRIC POPULATION IN PAKISTAN: A CROSS-SECTIONAL STUDY","authors":"Madeeha Khan Ms., Prof Fouzia Sadiq, Quratul Ain Ms, Dr Hijab Batool, Prof Mohammad Iqbal Khan, Prof Muhammad Qasim Hayat","doi":"10.1016/j.atherosclerosis.2024.118663","DOIUrl":"10.1016/j.atherosclerosis.2024.118663","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118663"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AtherosclerosisPub Date : 2024-12-01DOI: 10.1016/j.atherosclerosis.2024.118599
Michael S. Dodd , Lucy Ambrose , Vicky Ball , Kieran Clarke , Carolyn A. Carr , Damian J. Tyler
{"title":"The age-dependent development of abnormal cardiac metabolism in the peroxisome proliferator-activated receptor α-knockout mouse","authors":"Michael S. Dodd , Lucy Ambrose , Vicky Ball , Kieran Clarke , Carolyn A. Carr , Damian J. Tyler","doi":"10.1016/j.atherosclerosis.2024.118599","DOIUrl":"10.1016/j.atherosclerosis.2024.118599","url":null,"abstract":"<div><h3>Background and aims</h3><div>Peroxisome proliferator-activated receptor α (PPARα) is crucial for regulating cardiac β-oxidation in the heart, liver, and kidney. Ageing can induce cardiac metabolic alterations, but the role of PPARα has not been extensively characterised. The aim of this research was to investigate the role of PPARα in the aged heart.</div></div><div><h3>Methods</h3><div>Hyperpolarized [1–<sup>13</sup>C]pyruvate was used to evaluate <em>in vivo</em> cardiac carbohydrate metabolism in fed and fasted young (3 months) and old (20–22 months) PPARα knockout (KO) mice <em>versus</em> controls. Cine MRI assessed cardiac structural and functional changes. Cardiac tissue analysis included qRT-PCR and Western blotting for <em>Ppar</em>α<em>,</em> medium chain acyl-CoA dehydrenase (MCAD), uncoupling protein (UCP) 3, glucose transporter (GLUT) 4 and PDH kinase (PDK) 1,2, and 4 expression.</div></div><div><h3>Results</h3><div>PPARα-KO hearts from both young and old mice showed significantly reduced Pparα mRNA and a 58–59 % decrease in MCAD protein levels compared to controls. Cardiac PDH flux was similar in young control and PPARα-KO mice but 96 % higher in old PPARα-KO mice. Differences between genotypes were consistent in fed and fasted states, with reduced PDH flux when fasted. Increased PDH flux was accompanied by a 179 % rise in myocardial GLUT4 protein. No differences in PDK 1, 2, or 4 protein levels were observed between fed groups, indicating the increased PDH flux in aged PPARα-KO mice was not due to changes in PDH phosphorylation.</div></div><div><h3>Conclusions</h3><div>Aged PPARα-KO mice demonstrated higher cardiac PDH flux compared to controls, facilitated by increased myocardial GLUT4 protein levels, leading to enhanced glucose uptake and glycolysis.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118599"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AtherosclerosisPub Date : 2024-12-01DOI: 10.1016/j.atherosclerosis.2024.118640
Prof. Nasser Al-Daghri, Dr Kaiser Wani, Dr Balvir Kumar, Dr Shaun Sabico
{"title":"METABOLIC OBESITY PHENOTYPES AND THEIR ASCVD RISK IN ARAB ADULTS","authors":"Prof. Nasser Al-Daghri, Dr Kaiser Wani, Dr Balvir Kumar, Dr Shaun Sabico","doi":"10.1016/j.atherosclerosis.2024.118640","DOIUrl":"10.1016/j.atherosclerosis.2024.118640","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118640"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AtherosclerosisPub Date : 2024-12-01DOI: 10.1016/j.atherosclerosis.2024.118681
Dr. Fahmida Aslam, Dr. Yang Yue, Awais Khan Mr., Dr Muhammad Asadullah Madni, Dr. Naeem Majeed, Dr. Naveed Jafri, Dr. Abdur Rashid, Dr. Zaheer-Ud-Din Babar
{"title":"COMMUNITY ENGAGEMENT STRATEGY: ENHANCING VACCINE COVERAGE FOR CARDIOMETABOLIC DISEASE CONTROL","authors":"Dr. Fahmida Aslam, Dr. Yang Yue, Awais Khan Mr., Dr Muhammad Asadullah Madni, Dr. Naeem Majeed, Dr. Naveed Jafri, Dr. Abdur Rashid, Dr. Zaheer-Ud-Din Babar","doi":"10.1016/j.atherosclerosis.2024.118681","DOIUrl":"10.1016/j.atherosclerosis.2024.118681","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118681"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AtherosclerosisPub Date : 2024-12-01DOI: 10.1016/j.atherosclerosis.2024.118690
Dr. Soha Nabil, Dr. Maha Suleiman Shkokani, Dr. Amal Nashat Naim, Dr. Abeer S. El-Shawady, Dr. Yusra Talal Alnasser, Dr. Abdallah Badr, Dr. Sarah Ibrahim Elsayed, Dr. Mohamed R Ezz, Dr. Mohamed Hamouda Elkasaby, Dr. Asmaa Ahmed Elrashedy, Dr. Amr Khaled Hassan, Dr. Ahmed Bostamy Elsnhory, Dr. Mohamed Ibrahim Gbreel
{"title":"EFFICACY OF SAFFRON/CROCIN FOR TYPE 2 DIABETES AND/OR METABOLIC SYNDROME","authors":"Dr. Soha Nabil, Dr. Maha Suleiman Shkokani, Dr. Amal Nashat Naim, Dr. Abeer S. El-Shawady, Dr. Yusra Talal Alnasser, Dr. Abdallah Badr, Dr. Sarah Ibrahim Elsayed, Dr. Mohamed R Ezz, Dr. Mohamed Hamouda Elkasaby, Dr. Asmaa Ahmed Elrashedy, Dr. Amr Khaled Hassan, Dr. Ahmed Bostamy Elsnhory, Dr. Mohamed Ibrahim Gbreel","doi":"10.1016/j.atherosclerosis.2024.118690","DOIUrl":"10.1016/j.atherosclerosis.2024.118690","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118690"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AtherosclerosisPub Date : 2024-12-01DOI: 10.1016/j.atherosclerosis.2024.119032
{"title":"About the International Atherosclerosis Society and the 20th International Symposium on Atherosclerosis","authors":"","doi":"10.1016/j.atherosclerosis.2024.119032","DOIUrl":"10.1016/j.atherosclerosis.2024.119032","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 119032"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143149398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}