Atherosclerosis最新文献

{"title":"Publication bias in pharmacogenetics of statin-associated muscle symptoms: A meta-epidemiological study","authors":"A. Gougeon ,&nbsp;I. Aribi ,&nbsp;S. Guernouche ,&nbsp;J.C. Lega ,&nbsp;J.M. Wright ,&nbsp;C. Verstuyft ,&nbsp;A. Lajoinie ,&nbsp;F. Gueyffier ,&nbsp;G. Grenet","doi":"10.1016/j.atherosclerosis.2024.118624","DOIUrl":"10.1016/j.atherosclerosis.2024.118624","url":null,"abstract":"<div><h3>Background and aims</h3><div>Statin-associated muscle symptoms (SAMS) are a major cause of treatment discontinuation. Clinical Pharmacogenetics Implementation Consortium (CPIC) recommend dose adjustment for statin treatment according to known SLCO1B1 genotype to reduce SAMS. We hypothesized that the association between SLCO1B1 genotype and SAMS is misestimated because of publication bias.</div></div><div><h3>Methods</h3><div>We searched published systematic reviews on the association between SLCO1B1 genotype and SAMS. To assessed publication bias, we used funnel plot visual inspection, Egger's test, and the Bayes Factor (BF_{Publication-bias}) from Robust Bayesian Meta-Analysis (RoBMA). We compared the odds ratios (OR_Uncorrected) from meta-analyses before and after correcting for publication bias using trim-and-fill (OR_{Trim&amp;Fill}) and RoBMA (OR_RoBMA) methods.</div></div><div><h3>Results</h3><div>We included 8 cohort and 11 case-control studies, totaling 62 OR of three SLCO1B1 genotypes and six statin drugs. In the primary analysis, the funnel plot was suggestive of publication bias, confirmed by Egger's test (<em>p=</em>0.001) and RoBMA (BF_{Publication-bias} = 18). Correcting the estimate for publication bias resulted in loss of the association, from a significant OR_Uncorrected (1.31 95%CI [1.13–1.53]) to corrected ORs suggesting no difference: OR_{Trim&amp;Fill} (1.07 95%CI [0.89–1.30]) and OR_RoBMA (1.02 95%CI [1.00–1.33]). This suggested that publication bias overestimated the association by 18 % and 23 %, respectively. Similar results were found for genotype rs4149056, simvastatin and atorvastatin.</div></div><div><h3>Conclusions</h3><div>The effect of the SLCO1B1 genotype on the risk of developing SAMS is overestimated in the published literature, especially rs4149056. This could lead prescribers to incorrectly decreasing statin doses or even avoiding statin use, leading to a loss of the potential cardiovascular benefit of statins.</div></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"400 ","pages":"Article 118624"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the complex interplay of PPARα and age in cardiac metabolism: Implications for managing age-related cardiac dysfunctions","authors":"Sina Rashedi,&nbsp;Mohammad Keykhaei","doi":"10.1016/j.atherosclerosis.2024.118627","DOIUrl":"10.1016/j.atherosclerosis.2024.118627","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118627"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACCURACY OF MONITORING LIVER FUNCTION TESTS IN PATIENTS RECEIVING STATIN","authors":"Dr. Fatema Alfarsi,&nbsp;Dr. Manal AlKindi,&nbsp;Dr. Fahad Al Zadjali","doi":"10.1016/j.atherosclerosis.2024.118672","DOIUrl":"10.1016/j.atherosclerosis.2024.118672","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118672"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EPIGENETIC MODULATION OF ENDOTHELIAL-TO-MESENCHYMAL TRANSITION IN DIABETES ASSOCIATED ATHEROSCLEROSIS","authors":"Misbah Aziz Ms.,&nbsp;Prof Karin AM Jandeleit-Dahm,&nbsp;Dr Abdul Waheed Khan","doi":"10.1016/j.atherosclerosis.2024.118652","DOIUrl":"10.1016/j.atherosclerosis.2024.118652","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118652"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SHORT-TERM METABOLIC OUTCOMES AFTER LAPAROSCOPIC SLEEVE GASTRECTOMY: A COHORT STUDY","authors":"Dr. Hana Al Sumri,&nbsp;Dr Halah Abdullah,&nbsp;Dr Nawal Al Nabhani,&nbsp;Dr Bader Al Nabhani,&nbsp;Dr Sanaa Al Sumry","doi":"10.1016/j.atherosclerosis.2024.118641","DOIUrl":"10.1016/j.atherosclerosis.2024.118641","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118641"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ELECTRONIC HEALTH READINESS: A KEY TO SUCCESSFUL EHEALTH IMPLEMENTATION","authors":"Rofida Asmally Ms.,&nbsp;Eilaf Yassen,&nbsp;Ibrahim A. Atia,&nbsp;Gaffar Manhal,&nbsp;Mohammed Elhadi Elzein,&nbsp;Mozan Mohamed,&nbsp;Musab Siddig,&nbsp;Raghad Eltayeb,&nbsp;Sara Mohammed,&nbsp;Sujood Elhassan","doi":"10.1016/j.atherosclerosis.2024.118656","DOIUrl":"10.1016/j.atherosclerosis.2024.118656","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118656"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSING OLIVE OIL'S EFFECT ON ELDERLY HEALTH VIA PET IMAGING","authors":"Nada Zoubdane Ms.,&nbsp;redha-alla Abdo Mr,&nbsp;Pr. Michel Nguyen,&nbsp;Pr M'hamed Bentourkia,&nbsp;Pr. Eric E. Turcotte,&nbsp;Pr. Hicham Berrougui,&nbsp;Pr. Tamas Fulop,&nbsp;Pr. Abdelouahed Khalil","doi":"10.1016/j.atherosclerosis.2024.118665","DOIUrl":"10.1016/j.atherosclerosis.2024.118665","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118665"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DOWNREGULATION SIRT1 BY MIR23B TO LIPID ACCUMULATION IN HEPG2 CELLS","authors":"Dr. Mohammad Borji,&nbsp;Dr Mitra Nourbakhsh,&nbsp;Dr Sayed Mohammad Shafiee,&nbsp;Dr Seyyed Shamseddin Athari,&nbsp;Dr Hadi Khodabandehloo","doi":"10.1016/j.atherosclerosis.2024.118700","DOIUrl":"10.1016/j.atherosclerosis.2024.118700","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118700"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AP-1 INHIBITION ATTENUATES FOAM-CELL FORMATION REDUCING ATHEROSCLEROSIS IN TYPE-1-DIABETES","authors":"Misbah Aziz,&nbsp;Dr. Abdul Waheed Khan,&nbsp;Misbah Aziz Ms,&nbsp;Prof. Karin Jandeleit-Dahm","doi":"10.1016/j.atherosclerosis.2024.118636","DOIUrl":"10.1016/j.atherosclerosis.2024.118636","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118636"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143149399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFLUENCE OF LOW GLYCEMIC INDEX DIET ON LIPIDS IN CAD","authors":"Dr. Jamol Uzokov,&nbsp;Dr. Djamshid Payziev,&nbsp;Dr. Bakhromkhon Alyavi","doi":"10.1016/j.atherosclerosis.2024.118638","DOIUrl":"10.1016/j.atherosclerosis.2024.118638","url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"399 ","pages":"Article 118638"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143149401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}